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Review

Long Noncoding and Circular RNAs in Lung Cancer: Advances and Perspectives

, , &
Pages 1275-1287 | Received 06 Apr 2016, Accepted 21 Jun 2016, Published online: 02 Sep 2016

References

  • Jemal A , BrayF , CenterMMet al. Global cancer statistics . CA Cancer. J. Clin.61 ( 2 ), 69 – 90 ( 2011 ).
  • Polanski J , Jankowska-PolanskaB , RosinczukJet al. Quality of life of patients with lung cancer . Onco Targets Ther.9 , 1023 – 1028 ( 2016 ).
  • Reck M , PopatS , ReinmuthNet al. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up . Ann. Oncol.25 ( Suppl. 3 ), iii27 – iii39 ( 2014 ).
  • Fatica A , BozzoniI . Long non-coding RNAs: new players in cell differentiation and development . Nat. Rev. Genet.15 ( 1 ), 7 – 21 ( 2014 ).
  • Skroblin P , MayrM . ‘Going long’: long non-coding RNAs as biomarkers . Circ. Res.115 ( 7 ), 607 – 609 ( 2014 ).
  • Derrien T , JohnsonR , BussottiGet al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression . Genome Res.22 ( 9 ), 1775 – 1789 ( 2012 ).
  • Chen J , WangR , ZhangKet al. Long non-coding RNAs in non-small-cell lung cancer as biomarkers and therapeutic targets . J. Cell. Mol. Med.18 ( 12 ), 2425 – 2436 ( 2014 ).
  • Sang H , LiuH , XiongPet al. Long non-coding RNA functions in lung cancer . Tumour Biol.36 ( 6 ), 4027 – 4037 ( 2015 ).
  • Qu S , YangX , LiXet al. Circular RNA: a new star of noncoding RNAs . Cancer Lett.365 ( 2 ), 141 – 148 ( 2015 ).
  • Zhang Y , YangL , ChenLL . Life without a tail: new formats of long noncoding RNAs . Int. J. Biochem. Cell. Biol.54 , 338 – 349 ( 2014 ).
  • Gupta RA , ShahN , WangKCet al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis . Nature464 ( 7291 ), 1071 – 1076 ( 2010 ).
  • Nakagawa T , EndoH , YokoyamaMet al. Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small-cell lung cancer . Biochem. Biophys. Res. Commun.436 ( 2 ), 319 – 324 ( 2013 ).
  • Liu XH , LiuZL , SunMet al. The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small-cell lung cancer . BMC Cancer13 , 464 ( 2013 ).
  • Liu Z , SunM , LuKet al. The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression . PLoS ONE8 ( 10 ), e77293 ( 2013 ).
  • Ma XY , WangJH , WangJLet al. Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells . BMC Genomics16 , 676 ( 2015 ).
  • Tripathi V , ShenZ , ChakrabortyAet al. Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB . PLoS Genet.9 ( 3 ), e1003368 ( 2013 ).
  • Wei Y , NiuB . Role of MALAT1 as a prognostic factor for survival in various cancers: a systematic review of the literature with meta-analysis . Dis. Markers2015 , 164635 ( 2015 ).
  • Ling H , SpizzoR , AtlasiYet al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer . Genome Res.23 ( 9 ), 1446 – 1461 ( 2013 ).
  • Qiu M , XuY , YangXet al. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small-cell lung cancer . Tumour Biol.35 ( 6 ), 5375 – 5380 ( 2014 ).
  • Ayesh S , MatoukI , SchneiderTet al. Possible physiological role of H19 RNA . Mol. Carcinog.35 ( 2 ), 63 – 74 ( 2002 ).
  • Ariel I , de GrootN , HochbergA . Imprinted H19 gene expression in embryogenesis and human cancer: the oncofetal connection . Am. J. Med. Genet.91 ( 1 ), 46 – 50 ( 2000 ).
  • Thai P , StattS , ChenCHet al. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines . Am. J. Respir. Cell Mol. Biol.49 ( 2 ), 204 – 211 ( 2013 ).
  • Nie FQ , SunM , YangJSet al. Long noncoding RNA ANRIL promotes non-small-cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression . Mol. Cancer Ther.14 ( 1 ), 268 – 277 ( 2015 ).
  • Gao L , MaiA , LiXet al. LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene . Toxicol. Lett.223 ( 2 ), 205 – 210 ( 2013 ).
  • Wang HM , LuJH , ChenWYet al. Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma . Int. J. Clin. Exp. Med.8 ( 7 ), 11824 – 11830 ( 2015 ).
  • Zhang L , ZhouXF , PanGFet al. Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma . Biomed. Pharmacother.68 ( 4 ), 401 – 407 ( 2014 ).
  • Hou Z , ZhaoW , ZhouJet al. A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival . Int. J. Biochem. Cell. Biol.53 , 380 – 388 ( 2014 ).
  • Whiteside EJ , SeimI , PauliJPet al. Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small-cell lung cancer cell lines . Int. J. Oncol.43 ( 2 ), 566 – 574 ( 2013 ).
  • Luo J , TangL , ZhangJet al. Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small-cell lung cancer . Tumor Biol.35 ( 11 ), 11541 – 11549 ( 2014 ).
  • Zhou Y , ZhangX , KlibanskiA . MEG3 noncoding RNA: a tumor suppressor . J. Mol. Endocrinol.48 ( 3 ), R45 – R53 ( 2012 ).
  • Liu J , WanL , LuKet al. The long noncoding RNA MEG3 contributes to cisplatin resistance of human lung adenocarcinoma . PLoS ONE10 ( 5 ), e0114586 ( 2015 ).
  • Lu KH , LiW , LiuXHet al. Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression . BMC Cancer13 , 461 ( 2013 ).
  • Xia Y , HeZ , LiuBet al. Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/beta-catenin signaling pathway . Mol. Med. Rep.12 ( 3 ), 4530 – 4537 ( 2015 ).
  • Tan J , QiuK , LiMet al. Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells . FEBS Lett.589 ( 20 Pt B ), 3175 – 3181 ( 2015 ).
  • Huang MD , ChenWM , QiFZet al. Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2 . Mol. Cancer14 , 165 ( 2015 ).
  • Xu Y , WangJ , QiuMet al. Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma . Tumour Biol.36 ( 3 ), 1643 – 1651 ( 2015 ).
  • Sun M , LiuXH , LuKHet al. EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial–mesenchymal transition . Cell Death Dis.5 , e1298 ( 2014 ).
  • Han L , KongR , YinDDet al. Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC . Med. Oncol.30 ( 4 ), 694 ( 2013 ).
  • Sun M , LiuXH , WangKMet al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small-cell lung cancer and promotes metastasis by affecting epithelial–mesenchymal transition . Mol. Cancer.13 , 68 ( 2014 ).
  • Yang Y , LiH , HouSet al. The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell . PLoS ONE8 ( 5 ), e65309 ( 2013 ).
  • Yang F , HuoXS , YuanSXet al. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis . Mol. Cell49 ( 6 ), 1083 – 1096 ( 2013 ).
  • Shi X , SunM , LiuHet al. A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer . Mol. Carcinog.54 ( Suppl. 1 ), E1 – E12 ( 2015 ).
  • Li W , ZhaiL , WangHet al. Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer . Oncotarget doi:10.18632/oncotarget.8413 ( 2016 ) ( Epub ahead of print ).
  • Rinn JL , KerteszM , WangJKet al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs . Cell129 ( 7 ), 1311 – 1323 ( 2007 ).
  • Hauptman N , GlavacD . Long non-coding RNA in cancer . Int. J. Mol. Sci.14 ( 3 ), 4655 – 4669 ( 2013 ).
  • Tsai MC , ManorO , WanYet al. Long noncoding RNA as modular scaffold of histone modification complexes . Science329 ( 5992 ), 689 – 693 ( 2010 ).
  • Ji P , DiederichsS , WangWet al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small-cell lung cancer . Oncogene22 ( 39 ), 8031 – 8041 ( 2003 ).
  • Luo JH , RenB , KeryanovSet al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas . Hepatology44 ( 4 ), 1012 – 1024 ( 2006 ).
  • Tano K , MizunoR , OkadaTet al. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes . FEBS Lett.584 ( 22 ), 4575 – 4580 ( 2010 ).
  • UCSC Genome Browser . http://genome.ucsc.edu/ .
  • Kondo M , SuzukiH , UedaRet al. Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers . Oncogene10 ( 6 ), 1193 – 1198 ( 1995 ).
  • Kallen AN , ZhouXB , XuJet al. The imprinted H19 lncRNA antagonizes let-7 microRNAs . Mol. Cell52 ( 1 ), 101 – 112 ( 2013 ).
  • Li H , YuB , LiJet al. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer . Oncotarget5 ( 8 ), 2318 – 2329 ( 2014 ).
  • Mondal T , SubhashS , VaidRet al. MEG3 long noncoding RNA regulates the TGF-beta pathway genes through formation of RNA–DNA triplex structures . Nat. Commun.6 , 7743 ( 2015 ).
  • Yang L , LinC , LiuWet al. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs . Cell147 ( 4 ), 773 – 788 ( 2011 ).
  • Zhang EB , YinDD , SunMet al. P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small-cell lung cancer, partly through epigenetically regulating HOXB7 expression . Cell Death Dis.5 , e1243 ( 2014 ).
  • Zhang Q , GengPL , YinPet al. Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis . Asian Pac. J. Cancer Prev.14 ( 4 ), 2311 – 2315 ( 2013 ).
  • White NM , CabanskiCR , Silva-FisherJMet al. Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer . Genome Biol.15 ( 8 ), 429 ( 2014 ).
  • Zhang Y , ZhangXO , ChenTet al. Circular intronic long noncoding RNAs . Mol. Cell51 ( 6 ), 792 – 806 ( 2013 ).
  • Memczak S , JensM , ElefsiniotiAet al. Circular RNAs are a large class of animal RNAs with regulatory potency . Nature495 ( 7441 ), 333 – 338 ( 2013 ).
  • Jeck WR , SorrentinoJA , WangKet al. Circular RNAs are abundant, conserved, and associated with ALU repeats . RNA19 ( 2 ), 141 – 157 ( 2013 ).
  • Hansen TB , JensenTI , ClausenBHet al. Natural RNA circles function as efficient microRNA sponges . Nature495 ( 7441 ), 384 – 388 ( 2013 ).
  • Szabo L , MoreyR , PalpantNJet al. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development . Genome Biol.16 , 126 ( 2015 ).
  • Hansen TB , KjemsJ , DamgaardCK . Circular RNA and miR-7 in cancer . Cancer Res.73 ( 18 ), 5609 – 5612 ( 2013 ).
  • Hansen TB , WiklundED , BramsenJBet al. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA . EMBO J.30 ( 21 ), 4414 – 4422 ( 2011 ).
  • Chou YT , LinHH , LienYCet al. EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF . Cancer Res.70 ( 21 ), 8822 – 8831 ( 2010 ).
  • Cheng AM , ByromMW , SheltonJet al. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis . Nucleic Acids Res.33 ( 4 ), 1290 – 1297 ( 2005 ).
  • Guo JU , AgarwalV , GuoHet al. Expanded identification and characterization of mammalian circular RNAs . Genome Biol.15 ( 7 ), 409 ( 2014 ).
  • Liu YC , LiJR , SunCHet al. CircNet: a database of circular RNAs derived from transcriptome sequencing data . Nucleic Acids Res.44 ( D1 ), D209 – D215 ( 2016 ).
  • Del Vescovo V , GrassoM , BarbareschiMet al. MicroRNAs as lung cancer biomarkers . World J. Clin. Oncol.5 ( 4 ), 604 – 620 ( 2014 ).
  • Yang Y , AhnYH , ChenYet al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism . J. Clin. Invest.124 ( 6 ), 2696 – 2708 ( 2014 ).
  • Glazar P , PapavasileiouP , RajewskyN . circBase: a database for circular RNAs . RNA20 ( 11 ), 1666 – 1670 ( 2014 ).
  • Dudekula DB , PandaAC , GrammatikakisIet al. CircInteractome: a web tool for exploring circular RNAs and their interacting proteins and microRNAs . RNA Biol.13 ( 1 ), 34 – 42 ( 2015 ).
  • Ghosal S , DasS , SenRet al. Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits . Front Genet.4 , 283 ( 2013 ).
  • Soussi T , IshiokaC , ClaustresMet al. Locus-specific mutation databases: pitfalls and good practice based on the p53 experience . Nat. Rev. Cancer6 ( 1 ), 83 – 90 ( 2006 ).
  • Gong WJ , YinJY , LiXPet al. Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response . Tumour Biol.37 ( 6 ), 8349 – 8358 ( 2016 ).
  • Kumar V , WestraHJ , KarjalainenJet al. Human disease-associated genetic variation impacts large intergenic non-coding RNA expression . PLoS Genet.9 ( 1 ), e1003201 ( 2013 ).
  • Popadin K , Gutierrez-ArcelusM , DermitzakisETet al. Genetic and epigenetic regulation of human lincRNA gene expression . Am. J. Hum. Genet.93 ( 6 ), 1015 – 1026 ( 2013 ).
  • Schmidt LH , SpiekerT , KoschmiederSet al. The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small-cell lung cancer and induces migration and tumor growth . J. Thorac. Oncol.6 ( 12 ), 1984 – 1992 ( 2011 ).
  • Weber DG , JohnenG , CasjensSet al. Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small-cell lung cancer . BMC Res. Notes6 , 518 ( 2013 ).
  • Hu X , BaoJ , WangZet al. The plasma lncRNA acting as fingerprint in non-small-cell lung cancer . Tumour Biol.37 ( 3 ), 3497 – 504 ( 2015 ).
  • Zhou M , GuoM , HeDet al. A potential signature of eight long non-coding RNAs predicts survival in patients with non-small-cell lung cancer . J. Transl. Med.13 , 231 ( 2015 ).
  • Jiao F , HuH , HanTet al. Long noncoding RNA MALAT-1 enhances stem cell-like phenotypes in pancreatic cancer cells . Int. J. Mol. Sci.16 ( 4 ), 6677 – 6693 ( 2015 ).
  • Tung MC , LinPL , WangYCet al. Mutant p53 confers chemoresistance in non-small-cell lung cancer by upregulating Nrf2 . Oncotarget6 ( 39 ), 41692 – 41705 ( 2015 ).
  • Cheng N , CaiW , RenSet al. Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small-cell lung cancer . Oncotarget6 ( 27 ), 23582 – 23593 ( 2015 ).
  • Barshack I , Lithwick-YanaiG , AfekAet al. MicroRNA expression differentiates between primary lung tumors and metastases to the lung . Pathol. Res. Pract.206 ( 8 ), 578 – 584 ( 2010 ).
  • Li P , ChenS , ChenHet al. Using circular RNA as a novel type of biomarker in the screening of gastric cancer . Clin. Chim. Acta444 , 132 – 136 ( 2015 ).
  • Li CH , ChenY . Targeting long non-coding RNAs in cancers: progress and prospects . Int. J. Biochem. Cell. Biol.45 ( 8 ), 1895 – 1910 ( 2013 ).
  • Taucher V , ManggeH , HaybaeckJ . Non-coding RNAs in pancreatic cancer: challenges and opportunities for clinical application . Cell. Oncol. (Dordr.). doi:10.1007/s13402-016-0275-7 ( 2016 ) ( Epub ahead of print ).
  • Mamdani H , InduruR , JalalSI . Novel therapies in small-cell lung cancer . Transl. Lung Cancer Res.04 ( 05 ), 533 – 544 ( 2015 ).
  • Smaldone MC , DaviesBJ . BC-819, a plasmid comprising the H19 gene regulatory sequences and diphtheria toxin A, for the potential targeted therapy of cancers . Curr. Opin. Mol. Ther.12 ( 05 ), 607 – 616 ( 2010 ).
  • Hasenpusch G , PfeiferC , AnejaMKet al. Aerosolized BC-819 inhibits primary but not secondary lung cancer growth . PLoS ONE06 ( 06 ), e20760 ( 2011 ).
  • Khalil AM , GuttmanM , HuarteMet al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression . Proc. Natl Acad. Sci. USA106 ( 28 ), 11667 – 11672 ( 2009 ).

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