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Epigenomics Volume 8, 2016 - Issue 11
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Editorial

Putting a Brake on Stress Signaling: miR-625-3p as a Biomarker for Choice of Therapy in Colorectal Cancer

Iben Lyskjær1 Department of Molecular Medicine, Department of Clinical Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200Aarhus, Denmark
,
Mads H Rasmussen1 Department of Molecular Medicine, Department of Clinical Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200Aarhus, Denmark
&
Claus L Andersen1 Department of Molecular Medicine, Department of Clinical Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200Aarhus, DenmarkCorrespondence[email protected]
Pages 1449-1452 | Received 27 Sep 2016, Accepted 27 Sep 2016, Published online: 25 Oct 2016

References

  • Siegel R , DesantisC , JemalA . Colorectal cancer statistics, 2014 . CA Cancer J. Clin.64 ( 2 ), 104 – 117 ( 2014 ).
  • Schmoll HJ , Van CutsemE , SteinAet al. ESMO consensus guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making . Ann. Oncol.23 ( 10 ), 2479 – 2516 ( 2012 ).
  • Hammond WA , SwaikaA , ModyK . Pharmacologic resistance in colorectal cancer: a review . Ther. Adv. Med. Oncol.8 ( 1 ), 57 – 84 ( 2016 ).
  • Misale S , YaegerR , HoborSet al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer . Nature486 ( 7404 ), 532 – 536 ( 2012 ).
  • Rasmussen MH , JensenNF , TarpgaardLSet al. High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer . Mol. Oncol.7 ( 3 ), 637 – 646 ( 2013 ).
  • Bartel DP . MicroRNAs: genomics, biogenesis, mechanism, and function . Cell116 ( 2 ), 281 – 297 ( 2004 ).
  • Thomas J , OhtsukaM , PichlerM , LingH . MicroRNAs: clinical relevance in colorectal cancer . Int. J. Mol. Sci.16 ( 12 ), 28063 – 28076 ( 2015 ).
  • Zheng H , MaR , WangQet al. MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells . Oncotarget6 ( 29 ), 27805 – 27815 ( 2015 ).
  • Rasmussen MH , LyskjaerI , Jersie-ChristensenRRet al. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells . Nat. Commun.7 , 12436 ( 2016 ).
  • Cuadrado A , NebredaAR . Mechanisms and functions of p38 MAPK signalling . Biochem. J.429 ( 3 ), 403 – 417 ( 2010 ).
  • Chen Z , SeimiyaH , NaitoMet al. ASK1 mediates apoptotic cell death induced by genotoxic stress . Oncogene18 ( 1 ), 173 – 180 ( 1999 ).
  • Liu HF , HuHC , ChaoJI . Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells . Chem. Biol. Interact.188 ( 3 ), 535 – 545 ( 2010 ).
  • Santoro V , JiaR , ThompsonHet al. Role of reactive oxygen species in the abrogation of oxaliplatin activity by cetuximab in colorectal cancer . J. Natl. Cancer Inst.108 ( 6 ), djv394 ( 2016 ).
  • Tobiume K , MatsuzawaA , TakahashiTet al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis . EMBO Rep.2 ( 3 ), 222 – 228 ( 2001 ).
  • Ichijo H , NishidaE , IrieKet al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways . Science275 ( 5296 ), 90 – 94 ( 1997 ).
  • Laurent A , NiccoC , ChereauCet al. Controlling tumor growth by modulating endogenous production of reactive oxygen species . Cancer Res.65 ( 3 ), 948 – 956 ( 2005 ).
  • Benhar M , DalyotI , EngelbergD , LevitzkiA . Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress . Mol. Cell. Biol.21 ( 20 ), 6913 – 6926 ( 2001 ).
  • Dahan L , SadokA , FormentoJL , SeitzJF , KovacicH . Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines . Br. J. Pharmacol.158 ( 2 ), 610 – 620 ( 2009 ).
  • Paillas S , BoissiereF , BibeauFet al. Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma . Cancer Res.71 ( 3 ), 1041 – 1049 ( 2011 ).
  • Paillas S , CausseA , MarziLet al. MAPK14/p38alpha confers irinotecan resistance to TP53-defective cells by inducing survival autophagy . Autophagy8 ( 7 ), 1098 – 1112 ( 2012 ).
  • Van Der Ree MH , Van Der MeerAJ , De BruijneJet al. Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients . Antiviral Res.111 , 53 – 59 ( 2014 ).
  • Creemers EE , TijsenAJ , PintoYM . Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?Circ. Res.110 ( 3 ), 483 – 495 ( 2012 ).

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