Advanced search
Publication Cover
Epigenomics Volume 9, 2017 - Issue 5
Submit an article Journal homepage
287
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The SEPT9 gene methylation assay is capable of detecting colorectal adenoma in opportunistic screening

Lele Song1 Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR China;6 BioChain (Beijing) Science & Technology Inc., Beijing, PR ChinaCorrespondence[email protected]
View further author information
,
Xiumei Peng2 Medical School of Chinese PLA & Chinese PLA General Hospital, Beijing, PR China;3 Department of Oncology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, PR ChinaView further author information
,
Yuemin Li1 Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR ChinaView further author information
,
Wenhua Xiao3 Department of Oncology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, PR ChinaView further author information
,
Jia Jia1 Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR China;4 Department of Graduate, Hebei North University, Zhangjiakou, Hebei, PR ChinaView further author information
,
Cheng Dong1 Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR ChinaView further author information
,
Yuan Gong5 Department of Gastroenterology, the Chinese PLA General Hospital, Beijing, PR ChinaView further author information
,
Guangpeng Zhou6 BioChain (Beijing) Science & Technology Inc., Beijing, PR ChinaView further author information
&
Xiaoliang Han6 BioChain (Beijing) Science & Technology Inc., Beijing, PR ChinaView further author information
 show all
Pages 599-610 | Received 20 Oct 2016, Accepted 04 Jan 2017, Published online: 04 May 2017

References

  • American Cancer Society . Cancer Facts & Figures. Atlanta: American Cancer Society ( 2015 ). www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf
  • The American Cancer Society . Colorectal Cancer Facts & Figures 2011–2013. American Cancer Society, GA, USA ( 2011 ). www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-028312.pdf
  • National Cancer Institute . PDQ, Treatment, Health Professionals. Survival Rate for Colorectal Cancer by Stage.National Cancer Institute , MD, USA ( 1999 ).
  • Imperiale TF , RansohoffDF . Risk for colorectal cancer in persons with a family history of adenomatous polyps: a systematic review . Ann. Intern. Med.156 ( 10 ), 703 – 709 ( 2012 ).
  • Stegeman I , de WijkersloothTR , StoopEMet al. Colorectal cancer risk factors in the detection of advanced adenoma and colorectal cancer . Cancer Epidemiol.37 ( 3 ), 278 – 283 ( 2013 ).
  • Benson AB , Bekaii-SaabT , ChanEet al. Localized colon cancer, version 3.2013: featured updates to the NCCN Guidelines . J. Natl Compr. Canc. Netw.11 ( 5 ), 519 – 528 ( 2013 ).
  • Imperiale TF , RansohoffDF , ItzkowitzSHet al. Multitarget stool DNA testing for colorectal-cancer screening . N. Engl. J. Med.370 ( 14 ), 1287 – 1297 ( 2014 ).
  • Church TR , WandellM , Lofton-DayCet al. Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer . Gut63 ( 2 ), 317 – 325 ( 2014 ).
  • Wasserkort R , KalmarA , ValczGet al. Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island . BMC Cancer13 , 398 ( 2013 ).
  • Semaan A , van EllenA , MellerSet al. SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas . Clin. Epigenet.8 , 100 ( 2016 ).
  • Tóth K , GalambO , SpisákSet al. The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer . Pathol. Oncol. Res.17 ( 3 ), 503 – 509 ( 2011 ).
  • Bosman FT , World Health Organization , CarneiroF , International Agency for Research on Cancer , HrubanRH . WHO classification of tumours of the digestive system. Lyon: International Agency for Research on Cancer (2010) . www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/BB2.pdf
  • Potter NT , HurbanP , WhiteMNet al. Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma . Clin. Chem.60 ( 9 ), 1183 – 1191 ( 2014 ).
  • Watanabe T , ItabashiM , ShimadaYet al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer . Int. J. Clin. Oncol.20 ( 2 ), 207 – 239 ( 2015 ).
  • Song L , LiY . SEPT9: a specific circulating biomarker for colorectal cancer . Adv. Clin. Chem.72 , 171 – 204 ( 2015 ).
  • Jin P , KangQ , WangXet al. Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm . J. Gastroenterol. Hepatol.30 ( 5 ), 830 – 833 ( 2015 ).
  • Tóth K , SiposF , KalmárAet al. Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers . PLoS ONE7 ( 9 ), e46000 ( 2012 ).
  • Tóth K , WasserkortR , SiposFet al. Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA . PLoS ONE9 ( 12 ), e115415 ( 2014 ).
  • Wu D , ZhouG , JinPet al. Detection of colorectal cancer using a simplified SEPT9 gene methylation assay is a reliable method for opportunistic screening . J. Mol. Diagn.18 ( 4 ), 535 – 545 ( 2016 ).
  • deVos T , TetznerR , ModelFet al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer . Clin. Chem.55 ( 7 ), 1337 – 1346 ( 2009 ).
  • Tänzer M , BalluffB , DistlerJet al. Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions . PLoS ONE5 ( 2 ), e9061 ( 2010 ).
  • Warren JD , XiongW , BunkerAMet al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer . BMC Med.9 , 133 ( 2011 ).
  • Grützmann R , MolnarB , PilarskyCet al. Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay . PLoS ONE3 ( 11 ), e3759 ( 2008 ).
  • Song L , LiY , JiaJet al. Algorithm optimization in methylation detection with multiple RT-qPCR . PLoS ONE11 ( 11 ), e0163333 ( 2016 ).
  • Soriano-Tárraga C , Jiménez-CondeJ , Giralt-SteinhauerEet al. DNA isolation method is a source of global DNA methylation variability measured with LUMA. Experimental analysis and a systematic review . PLoS ONE8 ( 4 ), e60750 ( 2013 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.