BET Proteins are a Key Component of Immunoglobulin Gene Expression

References

• Kuby Immunology . KindtTJ , GolsbyRA , OsborneBA ( Eds ). WH Freeman and Company , NY, USA ( 2007 ).
   Google Scholar
• Hozumi N , TonegawaS . Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions . Proc. Natl Acad. Sci. USA73 ( 10 ), 3628 – 3632 ( 1976 ).
   PubMed Web of Science ®Google Scholar
• Steiner G , SmolenJ . Autoantibodies in rheumatoid arthritis and their clinical significance . Arthritis Res. Ther.4 ( 2 ), S1 – S5 ( 2002 ).
   Google Scholar
• Sawalha AH , HarleyJB . Antinuclear autoantibodies in systemic lupus erythematosus . Curr. Opin. Rheumatol.16 ( 5 ), 534 – 540 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Szczeklik A , NizankowskaE , SerafinA , DyczekA , DuplagaM , MusialJ . Autoimmune phenomena in bronchial asthma with special reference to aspirin intolerance . Am. J. Respir. Crit. Care Med.152 ( 6 ), 1753 – 1756 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Kirkham PA , CaramoriG , CasolariPet al. Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease . Am. J. Respir. Crit. Care Med.184 ( 7 ), 796 – 802 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Pelletier MR , HatadaEN , ScholzG , ScheidereitC . Efficient transcription of an immunoglobulin κ promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site . Nucleic Acids Res.25 ( 20 ), 3995 – 4003 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Hodson DJ , ShafferAL , XiaoWet al. Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2 . Proc. Natl Acad. Sci. USA113 ( 14 ), E2039 – E2046 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Saez AI , ArtigaMJ , Sanchez-BeatoMet al. Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas . Mod. Pathol.15 ( 3 ), 211 – 220 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Porton B , ZallerDM , LiebersonR , EckhardtLA . Immunoglobulin heavy-chain enhancer is required to maintain transfected gamma 2A gene expression in a pre-B-cell line . Mol. Cell. Biol.10 ( 3 ), 1076 – 1083 ( 1990 ).
   PubMed Web of Science ®Google Scholar
• Inlay MA , LinT , GaoHH , XuY . Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci . J. Exp. Med.203 ( 7 ), 1721 – 1732 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Durham A , ChouPC , KirkhamP , AdcockIM . Epigenetics in asthma and other inflammatory lung diseases . Epigenomics2 ( 4 ), 523 – 537 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Xu CR , FeeneyAJ . The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling . J. Immunol.182 ( 3 ), 1362 – 1369 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Bergman Y , CedarH . A stepwise epigenetic process controls immunoglobulin allelic exclusion . Nat. Rev. Immunol.4 ( 10 ), 753 – 761 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Kondilis-Mangum HD , WadePA . Epigenetics and the adaptive immune response . Mol. Aspects Med.34 ( 4 ), 813 – 825 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Berkovits BD , WolgemuthDJ . The role of the double bromodomain-containing BET genes during mammalian spermatogenesis (Chapter 11) . In : Current Topics in Developmental Biology . PaulMW ( Ed. ). Academic Press , 293 – 326 ( 2013 ).
   Google Scholar
• Jang MK , MochizukiK , ZhouM , JeongHS , BradyJN , OzatoK . The bromodomain protein Brd4 Is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription . Mol. Cell19 ( 4 ), 523 – 534 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Jung M , PhilpottM , MüllerSet al. Affinity Map of BRD4 interactions with the histone H4 tail and the small molecule inhibitor JQ1 . J. Biol. Chem.289 ( 13 ), 9304 – 9319 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Filippakopoulos P , QiJ , PicaudSet al. Selective inhibition of BET bromodomains . Nature468 ( 7327 ), 1067 – 1073 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Donato E , CrociO , SaboAet al. Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors . Leukemia31 ( 2 ), 479 – 490 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Durham AL , MclarenA , HayesBPet al. Regulation of Wnt4 in chronic obstructive pulmonary disease . FASEB J.27 ( 6 ), 2367 – 2381 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Low TB , GreeneCM , O’neillSJ , McelvaneyNG . Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung . Pulm. Med. 2011 , 826160 ( 2011 ).
   PubMedGoogle Scholar
• Pastori C , DanielM , PenasCet al. BET bromodomain proteins are required for glioblastoma cell proliferation . Epigenetics9 ( 4 ), 611 – 620 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Okamura D , MaedaI , TaniguchiHet al. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells . Genes Dev.26 ( 22 ), 2477 – 2482 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Dey A , NishiyamaA , KarpovaT , McnallyJ , OzatoK . Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription . Mol. Biol. Cell20 ( 23 ), 4899 – 4909 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Zhang W , PrakashC , SumCet al. Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells . J. Biol. Chem.287 ( 51 ), 43137 – 43155 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Belkina AC , NikolajczykBS , DenisGV . BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses . J. Immunol.190 ( 7 ), 3670 – 3678 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Tang X , PengR , PhillipsJEet al. Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis . Am. J. Pathol.183 ( 2 ), 470 – 479 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Wienerroither S , RauchI , RosebrockFet al. Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins . Mol. Cell. Biol.34 ( 3 ), 415 – 427 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Sepulveda MA , EmelyanovAV , BirshteinBK . NF-κB and Oct-2 synergize to activate the human 3′ Igh hs4 enhancer in B Cells . J. Immunol.172 ( 2 ), 1054 – 1064 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Zeng L , ZhouMM . Bromodomain: an acetyl-lysine binding domain . FEBS Lett.513 ( 1 ), 124 – 128 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Wu SY , ChiangCM . The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation . J. Biol. Chem.282 ( 18 ), 13141 – 13145 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Rahman S , SowaME , OttingerMet al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3 . Mol. Cell. Biol.31 ( 13 ), 2641 – 2652 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Yang Z , YikJHN , ChenRet al. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4 . Mol. Cell19 ( 4 ), 535 – 545 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Maruyama T , FarinaA , DeyAet al. A mammalian bromodomain protein, Brd4, interacts with replication factor C and inhibits progression to S phase . Mol. Cell. Biol.22 ( 18 ), 6509 – 6520 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Farina A , HattoriM , QinJ , NakataniY , MinatoN , OzatoK . Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating Its activity and subcellular localization . Mol. Cell. Biol.24 ( 20 ), 9059 – 9069 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Huang B , YangXD , ZhouMM , OzatoK , ChenLF . Brd4 coactivates transcriptional activation of NF-κB via specific binding to acetylated RelA . Mol. Cell. Biol.29 ( 5 ), 1375 – 1387 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Wu SY , LeeAY , HouSYet al. Brd4 links chromatin targeting to HPV transcriptional silencing . Genes Dev.20 ( 17 ), 2383 – 2396 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Ahmad I , HoessliDC , Walker-NasirE , RafikSM , ShakooriAR , Nasir-Ud-Din . Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation . Nucleic Acids Res.34 ( 1 ), 175 – 184 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Zwilling S , AnnweilerA , WirthT . The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP . Nucleic Acids Res.22 ( 9 ), 1655 – 1662 ( 1994 ).
   PubMed Web of Science ®Google Scholar
• Deeney JT , BelkinaAC , ShirihaiOS , CorkeyBE , DenisGV . BET bromodomain proteins Brd2, Brd3 and Brd4 selectively regulate metabolic pathways in the pancreatic beta-cell . PLoS ONE11 ( 3 ), e0151329 ( 2016 ).
   PubMed Web of Science ®Google Scholar