114
Views
0
CrossRef citations to date
0
Altmetric
Commentary

The End of The Beginning: Epigenetic Variation In Utero as a Mediator of Later Human Health and Disease

&
Pages 217-221 | Received 06 Jan 2017, Accepted 10 Jan 2017, Published online: 17 Feb 2017

References

  • Haugen AC , SchugTT , CollmanG , HeindelJJ . Evolution of DOHaD: the impact of environmental health sciences . J. Dev. Orig. Health Dis.6 ( 2 ), 55 – 64 ( 2015 ).
  • Yamada L , ChongS . Epigenetic studies in Developmental Origins of Health and Disease: pitfalls and key considerations for study design and interpretation . J. Dev. Orig. Health Dis.8 ( 1 ), 30 – 43 ( 2017 ).
  • Wadhwa PD , BussC , EntringerS , SwansonJM . Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms . Semin. Reprod. Med.27 ( 5 ), 358 – 368 ( 2009 ).
  • Bird A . Perceptions of epigenetics . Nature447 ( 7143 ), 396 – 398 ( 2007 ).
  • Tammen SA , FrisoS , ChoiS-W . Epigenetics: the link between nature and nurture . Mol. Aspects Med.34 ( 4 ), 753 – 764 ( 2013 ).
  • Kraushaar DC , ZhaoK . The epigenomics of embryonic stem cell differentiation . Int. J. Biol. Sci.9 ( 10 ), 1134 – 1144 ( 2013 ).
  • Cortessis VK , ThomasDC , LevineAJet al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships . Hum. Genet.131 ( 10 ), 1565 – 1589 ( 2012 ).
  • Pidsley R , ZotenkoE , PetersTJet al. Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling . Genome Biol.17 , 208 ( 2016 ).
  • McEachern LA . Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena . Genet. Res. Int. 2012 , 689819 ( 2012 ).
  • Michels KB , BinderAM , DedeurwaerderSet al. Recommendations for the design and analysis of epigenome-wide association studies . Nat. Methods10 ( 10 ), 949 – 955 ( 2013 ).
  • Fraga MF , BallestarE , PazMFet al. Epigenetic differences arise during the lifetime of monozygotic twins . Proc. Natl Acad. Sci. USA102 ( 30 ), 10604 – 10609 ( 2005 ).
  • Gordon L , JooJE , PowellJEet al. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence . Genome Res.22 ( 8 ), 1395 – 1406 ( 2012 ).
  • Joubert BR , HabergSE , NilsenRMet al. 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy . Environ. Health Perspect.120 ( 10 ), 1425 – 1431 ( 2012 ).
  • Joubert BR , FelixJF , YousefiPet al. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis . Am. J. Hum. Genet.98 ( 4 ), 680 – 696 ( 2016 ).
  • Mcrae AF , PowellJE , HendersAKet al. Contribution of genetic variation to transgenerational inheritance of DNA methylation . Genome Biol.15 ( 5 ), R73 ( 2014 ).
  • Teh AL , PanH , ChenLet al. The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes . Genome Res.24 ( 7 ), 1064 – 1074 ( 2014 ).
  • Lemire M , ZaidiSHE , BanMet al. Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci . Nat. Commun.6 , 6326 ( 2015 ).
  • Gibbs JR , Van Der BrugMP , HernandezDGet al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain . PLoS Genet.6 ( 5 ), e1000952 ( 2010 ).
  • Gaunt TR , ShihabHA , HemaniGet al. Systematic identification of genetic influences on methylation across the human life course . Genome Biol.17 , 61 ( 2016 ).
  • Mcvicker G , Van De GeijnB , DegnerJFet al. Identification of genetic variants that affect histone modifications in human cells . Science342 ( 6159 ), 747 – 749 ( 2013 ).
  • Kumar V , WestraHJ , KarjalainenJet al. Human disease-associated genetic variation impacts large intergenic non-coding RNA expression . PLoS Genet.9 ( 1 ), e1003201 ( 2013 ).
  • Bouwland-Both MI , Van MilNH , StolkLet al. DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study . PLoS ONE8 ( 12 ), e81731 ( 2013 ).
  • Devlin AM , BrainU , AustinJ , OberlanderTF . Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth . PLoS ONE5 ( 8 ), e12201 – e12201 ( 2010 ).
  • Melas PA , WeiY , WongCCet al. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities . Int. J. Neuropsychopharmacol.16 ( 7 ), 1513 – 1528 ( 2013 ).
  • Murphy SK , AdigunA , HuangZet al. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke . Gene494 ( 1 ), 36 – 43 ( 2012 ).
  • Mansell T , NovakovicB , MeyerBet al. The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood . Transl. Psychiatry6 , e765 ( 2016 ).
  • Adkins RM , ThomasF , TylavskyFA , KrushkalJ . Parental ages and levels of DNA methylation in the newborn are correlated . BMC Med. Genet.12 , 47 ( 2011 ).
  • Bouwland-Both MI , Van MilNH , TolhoekCPet al. Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study . Clin. Epigenetics7 ( 1 ), 83 ( 2015 ).
  • Tobi EW , LumeyLH , TalensRPet al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific . Hum. Mol. Genet.18 ( 21 ), 4046 – 4053 ( 2009 ).
  • Boyd A , GoldingJ , MacleodJet al. Cohort profile: the ‘children of the 90s’ – the index offspring of the Avon Longitudinal Study of Parents and Children . Int. J. Epidemiol.42 ( 1 ), 111 – 127 ( 2013 ).
  • Inskip HM , GodfreyKM , RobinsonSM , LawCM , BarkerDJ , CooperC ; SWS Study Group . Cohort profile: The Southampton Women’s Survey . Int. J. Epidemiol.35 ( 1 ), 42 – 48 ( 2006 ).
  • Magnus P , IrgensLM , HaugKet al. Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa) . Int. J. Epidemiol.35 ( 5 ), 1146 – 1150 ( 2006 ).
  • Kooijman MN , KruithofCJ , van DuijnCMet al. The Generation R Study: design and cohort update 2017 . Eur. J. Epidemiol.31 ( 12 ), 1243 – 1264 ( 2016 ).
  • Soh SE , TintMT , GluckmanPDet al. Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study . Int. J. Epidemiol.43 ( 5 ), 1401 – 1409 ( 2014 ).
  • Vuillermin P , SafferyR , AllenKJet al. Cohort profile: the Barwon Infant Study . Int. J. Epidemiol.44 ( 4 ), 1148 – 1160 ( 2015 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.