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Research Article

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

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Pages 59-69 | Received 30 Jul 2017, Accepted 26 Sep 2017, Published online: 10 Oct 2017

Reference

  • Wen H , LiJ , SongT , LuMet al. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation . J. Biol. Chem.285 ( 13 ), 9322 – 9326 ( 2010 ).
  • Sinha S , SinghRK , AlamNet al. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma . Mol. Cancer7 , 84 ( 2008 ).
  • Ghosh A , GhoshS , MaitiGPet al. Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck . Ann. Surg. Oncol.19 ( Suppl. 3 ), S528 – S538 ( 2012 ).
  • Baba A , OhtakeF , OkunoYet al. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B . Nat. Cell Biol.13 ( 6 ), 668 – 675 ( 2011 ).
  • Okuno Y , OhtakeF , IgarashiKet al. Epigenetic regulation of adipogenesis by PHF2 histone demethylase . Diabetes62 ( 5 ), 1426 – 1434 ( 2013 ).
  • Stender JD , PascualG , LiuWet al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20 . Mol. Cell48 ( 1 ), 28 – 38 ( 2012 ).
  • Lee KH , ParkJW , SungHSet al. PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer . Oncogene34 ( 22 ), 2897 – 2909 ( 2015 ).
  • Pattabiraman DR , BierieB , KoberKIet al. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability . Science351 ( 6277 ), aad3680 ( 2016 ).
  • Cloos PA , ChristensenJ , AggerKet al. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease . Genes Dev.22 ( 9 ), 1115 – 1140 ( 2008 ).
  • D’Oto A , TianQW , DavidoffAMet al. Histone demethylases and their roles in cancer epigenetics . J. Med. Oncol. Ther.1 ( 2 ), 34 – 40 ( 2016 ).
  • Pfister SX , AshworthA . Marked for death: targeting epigenetic changes in cancer . Nat. Rev. Drug Discov.16 ( 4 ), 241 – 263 ( 2017 ).
  • Ntziachristos P , TsirigosA , WelsteadGGet al. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia . Nature514 ( 7523 ), 513 – 517 ( 2014 ).
  • Wang H , SongC , DingYet al. Transcriptional regulation of JARID1B/KDM5B histone demethylase by IKAROS, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia . J. Biol. Chem.291 ( 8 ), 4004 – 4018 ( 2016 ).
  • Ablain J , de TheH . Retinoic acid signaling in cancer: the parable of acute promyelocytic leukemia . Int. J. Cancer135 ( 10 ), 2262 – 2272 ( 2014 ).
  • Wang Q , MaS , SongNet al. Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis . J. Clin. Invest.126 ( 6 ), 2205 – 2220 ( 2016 ).
  • Lee C , KimB , SongBet al. Implication of PHF2 expression in clear cell renal cell carcinoma . J. Pathol. Transl. Med.51 ( 4 ), 359 – 364 ( 2017 ).
  • Churchman ML , MullighanCG . Ikaros: exploiting and targeting the hematopoietic stem cellniche in B-progenitor acute lymphoblastic leukemia . Exp. Hematol.46 , 1 – 8 ( 2017 ).
  • Song C , GowdaC , PanXet al. Targeting casein kinase II restores IKAROS tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia . Blood126 ( 15 ), 1813 – 1822 ( 2015 ).
  • Song C , PanX , GeZet al. Epigenetic regulation of gene expression by IKAROS, HDAC1 and casein kinase II in leukemia . Leukemia30 ( 6 ), 1436 – 1440 ( 2016 ).
  • Ge Z , GuoX , LiJet al. Clinical significance of high c-MYC and low MYCBP2 expression and their association with IKAROS dysfunction in adult acute lymphoblastic leukemia . Oncotarget6 ( 39 ), 42300 – 42311 ( 2015 ).
  • Song C , LiZ , ErbeAKet al. Regulation of IKAROS function by casein kinase 2 and protein phosphatase 1 . World J. Biol. Chem.2 ( 6 ), 126 – 131 ( 2011 ).
  • Ge Z , GuY , HanQet al. Targeting high dynamin-2 (DNM2) expression by restoring IKAROS function in acute lymphoblastic leukemia . Sci. Rep.6 , 38004 ( 2016 ).
  • Guo X , ZhangR , LiuJet al. Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia . PLoS ONE10 , e0125429 ( 2015 ).
  • Campana D , JanossyG , BofillMet al. Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue . J. Immunol.134 ( 3 ), 1524 – 1530 ( 1985 ).
  • Popescu M , GurelZ , RonniTet al. IKAROS stability and pericentromeric localization are regulated by protein phosphatase 1 . J. Biol. Chem.284 ( 20 ), 13869 – 13880 ( 2009 ).
  • Wang H , SongC , GurelZet al. Protein phosphatase 1 (PP1) and casein kinase II (CK2) regulate IKAROS-mediated repression of TdT in thymocytes and T-cell leukemia . Pediatr. Blood Cancer61 ( 12 ), 2230 – 2235 ( 2014 ).
  • Homminga I , VuerhardMJ , LangerakAWet al. Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements . Haematologica97 ( 2 ), 258 – 261 ( 2012 ).
  • Kang H , ChenIM , WilsonCSet al. Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia . Blood115 ( 7 ), 1394 – 1405 ( 2010 ).
  • Harvey RC , MullighanCG , WangXet al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome . Blood116 ( 23 ), 4874 – 4884 ( 2010 ).
  • Hojfeldt JW , AggerK , HelinK . Histone lysine demethylases as targets for anticancer therapy . Nat. Rev. Drug Discov.12 ( 12 ), 917 – 930 ( 2013 ).
  • Zhu N , ChenM , EngRet al. MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C . J. Clin. Invest.126 ( 3 ), 997 – 1011 ( 2016 ).
  • Chen M , ZhuN , LiuXet al. JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors . Genes Dev.29 ( 20 ), 2123 – 2139 ( 2015 ).
  • Jung H , ChaeYC , KimJYet al. Regulatory role of G9a and LSD1 in the transcription of olfactory receptors during leukaemia cell differentiation . Sci. Rep.7 , 46182 ( 2017 ).

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