4,196
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts

, , , , , , , , , , , , , , , , , , , , , , , & show all
Pages 27-42 | Received 03 Aug 2017, Accepted 27 Sep 2017, Published online: 27 Nov 2017

References

  • Jones KL , SmithDW . Recognition of the fetal alcohol syndrome in early infancy . Lancet302 ( 7836 ), 999 – 1001 ( 1973 ).
  • Abel EL . Fetal Alcohol Abuse Syndrome.Springer Science and Business Media , NY, USA ( 1998 ).
  • Sokol RJ , Delaney-BlackV , NordstromB . Fetal alcohol spectrum disorder . JAMA290 ( 22 ), 2996 – 2999 ( 2003 ).
  • Bonthius DJ , GoodlettCR , WestJR . Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration . Alcohol5 ( 3 ), 209 – 214 ( 1988 ).
  • Goodlett CR , HornKH , ZhouFC . Alcohol teratogenesis: mechanisms of damage and strategies for intervention . Exp. Biol. Med. (Maywood)230 ( 6 ), 394 – 406 ( 2005 ).
  • O’Keeffe LM , KearneyPM , McCarthyFPet al. Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies . BMJ Open5 ( 7 ), e006323 ( 2015 ).
  • Henderson J , GrayR , BrocklehurstP . Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome . BJOG An. Int. J. Obstet. Gynaecol.114 ( 3 ), 243 – 252 ( 2007 ).
  • McCarthy FP , O’KeeffeLM , KhashanASet al. Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes . Obstet. Gynecol.122 ( 4 ), 830 – 837 ( 2013 ).
  • Patra J , BakkerR , IrvingH , JaddoeV , MaliniS , RehmJ . Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)-a systematic review and meta-analyses . BJOG An. Int. J. Obstet. Gynaecol.118 ( 12 ), 1411 – 1421 ( 2011 ).
  • O’Keeffe LM , GreeneRA , KearneyPM . The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review . Syst. Rev.3 ( 1 ), 1 ( 2014 ).
  • Gaskins AJ , Rich-EdwardsJW , WilliamsPL , TothTL , MissmerSA , ChavarroJE . Prepregnancy low to moderate alcohol intake is not associated with risk of spontaneous abortion or stillbirth . J. Nutr.146 ( 4 ), 799 – 805 ( 2016 ).
  • Flak AL , SuS , BertrandJ , DennyCH , KesmodelUS , CogswellME . The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis . Alcohol. Clin. Exp. Res.38 ( 1 ), 214 – 226 ( 2014 ).
  • Bay B , KesmodelUS . Prenatal alcohol exposure - a systematic review of the effects on child motor function . Acta Obstet. Gynecol. Scand.90 ( 3 ), 210 – 226 ( 2011 ).
  • Zuccolo L , DeRooLA , WillsAKet al. Pre-conception and prenatal alcohol exposure from mothers and fathers drinking and head circumference: results from the Norwegian Mother-Child Study (MoBa) . Sci. Rep.7 , 39535 ( 2016 ).
  • Mamluk L , EdwardsHB , SavovićJet al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses . BMJ Open7 ( 7 ), e015410 ( 2017 ).
  • Lewis SJ , ZuccoloL , Davey SmithGet al. Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study . PLoS ONE7 ( 11 ), e49407 ( 2012 ).
  • Zuccolo L , LewisSJ , Davey SmithGet al. Prenatal alcohol exposure and offspring cognition and school performance. A ‘Mendelian randomization’ natural experiment . Int. J. Epidemiol.42 ( 5 ), 1358 – 1370 ( 2013 ).
  • Murray J , BurgessS , ZuccoloL , HickmanM , GrayR , LewisSJ . Moderate alcohol drinking in pregnancy increases risk for children’s persistent conduct problems: Causal effects in a Mendelian randomisation study . J. Child Psychol. Psychiatry Allied Discip.57 ( 5 ), 575 – 584 ( 2016 ).
  • Gray R . Low-to-moderate alcohol consumption during pregnancy and child development – moving beyond observational studies . BJOG120 ( 9 ), 1039 – 1041 ( 2013 ).
  • Niclasen J . Drinking or not drinking in pregnancy: the multiplicity of confounding influences . Alcohol Alcohol.49 ( 3 ), 349 – 355 ( 2014 ).
  • Department of Health . UK Chief Medical Officers’ Alcohol Guidelines Review: summary of the proposed new guidelines ( 2016 ). www.gov.uk/government/uploads/system/uploads/attachment_data/file/489795/summary.pdf
  • Joubert BR , FelixJF , YousefiPet al. DNA methylation in newborns and maternal smoking in pregnancy: Genome-wide Consortium meta-analysis . Am. J. Hum. Genet.98 ( 4 ), 680 – 696 ( 2016 ).
  • Richmond RC , SimpkinAJ , WoodwardGet al. Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) . Hum. Mol. Genet.24 ( 8 ), 2201 – 2217 ( 2015 ).
  • Küpers LK , XuX , JankipersadsingSAet al. DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring . Int. J. Epidemiol.44 ( 4 ), 1224 – 1237 ( 2015 ).
  • Halsted CH , MediciV . Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis . Int. J. Hepatol.2012 , 959746 ( 2012 ).
  • Hutson JR , StadeB , LehotayDC , CollierCP , KapurBM . Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure . PLoS ONE7 ( 5 ), e38057 ( 2012 ).
  • Stouder C , SommE , Paoloni-GiacobinoA . Prenatal exposure to ethanol: a specific effect on the H19 gene in sperm . Reprod. Toxicol.31 ( 4 ), 507 – 512 ( 2011 ).
  • Perkins A , LehmannC , LawrenceRC , KellySJ . Alcohol exposure during development: Impact on the epigenome . Int. J. Dev. Neurosci.31 ( 6 ), 391 – 397 ( 2013 ).
  • Laufer BI , Chater-DiehlEJ , KapalangaJ , SinghSM . Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders . Alcohol60 , 67 – 75 ( 2017 ).
  • Khalid O , KimJJ , KimH-Set al. Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells . Stem Cell Res.12 ( 3 ), 791 – 806 ( 2014 ).
  • Portales-Casamar E , LussierAA , JonesMJet al. DNA methylation signature of human fetal alcohol spectrum disorder . Epigenetics Chromatin.9 , 25 ( 2016 ).
  • Liu C , MarioniRE , HedmanAKet al. A DNA methylation biomarker of alcohol consumption . Mol. Psychiatry. doi:10.1038/mp.2016.192 ( 2016 ) ( Epub ahead of print ).
  • Sandoval J , HeynHA , MoranSet al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome . Epigenetics6 ( 6 ), 692 – 702 ( 2011 ).
  • Relton CL , GauntT , McArdleWet al. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES) . Int. J. Epidemiol.44 ( 4 ), 1181 – 1190 ( 2015 ).
  • Boyd A , GoldingJ , MacleodJet al. Cohort Profile: the ‘children of the 90s’ – the index offspring of the Avon Longitudinal Study of Parents and Children . Int. J. Epidemiol.42 ( 1 ), 111 – 127 ( 2013 ).
  • Fraser A , Macdonald-WallisC , TillingKet al. Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort . Int. J. Epidemiol.42 ( 1 ), 97 – 110 ( 2013 ).
  • L’Abee C , SauerPJ , DamenM , RakeJ-P , CatsH , StolkRP . Cohort Profile: the GECKO Drenthe study, overweight programming during early childhood . Int. J. Epidemiol.37 ( 3 ), 486 – 489 ( 2008 ).
  • Kruithof CJ , KooijmanMN , van DuijnCMet al. The Generation R Study: Biobank update 2015 . Eur. J. Epidemiol.29 ( 12 ), 911 – 27 ( 2014 ).
  • Kooijman MN , KruithofCJ , van DuijnCMet al. The Generation R Study: design and cohort update 2017 . Eur. J. Epidemiol.31 ( 12 ), 1243 – 1264 ( 2016 ).
  • Magnus P , IrgensLM , HaugKet al. Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa) . Int. J. Epidemiol.35 ( 5 ), 1146 – 50 ( 2006 ).
  • R⊘nningen KS , PaltielL , MeltzerHMet al. The biobank of the Norwegian Mother and Child Cohort Study: a resource for the next 100 years . Eur. J. Epidemiol.21 ( 8 ), 619 – 25 ( 2006 ).
  • Oken E , BaccarelliAA , GoldDRet al. Cohort profile: project viva . Int. J. Epidemiol.44 ( 1 ), 37 – 48 ( 2015 ).
  • Houseman EA , AccomandoWP , KoestlerDCet al. DNA methylation arrays as surrogate measures of cell mixture distribution . BMC Bioinformatics13 ( 1 ), 86 ( 2012 ).
  • Reinius LE , AcevedoN , JoerinkMet al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility . PLoS ONE7 ( 7 ), e41361 ( 2012 ).
  • Tukey JW . Exploratory data analysis. Addison-Wesley Publishing Company Reading, Mass . Biometric Journal23 ( 4 ), 413 – 414 ( 1981 ).
  • Venables W , RipleyB . Modern Applied Statistics with S . Fourth . Springer , NY, USA ( 2002 ).
  • Willer CJ , LiY , AbecasisGR . METAL: fast and efficient meta-analysis of genomewide association scans . Bioinformatics26 ( 17 ), 2190 – 2191 ( 2010 ).
  • Benjamini Y , HochbergY . Controlling the false discovery rate: a practical and powerful approach to multiple testing . J. R. Stat. Soc. Ser. B.57 ( 1 ), 289 – 300 ( 1995 ).
  • Hansen K . IlluminaHumanMethylation450kanno.ilmn12.hg19: annotation for Illumina’s 450k methylation arrays . Bioconductor doi:10.18129/B9.bioc.IlluminaHumanMethylation450kanno.ilmn12.hg19 ( 2016 ) ( Epub ahead of print ).
  • Viechtbauer W . Conducting meta-analyses in R with the metafor Package . J. Stat. Softw.36 ( 3 ), 1 – 48 ( 2010 ).
  • Naeem H , WongN , ChattertonZet al. Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array . BMC Genomics15 ( 1 ), 51 ( 2014 ).
  • Andrews S , BakulskiK . FlowSorted.CordBlood.450k: Illumina 450k data on sorted cord blood cells . Bioconductor doi:10.18129/B9.bioc.FlowSorted.CordBlood.450k ( 2016 ) ( Epub ahead of print ).
  • Pedersen BS , SchwartzDA , YangIV , KechrisKJ . Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values . Bioinformatics28 ( 22 ), 2986 – 2988 ( 2012 ).
  • Peters TJ , BuckleyMJ , StathamALet al. De novo identification of differentially methylated regions in the human genome . Epigenetics Chromatin8 ( 1 ), 6 ( 2015 ).
  • Complex Disease Epigenetics Group. Blood Brain DNA Methylation Comparison Tool . http://epigenetics.iop.kcl.ac.uk/bloodbrain/
  • Hannon E , LunnonK , SchalkwykL , MillJ . Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes . Epigenetics10 ( 11 ), 1024 – 1032 ( 2015 ).
  • Lokk K , ModhukurV , RajashekarBet al. DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns . Genome Biol.15 ( 4 ), r54 ( 2014 ).
  • Horvath S . DNA methylation age of human tissues and cell types . Genome Biol.14 ( 10 ), R115 ( 2013 ).
  • Fraser HB , LamLL , NeumannSM , KoborMS . Population-specificity of human DNA methylation . Genome Biol.13 ( 2 ), R8 ( 2012 ).
  • Essex MJ , BoyceWT , HertzmanCet al. Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence . Child Dev.84 ( 1 ), 58 – 75 ( 2013 ).
  • Roth TL , LubinFD , FunkAJ , SweattJD . Lasting epigenetic influence of early-life adversity on the bdnf gene . Biol. Psychiatry65 ( 9 ), 760 – 769 ( 2009 ).
  • Birney E , Davey SmithG , GreallyJM . Epigenome-wide association studies and the interpretation of disease -omics . PLoS Genet.12 ( 6 ), e1006105 ( 2016 ).
  • Walton E , HassJ , LiuJet al. Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research . Schizophr. Bull.42 ( 2 ), 406 – 414 ( 2016 ).
  • Relton CL , HartwigFP , Davey SmithG . From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive . Int. J. Epidemiol.44 ( 4 ), 1083 – 1093 ( 2015 ).
  • Gruzieva O , XuC-J , BretonCVet al. Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure . Environ. Health Perspect.125 ( 1 ), 104 – 110 ( 2017 ).
  • Sharp GC , SalasLA , MonnereauCet al. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium . Hum. Mol. Genet.26 ( 20 ), 4067 – 4085 ( 2017 ).
  • Jacobson SW , JacobsonJL , SokolRJ , MartierSS , AgerJW , KaplanMG . Maternal recall of alcohol, cocaine, and marijuana use during pregnancy . Neurotoxicol. Teratol.13 ( 5 ), 535 – 540 ( 1991 ).
  • Jaffe AE , IrizarryRA . Accounting for cellular heterogeneity is critical in epigenome-wide association studies . Genome Biol.15 ( 2 ), R31 ( 2014 ).
  • Cueto HT , RiisAH , HatchEE , WiseLA , RothmanKJ , MikkelsenEM . Predictors of preconceptional folic acid or multivitamin supplement use: a cross-sectional study of Danish pregnancy planners . Clin. Epidemiol.4 , 259 – 265 ( 2012 ).
  • Richmond RC , Al-AminA , Davey SmithG , ReltonCL . Approaches for drawing causal inferences from epidemiological birth cohorts: a review . Early Hum. Dev.90 ( 11 ), 769 – 780 ( 2014 ).
  • Relton CL , Davey SmithG . Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease . Int. J. Epidemiol.41 ( 1 ), 161 – 176 ( 2012 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.