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Epigenomics Volume 10, 2018 - Issue 10
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Research Article

Detection of M6A-associated SNPs as Potential Functional Variants for Coronary Artery Disease

Xing-Bo Mo1 Jiangsu Key Laboratory of Preventive&Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;2 Center for Genetic Epidemiology&Genomics, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;3 Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR ChinaView further author information
,
Shu-Feng Lei1 Jiangsu Key Laboratory of Preventive&Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;2 Center for Genetic Epidemiology&Genomics, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;3 Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR ChinaView further author information
,
Yong-Hong Zhang1 Jiangsu Key Laboratory of Preventive&Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;3 Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR ChinaView further author information
&
Huan Zhang1 Jiangsu Key Laboratory of Preventive&Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR China;3 Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu215123, PR ChinaCorrespondence[email protected]
View further author information
Pages 1279-1287 | Received 11 Jan 2018, Accepted 23 Apr 2018, Published online: 17 Sep 2018

References

  • O’Donnell CJ , NabelEG . Genomics of cardiovascular disease . N. Engl. J. Med.365 ( 22 ), 2098 – 2109 ( 2011 ).
  • McPherson R , Tybjaerg-HansenA . Genetics of coronary artery disease . Circ. Res.118 ( 4 ), 564 – 578 ( 2016 ).
  • Nikpay M , GoelA , WonHHet al. A comprehensive 1000 genomes-based genome-wide association meta-analysis of coronary artery disease . Nat. Genet.47 ( 10 ), 1121 – 1130 ( 2015 ).
  • Schunkert H , KonigIR , KathiresanSet al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease . Nat. Genet.43 ( 4 ), 333 – 338 ( 2011 ).
  • Deloukas P , KanoniS , WillenborgCet al. Large-scale association analysis identifies new risk loci for coronary artery disease . Nat. Genet.45 ( 1 ), 25 – 33 ( 2013 ).
  • Nelson CP , GoelA , ButterworthASet al. Association analyses based on false discovery rate implicate new loci for coronary artery disease . Nat. Genet.49 ( 9 ), 1385 – 1391 ( 2017 ).
  • Webb TR , ErdmannJ , StirrupsKEet al. Systematic evaluation of pleiotropy identifies 6 further Loci associated with coronary artery disease . J. Am. Coll. Cardiol.69 ( 7 ), 823 – 836 ( 2017 ).
  • de Kovel CG , MulderF , van SettenJet al. Exome-wide association analysis of coronary artery disease in the Kingdom of Saudi Arabia population . PLoS ONE11 ( 2 ), e0146502 ( 2016 ).
  • Mao F , XiaoL , LiXet al. RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins . Nucleic Acids Res.44 ( D1 ), D154 – D163 ( 2016 ).
  • Wu X , HurstLD . Determinants of the usage of splice-associated cis-motifs predict the distribution of human pathogenic SNPs . Mol. Biol. Evol.33 ( 2 ), 518 – 529 ( 2016 ).
  • Ramaswami G , DengP , ZhangR , Anna CarboneM , MacKayTF , LiJB . Genetic mapping uncovers cis-regulatory landscape of RNA editing . Nat. Commun.6 , 8194 ( 2015 ).
  • Meyer KD , JaffreySR . The dynamic epitranscriptome: N6-methyladenosine and gene expression control . Nat. Rev. Mol. Cell Biol.15 ( 5 ), 313 – 326 ( 2014 ).
  • Wang X , LuZ , GomezAet al. N6-methyladenosine-dependent regulation of messenger RNA stability . Nature505 ( 7481 ), 117 – 120 ( 2014 ).
  • Edupuganti RR , GeigerS , LindeboomRGHet al. N(6)-methyladenosine (m(6)A) recruits and repels proteins to regulate mRNA homeostasis . Nat. Struct. Mol. Biol.24 ( 10 ), 870 – 878 ( 2017 ).
  • Visvanathan A , SomasundaramK . mRNA traffic control reviewed: N6-Methyladenosine (m(6) A) takes the driver’s seat . Bioessays40 ( 1 ), doi:10.1002/bies.201700093 ( 2018 ).
  • Zheng Y , NieP , PengDet al. m6AVar: a database of functional variants involved in m6A modification . Nucleic Acids Res.46 ( D1 ), D139 – D145 ( 2018 ).
  • Ward LD , KellisM . HaploReg: a resource for exploring chromatin states, conservation and regulatory motif alterations within sets of genetically linked variants . Nucleic Acids Res.40 , D930 – D934 ( 2012 ).
  • Kheradpour P , KellisM . Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments . Nucleic Acids Res.42 ( 5 ), 2976 – 2987 ( 2014 ).
  • Sham PC , PurcellSM . Statistical power and significance testing in large-scale genetic studies . Nat. Rev. Genet.15 ( 5 ), 335 – 346 ( 2014 ).

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