128
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Chronic Lymphocytic Leukemia Patients with Heterogeneously or Fully Methylated LPL Promotor Display Longer Time to Treatment

, , , , , , , , & show all
Pages 1155-1166 | Received 04 Feb 2018, Accepted 09 May 2018, Published online: 05 Sep 2018

References

  • Eichhorst B , RobakT , MontserratEet al. Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up . Ann. Oncol.26 ( Suppl. 5 ), v78 – v84 ( 2015 ).
  • Hallek M , ChesonBD , CatovskyDet al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines . Blood111 ( 12 ), 5446 – 5456 ( 2008 ).
  • Chiorazzi N , RaiKR , FerrariniM . Chronic lymphocytic leukemia . N. Engl. J. Med.352 ( 8 ), 804 – 815 ( 2005 ).
  • Ghia P , FerreriAM , Caligaris-CappioF . Chronic lymphocytic leukemia . Crit. Rev. Oncol. Hematol.64 ( 3 ), 234 – 246 ( 2007 ).
  • Inamdar KV , Bueso-RamosCE . Pathology of chronic lymphocytic leukemia: an update . Ann. Diagn. Pathol.11 ( 5 ), 363 – 389 ( 2007 ).
  • Shanafelt TD , GeyerSM , KayNE . Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL . Blood103 ( 4 ), 1202 – 1210 ( 2004 ).
  • Dighiero G , MaloumK , DesablensBet al. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia . N. Engl. J. Med.338 ( 21 ), 1506 – 1514 ( 1998 ).
  • Cramer P , HallekM . Prognostic factors in chronic lymphocytic leukemia-what do we need to know?Nat. Rev. Clin. Oncol.8 ( 1 ), 38 – 47 ( 2011 ).
  • Wierda WG , O’BrienS , WangXet al. Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia . Blood109 ( 11 ), 4679 – 4685 ( 2007 ).
  • Rossi D , RasiS , SpinaVet al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia . Blood121 ( 8 ), 1403 – 1412 ( 2013 ).
  • Pflug N , BahloJ , ShanafeltTDet al. Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia . Blood124 ( 1 ), 49 – 62 ( 2014 ).
  • International CLL-IPI working group . An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data . Lancet Oncol.17 ( 6 ), 779 – 790 ( 2016 ).
  • Rai KR , SawitskyA , CronkiteEP , ChananaAD , LevyRN , PasternackBS . Clinical staging of chronic lymphocytic leukemia . Blood46 ( 2 ), 219 – 234 ( 1975 ).
  • Binet JL , AuquierA , DighieroGet al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis . Cancer48 ( 1 ), 198 – 206 ( 1981 ).
  • Baliakas P , HadzidimitriouA , SuttonLAet al. Recurrent mutations refine prognosis in chronic lymphocytic leukemia . Leukemia29 ( 2 ), 329 – 336 ( 2015 ).
  • Rosenquist R , CorteseD , BhoiS , MansouriL , GunnarssonR . Prognostic markers and their clinical applicability in chronic lymphocytic leukemia: where do we stand?Leuk. Lymphoma54 ( 11 ), 2351 – 2364 ( 2013 ).
  • Baliakas P , MattssonM , StamatopoulosK , RosenquistR . Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?J. Intern. Med.279 ( 4 ), 347 – 357 ( 2016 ).
  • Schnaiter A , MertensD , StilgenbauerS . Genetics of chronic lymphocytic leukemia . Clin. Lab. Med.31 ( 4 ), 649 – 658 ; ix ( 2011 ).
  • Stilgenbauer S , BullingerL , LichterP , DohnerH , German CLLSGCll . Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course . Leukemia16 ( 6 ), 993 – 1007 ( 2002 ).
  • Fabbri G , Dalla-FaveraR . The molecular pathogenesis of chronic lymphocytic leukaemia . Nat. Rev. Cancer16 ( 3 ), 145 – 162 ( 2016 ).
  • Claus R , LucasDM , RuppertASet al. Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia . Blood124 ( 1 ), 42 – 48 ( 2014 ).
  • Weber M , HellmannI , StadlerMBet al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome . Nat. Genet.39 ( 4 ), 457 – 466 ( 2007 ).
  • Jones PA , BaylinSB . The fundamental role of epigenetic events in cancer . Nat. Rev. Genet.3 ( 6 ), 415 – 428 ( 2002 ).
  • Esteller M . Epigenetics in cancer . N. Engl. J. Med.358 ( 11 ), 1148 – 1159 ( 2008 ).
  • Rodriguez-Paredes M , EstellerM . Cancer epigenetics reaches mainstream oncology . Nat. Med.17 ( 3 ), 330 – 339 ( 2011 ).
  • Jones PA , BaylinSB . The epigenomics of cancer . Cell128 ( 4 ), 683 – 692 ( 2007 ).
  • Eden A , GaudetF , WaghmareA , JaenischR . Chromosomal instability and tumors promoted by DNA hypomethylation . Science300 ( 5618 ), 455 ( 2003 ).
  • Esteller M . Epigenetic gene silencing in cancer: the DNA hypermethylome . Hum. Mol. Genet.16 ( R1 ), R50 – R59 ( 2007 ).
  • Baylin SB , JonesPA . A decade of exploring the cancer epigenome – biological and translational implications . Nat. Rev. Cancer11 ( 10 ), 726 – 734 ( 2011 ).
  • Cahill N , BerghAC , KanduriMet al. 450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments . Leukemia27 ( 1 ), 150 – 158 ( 2013 ).
  • Chim CS , PangR , LiangR . Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia . J. Clin. Pathol.61 ( 11 ), 1214 – 1219 ( 2008 ).
  • Corcoran M , ParkerA , OrchardJet al. ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia . Haematologica90 ( 8 ), 1078 – 1088 ( 2005 ).
  • Guieze R , WuCJ . Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia . Blood126 ( 4 ), 445 – 453 ( 2015 ).
  • Kulis M , HeathS , BibikovaMet al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia . Nat. Genet.44 ( 11 ), 1236 – 1242 ( 2012 ).
  • Queiros AC , VillamorN , ClotGet al. A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact . Leukemia29 ( 3 ), 598 – 605 ( 2015 ).
  • Kristensen LS , WojdaczTK , ThestrupBB , WiufC , HagerH , HansenLL . Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM . BMC Cancer9 , 453 ( 2009 ).
  • Daugaard I , KjeldsenTE , HagerH , HansenLL , WojdaczTK . The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM . Exp. Mol. Pathol.99 ( 3 ), 632 – 640 ( 2015 ).
  • Paziewska A , DabrowskaM , GorycaKet al. DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy . Br. J. Cancer111 ( 4 ), 781 – 789 ( 2014 ).
  • Kristensen L , KristensenT , AbildgaardNet al. High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia . Leuk. Res.39 ( 6 ), 555 – 560 ( 2015 ).
  • Kristensen L , KristensenT , AbildgaardNet al. LPL gene expression is associated with poor prognosis in CLL and closely related to NOTCH1 mutations . Eur. J. Haematol.97 ( 2 ), 175 – 182 ( 2016 ).
  • Heintel D , KienleD , ShehataMet al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia . Leukemia19 ( 7 ), 1216 – 1223 ( 2005 ).
  • van’t Veer MB , BrooijmansAM , LangerakAWet al. The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia . Haematologica91 ( 1 ), 56 – 63 ( 2006 ).
  • Mansouri M , SevovM , FahlgrenEet al. Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity . Leuk. Res.34 ( 3 ), 301 – 306 ( 2010 ).
  • Kaderi MA , KanduriM , BuhlAMet al. LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia . Haematologica96 ( 8 ), 1153 – 1160 ( 2011 ).
  • Moreno P , AbreuC , BorgeMet al. Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment . Leukemia27 ( 3 ), 721 – 725 ( 2013 ).
  • Essakali S , CarneyD , WestermanD , GambellP , SeymourJF , DobrovicA . Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail . BMC Biotechnol.8 , 6 ( 2008 ).
  • Oakes CC , SeifertM , AssenovYet al. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia . Nat. Genet.48 ( 3 ), 253 – 264 ( 2016 ).
  • Wojdacz TK , DobrovicA , HansenLL . Methylation-sensitive high-resolution melting . Nat. Protoc.3 ( 12 ), 1903 – 1908 ( 2008 ).
  • Wojdacz TK , DobrovicA . Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation . Nucleic Acids Res.35 ( 6 ), e41 ( 2007 ).
  • Wojdacz TK , MollerTH , ThestrupBB , KristensenLS , HansenLL . Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies . Expert. Rev. Mol. Diagn.10 ( 5 ), 575 – 580 ( 2010 ).
  • Lim AM , CandiloroIL , WongNet al. Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome . Clin. Epigenet.6 ( 1 ), 22 ( 2014 ).
  • Abreu C , MorenoP , PalaciosFet al. Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia . Leuk. Lymphoma54 ( 8 ), 1844 – 1848 ( 2013 ).
  • Rombout A , VerhasseltB , PhilippeJ . Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications . Eur. J. Haematol.97 ( 5 ), 409 – 415 ( 2016 ).
  • Rozovski U , GrgurevicS , Bueso-RamosCet al. Aberrant LPL expression, driven by STAT3, mediates free fatty acid metabolism in CLL cells . Mol. Cancer Res.13 ( 5 ), 944 – 953 ( 2015 ).
  • Mead JR , IrvineSA , RamjiDP . Lipoprotein lipase: structure, function, regulation, and role in disease . J. Mol. Med. (Berl.)80 ( 12 ), 753 – 769 ( 2002 ).
  • Pallasch CP , SchwambJ , KonigsSet al. Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells . Leukemia22 ( 3 ), 585 – 592 ( 2008 ).
  • Oakes CC , ClausR , GuLet al. Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia . Cancer Discov.4 ( 3 ), 348 – 361 ( 2014 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.