References
- Association AP . Diagnostic and Statistical Manual of Mental Disorders. (Fifth Edition) (DSM-5) . American Psychiatric Publishing , Arlington, VA, USA ( 2013 ).
- Kessler RC , WangPS . The descriptive epidemiology of commonly occurring mental disorders in the United States . Ann. Rev. Public Health29 , 115 – 129 ( 2008 ).
- Koenen KC , RatanatharathornA , NgLet al. Posttraumatic stress disorder in the World Mental Health Surveys . Psychol. Med.47 , 2260 – 2274 ( 2017 ).
- Kessler RC , SonnegaA , BrometE , HughesM , NelsonCB . Posttraumatic stress disorder in the National Comorbidity Survey . Arch. Gen. Psychiatry52 , 1048 – 1060 ( 1995 ).
- Breslau N , KesslerRC , ChilcoatHD , SchultzLR , DavisGC , AndreskiP . Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma . Arch. Gen. Psychiatry55 , 626 – 632 ( 1998 ).
- Benjet C , BrometE , KaramEGet al. The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium . Psychol. Med.46 , 327 – 343 ( 2016 ).
- Bjornsson HT , SigurdssonMI , FallinMDet al. Intra-individual change over time in DNA methylation with familial clustering . JAMA299 , 2877 – 2883 ( 2008 ).
- Matosin N , CruceanuC , BinderEB . Preclinical and clinical evidence of DNA methylation changes in response to trauma and chronic stress . Chronic Stress (Thousand Oaks)1 , 1 – 20 ( 2017 ).
- Ryan J , ChaudieuI , AncelinML , SafferyR . Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics . Epigenomics8 , 1553 – 1569 ( 2016 ).
- Roth TL , ZoladzPR , SweattJD , DiamondDM . Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder . J. Psychiatr. Res.45 , 919 – 926 ( 2011 ).
- Brewin CR , AndrewsB , ValentineJD . Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults . J. Consult. Clin. Psychol.68 , 317 – 336 ( 2000 ).
- Bockmuhl Y , PatchevAV , MadejskaAet al. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress . Epigenetics10 , 247 – 257 ( 2015 ).
- McGowan PO , SasakiA , D’AlessioACet al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse . Nat. Neurosci.12 , 342 – 348 ( 2009 ).
- Wey HY , GilbertTM , ZurcherNRet al. Insights into neuroepigenetics through human histone deacetylase PET imaging . Sci. Transl. Med.8 , 351ra106 ( 2016 ).
- Uddin M , AielloAE , WildmanDEet al. Epigenetic and immune function profiles associated with posttraumatic stress disorder . Proc. Natl Acad. Sci. USA107 , 9470 – 9475 ( 2010 ).
- Smith AK , ConneelyKN , KilaruVet al. Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder . Am. J. Med. Genet. B Neuropsychiatr. Genet.156 , 700 – 708 ( 2011 ).
- Chen Y , LiX , KobayashiI , TsaoD , MellmanTA . Expression and methylation in posttraumatic stress disorder and resilience; evidence of a role for odorant receptors . Psychiatry Res.245 , 36 – 44 ( 2016 ).
- Mehta D , KlengelT , ConneelyKNet al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder . Proc. Natl Acad. Sci. USA110 , 8302 – 8307 ( 2013 ).
- Kuan PF , WaszczukMA , KotovRet al. An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders . Transl. Psychiatry7 , e1158 ( 2017 ).
- Rutten BPF , VermettenE , VinkersCHet al. Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder . Mol. Psychiatry23 , 1145 – 1156 ( 2017 ).
- Gaylord KM , HolcombJB , ZolezziME . A comparison of posttraumatic stress disorder between combat casualties and civilians treated at a military burn center . J. Trauma66 , S191 – S195 ( 2009 ).
- Naifeh JA , NorthTC , DavisJL , ReyesG , LoganCA , ElhaiJD . Clinical profile differences between PTSD-diagnosed military veterans and crime victims . J. Trauma Dissociation9 , 321 – 334 ( 2008 ).
- Reuveni I , BonneO , GiesserRet al. Anatomical and functional connectivity in the default mode network of post-traumatic stress disorder patients after civilian and military-related trauma . Hum. Brain Mapp.37 , 589 – 599 ( 2016 ).
- Fu SS , McFallM , SaxonAJet al. Post-traumatic stress disorder and smoking: a systematic review . Nicotine Tob. Res.9 , 1071 – 1084 ( 2007 ).
- Joehanes R , JustAC , MarioniREet al. Epigenetic signatures of cigarette smoking . Circ. Cardiovasc. Genet.9 , 436 – 447 ( 2016 ).
- Logue MW , AmstadterAB , BakerDGet al. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: posttraumatic stress disorder enters the age of large-scale genomic collaboration . Neuropsychopharmacology40 , 2287 – 2297 ( 2015 ).
- Blanchard EB , Jones-AlexanderJ , BuckleyTC , FornerisCA . Psychometric properties of the PTSD Checklist (PCL) . Behav. Res. Ther.34 , 669 – 673 ( 1996 ).
- Straus MA . Measuring intrafamily conflict and violence: the conflict tactics (CT) scales . J. Marriage Fam.41 , 75 – 88 ( 1979 ).
- Bernstein DP , AhluvaliaT , PoggeD , HandelsmanL . Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population . J. Am. Acad. Child. Adolesc. Psychiatry36 , 340 – 348 ( 1997 ).
- Wyatt GE . The sexual abuse of Afro–American and white-American women in childhood . Child Abuse Negl.9 , 507 – 519 ( 1985 ).
- Binder EB , BradleyRG , LiuWet al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults . JAMA299 , 1291 – 1305 ( 2008 ).
- Weathers FW , MarxBP , FriedmanMJ , SchnurrPP . Posttraumatic stress disorder in DSM-5: new criteria, new measures, and implications for assessment . Psychol. Inj. Law7 , 93 – 107 ( 2014 ).
- Lecrubier Y , SheehanDV , WeillerEet al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI . Eur. Psychiatry12 , 224 – 231 ( 1997 ).
- Sheehan DV , LecrubierY , Harnett SheehanKet al. The validity of the Mini International Neuropsychiatric Interview (MINI) according to the SCID-P and its reliability . Eur. Psychiatry12 , 232 – 241 ( 1997 ).
- Herbert R , MolineJ , SklootGet al. The World Trade Center disaster and the health of workers: 5-year assessment of a unique medical screening program . Environ. Health Perspect.1853 – 1858 ( 2006 ).
- Ratanatharathorn A , BoksMP , MaihoferAXet al. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline . Am. J. Med. Genet. B Neuropsychiatr. Genet.174 ( 6 ), 619 – 630 ( 2017 ).
- Ihaka R , GentlemanR . R: a language for data analysis and graphics . J. Comput. Graphical Stat.5 , 299 – 314 ( 1996 ).
- Barfield RT , KilaruV , SmithAK , ConneelyKN . CpGassoc: an R function for analysis of DNA methylation microarray data . Bioinformatics28 , 1280 – 1281 ( 2012 ).
- Chen Y-a , LemireM , ChoufaniSet al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray . Epigenetics8 , 203 – 209 ( 2013 ).
- Teschendorff AE , MarabitaF , LechnerMet al. A β-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data . Bioinformatics29 , 189 – 196 ( 2013 ).
- Leek JT , JohnsonWE , ParkerHS , JaffeAE , StoreyJD . The sva package for removing batch effects and other unwanted variation in high-throughput experiments . Bioinformatics28 , 882 – 883 ( 2012 ).
- Du P , ZhangX , HuangC-Cet al. Comparison of β-value and M-value methods for quantifying methylation levels by microarray analysis . BMC Bioinformatics11 , 587 ( 2010 ).
- Barfield RT , AlmliLM , KilaruVet al. Accounting for population stratification in DNA methylation studies . Genet. Epidemiol.38 , 231 – 241 ( 2014 ).
- Aryee MJ , JaffeAE , Corrada-BravoHet al. Minfi: a flexible and comprehensive bioconductor package for the analysis of Infinium DNA methylation microarrays . Bioinformatics30 , 1363 – 1369 ( 2014 ).
- Jaffe AE , IrizarryRA . Accounting for cellular heterogeneity is critical in epigenome-wide association studies . Genome Biol.15 , R31 ( 2014 ).
- Smyth G . Limma: Linear Models for Microarray Data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor . GentlemanR , CareyV , DudoitS , IrizarryR , HuberW ( Eds ). Springer , NY, USA ( 2005 ).
- Benjamini Y , HochbergY . Controlling the false discovery rate: a practical and powerful approach to multiple testing . J. R. Stat. Soc. Series B (Methodological)57 , 289 – 300 ( 1995 ).
- Cochran WG . The combination of estimates from different experiments . Biometrics10 , 101 – 129 ( 1954 ).
- Higgins J , ThompsonSG . Quantifying heterogeneity in a meta-analysis . Stat. Med.21 , 1539 – 1558 ( 2002 ).
- Orr M , LiuP . Sample size estimation while controlling false discovery rate for microarray experiments using the size. FDR package . R J.1 , 47 – 53 ( 2009 ).
- Liu P , HwangJT . Quick calculation for sample size while controlling false discovery rate with application to microarray analysis . Bioinformatics23 , 739 – 746 ( 2007 ).
- Logue MW , SmithAK , BaldwinCet al. An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress . Psychoneuroendocrinology57 , 1 – 13 ( 2015 ).
- Wingo AP , AlmliLM , StevensJJet al. DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression . Nat. Commun.6 , 10106 ( 2015 ).
- Pitman RK , RasmussonAM , KoenenKCet al. Biological studies of post-traumatic stress disorder . Nat. Rev. Neurosci.13 , 769 – 787 ( 2012 ).
- GTEx Consortium . Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans . Science348 , 648 – 660 ( 2015 ).
- Zerbino DR , AchuthanP , AkanniWet al. Ensembl 2018 . Nucleic Acids Res.46 , D754 – D761 ( 2018 ).
- National Center for Biotechnology Information (NCBI) . Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information ( 1988 ). www.ncbi.nlm.nih.gov/ .
- Harrison PJ , LawAJ . Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology . Biol. Psychiatry60 , 132 – 140 ( 2006 ).
- Mei L , XiongWC . Neuregulin 1 in neural development, synaptic plasticity and schizophrenia . Nat. Rev. Neurosci.9 , 437 – 452 ( 2008 ).
- Liu X , BatesR , YinDMet al. Specific regulation of NRG1 isoform expression by neuronal activity . J. Neurosci.31 , 8491 – 8501 ( 2011 ).
- Fang SJ , LiPY , WangCMet al. Inhibition of endoplasmic reticulum stress by neuregulin-1 protects against myocardial ischemia/reperfusion injury . Peptides88 , 196 – 207 ( 2017 ).
- Komada M , KitamuraN . Hrs and hbp: possible regulators of endocytosis and exocytosis . Biochem. Biophys. Res. Commun.281 , 1065 – 1069 ( 2001 ).
- Raiborg C , BacheKG , MehlumA , StenmarkH . Function of Hrs in endocytic trafficking and signalling . Biochem. Soc. Trans.29 , 472 – 475 ( 2001 ).
- Mei L , NaveKA . Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases . Neuron83 , 27 – 49 ( 2014 ).
- Taylor SB , TaylorAR , MarkhamJA , GeurtsAM , KanaskieBZ , KoenigJI . Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli . Physiol. Behav.104 , 205 – 214 ( 2011 ).
- Taylor SB , MarkhamJA , TaylorAR , KanaskieBZ , KoenigJI . Sex-specific neuroendocrine and behavioral phenotypes in hypomorphic type II neuregulin 1 rats . Behav. Brain Res.224 , 223 – 232 ( 2011 ).
- Taylor SB , TaylorAR , KoenigJI . The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors . Neuroscience249 , 31 – 42 ( 2013 ).
- Duffy L , CappasE , ScimoneA , SchofieldPR , KarlT . Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1 . Behav. Neurosci.122 , 748 – 759 ( 2008 ).
- Paterson C , WangY , KleinmanJE , LawAJ . Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development . Am. J. Psychiatry171 , 979 – 989 ( 2014 ).
- Mostaid MS , MancusoSG , LiuCet al. Meta-analysis reveals associations between genetic variation in the 5′ and 3′ regions of neuregulin-1 and schizophrenia . Translational Psychiatry7 , e1004 ( 2017 ).
- Edwards AC , BigdeliTB , DochertyARet al. Meta-analysis of positive and negative symptoms reveals schizophrenia modifier genes . Schizophr. Bull.42 , 279 – 287 ( 2016 ).
- Li D , CollierDA , HeL . Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia . Hum. Mol. Genet.15 , 1995 – 2002 ( 2006 ).
- Munafo MR , ThiseltonDL , ClarkTG , FlintJ . Association of the NRG1 gene and schizophrenia: a meta-analysis . Mol. Psychiatry11 , 539 – 546 ( 2006 ).
- Petryshen TL , MiddletonFA , KirbyAet al. Support for involvement of neuregulin 1 in schizophrenia pathophysiology . Mol. Psychiatry10 , 366 – 374328 ( 2005 ).
- Prata DP , BreenG , OsborneS , MunroJ , St ClairD , CollierDA . An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis . Psychiatr. Genet.19 , 113 – 116 ( 2009 ).
- Wen Z , ChenJ , KhanRAet al. Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population . Am. J. Med. Genet. B Neuropsychiatr. Genet.171B , 468 – 478 ( 2016 ).
- Duncan LE , RatanatharathornA , AielloAEet al. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability . Mol. Psychiatry23 ( 3 ), 666 – 673 ( 2017 ).
- Logue MW , SchuM , VardarajanBNet al. Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways . Neurobiol. Aging35 , 1510 e7 – 1510 e18 ( 2014 ).
- Yehuda R , HogeCW , McFarlaneACet al. Post-traumatic stress disorder . Nat. Rev. Dis. Primers1 , 15057 ( 2015 ).
- Hislop JN , von ZastrowM . Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors . Traffic12 , 137 – 148 ( 2011 ).
- von Zastrow M , WilliamsJT . Modulating neuromodulation by receptor membrane traffic in the endocytic pathway . Neuron76 , 22 – 32 ( 2012 ).
- Nagata T , MurataK , MurataRet al. Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells . Biochem. Biophys. Res. Commun.443 , 351 – 356 ( 2014 ).
- Tamai K , TanakaN , NakanoTet al. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein . Biochem. Biophys. Res. Commun.399 , 384 – 390 ( 2010 ).
- Tanaka Y , TanakaN , SaekiYet al. c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130 . Mol. Cell Biol.28 , 4805 – 4818 ( 2008 ).
- Schaefer CF , AnthonyK , KrupaSet al. PID: the Pathway Interaction Database . Nucleic Acids Res.37 , D674 – D679 ( 2009 ).
- Tamai K , ToyoshimaM , TanakaNet al. Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration . Am. J. Pathol.173 , 1806 – 1817 ( 2008 ).
- Lozupone M , SeripaD , StellaEet al. Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry . Expert Rev. Proteomics14 , 809 – 824 ( 2017 ).