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Epigenomics Volume 10, 2018 - Issue 7
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Editorial

Modus Operandi of COMPASS/MLL Epigenetic Writers in the Mammalian Genome

Dashzeveg Bayarsaihan1 Institute for System Genomics & Center for Regenerative Medicine & Skeletal Development, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT06030, USACorrespondence[email protected]
Pages 861-863 | Received 01 May 2018, Accepted 11 May 2018, Published online: 29 Jun 2018

References

  • Sze CC , ShilatifardA . MLL3/MLL4/COMPASS family on epigenetic regulation of enhancer function and cancer . Cold Spring Harb. Perspect. Med.6 ( 11 ), pii: a026427 ( 2016 ).
  • Bayarsaihan D . Deciphering the epigenetic code in embryonic and dental pulp stem cells . Yale J. Biol. Med.89 ( 4 ), 539 – 563 ( 2016 ).
  • Lovén J , HokeHA , LinCYet al. Selective inhibition of tumor oncogenes by disruption of super-enhancers . Cell153 ( 2 ), 320 – 334 ( 2013 ).
  • Rickels R , HuD , CollingsCKet al. An evolutionary conserved epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS . Mol. Cell63 ( 2 ), 318 – 328 ( 2016 ).
  • Rada-Iglesias A , BajpaiR , SwigutT , BrugmannSA , FlynnRA , WysockaJ . A unique chromatin signature uncovers early developmental enhancers in humans . Nature470 ( 7333 ), 279 – 283 ( 2011 ).
  • Lee JE , ParkYK , ParkSet al. Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis . Nat. Commun.8 ( 1 ), 2217 ( 2017 ).
  • Sun J , ZhaoY , McGrealRet al. Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers . Epigenetics Chromatin9 ( 1 ), 37 ( 2016 ).
  • Lin-Shiao E , LanY , CoradinMet al. KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis . Genes Dev.32 ( 2 ), 181 – 193 ( 2018 ).
  • Wang C , LeeJE , LaiBet al. Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition . Proc. Natl Acad. Sci. USA113 ( 42 ), 11871 – 11876 ( 2016 ).
  • Wang SP , TangZ , ChenCWet al. A UTX-MLL4-p300 transcriptional regulatory network coordinately shapes active enhancer landscapes for eliciting transcription . Mol. Cell67 ( 2 ), 308 – 321 ( 2017 ).
  • Lai B , LeeJE , JangY , WangL , PengW , GeK . MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis . Nucleic Acids Res.45 ( 11 ), 6388 – 6403 ( 2017 ).
  • Cao K , CollingsCK , MorganMAet al. An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells . Sci. Adv.4 ( 1 ), eaap8747 ( 2018 ).
  • Yan J , ChenSA , LocalAet al. Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers . Cell Res.28 ( 3 ), 204 – 220 ( 2018 ).
  • Barrington C , FinnR , HadjurS . Cohesin biology meets the loop extrusion model . Chromosome Res.25 ( 1 ), 51 – 60 ( 2017 ).
  • Placek K , HuG , CuiKet al. MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping . Nat. Immunol.18 ( 9 ), 1035 – 1045 ( 2017 ).
  • Hanna CW , TaudtA , HuangJet al. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes . Nat. Struct. Mol. Biol.25 ( 1 ), 73 – 82 ( 2018 ).
  • Jones WD , DafouD , McEntagartMet al. De novo mutations in MLL cause Wiedemann–Steiner syndrome . Am. J. Hum. Genet.91 ( 2 ), 358 – 364 ( 2012 ).
  • Lintas C , PersicoAM . Unraveling molecular pathways shared by Kabuki and Kabuki-like syndromes . Clin. Genet. doi:10.1111/cge.12983 ( 2017 ) ( Epub ahead of print ).
  • Hauser AT , RobaaD , JungM . Epigenetic small molecule modulators of histone and DNA methylation . Curr. Opin. Chem. Biol.45 , 73 – 85 ( 2018 ).

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