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Editorial

Metabolic–Epigenetic Crosstalk in Macrophage Activation: An Updated View

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Pages 719-721 | Received 20 Mar 2019, Accepted 29 Mar 2019, Published online: 31 May 2019

References

  • Baardman J , LichtI , de WintherMP , Vanden Bossche J. Metabolic–epigenetic crosstalk in macrophage activation. Epigenomics7(7), 1155–1164 (2015).
  • Hoeksema MA , GijbelsMJ , Vanden Bossche Jet al. Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol. Med.6(9), 1124–1132 (2014).
  • Van den Bossche J , NeeleAE , HoeksemaMA , de WintherMP. Macrophage polarization: the epigenetic point of view. Curr. Opin. Lipidol.25(5), 367–373 (2014).
  • Rodriguez RM , Suarez-AlvarezB , Lopez-LarreaC. Therapeutic epigenetic reprogramming of trained immunity in myeloid cells. Trends Immunol.40(1), 66–80 (2019).
  • Van den Bossche J , O’NeillLA , MenonD. Macrophage immunometabolism: where are we (going)?Trends Immunol.38(6), 395–406 (2017).
  • Vats D , MukundanL , OdegaardJIet al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab.4(1), 13–24 (2006).
  • Pearce EL , PearceEJ. Metabolic pathways in immune cell activation and quiescence. Immunity38(4), 633–643 (2013).
  • Huang SC , EvertsB , IvanovaYet al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat. Immunol.15(9), 846–855 (2014).
  • Huang SC , SmithAM , EvertsBet al. Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity45(4), 817–830 (2016).
  • Van den Bossche J , BaardmanJ , OttoNAet al. Mitochondrial dysfunction prevents repolarization of inflammatory macrophages. Cell Rep.17(3), 684–696 (2016).
  • Moon JS , NakahiraK , ChungKPet al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat. Med.22(9), 1002–1012 (2016).
  • Divakaruni AS , HsiehWY , MinarrietaLet al. Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis. Cell Metab.28(3), 490–503 (2018).
  • Nomura M , LiuJ , RoviraIIet al. Fatty acid oxidation in macrophage polarization. Nat. Immunol.17(3), 216–217 (2016).
  • Van den Bossche J , Vander Windt GJW. Fatty acid oxidation in macrophages and T cells: time for reassessment?Cell Metab.28(4), 538–540 (2018).
  • Galvan-Pena S , CarrollRG , NewmanCet al. Malonylation of GAPDH is an inflammatory signal in macrophages. Nat Commun.10(1), 338 (2019).
  • O’Neill LAJ , ArtyomovMN. Itaconate: the poster child of metabolic reprogramming in macrophage function. Nat. Rev. Immunol. (Epub ahead of print) (2019).
  • Covarrubias AJ , AksoylarHI , YuJet al. Akt-mTORC1 signaling regulates ACLY to integrate metabolic input to control of macrophage activation. Elife5, pii: e11612 (2016).
  • Namgaladze D , ZukunftS , SchnutgenFet al. Polarization of human macrophages by interleukin-4 does not require ATP-citrate lyase. Front. Immunol.9, 2858 (2018).
  • Liu PS , WangH , LiXet al. Alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat. Immunol.18(9), 985–994 (2017).
  • Arts RJ , NovakovicB , TerHorst Ret al. Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity. Cell Metab.24(6), 807–819 (2016).

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