Epigenetic Protein Complexes: The Adequate Candidates for the Use of a New Generation of Epidrugs in Personalized and Precision Medicine in Cancer

References

• Tabolacci E , ChiurazziP. Epigenetics, fragile X syndrome and transcriptional therapy. Am. J. Med. Genet. A161A(11), 2797–2808 (2013).
   PubMed Web of Science ®Google Scholar
• Post WS , Goldschmidt-ClermontPJ , WilhideCCet al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc. Res.43(4), 985–991 (1999).
   PubMed Web of Science ®Google Scholar
• Arguelles AO , MeruvuS , BowmanJD , ChoudhuryM. Are epigenetic drugs for diabetes and obesity at our door step?Drug Discov. Today21(3), 499–509 (2016).
   PubMed Web of Science ®Google Scholar
• Li J , HaoD , WangLet al. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci. Rep.7(1), 4035 (2017).
   PubMedGoogle Scholar
• Kaminskas E , FarrellAT , WangYC , SridharaR , PazdurR. FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension. Oncologist10(3), 176–182 (2005).
   PubMed Web of Science ®Google Scholar
• Kantarjian H , IssaJP , RosenfeldCSet al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a Phase III randomized study. Cancer106(8), 1794–1803 (2006).
   PubMed Web of Science ®Google Scholar
• Schermelleh L , HaemmerA , SpadaFet al. Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res.35(13), 4301–4312 (2007).
   PubMed Web of Science ®Google Scholar
• Schneider K , FuchsC , DobayAet al. Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling. Nucleic Acids Res.41(9), 4860–4876 (2013).
   PubMed Web of Science ®Google Scholar
• Hervouet E , NadaradjaneA , GueguenM , ValletteFM , CartronPF. Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle. Cell Div.7, 5 (2012).
   PubMed Web of Science ®Google Scholar
• Brenner C , DeplusR , DidelotCet al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J.24(2), 336–346 (2005).
   PubMed Web of Science ®Google Scholar
• Hervouet E , ValletteFM , CartronPF. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics4(7), 487–499 (2009).
   PubMed Web of Science ®Google Scholar
• Blanquart C , LinotC , CartronPF , TomaselliD , MaiA , BertrandP. Epigenetic metalloenzymes. Curr. Med. Chem.26(15), 2748–2785 (2019).
   PubMed Web of Science ®Google Scholar
• Reuter S , GuptaSC , ParkB , GoelA , AggarwalBB. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr.6(2), 93–108 (2011).
   PubMed Web of Science ®Google Scholar
• Billam M , SobolewskiMD , DavidsonNE. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res. Treat.120(3), 581–592 (2010).
   PubMed Web of Science ®Google Scholar
• Kim K , ParkSJ , KimJ-Eet al. First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies. Invest. New Drugs33(5), 1048–1057 (2015).
   PubMed Web of Science ®Google Scholar
• Muller S , FilippakopoulosP , KnappS. Bromodomains as therapeutic targets. Expert Rev. Mol. Med.13, e29 (2011).
   PubMed Web of Science ®Google Scholar
• Amato RJ , StephensonJ , HotteSet al. MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma. Cancer Invest.30(5), 415–421 (2012).
   PubMed Web of Science ®Google Scholar
• Lee BH , YegnasubramanianS , LinX , NelsonWG. Procainamide is a specific inhibitor of DNA methyltransferase 1. J. Biol. Chem.280(49), 40749–40756 (2005).
   PubMed Web of Science ®Google Scholar
• Kuck D , CaulfieldT , LykoF , Medina-FrancoJL. Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol. Cancer Ther.9(11), 3015–3023 (2010).
   PubMed Web of Science ®Google Scholar
• Rajavelu A , TulyashevaZ , JaiswalR , JeltschA , KuhnertN. The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC Biochem.12, 16 (2011).
   PubMed Web of Science ®Google Scholar
• Sun X , XieY , SunXet al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci. Rep.39(3), pii: BSR20181916 (2019).
   Google Scholar
• Joshi P , GrecoTM , GuiseAJet al. The functional interactome landscape of the human histone deacetylase family. Mol. Syst. Biol.9, 672 (2013).
   PubMed Web of Science ®Google Scholar
• Livyatan I , MeshorerE. The HDAC interaction network. Mol. Syst. Biol.9, 671 (2013).
   PubMed Web of Science ®Google Scholar
• Pan F , WeeksO , YangFC , XuM. The TET2 interactors and their links to hematological malignancies. IUBMB Life67(6), 438–445 (2015).
   PubMed Web of Science ®Google Scholar
• Hervouet E , PeixotoP , Delage-MourrouxR , Boyer-GuittautM , CartronPF. Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma. Clin. Epigenetics10, 17 (2018).
   PubMed Web of Science ®Google Scholar
• Hervouet E , ValletteFM , CartronPF. Dnmt1/transcription factor interactions: an alternative mechanism of DNA methylation inheritance. Genes Cancer1(5), 434–443 (2010).
   PubMedGoogle Scholar
• Pacaud R , SeryQ , OliverL , ValletteFM , TostJ , CartronPF. DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1. Biochimie104, 36–49 (2014).
   PubMed Web of Science ®Google Scholar
• Kronfol MM , DozmorovMG , HuangR , SlattumPW , McClayJL. The role of epigenomics in personalized medicine. Expert Rev. Precis. Med. Drug Dev.2(1), 33–45 (2017).
   PubMed Web of Science ®Google Scholar
• Majchrzak-Celińska A , Baer-DubowskaW. Pharmacoepigenetics: an element of personalized therapy?Expert Opin. Drug Metab. Toxicol.13(4), 387–398 (2017).
   PubMed Web of Science ®Google Scholar
• Kabekkodu SP , ChakrabartyS , GhoshS , BrandA , SatyamoorthyK. Epigenomics, pharmacoepigenomics, and personalized medicine in cervical cancer. Public Health Genomics20(2), 100–115 (2017).
   PubMed Web of Science ®Google Scholar
• Díaz-Eufracio BI , NavejaJJ , Medina-FrancoJL. Protein–protein interaction modulators for epigenetic therapies. Adv. Protein Chem. Struct. Biol.110, 65–84 (2018).
   PubMed Web of Science ®Google Scholar
• Kong X , ChenL , JiaoLet al. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2. J. Med. Chem.57(22), 9512–9521 (2014).
   PubMed Web of Science ®Google Scholar
• Ferrari-Amorotti G , FragliassoV , EstekiRet al. Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res.73(1), 235–245 (2013).
   PubMed Web of Science ®Google Scholar
• Kang HJ , YiYW , HouSJet al. Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor. Oncotarget8(48), 83457–83468 (2017).
   PubMedGoogle Scholar
• Harding RJ , Ferreirade Freitas R , CollinsPet al. Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin. J. Med. Chem.60(21), 9090–9096 (2017).
   PubMed Web of Science ®Google Scholar
• Albert L , XuJ , WanR , SrinivasanV , DouY , VázquezO. Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem. Sci.8(6), 4612–4618 (2017).
   PubMed Web of Science ®Google Scholar
• Cheray M , PacaudR , NadaradjaneA , OliverL , ValletteFM , CartronPF. Specific inhibition of DNMT3A/ISGF3γ interaction increases the temozolomide efficiency to reduce tumor growth. Theranostics6(11), 1988–1999 (2016).
   PubMed Web of Science ®Google Scholar
• Cheray M , NadaradjaneA , BonnetP , RoutierS , ValletteFM , CartronPF. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics6(3), 267–275 (2014).
   PubMed Web of Science ®Google Scholar
• Cheray M , PacaudR , NadaradjaneA , ValletteFM , CartronPF. Specific inhibition of one DNMT1-including complex influences tumor initiation and progression. Clin. Epigenetics5(1), 9 (2013).
   PubMedGoogle Scholar
• Chatterjee P , RoyD , RathiN. Epigenetic drug repositioning for Alzheimer’s disease based on epigenetic targets in human interactome. J. Alzheimers Dis.61(1), 53–65 (2018).
   PubMed Web of Science ®Google Scholar