References
- Ballard C , GauthierS , CorbettA , BrayneC , AarslandD , JonesE. Alzheimer’s disease. Lancet377(9770), 1019–1031 (2011).
- Uddin MS , StachowiakA , MamunAAet al. Autophagy and Alzheimer’s disease: from molecular mechanisms to therapeutic implications. Front. Aging. Neurosci.10, 4 (2018).
- Palop JJ , MuckeL. Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat. Neurosci.13(7), 812–818 (2010).
- Selkoe DJ . Alzheimer’s disease. Cold. Spring. Harb. Perspect. Biol.3(7), a004457 (2011).
- Reiman EM , LangbaumJB , FleisherASet al. Alzheimer’s Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J. Alzheimers. Dis.26(Suppl. 3), S321–S329 (2011).
- Gibson GE , ShiQ. A mitocentric view of Alzheimer’s disease suggests multi-faceted treatments. J. Alzheimers. Dis.20(Suppl. 2), S591–S607 (2010).
- Greenberg DS , SoreqH. MicroRNA therapeutics in neurological disease. Curr. Pharm. Des.20(38), 6022–6027 (2014).
- Denk J , BoelmansK , SiegismundC , LassnerD , ArltS , JahnH. MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer’s disease. PLoS ONE10(5), e0126423 (2015).
- Li YY , CuiJG , HillJM , BhattacharjeeS , ZhaoY , LukiwWJ. Increased expression of miRNA-146a in Alzheimer’s disease transgenic mouse models. Neurosci. Lett.487(1), 94–98 (2011).
- Xie W , YangSY , ZhangQet al. Knockdown of MicroRNA-21 promotes neurological recovery after acute spinal cord injury. Neurochem. Res.43(8), 1641–1649 (2018).
- Lv J , ZengY , QianY , DongJ , ZhangZ , ZhangJ. MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation. Brain Res.1685, 91–104 (2018).
- Xie Y , ChenY. microRNAs: emerging targets regulating oxidative stress in the models of Parkinson’s disease. Front. Neurosci.10, 298 (2016).
- Paroni G , SeripaD , FontanaAet al. FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer’s disease. Clin. Interv. Aging9, 1783–1791 (2014).
- Jenwitheesuk A , BoontemP , WongchitratP , TocharusJ , MukdaS , GovitrapongP. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. EXCLI. J.16, 340–353 (2017).
- Song J , KimOY. Perspectives in lipocalin-2: emerging biomarker for medical diagnosis and prognosis for Alzheimer’s disease. Clin. Nutr. Res.7(1), 1–10 (2018).
- Naude PJ , NyakasC , EidenLEet al. Lipocalin 2: novel component of proinflammatory signaling in Alzheimer’s disease. FASEB J.26(7), 2811–2823 (2012).
- Ubhi K , RockensteinE , KraghCet al. Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Eur. J. Neurosci.39(6), 1026–1041 (2014).
- Yang Z , KuboyamaT , TohdaC. A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule. Front. Pharmacol.8, 340 (2017).
- Liu J , XiaoX , ShenYet al. MicroRNA-32 promotes calcification in vascular smooth muscle cells: implications as a novel marker for coronary artery calcification. PLoS ONE12(3), e0174138 (2017).
- Chao CT , LiuYP , SuSFet al. Circulating microRNA-125b predicts the presence and progression of uremic vascular calcification. Arterioscler. Thromb. Vasc. Biol.37(7), 1402–1414 (2017).
- Furukawa T , ShimoyamaS , MikiYet al. Chronic diazepam administration increases the expression of Lcn2 in the CNS. Pharmacol. Res. Perspect.5(1), e00283 (2017).
- Estevez AO , MorganKL , SzewczykNJ , GemsD , EstevezM. The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology41, 28–43 (2014).
- Zhao Y , YangJ , LiaoWet al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell. Biol.12(7), 665–675 (2010).
- Jiang X , NiuX , GuoQet al. FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. Behav. Brain Res.356, 98–106 (2019).
- Guo Y , LiuH , ZhangH , ShangC , SongY. miR-96 regulates FOXO1-mediated cell apoptosis in bladder cancer. Oncol. Lett.4(3), 561–565 (2012).
- Song HM , LuoY , LiDFet al. MicroRNA-96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells. Int. J. Clin. Exp. Pathol.8(9), 9889–9900 (2015).
- Yu JJ , WuYX , ZhaoFJ , XiaSJ. miR-96 promotes cell proliferation and clonogenicity by down-regulating of FOXO1 in prostate cancer cells. Med. Oncol.31(4), 910 (2014).
- Kinoshita C , AoyamaK , MatsumuraN , Kikuchi-UtsumiK , WatabeM , NakakiT. Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels. Nat. Commun.5, 3823 (2014).
- Chen R , QiQL , WangMT , LiQY. Therapeutic potential of naringin: an overview. Pharm. Biol.54(12), 3203–3210 (2016).
- Aggarwal A , GaurV , KumarA. Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. Life Sci.86(25–26), 928–935 (2010).
- Li P , WangS , GuanXet al. Six months chronic toxicological evaluation of naringin in Sprague-Dawley rats. Food. Chem. Toxicol.66, 65–75 (2014).