1,784
Views
0
CrossRef citations to date
0
Altmetric
Short Communication

Repeat UVA Exposure of Human Skin Fibroblasts Induces Both a Transitionary and Recovery DNA Methylation Response

, , , , , , , & show all
Pages 563-573 | Received 03 Sep 2019, Accepted 19 Feb 2020, Published online: 09 Jun 2020

References

  • Singer RS , HamiltonTA , VoorheesJJ , GriffithsCE. Association of asymmetrical facial photodamage with automobile driving. Arch. Dermatol.130(1), 121–123 (1994).
  • Goukassian DA , GilchrestBA. The interdependence of skin aging, skin cancer, and DNA repair capacity: a novel perspective with therapeutic implications. Rejuvenation Res7(3), 175–185 (2004).
  • Rijken F , BruijnzeelPL , Van WeeldenH , KiekensRC. Responses of black and white skin to solar-simulating radiation: differences in DNA photodamage, infiltrating neutrophils, proteolytic enzymes induced, keratinocyte activation, and IL-10 expression. J. Invest. Dermatol.122(6), 1448–1455 (2004).
  • Slominski AT , ZmijewskiMA , PlonkaPM , SzaflarskiJP , PausR. How UV light touches the brain and endocrine system through skin, and why. Endocrinology159(5), 1992–2007 (2018).
  • Svobodova AR , GalandakovaA , SianskaJet al. DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Arch. Dermatol. Res.304(5), 407–412 (2012).
  • Courdavault S , BaudouinC , CharveronM , FavierA , CadetJ , DoukiT. Larger yield of cyclobutane dimers than 8-oxo-7,8-dihydroguanine in the DNA of UVA-irradiated human skin cells. Mutat. Res.556(1–2), 135–142 (2004).
  • Cadet J , MouretS , RavanatJL , DoukiT. Photoinduced damage to cellular DNA: direct and photosensitized reactions. Photochem. Photobiol.88(5), 1048–1065 (2012).
  • Chadwick CA , PottenCS , NikaidoO , MatsunagaT , ProbyC , YoungAR. The detection of cyclobutane thymine dimers, (6–4) photolesions and the Dewar photoisomers in sections of UV-irradiated human skin using specific antibodies, and the demonstration of depth penetration effects. J. Photochem. Photobiol. B.28(2), 163–170 (1995).
  • Tewari A , SarkanyRP , YoungAR. UVA1 induces cyclobutane pyrimidine dimers but not 6–4 photoproducts in human skin in vivo. J. Invest. Dermatol.132(2), 394–400 (2012).
  • Herrmann G , WlaschekM , LangeTS , PrenzelK , GoerzG , Scharffetter-KochanekK. UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts. Exp. Dermatol.2(2), 92–97 (1993).
  • Bredberg A . DNA damage in human skin fibroblasts exposed to UVA light used in clinical PUVA treatment. J. Invest. Dermatol.76(6), 449–451 (1981).
  • Polte T , TyrrellRM. Involvement of lipid peroxidation and organic peroxides in UVA-induced matrix metalloproteinase-1 expression. Free Radic. Biol. Med.36(12), 1566–1574 (2004).
  • Bormann F , Rodriguez-ParedesM , HagemannSet al. Reduced DNA methylation patterning and transcriptional connectivity define human skin aging. Aging Cell15(3), 563–571 (2016).
  • Gronniger E , WeberB , HeilOet al. Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet.6(5), e1000971 (2010).
  • Vandiver AR , IrizarryRA , HansenKDet al. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol.16, 80 (2015).
  • Horvath S , OshimaJ , MartinGMet al. Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies. Aging (Albany NY)10(7), 1758–1775 (2018).
  • Maier AB , LeCessie S , DeKoning-Treurniet C , BlomJ , WestendorpRG , Van HeemstD. Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians. Aging Cell6(1), 27–33 (2007).
  • Bonder MJ , LuijkR , ZhernakovaDVet al. Disease variants alter transcription factor levels and methylation of their binding sites. Nat. Genet.49(1), 131–138 (2017).
  • Van Iterson M , TobiEW , SliekerRCet al. MethylAid: visual and interactive quality control of large Illumina 450 k datasets. Bioinformatics30(23), 3435–3437 (2014).
  • Aryee MJ , JaffeAE , Corrada-BravoHet al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics30(10), 1363–1369 (2014).
  • Morris TJ , BeckS. Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450 k) data. Methods72, 3–8 (2015).
  • Wickham H . Ggplot2: Elegant Graphics for Data AnalysisSpringer, NY, USA (2009).
  • Du P , ZhangX , HuangCCet al. Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics11, 587 (2010).
  • J Wang , QZhao. The CATE Package for High Dimensional Factor Analysis and Confounder Adjusted Multiple Testing. (2015). https://cran.r-project.org/web/packages/cate/vignettes/cate-vignette.pdf
  • Van Iterson M , Van ZwetEW , ConsortiumB , HeijmansBT. Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution. Genome Biol.18(1), 19 (2017).
  • Slieker RC , BosSD , GoemanJJet al. Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450 k array. Epigenetics Chromatin6(1), 26 (2013).
  • Roadmap Epigenomics C , KundajeA , MeulemanWet al. Integrative analysis of 111 reference human epigenomes. Nature518(7539), 317–330 (2015).
  • Kent WJ , SugnetCW , FureyTSet al. The human genome browser at UCSC. Genome Res.12(6), 996–1006 (2002).
  • Szklarczyk D , FranceschiniA , WyderSet al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res.43(Database issue), D447–D452 (2015).
  • Fleischer JG , SchulteR , TsaiHHet al. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biol.19(1), 221 (2018).
  • Slieker RC , ReltonCL , GauntTR , SlagboomPE , HeijmansBT. Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. Epigenetics Chromatin11(1), 25 (2018).
  • Suh Y , AtzmonG , ChoMOet al. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl Acad. Sci. USA105(9), 3438–3442 (2008).
  • Passtoors WM , BeekmanM , DeelenJet al. Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell12(1), 24–31 (2013).
  • Mori R , TanakaK , DeKerckhove Met al. Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. Am. J. Pathol.184(9), 2465–2479 (2014).
  • Slieker RC , Van ItersonM , LuijkRet al. Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biol.17(1), 191 (2016).
  • Rigel EG , LebwohlMG , RigelAC , RigelDS. Ultraviolet radiation in alpine skiing: magnitude of exposure and importance of regular protection. Arch. Dermatol.139(1), 60–62 (2003).