A New Era for Epigenetic Epidemiology

References

• Dor Y , CedarH. Principles of DNA methylation and their implications for biology and medicine. Lancet392(10149), 777–786 (2018).
   PubMed Web of Science ®Google Scholar
• Jablonka E . Epigenetic epidemiology. Int. J. Epidemiol.33(5), 929–935 (2004).
   PubMed Web of Science ®Google Scholar
• Waterland RA , MichelsKB. Epigenetic epidemiology of the developmental origins hypothesis. Annu. Rev. Nutr.27, 363–388 (2007).
   PubMed Web of Science ®Google Scholar
• Viana J , HannonE , DempsterEet al. Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum. Mol. Genet.26(1), 210–225 (2017).
   PubMed Web of Science ®Google Scholar
• Wang L , FuX , PengXet al. DNA Methylation Profiling Reveals Correlation of Differential Methylation Patterns with Gene Expression in Human Epilepsy. J. Mol. Neurosci.59(1), 68–77 (2016).
   PubMed Web of Science ®Google Scholar
• Young JI , SivasankaranSK , WangLet al. Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease. Neurol. Genet.5(4), e342 (2019).
   PubMedGoogle Scholar
• Bibikova M , BarnesB , TsanCet al. High density DNA methylation array with single CpG site resolution. Genomics98(4), 288–295 (2011).
   PubMed Web of Science ®Google Scholar
• Lokk K , ModhukurV , RajashekarBet al. DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biol.15(4), r54 (2014).
   PubMed Web of Science ®Google Scholar
• Pidsley R , ZotenkoE , PetersTJet al. Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol.17(1), 208 (2016).
   PubMed Web of Science ®Google Scholar
• Grundberg E , MeduriE , SandlingJKet al. Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements. Am. J. Hum. Genet.93(5), 876–890 (2013).
   PubMed Web of Science ®Google Scholar
• Hannon E , LunnonK , SchalkwykL , MillJ. Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics10(11), 1024–1032 (2015).
   PubMed Web of Science ®Google Scholar
• Zaimi I , PeiD , KoestlerDCet al. Variation in DNA methylation of human blood over a 1-year period using the Illumina MethylationEPIC array. Epigenetics13(10-11), 1056–1071 (2018).
   PubMed Web of Science ®Google Scholar
• Silver MJ , KesslerNJ , HennigBJet al. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol.16, 118 (2015).
   PubMed Web of Science ®Google Scholar
• Waterland RA , KellermayerR , LaritskyEet al. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet.6(12), e1001252 (2010).
   PubMed Web of Science ®Google Scholar
• Gunasekara CJ , ScottCA , LaritskyEet al. A genomic atlas of systemic interindividual epigenetic variation in humans. Genome Biol.20(1), 105 (2019).
   PubMedGoogle Scholar
• Kessler NJ , WaterlandRA , PrenticeAM , SilverMJ. Establishment of environmentally sensitive DNA methylation states in the very early human embryo. Sci. Adv.4(7), eaat2624 (2018).
   PubMed Web of Science ®Google Scholar
• Rakyan VK , BlewittME , DrukerR , PreisJI , WhitelawE. Metastable epialleles in mammals. Trends Genet.18(7), 348–351 (2002).
   PubMed Web of Science ®Google Scholar
• Liu D , ZhaoL , WangZet al. EWASdb: epigenome-wide association study database. Nucleic Acids Res.47(D1), D989–D993 (2019).
   PubMed Web of Science ®Google Scholar
• Sanchez-Mut JV , HeynH , SilvaBAet al. PM20D1 is a quantitative trait locus associated with Alzheimer’s disease. Nat. Med.24(5), 598–603 (2018).
   PubMed Web of Science ®Google Scholar
• Dall’aglio L , MukaT , CecilCAMet al. The role of epigenetic modifications in neurodevelopmental disorders: A systematic review. Neurosci. Biobehav. Rev.94, 17–30 (2018).
   PubMed Web of Science ®Google Scholar
• Zhu Y , MordauntCE , YasuiDHet al. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Hum. Mol. Genet.28(16), 2659–2674 (2019).
   PubMed Web of Science ®Google Scholar
• Yang Y , WuL , ShuXOet al. Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent. J. Natl Cancer Inst. doi:10.1093/jnci/djz109 (2019).
   Google Scholar
• Gonseth S , ShawGM , RoyRet al. Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk. Epigenetics14(2), 198–213 (2019).
   PubMed Web of Science ®Google Scholar
• Kuhnen P , HandkeD , WaterlandRAet al. Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity. Cell Metab.24(3), 502–509 (2016).
   PubMed Web of Science ®Google Scholar
• Mok A , RheadB , HolingueCet al. Hypomethylation of CYP2E1 and DUSP22 promoters associated with disease activity and erosive disease among rheumatoid arthritispatients. Arthritis Rheumatol.70(4), 528–536 (2018).
   PubMed Web of Science ®Google Scholar
• Boks MP , HoutepenLC , XuZet al. Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation betweenin utero famine exposure and schizophrenia. NPJ Schizophr.4(1), 16 (2018).
   PubMedGoogle Scholar
• Van Baak TE , CoarfaC , DuguePAet al. Epigenetic supersimilarity of monozygotic twin pairs. Genome Biol.19(1), 2 (2018).
   PubMedGoogle Scholar
• Van Dijk SJ , PetersTJ , BuckleyMet al. DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood. Int. J. Obes. (Lond.)42(1), 28–35 (2018).
   PubMed Web of Science ®Google Scholar
• Dominguez-Salas P , MooreSE , BakerMSet al. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat. Commun.5, 3746 (2014).
   PubMed Web of Science ®Google Scholar
• Estill MS , BolnickJM , WaterlandRA , BolnickAD , DiamondMP , KrawetzSA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil. Steril.106(3), 629–639 (2016).
   PubMed Web of Science ®Google Scholar
• Waterland RA , GarzaC. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am. J. Clin. Nutr.69(2), 179–197 (1999).
   PubMed Web of Science ®Google Scholar