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Research Article

CACNA1C Methylation: Association with Cortisol, Perceived Stress, rs1006737 and Childhood Trauma in Males

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Pages 1739-1749 | Received 24 Jan 2020, Accepted 13 Aug 2020, Published online: 10 Nov 2020

References

  • Schizophrenia Working Group of the Psychiatric Genomics C . Biological insights from 108 schizophrenia-associated genetic loci. Nature511(7510), 421–427 (2014).
  • Stefansson H , OphoffRA , SteinbergSet al. Common variants conferring risk of schizophrenia. Nature460(7256), 744–747 (2009).
  • Cross-Disorder Group of the Psychiatric Genomics C . Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet381(9875), 1371–1379 (2013).
  • Moon AL , HaanN , WilkinsonLS , ThomasKL , HallJ. CACNA1C: association with psychiatric disorders, behavior, and neurogenesis. Schizophr. Bull.44(5), 958–965 (2018).
  • Rao S , YaoY , ZhengCet al. Common variants in CACNA1C and MDD susceptibility: a comprehensive meta-analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet.171(6), 896–903 (2016).
  • Li J , ZhaoL , YouYet al. Schizophrenia related variants in CACNA1C also confer risk of autism. PLoS ONE10(7), e0133247 (2015).
  • Krzyzewska IM , EnsinkJBM , NawijnLet al. Genetic variant in CACNA1C is associated with PTSD in traumatized police officers. Eur. J. Hum. Genet.26(2), 247–257 (2018).
  • Striessnig J , PinggeraA , KaurG , BockG , TulucP. L-type Ca(2+) channels in heart and brain. Wiley Interdiscip. Rev. Membr. Transp. Signal.3(2), 15–38 (2014).
  • Bhat S , DaoDT , TerrillionCEet al. CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog. Neurobiol.99(1), 1–14 (2012).
  • Karst H , NairS , VelzingEet al. Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neurons. Eur. J. Neurosci.16(6), 1083–1089 (2002).
  • Kerr DS , CampbellLW , ThibaultO , LandfieldPW. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Proc. Natl Acad. Sci. USA89(18), 8527–8531 (1992).
  • Qin Y , KarstH , JoelsM. Chronic unpredictable stress alters gene expression in rat single dentate granule cells. J. Neurochem.89(2), 364–374 (2004).
  • Van Gemert NG , JoelsM. Effect of chronic stress and mifepristone treatment on voltage-dependent Ca2+ currents in rat hippocampal dentate gyrus. J. Neuroendocrinol.18(10), 732–741 (2006).
  • Preston GA , WeinbergerDR. Intermediate phenotypes in schizophrenia: a selective review. Dialogues Clin. Neurosci.7(2), 165–179 (2005).
  • Maigaard K , HagemanI , JorgensenA , JorgensenMB , WortweinG. Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala. Neurosci. Lett.516(1), 24–28 (2012).
  • Lee AS , RaS , RajadhyakshaAMet al. Forebrain elimination of cacna1c mediates anxiety-like behavior in mice. Mol. Psychiatry17(11), 1054–1055 (2012).
  • Dedic N , PohlmannML , RichterJSet al. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Mol. Psychiatry23(3), 533–543 (2018).
  • Bigos KL , MattayVS , CallicottJHet al. Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch. Gen. Psychiatry67(9), 939–945 (2010).
  • Eckart N , SongQ , YangRet al. Functional characterization of schizophrenia-associated variation in CACNA1C. PLoS ONE11(6), e0157086 (2016).
  • Krug A , NieratschkerV , MarkovVet al. Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals. Neuroimage49(2), 1831–1836 (2010).
  • Roussos P , GiakoumakiSG , GeorgakopoulosA , RobakisNK , BitsiosP. The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disord.13(3), 250–259 (2011).
  • Klaus K , ButlerK , GutierrezH , DurrantSJ , PenningtonK. Interactive effects of early life stress and CACNA1C genotype on cortisol awakening response. Biol. Psychol.136, 22–28 (2018).
  • Butler K , KlausK , EdwardsL , PenningtonK. Elevated cortisol awakening response associated with early life stress and impaired executive function in healthy adult males. Horm. Behav.95, 13–21 (2017).
  • Pennebaker JW , SusmanJR. Disclosure of traumas and psychosomatic processes. Soc. Sci. Med.26(3), 327–332 (1988).
  • Zigmond AS , SnaithRP. The hospital anxiety and depression scale. Acta Psychiatr. Scand.67(6), 361–370 (1983).
  • Cohen S , KamarckT , MermelsteinR. A global measure of perceived stress. J. Health Soc. Behav.24(4), 385–396 (1983).
  • Kim YJ , ParkHJ , JahngGHet al. A pilot study of differential brain activation to suicidal means and DNA methylation of CACNA1C gene in suicidal attempt patients. Psychiatry Res.255, 42–48 (2017).
  • Kantojärvi K , LiuhanenJ , Saarenpää-HeikkiläOet al. Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants.. PLoS ONE12(8), e0180652 (2017).
  • Bali A , GuptaS , SinghN , JaggiAS. Implicating the role of plasma membrane localized calcium channels and exchangers in stress-induced deleterious effects. Eur. J. Pharmacol.714(1-3), 229–238 (2013).
  • Rusconi F , BattaglioliE. Acute stress-induced epigenetic modulations and their potential protective role toward depression. Front. Mol. Neurosci.11, 184 (2018).
  • Bishop JR , LeeAM , MillsLJet al. Methylation of FKBP5 and SLC6A4 in relation to treatment response to mindfulness based stress reduction for posttraumatic stress disorder. Front. Psychiatry9, 418 (2018).
  • Chrousos GP , KinoT. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci. STKE2005(304), pe48 (2005).
  • Klengel T , MehtaD , AnackerCet al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci.16(1), 33–41 (2013).
  • Li HM , ChenD. [Analysis of transcriptional regulatory sites in introns of human and mouse ribosomal protein genes]. Yi Chuan34(12), 1577–1582 (2012).
  • Shaul O . How introns enhance gene expression. Int. J. Biochem. Cell Biol.91(Pt B), 145–155 (2017).
  • Anastasiadi D , Esteve-CodinaA , PiferrerF. Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species. Epigenetics Chromatin11(1), 37 (2018).
  • Starnawska A , DemontisD , PenAet al. CACNA1C hypermethylation is associated with bipolar disorder. Transl. Psychiatry6(6), e831 (2016).
  • Clark MB , WrzesinskiT , GarciaABet al. Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain. Mol. Psychiatry doi:10.1038/s41380-019-0583-1 (2019) ( Epub ahead of print).
  • Backes H , DietscheB , NagelsAet al. Genetic variation in CACNA1C affects neural processing in major depression. J. Psychiatr. Res.53, 38–46 (2014).
  • Gurung R , PrataDP. What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review. Psychol. Med.45(12), 2461–2480 (2015).
  • Gershon ES , GrennanK , BusnelloJet al. A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain. Mol. Psychiatry19(8), 890–894 (2014).
  • Yoshimizu T , PanJQ , MungenastAEet al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol. Psychiatry20(2), 162–169 (2015).
  • Stalder T , KirschbaumC , KudielkaBMet al. Assessment of the cortisol awakening response: expert consensus guidelines. Psychoneuroendocrinology63, 414–432 (2016).
  • Wöhr M , WilladsenM , KiskoTM , SchwartingRKW , FendtM. Sex-dependent effects of Cacna1c haploinsufficiency on behavioral inhibition evoked by conspecific alarm signals in rats. Science Direct99, 109849 (2020).
  • Koch A , DeMeyer T , JeschkeJ , Van CriekingeW. MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data. BMC Genomics16, 636 (2015).

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