72
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Epigenetic fragility of the endocannabinoid system under stress: risk for mood disorders and pharmacogenomic implications

, &
Pages 657-660 | Received 28 Jan 2020, Accepted 19 Feb 2020, Published online: 12 May 2020

References

  • Goldstein Ferber S , TrezzaV , WellerA Early life stress and development of the endocannabinoid system: a bidirectional process in programming future coping. Dev. Psychobiol. doi:10.1002/dev.21944 (2019).
  • Basavarajappa B , NixonR , ArancioO. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Rev. Med. Chem.9(4), 448–462 (2009).
  • Monory K , LutzB. The endocannabinoid system as a therapeutic target in epilepsy. In: Cannabinoids and the Brain.Springer, USA, 407–422 (2008).
  • Yadid G , FriedmanA. Dynamics of the dopaminergic system as a key component to the understanding of depression. Prog. Brain Res.172, 265–286 (2008).
  • Ashton CH , MoorePB. Endocannabinoid system dysfunction in mood and related disorders. Acta. Psychiatr. Scand.124(4), 250–261 (2011).
  • Hoehe MR , CaenazzoL , MartinezMMet al. Genetic and physical mapping of the human cannabinoid receptor gene tochromosome 6q14-q15. New Biol!.3, 880–885 (1991).
  • Hillard CJ , WeinlanderKM , StuhrKL. Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience204, 207–229 (2012).
  • Carnevali L , StatelloR , VacondioFet al. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. Eur. Neuropsychopharmacol.32, 77–87 (2020).
  • Conradt E , AdkinsDE , CrowellSE , RabyKL , DiamondLM , EllisB. Incorporating epigenetic mechanisms to advance fetal programming theories. Dev. Psychopathol.30(3), 807–824 (2018).
  • Wirz L , ReuterM , FeltenA , SchwabeL. An endocannabinoid receptor polymorphism modulates affective processing under stress. Soc. Cogn. Affect. Neurosci.13, 1177–1189 (2018).
  • Conzelmann A , ReifA , JacobCet al. A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity. Psychopharmacology (Berl).224(4), 573–579 (2012).
  • Ruehle S , ReyAA , RemmersF , LutzB. The endocannabinoid system in anxiety, fear memory and habituation. J. Psychopharmacol.26(1), 23–39 (2012).
  • Lazary J Eszlari N Juhasz G Bagdy G .Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma. Eur. Neuropsychopharmacol.26(6), 1020–1028 (2016).
  • Morena M , PatelS , BainsJS , HillMN. Neurobiological interactions between stress and the endocannabinoid system. Neuropsychopharmacology41(1), 80–102 (2016).
  • Hill MN , PatelS. Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses. Biol. Mood Anxiety Disord.3(1), 19 (2013).
  • Mota N , SumnerJA , LoweSRet al. The rs1049353 polymorphism in the CNR1 gene interacts with childhood abuse to predict posttraumatic threat symptoms. J. Clin. Psychiatry76(12), e1622–e1623 (2015).
  • Doherty TS , RothTL. Epigenetic landscapes of the adversity-exposed brain. In: Prog. Mol. Biol. Transl. Sci.Elsevier B.V., 1–19 (2018).
  • Franklin TB , RussigH , WeissICet al. Epigenetic transmission of the impact of early stress across generations. Biol. Psychiatry68(5), 408–415 (2010).
  • Domschke K , DannlowskiU , OhrmannPet al. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. Eur. Neuropsychopharmacol.18(10), 751–759 (2008).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.