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Research Article

Differential Expression of DNA Methyltransferases and Demethylases among the Various Testicular Germ Cell Tumor Subtypes

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Pages 1579-1592 | Received 17 Feb 2020, Accepted 03 May 2020, Published online: 22 Sep 2020

References

  • Lobo J , GillisAJM , JeronimoC , HenriqueR , LooijengaLHJ. Human germ cell tumors are developmental cancers: impact of epigenetics on pathobiology and clinic. Int. J. Mol. Sci.20(2), 258 (2019).
  • Oosterhuis JW , LooijengaLHJ. Human germ cell tumours from a developmental perspective. Nat. Rev. Cancer19(9), 522–537 (2019).
  • Oosterhuis JW , LooijengaLH. Testicular germ-cell tumours in a broader perspective. Nat. Rev. Cancer5(3), 210–222 (2005).
  • Cheng L , AlbersP , BerneyDMet al. Testicular cancer. Nat Rev Dis Primers4(1), 29 (2018).
  • Rajpert-De Meyts E , McglynnKA , OkamotoK , JewettMA , BokemeyerC. Testicular germ cell tumours. Lancet387(10029), 1762–1774 (2016).
  • Bray F , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. doi:10.3322/caac.21492 (2018).
  • Trabert B , ChenJ , DevesaSS , BrayF , McglynnKA. International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973–2007. Andrology3(1), 4–12 (2015).
  • Lobo J , CostaAL , Vilela-SalgueiroBet al. Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists. Hum. Pathol.82, 113–124 (2018).
  • Moch H , HumphreyP , UlbrightT , ReuterV. WHO Classification of Tumours of the Urinary System and Male Genital Organs (4th Edition). IARC, Lyon (2016).
  • Grobner SN , WorstBC , WeischenfeldtJet al. The landscape of genomic alterations across childhood cancers. Nature555(7696), 321–327 (2018).
  • Shen H , ShihJ , HollernDPet al. Integrated molecular characterization of testicular germ cell tumors. Cell. Rep.23(11), 3392–3406 (2018).
  • Rijlaarsdam MA , LooijengaLH. An oncofetal and developmental perspective on testicular germ cell cancer. Semin. Cancer Biol.29, 59–74 (2014).
  • Looijenga LH , StoopH , BiermannK. Testicular cancer: biology and biomarkers. Virchows Arch.464(3), 301–313 (2014).
  • Lobo J , GillisAJM , VanDen Berg Aet al. Identification and validation model for informative liquid biopsy-based microRNA biomarkers: insights from germ cell tumor in vitro, in vivo and patient-derived data. Cells8(12), (2019).
  • Almstrup K , LoboJ , MorupNet al. Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours. Nat. Rev. Urol. doi:10.1038/s41585-020-0296-x (2020).
  • Costa AL , LoboJ , JeronimoC , HenriqueR. The epigenetics of testicular germ cell tumors: looking for novel disease biomarkers. Epigenomics9(2), 155–169 (2017).
  • Kato Y , KanedaM , HataKet al. Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet.16(19), 2272–2280 (2007).
  • Zhang W , XuJ. DNA methyltransferases and their roles in tumorigenesis. Biomark. Res.5, 1 (2017).
  • Guo F , LiX , LiangDet al. Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote. Cell Stem Cell15(4), 447–459 (2014).
  • An J , RaoA , KoM. TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp. Mol. Med.49(4), e323 (2017).
  • Rasmussen KD , HelinK. Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev.30(7), 733–750 (2016).
  • La Salle S , TraslerJM. Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse. Dev. Biol.296(1), 71–82 (2006).
  • Nettersheim D , HeukampLC , FronhoffsFet al. Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development. PLoS One8(12), e82881 (2013).
  • Uysal F , AkkoyunluG , OzturkS. DNA methyltransferases exhibit dynamic expression during spermatogenesis. Reprod. Biomed. Online33(6), 690–702 (2016).
  • Marques CJ , JoaoPinho M , CarvalhoF , BiecheI , BarrosA , SousaM. DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stages. Epigenetics6(11), 1354–1361 (2011).
  • Dawlaty MM , BreilingA , LeTet al. Loss of Tet enzymes compromises proper differentiation of embryonic stem cells. Dev. Cell29(1), 102–111 (2014).
  • Rijlaarsdam MA , TaxDM , GillisAJet al. Genome wide DNA methylation profiles provide clues to the origin and pathogenesis of germ cell tumors. PLoS One10(4), e0122146 (2015).
  • Smiraglia DJ , SzymanskaJ , KraggerudSM , LotheRA , PeltomakiP , PlassC. Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors. Oncogene21(24), 3909–3916 (2002).
  • Costa AL , Moreira-BarbosaC , LoboJet al. DNA methylation profiling as a tool for testicular germ cell tumors subtyping. Epigenomics10(12), 1511–1523 (2018).
  • Killian JK , DorssersLC , TrabertBet al. Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors. Genome Res.26(11), 1490–1504 (2016).
  • Lister R , PelizzolaM , DowenRHet al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature462(7271), 315–322 (2009).
  • Ishii T , KohuK , YamadaSet al. Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors. Tohoku J. Exp. Med.212(2), 177–190 (2007).
  • Yamada S , KohuK , IshiiTet al. Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma. DNA Res.11(5), 335–344 (2004).
  • Chen BF , GuS , SuenYK , LiL , ChanWY. microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer. Epigenetics9(1), 119–128 (2014).
  • Arai E , NakagawaT , Wakai-UshijimaS , FujimotoH , KanaiY. DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma. Histopathology60(6B), E12–18 (2012).
  • Beyrouthy MJ , GarnerKM , HeverMPet al. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. Cancer Res.69(24), 9360–9366 (2009).
  • Kristensen DG , NielsenJE , JorgensenA , SkakkebaekNE , Rajpert-DeMeyts E , AlmstrupK. Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. Br. J. Cancer110(3), 668–678 (2014).
  • Lobo J , HenriqueR , JeronimoC. The Role of DNA/histone modifying enzymes and chromatin remodeling complexes in testicular germ cell tumors. Cancers (Basel)11(1), (2018).
  • Cerami E , GaoJ , DogrusozUet al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov.2(5), 401–404 (2012).
  • International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers . International Germ Cell Cancer Collaborative Group. J. Clin. Oncol.15(2), 594–603 (1997).
  • Fankhauser CD , GerkeTA , RothLet al. Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment. J. Cancer Res. Clin. Oncol.145(3), 781–785 doi:10.1007/s00432-019-02844-z (2019).
  • Lobo J , CostaAL , CantanteMet al. m(6)A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance. J. Transl. Med.17(1), 79 (2019).
  • De Jong J , StoopH , GillisAJet al. Further characterization of the first seminoma cell line TCam-2. Genes Chromosomes Cancer47(3), 185–196 (2008).
  • Lobo J , NunesSP , GillisAJMet al. XIST-promoter demethylation as tissue biomarker for testicular germ cell tumors and spermatogenesis quality. Cancers (Basel)11(9), 1385 (2019).
  • Lobo J , RodriguesA , GuimaraesRet al. Detailed characterization of immune cell infiltrate and expression of immune checkpoint molecules PD-L1/CTLA-4 and MMR proteins in testicular germ cell tumors disclose novel disease biomarkers. Cancers (Basel)11(10), 1535 (2019).
  • Chovanec M , AbuZaid M , HannaN , El-KouriN , EinhornLH , AlbanyC. Long-term toxicity of cisplatin in germ-cell tumor survivors. Ann Oncol28(11), 2670–2679 (2017).
  • He YF , LiBZ , LiZet al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science333(6047), 1303–1307 (2011).
  • Hackett JA , SenguptaR , ZyliczJJet al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science339(6118), 448–452 (2013).
  • Benesova M , TrejbalovaK , KucerovaDet al. Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation. Mol. Carcinog.56(8), 1837–1850 (2017).
  • Tickoo SK , HutchinsonB , BacikJet al. Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. Int. J. Surg. Pathol.10(1), 23–32 (2002).
  • Nettersheim D , HeimsoethA , JostesSet al. SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. Oncotarget7(30), 47095–47110 (2016).
  • Peng Z , ZhouW , ZhangC , LiuH , ZhangY. Curcumol controls choriocarcinoma stem-like cells self-renewal via repression of DNA methyltransferase (DNMT)- and histone deacetylase (HDAC)-mediated epigenetic regulation. Med. Sci. Monit.24, 461–472 (2018).

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