Alteration of N⁶-Methyladenosine Epitranscriptome Profile in Unilateral Ureteral Obstructive Nephropathy

References

• Uhlig K , BernsJS , KestenbaumBet al. KDOQI US commentary on the 2009 KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation and Treatment of CKD-Mineral and Bone Disorder (CKD-MBD). Am. J. Kidney Dis.55(5), 773–799 (2010).
   PubMed Web of Science ®Google Scholar
• Martinez-Klimova E , Aparicio-TrejoOE , TapiaE , Pedraza-ChaverriJ. Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments. Biomolecules9(4), 141 (2019).
   Web of Science ®Google Scholar
• Cheng J , TruongLD , WuX , KuhlD , LangF , DuJ. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int.78(7), 668–678 (2010).
   PubMed Web of Science ®Google Scholar
• Iwano M , PliethD , DanoffTM , XueC , OkadaH , NeilsonEG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest.110(3), 341–350 (2002).
   PubMed Web of Science ®Google Scholar
• Chevalier RL , KimA , ThornhillBA , WolstenholmeJT. Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Kidney Int.55(3), 793–807 (1999).
   PubMed Web of Science ®Google Scholar
• Tapmeier TT , BrownKL , TangZ , SacksSH , SheerinNS , WongW. Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation. Kidney Int.73(7), 885–889 (2008).
   PubMed Web of Science ®Google Scholar
• Chaabane W , PraddaudeF , BuleonMet al. Renal functional decline and glomerulotubular injury are arrested but not restored by release of unilateral ureteral obstruction (UUO). Am. J. Physiol. Renal Physiol.304(4), F432–439 (2013).
   PubMed Web of Science ®Google Scholar
• Venkatachalam MA , WeinbergJM , KrizW , BidaniAK. Failed tubule recovery, AKI-CKD transition and kidney disease progression. J. Am. Soc. Nephrol.26(8), 1765–1776 (2015).
   PubMed Web of Science ®Google Scholar
• Chau BN , XinC , HartnerJet al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci. Transl. Med.4(121), 121ra118 (2012).
   Web of Science ®Google Scholar
• Fontecha-Barriuso M , Martin-SanchezD , Ruiz-AndresOet al. Targeting epigenetic DNA and histone modifications to treat kidney disease. Nephrol. Dial. Transplant.33(11), 1875–1886 (2018).
   PubMed Web of Science ®Google Scholar
• Wang P , LuoML , SongEet al. Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway. Sci. Transl. Med.10(462), eaat2039 (2018).
   Web of Science ®Google Scholar
• Wang X , ZhaoBS , RoundtreeIAet al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell161(6), 1388–1399 (2015).
   PubMed Web of Science ®Google Scholar
• Yang Y , HsuPJ , ChenYS , YangYG. Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res.28(6), 616–624 (2018).
   PubMed Web of Science ®Google Scholar
• Roundtree IA , EvansME , PanT , HeC. Dynamic RNA modifications in gene expression regulation. Cell169(7), 1187–1200 (2017).
   PubMed Web of Science ®Google Scholar
• Shen F , HuangW , HuangJTet al. Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5. J. Clin. Endocrinol. Metab.100(1), E148–154 (2015).
   PubMed Web of Science ®Google Scholar
• Deng X , SuR , WengH , HuangH , LiZ , ChenJ. RNA N(6)-methyladenosine modification in cancers: current status and perspectives. Cell Res.28(5), 507–517 (2018).
   PubMed Web of Science ®Google Scholar
• Mathiyalagan P , AdamiakM , MayourianJet al. FTO-dependent N(6)-methyladenosine regulates cardiac function during remodeling and repair. Circulation139(4), 518–532 (2019).
   PubMed Web of Science ®Google Scholar
• Hubacek JA , ViklickyO , DlouhaDet al. The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population. Nephrol. Dial. Transplant.27(3), 1030–1035 (2012).
   PubMed Web of Science ®Google Scholar
• Spoto B , Mattace-RasoF , SijbrandsEet al. The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity. Nephrol. Dial. Transplant.27(Suppl. 4), iv58–62 (2012).
   PubMedGoogle Scholar
• Satoh M , KashiharaN , YamasakiYet al. Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice. J. Am. Soc. Nephrol.12(2), 317–325 (2001).
   PubMed Web of Science ®Google Scholar
• Ping XL , SunBF , WangLet al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res.24(2), 177–189 (2014).
   PubMed Web of Science ®Google Scholar
• Kuppers DA , AroraS , LimYet al. N(6)-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis. Nat. Commun.10(1), 4596 (2019).
   PubMedGoogle Scholar
• Sorci M , IannielloZ , CrucianiSet al. METTL3 regulates WTAP protein homeostasis. Cell Death Dis9(8), 796 (2018).
   PubMedGoogle Scholar
• Little NA , HastieND , DaviesRC. Identification of WTAP, a novel Wilms’ tumour 1-associating protein. Hum. Mol. Genet.9(15), 2231–2239 (2000).
   PubMed Web of Science ®Google Scholar
• Barisoni L , BruggemanLA , MundelP , D’agatiVD , KlotmanPE. HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. Kidney Int.58(1), 173–181 (2000).
   PubMed Web of Science ®Google Scholar
• Zhang J , TsoiH , LiXet al. Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis. Gut65(9), 1482–1493 (2016).
   PubMed Web of Science ®Google Scholar
• Hosono S , GrossI , EnglishMA , HajraKM , FearonER , LichtJD. E-cadherin is a WT1 target gene. J. Biol. Chem.275(15), 10943–10953 (2000).
   PubMed Web of Science ®Google Scholar
• Mazzei LJ , GarciaIM , AltamiranoL , DochertyNG , ManuchaW. Rosuvastatin preserves renal structure following unilateral ureteric obstruction in the neonatal rat. Am. J. Nephrol.35(2), 103–113 (2012).
   PubMed Web of Science ®Google Scholar
• Loos RJ , YeoGS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nat. Rev. Endocrinol.10(1), 51–61 (2014).
   PubMed Web of Science ®Google Scholar
• Wang CY , ShieSS , TsaiMLet al. FTO modulates fibrogenic responses in obstructive nephropathy. Sci. Rep.6, 18874 (2016).
   PubMed Web of Science ®Google Scholar
• Fukasawa H , YamamotoT , TogawaAet al. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc. Natl Acad. Sci. USA101(23), 8687–8692 (2004).
   PubMed Web of Science ®Google Scholar
• Hong S , LimS , LiAGet al. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat. Immunol.8(5), 504–513 (2007).
   PubMed Web of Science ®Google Scholar
• Chung AC , HuangXR , ZhouL , HeuchelR , LaiKN , LanHY. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol. Dial. Transplant.24(5), 1443–1454 (2009).
   PubMed Web of Science ®Google Scholar
• Nakao A , AfrakhteM , MorenAet al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-β signalling. Nature389(6651), 631–635 (1997).
   PubMed Web of Science ®Google Scholar
• Liu FY , LiXZ , PengYM , LiuH , LiuYH. Arkadia-Smad7-mediated positive regulation of TGF-β signaling in a rat model of tubulointerstitial fibrosis. Am. J. Nephrol.27(2), 176–183 (2007).
   PubMed Web of Science ®Google Scholar
• Feng M , TangPM , HuangXRet al. TGF-β mediates renal fibrosis via the Smad3-Erbb4-IR long noncoding RNA axis. Mol. Ther.26(1), 148–161 (2018).
   PubMed Web of Science ®Google Scholar
• Sun Q , MiaoJ , LuoJet al. The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis. J. Cell Sci.131(6), jcs202317 (2018).
   Web of Science ®Google Scholar
• Dirocco DP , KobayashiA , TaketoMM , McmahonAP , HumphreysBD. Wnt4/beta-catenin signaling in medullary kidney myofibroblasts. J. Am. Soc. Nephrol.24(9), 1399–1412 (2013).
   PubMed Web of Science ®Google Scholar
• Chang Y , LauWL , JoHet al. Pharmacologic Blockade of alphavbeta1 integrin ameliorates renal failure and fibrosis In Vivo. J. Am. Soc. Nephrol.28(7), 1998–2005 (2017).
   PubMed Web of Science ®Google Scholar
• Grande MT , Sanchez-LaordenB , Lopez-BlauCet al. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat. Med.21(9), 989–997 (2015).
   PubMed Web of Science ®Google Scholar
• Lovisa S , LebleuVS , TampeBet al. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat. Med.21(9), 998–1009 (2015).
   PubMed Web of Science ®Google Scholar
• Shin GT , KimDR , LimJE , YimH , KimH. Upregulation and function of GADD45gamma in unilateral ureteral obstruction. Kidney Int.73(11), 1251–1265 (2008).
   PubMed Web of Science ®Google Scholar
• Wolf G , MentzelS , AssmannKJ. Aminopeptidase A: a key enzyme in the intrarenal degradation of angiotensin II. Exp. Nephrol.5(5), 364–369 (1997).
   PubMedGoogle Scholar
• Berulava T , BuchholzE , ElerdashviliVet al. Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur. J. Heart Fail.22(1), 54–66 (2020).
   PubMed Web of Science ®Google Scholar
• Choi J , IeongKW , DemirciHet al. N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat. Struct. Mol. Biol.23(2), 110–115 (2016).
   PubMed Web of Science ®Google Scholar
• Li T , HuPS , ZuoZet al. METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma. Mol. Cancer18(1), 112 (2019).
   PubMed Web of Science ®Google Scholar
• Lin X , ChaiG , WuYet al. RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat. Commun.10(1), 2065 (2019).
   PubMed Web of Science ®Google Scholar
• Mao Y , DongL , LiuXMet al. m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2. Nat. Commun.10(1), 5332 (2019).
   PubMed Web of Science ®Google Scholar
• Klahr S , MorrisseyJ. Obstructive nephropathy and renal fibrosis. Am. J. Physiol. Renal Physiol.283(5), F861–F875 (2002).
   PubMed Web of Science ®Google Scholar
• Hao J , HuH , JiangZet al. microRNA-670 modulates Igf2bp1 expression to regulate RNA methylation in parthenogenetic mouse embryonic development. Sci. Rep.10(1), 4782 (2020).
   PubMed Web of Science ®Google Scholar
• Nakano M , OndoK , TakemotoS , FukamiT , NakajimaM. Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem. Pharmacol.171, 113697 (2020).
   PubMed Web of Science ®Google Scholar
• Bachellerie JP , AmalricF , CabocheM. Biosynthesis and utilization of extensively undermethylated poly(A)+ RNA in CHO cells during a cycloleucine treatment. Nucleic Acids Res.5(8), 2927–2943 (1978).
   PubMed Web of Science ®Google Scholar
• Chiang PK . Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine. Science211(4487), 1164–1166 (1981).
   PubMed Web of Science ®Google Scholar
• Caboche M , BachellerieJP. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur. J. Biochem.74(1), 19–29 (1977).
   PubMedGoogle Scholar
• Camper SA , AlbersRJ , CowardJK , RottmanFM. Effect of undermethylation on mRNA cytoplasmic appearance and half-life. Mol. Cell. Biol.4(3), 538–543 (1984).
   PubMed Web of Science ®Google Scholar