147
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Association of HERV-K and LINE-1 Hypomethylation with Reduced Disease-Free Survival in Melanoma Patients

ORCID Icon, ORCID Icon, , , ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 1689-1706 | Received 31 Mar 2020, Accepted 24 Jul 2020, Published online: 30 Oct 2020

References

  • Gershenwald JE , ScolyerRA , HessKRet al. Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J. Clin.67(6), 472–492 (2017).
  • Romano E , ScordoM , DuszaSW , CoitDG , ChapmanPB. Site and timing of first relapse in stage III melanoma patients: implications for follow-up guidelines. J. Clin. Oncol.28(18), 3042–3047 (2010).
  • Jayawardana K , SchrammSJ , HayduLet al. Determination of prognosis in metastatic melanoma through integration of clinico-pathologic, mutation, mRNA, microRNA, and protein information. Int. J. Cancer136(4), 863–874 (2015).
  • Bergman Y , CedarH. DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol.20(3), 274–281 (2013).
  • Pfeifer GP . Defining driver DNA methylation changes in human cancer. Int. J. Mol. Sci.19(4), E1166 (2018).
  • Luo Y , LuX , XieH. Dynamic Alu methylation during normal development, aging, and tumorigenesis. Biomed. Res. Int.2014, 784706 (2014).
  • Cardelli M . The epigenetic alterations of endogenous retroelements in aging. Mech. Ageing Dev.174, 30–46 (2018).
  • Chen RZ , PetterssonU , BeardC , Jackson-GrusbyL , JaenischR. DNA hypomethylation leads to elevated mutation rates. Nature395(6697), 89–93 (1998).
  • Cadieux B , ChingTT , VandenBergSR , CostelloJF. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res.66(17), 8469–8476 (2006).
  • Iskow RC , McCabeMT , MillsREet al. Natural mutagenesis of human genomes by endogenous retrotransposons. Cell141(7), 1253–1261 (2010).
  • Shukla R , UptonKR , Muñoz-LopezMet al. Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell153(1), 101–111 (2013).
  • Clayton EA , WangL , RishishwarL , WangJ , McDonaldJF , JordanIK. Patterns of transposable element expression and insertion in cancer. Front. Mol. Biosci.3, 76 (2016).
  • Scott EC , DevineSE. The role of somatic L1 retrotransposition in human cancers. Viruses9(6), E131 (2017).
  • Richardson SR , DoucetAJ , KoperaHC , MoldovanJB , Garcia-PerezJL , MoranJV. The influence of LINE −1 and SINE retrotransposons on mammalian genomes. Microbiol. Spectr.3(2), MDNA3-0061-2014 (2015).
  • Ogino S , NoshoK , KirknerGJet al. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J. Natl Cancer Inst.100(23), 1734–1738 (2008).
  • Pattamadilok J , HuapaiN , RattanatanyongPet al. LINE-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer. Int. J. Gynecol. Cancer18(4), 711–717 (2008).
  • Cho NY , KimJH , MoonKC , KangGH. Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm. Virchows Arch.454(1), 17–23 (2009).
  • Saito K , KawakamiK , MatsumotoI , OdaM , WatanabeG , MinamotoT. Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. Clin. Cancer Res.16(8), 2418–2426 (2010).
  • Ohka F , NatsumeA , MotomuraKet al. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. PLoS ONE6(8), e23332 (2011).
  • Iwagami S , BabaY , WatanabeMet al. LINE-1 hypomethylation is associated with a poor prognosis among patients with curatively resected esophageal squamous cell carcinoma. Ann. Surg.257(3), 449–455 (2013).
  • Zhu C , UtsunomiyaT , IkemotoTet al. Hypomethylation of long interspersed nuclear element-1 (LINE-1) is associated with poor prognosis via activation of c-MET in hepatocellular carcinoma. Ann. Surg. Oncol.21(Suppl. 4), S729–S735 (2014).
  • Furlan C , PoleselJ , BarzanLet al. Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma. Clin. Epigenetics9, 58 (2017).
  • Lavasanifar A , SharpCN , KorteEA , YinT , HosseinnejadK , JortaniSA. Long interspersed nuclear element-1 mobilization as a target in cancer diagnostics, prognostics and therapeutics. Clin. Chim. Acta493, 52–62 (2019).
  • Sigalotti L , FrattaE , BidoliEet al. Methylation levels of the “long interspersed nucleotide element-1” repetitive sequences predict survival of melanoma patients. J. Transl. Med.9, 78 (2011).
  • Hoshimoto S , KuoCT , ChongKKet al. AIM1 and LINE-1 epigenetic aberrations in tumor and serum relate to melanoma progression and disease outcome. J. Invest. Dermatol.132(6), 1689–1697 (2012).
  • Ecsedi SI , Hernandez-VargasH , LimaSC , HercegZ , AdanyR , BalazsM. Transposable hypomethylation is associated with metastatic capacity of primary melanomas. Int. J. Clin. Exp. Pathol.6(12), 2943–2948 (2013).
  • Pramio DT , PennacchiPC , Maria-EnglerSSet al. LINE-1 hypomethylation and mutational status in cutaneous melanomas. J. Investig. Med.64(4), 899–904 (2016).
  • Hohn O , HankeK , BannertN. HERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease. Front. Oncol.3, 246 (2013).
  • Schmitt K , ReichrathJ , RoeschA , MeeseE , MayerJ. Transcriptional profiling of human endogenous retrovirus group HERV-K(HML-2) loci in melanoma. Genome Biol. Evol.5(2), 307–328 (2013).
  • Singh S , KayeS , GoreME , McClureMO , BunkerCB. The role of human endogenous retroviruses in melanoma. Br. J. Dermatol.161(6), 1225–1231 (2009).
  • Cegolon L , SalataC , WeiderpassE , VineisP , PalùG , MastrangeloG. Human endogenous retroviruses and cancer prevention: evidence and prospects. BMC Cancer13, 4 (2013).
  • Stengel S , FiebigU , KurthR , DennerJ. Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation. Genes Chromosomes Cancer49(5), 401–411 (2010).
  • Yang AS , EstecioMR , DoshiK , KondoY , TajaraEH , IssaJP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res.32, e38 (2004).
  • Bollati V , BaccarelliA , HouLet al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res.67, 876–880 (2007).
  • Bao W , KojimaKK , KohanyO. Repbase Update, a database of repetitive elements in eukaryotic genomes. Mobile DNA6, 11 (2015).
  • Subramanian RP , WildschutteJH , RussoC , CoffinJM. Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses. Retrovirology8, 90 (2011).
  • Hubley R , FinnRD , ClementsJet al. The Dfam database of repetitive DNA families. Nucleic Acids Res.44(D1), D81–D89 (2016).
  • Manghera M , DouvilleRN. Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?Retrovirology10, 16 (2013).
  • Youden WJ . Index for rating diagnostic tests. Cancer3(1), 32–35 (1950).
  • Ruopp MD , PerkinsNJ , WhitcombBW , SchistermanEF. Youden Index and optimal cut-point estimated from observations affected by a lower limit of detection. Biom. J.50(3), 419–430 (2008).
  • Bellera CA , MacGroganG , DebledM , de LaraCT , BrousteV , Mathoulin-PélissierS. Variables with time-varying effects and the Cox model: some statistical concepts illustrated with a prognostic factor study in breast cancer. BMC Med. Res. Methodol.10, 20 (2010).
  • Rauch TA , ZhongX , WuXet al. High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc. Natl Acad. Sci. USA105(1), 252–257 (2008).
  • Thomas NE , SlaterNA , EdmistonSNet al. DNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features. Pigment Cell Melanoma Res.27(6), 1097–1105 (2014).
  • Delgado-Cruzata L , HrubyGW , GonzalezKet al. DNA methylation changes correlate with Gleason score and tumor stage in prostate cancer. DNA Cell Biol.31(2), 187–192 (2012).
  • Park SY , SeoAN , JungHYet al. Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer. PLoS ONE9(6), e100429 (2014).
  • Knothe C , ShiratoriH , ReschEet al. Disagreement between two common biomarkers of global DNA methylation. Clin. Epigenetics8, 60 (2016).
  • Min J , ChoiB , HanTSet al. Methylation levels of LINE-1 as a useful marker for venous invasion in both FFPE and frozen tumor tissues of gastric cancer. Mol. Cells40(5), 346–354 (2017).
  • Anwar SL , HasemeierB , SchipperE , VogelA , KreipeH , LehmannU. LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype. PLoS ONE14(5), e0216374 (2019).
  • Lemaître C , TsangJ , BireauC , HeidmannT , DewannieuxM. A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion. PLoS Pathog.13(6), e1006451 (2017).
  • Chiappinelli KB , StrisselPL , DesrichardAet al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell162(5), 974–986 (2015).
  • Jung H , KimHS , KimJYet al. DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load. Nat. Commun.10(1), 4278 (2019).
  • Cardelli M , GiacconiR , MalavoltaM , ProvincialiM. Endogenous retroelements in cellular senescence and related pathogenic processes: promising drug targets in age-related diseases. Curr. Drug Targets17(4), 416–427 (2016).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.