235
Views
0
CrossRef citations to date
0
Altmetric
Research Article

miRNA 146b-5p Protects Against Atherosclerosis by Inhibiting Vascular Smooth Muscle Cell Proliferation and Migration

, , , , , & ORCID Icon show all
Pages 2189-2204 | Received 17 Apr 2020, Accepted 04 Oct 2020, Published online: 21 Oct 2020

References

  • Husain K , HernandezW , AnsariRA , FerderL. Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. World J. Biol. Chem.6(3), 209–217 (2015).
  • Rader DJ , DaughertyA. Translating molecular discoveries into new therapies for atherosclerosis. Nature451(7181), 904–913 (2008).
  • Gangwar RS , RajagopalanS , NatarajanR , DeiuliisJA. Noncoding RNAs in cardiovascular disease: pathological relevance and emerging role as biomarkers and therapeutics. Am. J. Hypertens.31(2), 150–165 (2018).
  • Reith C , ArmitageJ. Management of residual risk after statin therapy. Atherosclerosis245, 161–170 (2016).
  • Lusis AJ . Atherosclerosis. Nature407(6801), 233–241 (2000).
  • Ross R . Atherosclerosis – an inflammatory disease. N. Engl. J. Med.340(2), 115–126 (1999).
  • Libby P , RidkerPM , MaseriA. Inflammation and atherosclerosis. Circulation105(9), 1135–1143 (2002).
  • Libby P . Inflammation in atherosclerosis. Nature420(6917), 868–874 (2002).
  • Wu MY , LiCJ , HouMF , ChuPY. New insights into the role of inflammation in the pathogenesis of atherosclerosis. Int. J. Mol. Sci.18 (10), 2034 (2017).
  • Weber C , NoelsH. Atherosclerosis: current pathogenesis and therapeutic options. Nat. Med.17(11), 1410–1422 (2011).
  • Dzau VJ , Braun-DullaeusRC , SeddingDG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med.8(11), 1249–1256 (2002).
  • Libby P . Changing concepts of atherogenesis. J. Intern. Med.247(3), 349–358 (2000).
  • Feinberg MW , MooreKJ. MicroRNA regulation of atherosclerosis. Circ. Res.118(4), 703–720 (2016).
  • Lin N , AnY. Blockade of 146b-5p promotes inflammation in atherosclerosis-associated foam cell formation by targeting TRAF6. Exp. Ther. Med.14(5), 5087–5092 (2017).
  • Raitoharju E , LyytikainenLP , LevulaMet al. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis219(1), 211–217 (2011).
  • Zhao L , YangXR , HanX. MicroRNA-146b induces the PI3K/Akt/NF-kappaB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Exp. Ther. Med.17(2), 1171–1181 (2019).
  • Li Y , WangY , YuLet al. miR-146b-5p inhibits glioma migration and invasion by targeting MMP16. Cancer Lett.339(2), 260–269 (2013).
  • Xia H , QiY , NgSSet al. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res.1269, 158–165 (2009).
  • Xu J , ZhangZ , ChenQ , YangL , YinJ. miR-146b regulates cell proliferation and apoptosis in gastric cancer by targeting PTP1B. Dig. Dis. Sci.65(2), 457–4632019).
  • Li C , MiaoR , LiuSet al. Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis. Oncotarget8(17), 28683–28695 (2017).
  • Gomez D , OwensGK. Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc. Res.95(2), 156–164 (2012).
  • Sun D , ZhangM , LiY , MeiS , QinJ , YanJ. cJun/Ap1 is upregulated in an Ang II-induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells. Mol. Med. Rep.19(5), 3459–3468 (2019).
  • Bauer RC , TohyamaJ , CuiJet al. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation131(13), 1202–1213 (2015).
  • Bildirici AE , ArslanS , OzbilumSahin N , BerkanO , BetonO , YilmazMB. MicroRNA-221/222 expression in atherosclerotic coronary artery plaque versus internal mammarian artery and in peripheral blood samples. Biomarkers23(7), 670–675 (2018).
  • Comer BS , Camoretti-MercadoB , KogutPC , HalaykoAJ , SolwayJ , GerthofferWT. MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol.307(9), L727–734 (2014).
  • Cheng HS , SivachandranN , LauAet al. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol. Med.5(7), 1017–1034 (2013).
  • Taganov KD , BoldinMP , ChangKJ , BaltimoreD. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl Acad. Sci. USA103(33), 12481–12486 (2006).
  • Wang HG , TakayamaS , RappUR , ReedJC. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl Acad. Sci. USA93(14), 7063–7068 (1996).
  • Song J , TakedaM , MorimotoRI. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell. Biol.3(3), 276–282 (2001).
  • Hui DY . Intimal hyperplasia in murine models. Curr. Drug Targets9(3), 251–260 (2008).
  • Cheng HS , BeslaR , LiAet al. Paradoxical suppression of atherosclerosis in the absence of microRNA-146a. Circ. Res.121(4), 354–367 (2017).
  • Planutiene M , PlanutisK , HolcombeRF. Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion. Vasc. Cell3, 28 (2011).
  • Zhao H , BernardoMM , OsenkowskiPet al. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation. J. Biol. Chem.279(10), 8592–8601 (2004).
  • Nicholls SJ , BallantyneCM , BarterPJet al. Effect of two intensive statin regimens on progression of coronary disease. N. Engl. J. Med.365(22), 2078–2087 (2011).
  • Kastelein JJ , AkdimF , StroesESet al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N. Engl. J. Med.358(14), 1431–1443 (2008).
  • Takahashi Y , SatohM , MinamiY , TabuchiT , ItohT , NakamuraM. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin. Sci.119(9), 395–405 (2010).
  • Deng M , SuD , XuSet al. Metformin and vascular diseases: a focused review on smooth muscle cell function. Front. Pharmacol.11, 635 (2020).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.