References
- Bray F , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA-Cancer J. Clin.68(6), 394–424 (2018).
- Allemani C , MatsudaT , DiCarlo Vet al. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet391(10125), 1023–1075 (2018).
- Wakelee H , KellyK , EdelmanMJ. 50 years of progress in the systemic therapy of non-small cell lung cancer. Am. Soc. Clin. Oncol. Educ. Book34, 177–189 (2014).
- Grasse S , LienhardM , FreseSet al. Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance. Genome Med.10(1), 55 (2018).
- Xu JH , HuSL , ShenGD , ShenG. Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy. Cancer Cell Int.16, 13 (2016).
- You Y , YangW , QinXet al. ECRG4 acts as a tumor suppressor and as a determinant of chemotherapy resistance in human nasopharyngeal carcinoma. Cell. Oncol. (Dordrecht)38(3), 205–214 (2015).
- Ben Shachar B , FeldsteinO , HacohenD , GinsbergD. The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy. Mol. Cancer Res.8(3), 363–372 (2010).
- Baylin SB , HermanJG , GraffJR , VertinoPM , IssaJP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res.72, 141–196 (1998).
- Schmutte C , JonesPA. Involvement of DNA methylation in human carcinogenesis. Biol. Chem.379(4–5), 377–388 (1998).
- Gupta R , ToufailyC , AnnabiB. Caveolin and cavin family members: dual roles in cancer. Biochimie107(Pt B), 188–202 (2014).
- Otsuka T , KohnoT , MoriM , NoguchiM , HirohashiS , YokotaJ. Deletion mapping of chromosome 2 in human lung carcinoma. Gene Chromosomes Cancer16(2), 113–119 (1996).
- Gustincich S , SchneiderC. Serum deprivation response gene is induced by serum starvation but not by contact inhibition. Cell Growth Differ.4(9), 753–760 (1993).
- Gustincich S , VattaP , GoruppiSet al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics57(1), 120–129 (1999).
- Nabi IR . Cavin fever: regulating caveolae. Nat. Cell Biol.11(7), 789–791 (2009).
- Ozturk S , PapageorgisP , WongCKet al. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl Acad. Sci. USA113(3), 638–643 (2016).
- Tian Y , YuY , HouLKet al. Serum deprivation response inhibits breast cancer progression by blocking transforming growth factor-beta signaling. Cancer Sci.107(3), 274–280 (2016).
- Jing W , LuoP , ZhuM , AiQ , ChaiH , TuJ. Prognostic and diagnostic significance of SDPR-cavin-2 in hepatocellular carcinoma. Cell. Physiol. Biochem.39(3), 950–960 (2016).
- Luo Y , WuJ , WuQet al. miR-577 regulates TGF-beta induced cancer progression through a SDPR-modulated positive-feedback loop with ERK-NF-κB in gastric cancer. Mol. Ther.27(6), 1166–1182 (2019).
- Tahara S , NojimaS , OhshimaKet al. Serum deprivation-response protein regulates aldehyde dehydrogenase 1 through integrin-linked kinase signaling in endometrioid carcinoma cells. Cancer Sci.110(5), 1804–1813 (2019).
- Wang QX , ChenED , CaiYFet al. Serum deprivation response functions as a tumor suppressor gene in papillary thyroid cancer. Clin. Genet.96(5), 418–428 (2019).
- Ni W , SongE , GongM , LiY , YaoJ , AnR. Downregulation of lncRNA SDPR-AS is associated with poor prognosis in renal cell carcinoma. OncoTargets Ther.10, 3039–3047 (2017).
- Unozawa M , KasamatsuA , HigoMet al. Cavin-2 in oral cancer: a potential predictor for tumor progression. Mol. Carcinog.55(6), 1037–1047 (2016).
- Zhang Y , XuH , MuJet al. Inactivation of ADAMTS18 by aberrant promoter hypermethylation contribute to lung cancer progression. J. Cell. Physiol.234(5), 6965–6975 (2019).
- Feng Y , WuM , LiSet al. The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism. J. Exp. Clin. Cancer Res.37(1), 313 (2018).
- Mu H , WangN , ZhaoLet al. Methylation of PLCD1 and adenovirus-mediated PLCD1 overexpression elicits a gene therapy effect on human breast cancer. Exp. Cell Res.332(2), 179–189 (2015).
- Zhao L , LiS , GanLet al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering beta-catenin signalling and GADD45G expression. J. Cell. Mol. Med.20(5), 842–854 (2016).
- Xiang T , LiL , YinXet al. The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS ONE7(1), e29783 (2012).
- Zhao L , LiS , GanLet al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression. J. Cell. Mol. Med.20(5), 842–854 (2016).
- Yin X , XiangT , LiLet al. DACT1, an antagonist to Wnt/beta-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer. Breast Cancer Res.15(2), R23 (2013).
- Kornbluth S , SebastianB , HunterT , NewportJ. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Mol. Biol. Cell5(3), 273–282 (1994).
- Lindqvist A , Rodriguez-BravoV , MedemaRH. The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol.185(2), 193–202 (2009).
- Lobrich M , JeggoPA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat. Rev. Cancer7(11), 861–869 (2007).
- Nurse P . Universal control mechanism regulating onset of M-phase. Nature344(6266), 503–508 (1990).
- Gornstein E , SchwarzTL. The paradox of paclitaxel neurotoxicity: mechanisms and unanswered questions. Neuropharmacology76(Pt A), 175–183 (2014).
- Longley DB , HarkinDP , JohnstonPG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat. Rev. Cancer3(5), 330–338 (2003).
- Zhu S , PablaN , TangC , HeL , DongZ. DNA damage response in cisplatin-induced nephrotoxicity. Arch. Toxicol.89(12), 2197–2205 (2015).
- Dasari S , TchounwouPB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur. J. Pharmacol.740, 364–378 (2014).
- Zhang R , WangY , LiJ , JinH , SongS , HuangC. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J. Biol. Chem.289(10), 6394–6403 (2014).
- Wang Y , PrivesC. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature376(6535), 88–91 (1995).
- Tchou WW , RomWN , Tchou-WongKM. Novel form of p21(WAF1/CIP1/SDI1) protein in phorbol ester-induced G2/M arrest. J. Biol. Chem.271(47), 29556–29560 (1996).
- Lv C , HongY , MiaoLet al. Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. Cell Death Dis.4, e952 (2013).
- Fischer M , QuaasM , SteinerL , EngelandK. The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes. Nucleic Acids Res.44(1), 164–174 (2016).
- Dvory-Sobol H , Cohen-NoymanE , KazanovDet al. Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner. Eur. J. Cancer42(3), 422–426 (2006).
- Yuan L , MuP , HuangB , LiH , MuH , DengY. EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3DeltaZip2a/2b-EGR1-p21 pathway. Toxicol. Lett.299, 95–103 (2018).
- Wang LH , JiangXR , ChenGLet al. Anti-tumor activity of SL4 against breast cancer cells: induction of G2/M arrest through modulation of the MAPK-dependent p21 signaling pathway. Sci Rep6, 36486 (2016).
- Gong FR , WuMY , ShenMet al. PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21. Oncotarget6(21), 18469–18483 (2015).