Melatonin and Regulation of miRNAs: Novel Targeted Therapy for Cancerous and Noncancerous Disease

References

• Lee YS , DuttaA. MicroRNAs in cancer. Annu. Rev. Pathol.4, 199–227 (2009).
   PubMed Web of Science ®Google Scholar
• Bates DJ , LiangR , LiN , WangE. The impact of noncoding RNA on the biochemical and molecular mechanisms of aging. Biochim. Biophys. Acta1790(10), 970–979 (2009).
   PubMed Web of Science ®Google Scholar
• Bartel DP , ChenCZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat. Rev. Genet.5(5), 396–400 (2004).
   PubMed Web of Science ®Google Scholar
• Hardeland R . Melatonin and the pathologies of weakened or dysregulated circadian oscillators. J. Pineal. Res.62(1), doi:10.1111/jpi.12377 (2017).
   PubMed Web of Science ®Google Scholar
• Hardeland R . Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives. Int. J. Mol. Sci.15(10), 18221–18252 (2014).
   PubMed Web of Science ®Google Scholar
• Korkmaz A , Rosales-CorralS , ReiterRJ. Gene regulation by melatonin linked to epigenetic phenomena. Gene503(1), 1–11 (2012).
   PubMed Web of Science ®Google Scholar
• Mehrzadi S , HematiK , ReiterRJ , HosseinzadehA. Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment. Expert Opin. Ther. Targets24(4), 359–378 (2020).
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh A , Javad-MoosaviSA , ReiterRJ , YarahmadiR , GhaznaviH , MehrzadiS. Oxidative/nitrosative stress, autophagy and apoptosis as therapeutic targets of melatonin in idiopathic pulmonary fibrosis. Expert Opin. Ther. Targets22(12), 1049–1061 (2018).
   PubMed Web of Science ®Google Scholar
• Reiter RJ , TanDX , ParedesSD , Fuentes-BrotoL. Beneficial effects of melatonin in cardiovascular disease. Ann. Med.42(4), 276–285 (2010).
   PubMed Web of Science ®Google Scholar
• Wang X . The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci. Ther.15(4), 345–357 (2009).
   PubMed Web of Science ®Google Scholar
• Hemati K , AminiKadijani A , SayehmiriFet al. Melatonin in the treatment of fibromyalgia symptoms: a systematic review. Complement Ther. Clin. Pract.38, 101072 (2020).
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh A , Javad-MoosaviSA , ReiterRJ , HematiK , GhaznaviH , MehrzadiS. Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. Life Sci.201, 17–29 (2018).
   PubMed Web of Science ®Google Scholar
• Dehdashtian E , PourhanifehMH , HematiK , MehrzadiS , HosseinzadehA. Therapeutic application of nutraceuticals in diabetic nephropathy: current evidence and future implications. Diabetes Metab. Res. Rev. doi:10.1002/dmrr.3336. (2020).
   PubMed Web of Science ®Google Scholar
• Pourhanifeh MH , HosseinzadehA , DehdashtianE , HematiK , MehrzadiS. Melatonin: new insights on its therapeutic properties in diabetic complications. Diabet. Metab. Syndr.12, 1–20 (2020).
   PubMed Web of Science ®Google Scholar
• Dehdashtian E , MehrzadiS , YousefiBet al. Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress. Life Sci.193, 20–33 (2018).
   PubMed Web of Science ®Google Scholar
• Reiter RJ , Rosales-CorralSA , TanDXet al. Melatonin, a Full service anti-cancer agent: inhibition of initiation, progression and metastasis. Int. J. Mol. Sci.18(4), 843 (2017).
   PubMed Web of Science ®Google Scholar
• Lellupitiyage Don SS , LinH-H , FurtadoJJ , QraitemM , TaylorSR , FarkasME. Circadian oscillations persist in low malignancy breast cancer cells. Cell Cycle18(19), 2447–2453 (2019).
   PubMed Web of Science ®Google Scholar
• Hardeland R . Interactions of melatonin and microRNAs. Biochem. Mol. Biol. J4(1), 7 (2018).
   Google Scholar
• Pagan C , Goubran-BotrosH , DelormeRet al. Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Sci. Rep.7(1), 1–11 (2017).
   PubMedGoogle Scholar
• Anderson G . Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology. Biochem. Pharmacol.168, 259–268 (2019).
   PubMed Web of Science ®Google Scholar
• Markus RP , FernandesPA , KinkerGS , DaSilveira Cruz-Machado S , MarçolaM. Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. Br. J. Pharmacol.175(16), 3239–3250 (2018).
   PubMed Web of Science ®Google Scholar
• Muxel SM , Pires-LapaMA , MonteiroAWAet al. NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS One7(12), e52010 (2012).
   PubMed Web of Science ®Google Scholar
• Anderson G , ReiterRJ. Glioblastoma: role of mitochondria n-acetylserotonin/melatonin ratio in mediating effects of mir-451 and aryl hydrocarbon receptor and in coordinating wider biochemical changes. Int. J. Tryptophan Res.12, doi:10.1177/1178646919855942 (2019).
   PubMed Web of Science ®Google Scholar
• Marques JHM , MotaAL , OliveiraJGet al. Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: in vivo and in vitro studies. Life Sci.208, 131–138 (2018).
   PubMed Web of Science ®Google Scholar
• Lacerda JZ , FerreiraLC , LopesBCet al. Therapeutic potential of melatonin in the regulation of MiR-148a-3p and angiogenic factors in breast cancer. Microrna8(3), 237–247 (2019).
   PubMedGoogle Scholar
• Ferreira LC , OrsoF , DettoriDet al. The role of melatonin on miRNAs modulation in triple-negative breast cancer cells. PLoS One15(2), e0228062 (2020).
   PubMed Web of Science ®Google Scholar
• Lee SE , KimSJ , YounJP , HwangSY , ParkCS , ParkYS. MicroRNA and gene expression analysis of melatonin-exposed human breast cancer cell lines indicating involvement of the anticancer effect. J. Pineal Res.51(3), 345–352 (2011).
   PubMed Web of Science ®Google Scholar
• De Oliveira JG , DeMora Marques JH , LacerdaJZ , FerreiraLC , CoelhoMMC , DeCampos Zuccari DaP. Melatonin down-regulates microRNA-10a and decreases invasion and migration of triple-negative breast cancer cells. Melatonin Research2(2), 86–99 (2019).
   Google Scholar
• Menéndez-Menéndez J , Hermida-PradoF , Granda-DíazRet al. Deciphering the molecular basis of melatonin protective effects on breast cells treated with doxorubicin: TWIST1 a transcription factor involved in EMT and metastasis, a novel target of melatonin. Cancers (Basel)11(7), 1011 (2019).
   PubMed Web of Science ®Google Scholar
• Wen YC , LinYW , ChuCYet al. Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma. J. Pineal Res. doi:10.1111/jpi.12668 69(2), e12668 (2020).
   PubMed Web of Science ®Google Scholar
• Gu J , LuZ , JiCet al. Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells. Biomed. Pharmacother.93, 969–975 (2017).
   PubMed Web of Science ®Google Scholar
• Zhu C , HuangQ , ZhuH. Melatonin inhibits the proliferation of gastric cancer cells through regulating the miR-16-5p-Smad3 pathway. DNA Cell Biol.37(3), 244–252 (2018).
   PubMed Web of Science ®Google Scholar
• Wang TH , HsuehC , ChenCCet al. Melatonin inhibits the progression of hepatocellular carcinoma through MicroRNA Let7i-3p mediated RAF1 reduction. Int. J. Mol. Sci.19(9), 2687 (2018).
   PubMed Web of Science ®Google Scholar
• Sakatani A , SonoharaF , GoelA. Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells. Carcinogenesis40(3), 422–431 (2019).
   PubMed Web of Science ®Google Scholar
• Jung JH , ShinEA , KimJHet al. NEDD9 inhibition by miR-25-5p activation is critically involved in co-treatment of melatonin- and pterostilbene-induced apoptosis in colorectal cancer cells. Cancers (Basel)11(11), 1684 (2019).
   PubMed Web of Science ®Google Scholar
• Mori F , FerraiuoloM , SantoroRet al. Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget7(15), 20532–20548 (2016).
   PubMedGoogle Scholar
• Hsieh MJ , LinCW , SuSCet al. Effects of miR-34b/miR-892a upregulation and inhibition of ABCB1/ABCB4 on melatonin-induced apoptosis in VCR-resistant oral cancer cells. Mol. Ther. Nucleic Acids19, 877–889 (2020).
   PubMedGoogle Scholar
• Kartini D , TaherA , PanigoroSSet al. Effect of melatonin supplementation in combination with neoadjuvant chemotherapy to miR-210 and CD44 expression and clinical response improvement in locally advanced oral squamous cell carcinoma: a randomized controlled trial. J. Egypt Natl. Canc. Inst.32(1), 12 (2020).
   PubMed Web of Science ®Google Scholar
• Hunsaker M , BarbaG , KingsleyK , HowardKM. Differential microRNA expression of miR-21 and miR-155 within oral cancer extracellular vesicles in response to melatonin. Dent. J. (Basel)7(2), 48 (2019).
   PubMedGoogle Scholar
• Sohn EJ , WonG , LeeJ , LeeS , KimSH. Upregulation of miRNA3195 and miRNA374b Mediates the anti-angiogenic properties of melatonin in hypoxic PC-3 prostate cancer cells. J. Cancer6(1), 19–28 (2015).
   PubMed Web of Science ®Google Scholar
• Zhou B , YeH , XingCet al. Targeting miR-193a-AML1-ETO-beta-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation. J. Cell Mol. Med.23(8), 5246–5258 (2019).
   PubMed Web of Science ®Google Scholar
• Vimalraj S , SaravananS , RaghunandhakumarS , AnuradhaD. Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma. Life Sci. doi:10.1016/j.lfs.2020.118011 256, 118011 (2020).
   PubMed Web of Science ®Google Scholar
• Kim SJ , KangHS , LeeJHet al. Melatonin ameliorates ER stress-mediated hepatic steatosis through miR-23a in the liver. Biochem. Biophys. Res. Commun.458(3), 462–469 (2015).
   PubMed Web of Science ®Google Scholar
• Kim YD , HwangSL , LeeEJet al. Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression. J. Pineal Res.62(2), e12386 (2017).
   Web of Science ®Google Scholar
• Stacchiotti A , GrossiI , García-GómezRet al. Melatonin effects on non-alcoholic fatty liver disease are related to MicroRNA-34a-5p/Sirt1 axis and autophagy. Cells8(9), 1053 (2019).
   PubMed Web of Science ®Google Scholar
• Carloni S , FavraisG , SalibaEet al. Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway. J. Pineal Res.61(3), 370–380 (2016).
   PubMed Web of Science ®Google Scholar
• Zhao Y , ZhaoR , WuJet al. Melatonin protects against Abeta-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway. Biofactors44(6), 609–618 (2018).
   PubMed Web of Science ®Google Scholar
• Li N , WangZ , GaoF , LeiY , LiZ. Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation. J. Cell Mol. Med.24(10), 5615–5628 (2020).
   PubMed Web of Science ®Google Scholar
• Yoon YM , GoG , YunCW , LimJH , LeeJH , LeeSH. Melatonin suppresses renal cortical fibrosis by inhibiting cytoskeleton reorganization and mitochondrial dysfunction through regulation of miR-4516. Int. J. Mol. Sci.21(15), 5323 (2020).
   Web of Science ®Google Scholar
• Che H , WangY , LiHet al. Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. Faseb j34(4), 5282–5298 (2020).
   PubMed Web of Science ®Google Scholar
• Tu Y , ZhuM , WangZet al. Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. J. Cell Physiol. doi:10.1002/jcp.29716 (2020).
   Web of Science ®Google Scholar
• Xia D-Y , JiangX-C , LiZ-B , DaiY , ZhangZ-H , YangS. Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4. PREPRINT (Version 1) available at Research Square (2020).
   Google Scholar
• Bae H , YangC , LeeJYet al. Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy. J. Pineal Res. doi:10.1111/jpi.12670 69(2), e12670 (2020).
   PubMed Web of Science ®Google Scholar
• Yang S , TangW , HeY , WenL , SunB , LiS. Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor. Cell Death Dis.9(2), 99 (2018).
   PubMedGoogle Scholar
• Wang X , WangZ-H , WuY-Yet al. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway. Mol. Neurobiol.47(1), 373–381 (2013).
   PubMed Web of Science ®Google Scholar
• Li Z , LiX , BiJ , ChanMT , WuWKK , ShenJ. Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling. J. Pineal Res.66(3), e12558 (2019).
   PubMed Web of Science ®Google Scholar
• Li N , WangZ , GaoF , LeiY , LiZ. Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation. J. Cell Mol. Med.24(10), 5615–5628 (2020).
   PubMed Web of Science ®Google Scholar
• Liu F , ZhangS , XuR , GaoS , YinJ. Melatonin attenuates endothelial-to-mesenchymal transition of glomerular endothelial cells via Regulating miR-497/ROCK in diabetic nephropathy. Kidney Blood Press Res.43(5), 1425–1436 (2018).
   PubMed Web of Science ®Google Scholar
• Che H , WangY , LiHet al. Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. FASEB J 34(4), 5282-5298 (2020).
   Web of Science ®Google Scholar
• Tu Y , ZhuM , WangZet al. Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. J. Cell Physiol.235(11), 8724–8735 (2020).
   PubMed Web of Science ®Google Scholar
• Ali T , MushtaqI , MaryamSet al. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Arch Biochem. Biophys.661, 56–65 (2019).
   PubMed Web of Science ®Google Scholar
• Han Y-S , LeeJH , LeeSH. Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. Biochem. Biophys. Res. Commun.525(2), 354 –359 (2020).
   PubMed Web of Science ®Google Scholar
• Yang B , ZangLE , CuiJW , ZhangMY , MaX , WeiLL. Melatonin plays a protective role by regulating miR-26a-5p-NRSF and JAK2-STAT3 pathway to improve autophagy, inflammation and oxidative stress of cerebral ischemia-reperfusion injury. Drug Des. Devel. Ther.14, 3177–3188 (2020).
   PubMed Web of Science ®Google Scholar
• Che H , LiH , LiYet al. Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ-induced diabetic mice. Faseb J. doi:10.1096/fj.202001328R 34(10), 14042-14054 (2020).
   Web of Science ®Google Scholar
• Wang Y , HanD , ZhouTet al. Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. J. Pineal Res.e12666, 69(2) (2020).
   Web of Science ®Google Scholar
• Xu F , ZhongJY , LinXet al. Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. J. Pineal Res.68(3), e12631 (2020).
   PubMed Web of Science ®Google Scholar
• Wu X , JiH , WangYet al. Melatonin alleviates radiation-induced lung injury via regulation of miR-30e/NLRP3 axis. Oxid. Med. Cell Longev. 2019, 9705929 (2019).
   PubMed Web of Science ®Google Scholar
• Fernandes JCR , AokiJI , MaiaAcuña Set al. Melatonin and Leishmania amazonensis infection altered miR-294, miR-30e and miR-302d impacting on Tnf, Mcp-1 and Nos2 expression. Front. Cell Infect. Microbiol.9, 60 (2019).
   PubMed Web of Science ®Google Scholar
• Hai B , MaY , PanXet al. Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting mir-106a-5p/ATg7 signaling pathway. Clin. Interv. Aging14, 621 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang Y , LinJ , ZhouXet al. Melatonin prevents osteoarthritis-induced cartilage degradation via targeting microRNA-140. Oxid. Med. Cell Longev.2019, 9705929 (2019).
   PubMed Web of Science ®Google Scholar
• Huang CC , ChiouCH , LiuSCet al. Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis. J. Pineal Res.66(3), e12560 (2019).
   PubMed Web of Science ®Google Scholar
• O’brien J , HayderH , ZayedY , PengC. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front. Endocrinol.9, 402–402 (2018).
   PubMed Web of Science ®Google Scholar
• Treiber T , TreiberN , MeisterG. Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat. Rev. Mol. Cell. Biol.20(1), 5–20 (2019).
   PubMed Web of Science ®Google Scholar
• Lee HY , DoudnaJA. TRBP alters human precursor microRNA processing in vitro. RNA (New York, N.Y.)18(11), 2012–2019 (2012).
   PubMed Web of Science ®Google Scholar
• Liu J , CloughSJ , HutchinsonAJ , Adamah-BiassiEB , Popovska-GorevskiM , DubocovichML. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu. Rev. Pharmacol. Toxicol.56, 361–383 (2016).
   PubMed Web of Science ®Google Scholar
• Jin X , Von GallC , PieschlRLet al. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol. Cell Biol.23(3), 1054–1060 (2003).
   PubMed Web of Science ®Google Scholar
• Ekmekcioglu C . Melatonin receptors in humans: biological role and clinical relevance. Biomed. Pharmacother.60(3), 97–108 (2006).
   PubMed Web of Science ®Google Scholar
• Karasek M , WinczykK. Melatonin in humans. J. Physiol. Pharmacol.57(Suppl. 5), 19–39 (2006).
   PubMedGoogle Scholar
• Demuro RL , NafzigerAN , BlaskDE , MenhinickAM , BertinoJSJr. The absolute bioavailability of oral melatonin. J. Clin. Pharmacol.40(7), 781–784 (2000).
   PubMed Web of Science ®Google Scholar
• Zhdanova IV , LynchHJ , WurtmanRJ. Melatonin: a sleep-promoting hormone. Sleep20(10), 899–907 (1997).
   PubMed Web of Science ®Google Scholar
• Reiter RJ , TanDX , MaldonadoMD. Melatonin as an antioxidant: physiology versus pharmacology. J. Pineal. Res.39(2), 215–216 (2005).
   PubMed Web of Science ®Google Scholar
• Jockers R , MauriceP , BoutinJA , DelagrangeP. Melatonin receptors, heterodimerization, signal transduction and binding sites: what’s new?Br. J. Pharmacol.154(6), 1182–1195 (2008).
   PubMed Web of Science ®Google Scholar
• Iuvone PM , TosiniG , PozdeyevN , HaqueR , KleinDC , ChaurasiaSS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog. Retin. Eye Res.24(4), 433–456 (2005).
   PubMed Web of Science ®Google Scholar
• Scheer FA , Van MontfransGA , Van SomerenEJ , MairuhuG , BuijsRM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension43(2), 192–197 (2004).
   PubMed Web of Science ®Google Scholar
• Alghamdi BS . The neuroprotective role of melatonin in neurological disorders. J. Neurosci. Res.96(7), 1136–1149 (2018).
   PubMed Web of Science ®Google Scholar
• Carrillo-Vico A , GuerreroJM , LardonePJ , ReiterRJ. A review of the multiple actions of melatonin on the immune system. Endocrine27(2), 189–200 (2005).
   PubMed Web of Science ®Google Scholar
• Miller SC , Pandi-PerumalSR , EsquifinoAI , CardinaliDP , MaestroniGJ. The role of melatonin in immuno-enhancement: potential application in cancer. Int. J. Exp. Pathol.87(2), 81–87 (2006).
   PubMed Web of Science ®Google Scholar
• Srinivasan V , Pandi-PerumalSR , MaestroniGJ , EsquifinoAI , HardelandR , CardinaliDP. Role of melatonin in neurodegenerative diseases. Neurotox. Res.7(4), 293–318 (2005).
   PubMed Web of Science ®Google Scholar
• Maestroni GJ , CardinaliDP , EsquifinoAI , Pandi-PerumalS. Does melatonin play a disease-promoting role in rheumatoid arthritis?J. Neuroimmunol.158(1–2), 106–111 (2005).
   PubMed Web of Science ®Google Scholar
• Zhang JJ , MengX , LiYet al. Effects of melatonin on liver injuries and diseases. Int. J. Mol. Sci.18(4), 673 (2017).
   PubMed Web of Science ®Google Scholar
• Pourhanifeh MH , MahdaviniaM , ReiterRJ , AsemiZ. Potential use of melatonin in skin cancer treatment: a review of current biological evidence. J. Cell. Physiol.234(8), 12142–12148 (2019).
   PubMed Web of Science ®Google Scholar
• Pourhanifeh MH , SharifiM , ReiterRJ , DavoodabadiA , AsemiZ. Melatonin and non-small cell lung cancer: new insights into signaling pathways. Cancer Cell Int.19, 131 (2019).
   PubMed Web of Science ®Google Scholar
• Moretti E , FaveroG , RodellaLF , RezzaniR. Melatonin’s antineoplastic potential against glioblastoma. Cells9(3), 599 (2020).
   PubMed Web of Science ®Google Scholar
• González A , González-GonzálezA , Alonso-GonzálezC , Menéndez-MenéndezJ , Martínez-CampaC , CosS. Melatonin inhibits angiogenesis in SH-SY5Y human neuroblastoma cells by downregulation of VEGF. Oncol. Rep.37(4), 2433–2440 (2017).
   PubMed Web of Science ®Google Scholar
• Lu KH , SuSC , LinCWet al. Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway. J. Pineal Res.65(3), e12507 (2018).
   PubMed Web of Science ®Google Scholar
• Tang YL , SunX , HuangLBet al. Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. Cancer Lett.443, 167–178 (2019).
   PubMed Web of Science ®Google Scholar
• Zou ZW , LiuT , LiYet al. Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS. Redox Biol.16, 226–236 (2018).
   PubMed Web of Science ®Google Scholar
• Chen L , LiuL , LiY , GaoJ. Melatonin increases human cervical cancer HeLa cells apoptosis induced by cisplatin via inhibition of JNK/Parkin/mitophagy axis. In Vitro Cell Dev. Biol. Anim.54(1), 1–10 (2018).
   PubMed Web of Science ®Google Scholar
• Chuffa LGA , ReiterRJ , LupiLA. Melatonin as a promising agent to treat ovarian cancer: molecular mechanisms. Carcinogenesis38(10), 945–952 (2017).
   PubMed Web of Science ®Google Scholar
• Chok KC , NgCH , KohRY , NgKY , ChyeSM. The potential therapeutic actions of melatonin in colorectal cancer. Horm. Mol. Biol. Clin. Investig.39(1), 20190001 (2019).
   Web of Science ®Google Scholar
• Fang Z , JungKH , YanHHet al. Melatonin synergizes with sorafenib to suppress pancreatic cancer via melatonin receptor and PDGFR-β/STAT3 pathway. Cell Physiol. Biochem.47(5), 1751–1768 (2018).
   PubMedGoogle Scholar
• Zhou N , WeiZX , QiZX. Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells. BMC Neurosci.20(1), 63 (2019).
   PubMed Web of Science ®Google Scholar
• Zheng Y , TuJ , WangXet al. The therapeutic effect of melatonin on GC by inducing cell apoptosis and autophagy induced by endoplasmic reticulum stress. Onco. Targets Ther.12, 10187–10198 (2019).
   PubMed Web of Science ®Google Scholar
• Shen YQ , Guerra-LibreroA , Fernandez-GilBIet al. Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. J. Pineal Res.64(3), e12461 (2018).
   Web of Science ®Google Scholar
• Laothong U , HirakuY , OikawaS , IntuyodK , MurataM , PinlaorS. Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway. Oncol. Rep.33(3), 1443–1449 (2015).
   PubMed Web of Science ®Google Scholar
• Farhood B , GoradelNH , MortezaeeKet al. Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization. Clin. Transl. Oncol.21(3), 268–279 (2019).
   PubMed Web of Science ®Google Scholar
• Asghari MH , GhobadiE , MoloudizargariM , FallahM , AbdollahiM. Does the use of melatonin overcome drug resistance in cancer chemotherapy?Life Sci.196, 143–155 (2018).
   PubMed Web of Science ®Google Scholar
• Murodumi H , ShigeishiH , KatoHet al. Melatonin-induced miR-181c-5p enhances osteogenic differentiation and mineralization of human jawbone-derived osteoblastic cells. Mol. Med. Rep.22(4), 3549–3558 (2020).
   PubMed Web of Science ®Google Scholar
• Meng X , ZhuY , TaoL , ZhaoS , QiuS. miR-590-3p mediates melatonin-induced cell apoptosis by targeting septin 7 in the human osteoblast cell line hFOB 1.19. Mol. Med. Rep.17(5), 7202–7208 (2018).
   PubMed Web of Science ®Google Scholar
• Li Y , FengC , GaoMet al. MicroRNA-92b-5p modulates melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM-1. J. Cell. Mol. Med.23(9), 6140–6153 (2019).
   PubMed Web of Science ®Google Scholar
• Candia J , FernandezA , SomarrivaC , Horna-CamposO. [Deaths due to oral cancer in Chile in the period 2002–2012]. Rev. Med. Chil.146(4), 487–493 (2018).
   PubMed Web of Science ®Google Scholar
• Ferlay J , SoerjomataramI , DikshitRet al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer136(5), E359–386 (2015).
   PubMed Web of Science ®Google Scholar
• Scott SE , GrunfeldEA , McgurkM. The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. Oral Oncol.41(4), 396–403 (2005).
   PubMed Web of Science ®Google Scholar
• Alves AM , DielLF , LamersML. Macrophages and prognosis of oral squamous cell carcinoma: a systematic review. J. Oral Pathol. Med.47(5), 460–467 (2018).
   PubMed Web of Science ®Google Scholar
• Safi A-F , GrochauK , DrebberUet al. A novel histopathological scoring system for patients with oral squamous cell carcinoma. Clin. Oral Investig.23(10), 3759–3765 (2019).
   PubMed Web of Science ®Google Scholar
• Ribeiro IL , DeMedeiros JJ , RodriguesLV , ValencaAM , LimaNeto Ede A. Factors associated with lip and oral cavity cancer. Rev. Bras. Epidemiol.18(3), 618–629 (2015).
   PubMedGoogle Scholar
• Rapado-Gonzalez O , Lopez-LopezR , Lopez-CedrunJL , Triana-MartinezG , Muinelo-RomayL , Suarez-CunqueiroMM. Cell-Free microRNAs as potential oral cancer biomarkers: from diagnosis to therapy. Cells8(12), 1653 (2019).
   PubMed Web of Science ®Google Scholar
• Capote-Moreno A , RamosE , EgeaJ , López-MuñozF , Gil-MartínE , RomeroA. Potential of melatonin as adjuvant therapy of oral cancer in the era of epigenomics. Cancers11(11), 1712 (2019).
   PubMed Web of Science ®Google Scholar
• Bray F , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
   PubMed Web of Science ®Google Scholar
• El-Deiry WS , VijayvergiaN , XiuJet al. Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites. Cancer Biol. Ther.16(12), 1726–1737 (2015).
   PubMed Web of Science ®Google Scholar
• Guraya SY . Pattern, stage, and time of recurrent colorectal cancer after curative surgery. Clin. Colorectal Cancer18(2), e223–e228 (2019).
   PubMed Web of Science ®Google Scholar
• Lan YT , ChangSC , YangSHet al. Comparison of clinicopathological characteristics and prognosis between early and late recurrence after curative surgery for colorectal cancer. Am. J. Surg.207(6), 922–930 (2014).
   PubMed Web of Science ®Google Scholar
• Liu H , LiD , FangH , NingJ. Species-specific function of microRNA-7702 in human colorectal cancer cells via targeting TADA1. Am. J. Transl. Res.10(8), 2579–2589 (2018).
   PubMed Web of Science ®Google Scholar
• Fang L , LiH , WangLet al. MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. Oncotarget5(10), 2974–2987 (2014).
   PubMedGoogle Scholar
• Xu K , LiuX , MaoXet al. MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1. Cell Physiol. Biochem.35(2), 499–515 (2015).
   PubMedGoogle Scholar
• Iravani S , EslamiP , DooghaieMoghadam Aet al. The role of melatonin in colorectal cancer. J. Gastrointest. Cancer doi:10.1007/s12029-019-00336-4 51(3), 748-753 (2020).
   Web of Science ®Google Scholar
• Rawla P , SunkaraT , MuralidharanP , RajJP. Update in global trends and aetiology of hepatocellular carcinoma. Contemp. Oncol. (Pozn)22(3), 141–150 (2018).
   PubMed Web of Science ®Google Scholar
• Llovet JM , RicciS , MazzaferroVet al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med.359(4), 378–390 (2008).
   PubMed Web of Science ®Google Scholar
• Jiang Y , HeJ , LiY , GuoY , TaoH. The diagnostic value of MicroRNAs as a biomarker for hepatocellular carcinoma: a meta-analysis. Biomed. Res. Int.2019, 5179048 (2019).
   PubMed Web of Science ®Google Scholar
• Klingenberg M , MatsudaA , DiederichsS , PatelT. Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets. J. Hepatol.67(3), 603–618 (2017).
   PubMed Web of Science ®Google Scholar
• Mortezaee K . Human hepatocellular carcinoma: protection by melatonin. J. Cell. Physiol.233(10), 6486–6508 (2018).
   PubMed Web of Science ®Google Scholar
• Ang TL , FockKM. Clinical epidemiology of gastric cancer. Singapore Med. J.55(12), 621–628 (2014).
   PubMed Web of Science ®Google Scholar
• Hohenberger P , GretschelS. Gastric cancer. Lancet362(9380), 305–315 (2003).
   PubMed Web of Science ®Google Scholar
• Shin VY , ChuKM. MiRNA as potential biomarkers and therapeutic targets for gastric cancer. World J. Gastroenterol.20(30), 10432–10439 (2014).
   PubMed Web of Science ®Google Scholar
• Wei X , ChenS , XuZet al. Melatonin inhibits the migration of human gastric carcinoma cells at least in part by remodeling tight junction. J. Cell Biochem.120(6), 9781–9786 (2019).
   PubMed Web of Science ®Google Scholar
• Torre LA , BrayF , SiegelRL , FerlayJ , Lortet-TieulentJ , JemalA. Global cancer statistics, 2012. CA Cancer J. Clin.65(2), 87–108 (2015).
   PubMed Web of Science ®Google Scholar
• Deng X , WuH , GaoFet al. Brachytherapy in the treatment of breast cancer. Int. J. Clin. Oncol.22(4), 641–650 (2017).
   PubMed Web of Science ®Google Scholar
• Castaneda SA , StrasserJ. Updates in the treatment of breast cancer with radiotherapy. Surg. Oncol. Clin. N. Am.26(3), 371–382 (2017).
   PubMed Web of Science ®Google Scholar
• Merino Bonilla JA , TorresTabanera M , RosMendoza LH. Breast cancer in the 21st century: from early detection to new therapies. Radiologia59(5), 368–379 (2017).
   PubMedGoogle Scholar
• Tang Q , OuyangH , HeD , YuC , TangG. MicroRNA-based potential diagnostic, prognostic and therapeutic applications in triple-negative breast cancer. Artif. Cells Nanomed. Biotechnol.47(1), 2800–2809 (2019).
   PubMed Web of Science ®Google Scholar
• Petrescu GED , SaboAA , TorsinLI , CalinGA , DragomirMP. MicroRNA based theranostics for brain cancer: basic principles. J. Exp. Clin. Cancer Res.38(1), 231 (2019).
   PubMedGoogle Scholar
• Ahmadloo N , KaniAA , MohammadianpanahMet al. Treatment outcome and prognostic factors of adult glioblastoma multiforme. J. Egypt Natl. Canc. Inst.25(1), 21–30 (2013).
   PubMedGoogle Scholar
• Maitra S , BhattacharyaD , DasS , BhattacharyaS. Melatonin and its anti-glioma functions: a comprehensive review. Rev. Neurosci.30(5), 527–541 (2019).
   PubMed Web of Science ®Google Scholar
• Gu J , LuZ , JiCet al. Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells. Biomed. Pharmacother.93, 969–975 (2017).
   PubMed Web of Science ®Google Scholar
• Fendler A , JungM , StephanCet al. miRNAs can predict prostate cancer biochemical relapse and are involved in tumor progression. Int. J. Oncol.39(5), 1183–1192 (2011).
   PubMed Web of Science ®Google Scholar
• Li HZ , ZhangYS. [Review of hot topics in the diagnosis and treatment of prostate cancer in 2016]. Zhonghua Wai Ke Za Zhi55(1), 59–62 (2017).
   PubMedGoogle Scholar
• Jayaraj R , RaymondG , KrishnanSet al. Clinical theragnostic potential of diverse miRNA expressions in prostate cancer: a systematic review and meta-analysis. Cancers (Basel)12(5), 1199 (2020).
   PubMed Web of Science ®Google Scholar
• Liu VWS , YauWL , TamCW , YaoKM , ShiuSYW. Melatonin inhibits androgen receptor splice variant-7 (AR-V7)-induced nuclear factor-kappa B (NF-kappaB) activation and NF-kappaB activator-induced AR-V7 expression in prostate cancer cells: potential implications for the use of melatonin in castration-resistant prostate Cancer (CRPC) therapy. Int. J. Mol. Sci.18(6), 1130 (2017).
   PubMed Web of Science ®Google Scholar
• Cotterill SJ , WrightCM , PearceMS , CraftAW. Stature of young people with malignant bone tumors. Pediatr. Blood Cancer42(1), 59–63 (2004).
   PubMed Web of Science ®Google Scholar
• Vimalraj S , SaravananS , RaghunandhakumarS , AnuradhaD. Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma. Life Sci.256, 118011 (2020).
   PubMed Web of Science ®Google Scholar
• Zhu LQ , WangSH , LingZQ , WangDL , WangJZ. Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat. J. Pineal Res.37(2), 71–77 (2004).
   PubMed Web of Science ®Google Scholar
• Rao JY , WangQ , WangYCet al. [β-caryophyllene alleviates cerebral ischemia/reperfusion injury in mice by activating autophagy]. Zhongguo Zhong Yao Za Zhi45(4), 932–936 (2020).
   PubMedGoogle Scholar
• Hou Y , WangJ , FengJ. The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury. Drug Des. Devel. Ther.13, 1135–1144 (2019).
   PubMed Web of Science ®Google Scholar
• Chen Y , HeL , PangMet al. Melatonin PROMOTES NEUROprotection of H(2)O(2)-induced neural stem cells via lncRNA MEG3/miRNA-27a-3p/MAP2K4 axis. Neuroscience446, 69–79 (2020).
   PubMed Web of Science ®Google Scholar
• Peng H , LiY , WangCet al. ROCK1 induces endothelial-to-mesenchymal transition in glomeruli to aggravate albuminuria in diabetic nephropathy. Sci. Rep.6, 20304 (2016).
   PubMed Web of Science ®Google Scholar
• Ma WY , SongRJ , XuBBet al. Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway. Acta. Pharmacol. Sin. doi:10.1038/s41401-020-0495-2 (2020).
   Web of Science ®Google Scholar
• Daryani A , MontazeriM , PaghehASet al. The potential use of melatonin to treat protozoan parasitic infections: a review. Biomed. Pharmacother.97, 948–957 (2018).
   PubMed Web of Science ®Google Scholar
• Zhang S-J , YangW , WangCet al. Autophagy: A double-edged sword in intervertebral disk degeneration. Clinica. Chimica. Acta.457, 27–35 (2016).
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh A , KamravaSK , MooreBCet al. Molecular aspects of melatonin treatment in tinnitus: a review. Curr. Drug Targets20(11), 1112–1128 (2019).
   PubMed Web of Science ®Google Scholar
• Juybari KB , HosseinzadehA , GhaznaviHet al. Melatonin as a modulator of degenerative and regenerative signaling pathways in injured retinal ganglion cells. Curr. Pharm. Des.25(28), 3057–3073 (2019).
   PubMed Web of Science ®Google Scholar
• Wu Z , QiuX , GaoBet al. Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells. J. Pineal Res.65(1), e12483 (2018).
   PubMed Web of Science ®Google Scholar