Advanced search
Publication Cover
Epigenomics Volume 13, 2021 - Issue 11
Submit an article Journal homepage
178
Views
1
CrossRef citations to date
0
Altmetric
Short Communication

Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals

Misty Good1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0264-5721
ORCID Icon,
Tianjiao Chu2 Departments of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA15213, USA;5 Magee-Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA15213, USAORCID Iconhttps://orcid.org/0000-0001-9644-771X
ORCID Icon,
Patricia Shaw5 Magee-Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA15213, USA
,
Lila S Nolan1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USAORCID Iconhttps://orcid.org/0000-0002-4185-2686
ORCID Icon,
Lora McClain4 Psychiatry, University of Pittsburgh, Pittsburgh, PA15213, USA
,
Austin Chamberlain5 Magee-Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA15213, USA
,
Carlos Castro5 Magee-Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA15213, USAORCID Iconhttps://orcid.org/0000-0003-2419-3604
ORCID Icon,
Qingqing Gong1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USA
,
Krista Cooksey1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USAORCID Iconhttps://orcid.org/0000-0001-7236-0089
ORCID Icon,
Laura Linneman1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USA
,
Olivia N DeWitt1 Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO63110, USA
,
David N Finegold3 Human Genetics, University of Pittsburgh, Pittsburgh, PA15261, USAORCID Iconhttps://orcid.org/0000-0001-9901-2578
ORCID Icon &
David G Peters2 Departments of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA15213, USA;3 Human Genetics, University of Pittsburgh, Pittsburgh, PA15261, USA;4 Psychiatry, University of Pittsburgh, Pittsburgh, PA15213, USA;5 Magee-Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA15213, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4354-1125
ORCID Icon show all
Pages 829-844 | Received 02 Mar 2021, Accepted 12 Apr 2021, Published online: 27 Apr 2021

References

  • Patel RM , KandeferS , WalshMCet al. Causes and timing of death in extremely premature infants from 2000 through 2011. N. Engl. J. Med.372(4), 331–340 (2015).
  • Neu J , WalkerWA. Necrotizing enterocolitis. N. Engl. J. Med.364(3), 255–264 (2011).
  • Bosch LJW , MelotteV , MongeraSet al. Multitarget stool DNA test performance in an average-risk colorectal cancer screening population. Am. J. Gastroenterol.114(12), 1909–1918 (2019).
  • Ngo TTM , MoufarrejMN , RasmussenM-LHet al. Noninvasive blood tests for fetal development predict gestational age and preterm delivery. Science360(6393), 1133–1136 (2018).
  • Karlas T , WeiseL , KuhnSet al. Correlation of cell-free DNA plasma concentration with severity of non-alcoholic fatty liver disease. J. Transl. Med.15(1), 106 (2017).
  • van der Meer AJ , KroezeA , HoogendijkAJet al. Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans. Blood Adv.3(5), 724–728 (2019).
  • Blauwkamp TA , ThairS , RosenMJet al. Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease. Nat. Microbiol.4(4), 663–674 (2019).
  • Chu T , ShawPA , YeniterziSet al. Comparative evaluation of the Minimally-Invasive Karyotyping (MINK) algorithm for non-invasive prenatal testing. PLoS ONE12(3), e0171882 (2017).
  • McDermott E , RyanEJ , TosettoMet al. DNA methylation profiling in inflammatory bowel disease provides new insights into disease pathogenesis. J. Crohns Colitis10(1), 77–86 (2016).
  • Karatzas PS , MantzarisGJ , SafioleasM , GazouliM. DNA methylation profile of genes involved in inflammation and autoimmunity in inflammatory bowel disease. Medicine (Baltimore)93(28), e309 (2014).
  • Lin Z , HegartyJP , YuWet al. Identification of disease-associated DNA methylation in B cells from Crohn’s disease and ulcerative colitis patients. Dig. Dis. Sci.57(12), 3145–3153 (2012).
  • Nimmo ER , PrendergastJG , AldhousMCet al. Genome-wide methylation profiling in Crohn’s disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm. Bowel Dis.18(5), 889–899 (2012).
  • Cooke J , ZhangH , GregerLet al. Mucosal genome-wide methylation changes in inflammatory bowel disease. Inflamm. Bowel Dis.18(11), 2128–2137 (2012).
  • Krueger F , AndrewsSR. Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics27(11), 1571–1572 (2011).
  • Park Y , FigueroaME , RozekLS , SartorMA. MethylSig: a whole genome DNA methylation analysis pipeline. Bioinformatics30(17), 2414–2422 (2014).
  • Park Y , WuH. Differential methylation analysis for BS-seq data under general experimental design. Bioinformatics32(10), 1446–1453 (2016).
  • Good M , ChuT , ShawPet al. Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis. Clin. Epigenetics12(1), 190 (2020).
  • Uchiyama K , SakiyamaT , HasebeTet al. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci. Rep.6, 32094 (2016).
  • Li B , LeeC , CadeteMet al. Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis. Cell Death Dis.10(10), 743 (2019).
  • Siakavellas SI , BamiasG. Tumor necrosis factor-like cytokine TL1A and its receptors DR3 and DcR3: important new factors in mucosal homeostasis and inflammation. Inflamm. Bowel Dis.21(10), 2441–2452 (2015).
  • Agbo KC , HuangJZ , GhalebAMet al. Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial–mesenchymal transition in colorectal cancer. J. Cancer Metastasis Treat.5, 77. (2019).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.