Advanced search
Publication Cover
Epigenomics Volume 13, 2021 - Issue 18
Submit an article Journal homepage
89
Views
0
CrossRef citations to date
0
Altmetric
Commentary

Exosome-Derived ncRNAs as Potential Drivers of Epigenetic Reprogramming of Cancer Stem Cells

Vijayashree Priyadharsini Jayaseelan1 Clinical Genetics Lab, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, 60077, Tamil Nadu, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7884-5466View further author information
ORCID Icon &
Paramasivam Arumugam2 Molecular Biology Lab, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 60077, Tamil Nadu, IndiaORCID Iconhttps://orcid.org/0000-0001-6117-1178View further author information
ORCID Icon
Pages 1439-1441 | Received 24 Apr 2021, Accepted 10 Sep 2021, Published online: 01 Oct 2021

References

  • Sung H , FerlayJ , SiegelRLet al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.71(3), 209–249 (2021).
  • Yang Y , WangY. Role of epigenetic regulation in plasticity of tumor immune microenvironment. Front. Immunol.12, 640369 (2021).
  • Yang E , WangX , GongZet al. Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduct. Target. Ther.5(1), 242 (2020).
  • Tan S , XiaL , YiPet al. Exosomal miRNAs in tumor microenvironment. J. Exp. Clin. Cancer Res.39(1), 67 (2020).
  • Sansone P , BerishajM , RajasekharVKet al. Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res.77(19), 5438 (2017).
  • Biswas S , MandalG , ChowdhurySRet al. Exosomes produced by mesenchymal stem cells drive differentiation of myeloid cells into immunosuppressive M2-polarized macrophages in breast cancer. J. Immunol.203(12), 3447–3460 (2019).
  • Xu J , LiaoK , ZhouW. Exosomes regulate the transformation of cancer cells in cancer stem cell homeostasis. Stem Cells Int.2018, 4837370 (2018).
  • Sun Z , WangL , DongLet al. Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium. J. Cell. Mol. Med.22(8), 3719–3728 (2018).
  • Dai W , JinX , HanLet al. Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma. Cell Death Dis.11(9), 743 (2020).
  • Wang L , BoX , YiXet al. Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway. Cell Death Dis.11(9), 723 (2020).
  • Wang L , HeM , FuLet al. Exosomal release of microRNA-454 by breast cancer cells sustains biological properties of cancer stem cells via the PRRT2/Wnt axis in ovarian cancer. Life Sci.257, 118024 (2020).
  • Gao Z , WangQ , JiMet al. Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis. J. Transl. Med.19(1), 229 (2021).
  • Shen M , DongC , RuanXet al. Chemotherapy-induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2. Cancer Res.79(14), 3608–3621 (2019).
  • Yang Q , ZhaoS , ShiZet al. Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling. J. Exp. Clin. Cancer Res.40(1), 120 (2021).
  • Lin H , ZhangL , ZhangCet al. Exosomal MiR-500a-3p promotes cisplatin resistance and stemness via negatively regulating FBXW7 in gastric cancer. J. Cell. Mol. Med.24(16), 8930–8941 (2020).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.