H3K9 Methyltransferase EHMT2/G9a Controls ERVK-Driven Noncanonical Imprinted Genes

References

• Bartolomei MS , Ferguson-SmithAC. Mammalian genomic imprinting. Cold Spring Harb. Perspect. Biol.3(7), 1–17 (2011).
   Web of Science ®Google Scholar
• Tucci V , IslesAR , KelseyG , Ferguson-SmithAC , EriceImprinting Group. Genomic imprinting and physiological processes in mammals. Cell176(5), 952–965 (2019).
   PubMed Web of Science ®Google Scholar
• Bourc’his D , XuGL , LinCS , BollmanB , BestorTH. Dnmt3L and the establishment of maternal genomic imprints. Science294(5551), 2536–2539 (2001).
   PubMed Web of Science ®Google Scholar
• Kaneda M , OkanoM , HataKet al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature429(6994), 900–903 (2004).
   PubMed Web of Science ®Google Scholar
• Okae H , HiuraH , NishidaYet al. Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression. Hum. Mol. Genet.21(3), 548–558 (2012).
   PubMed Web of Science ®Google Scholar
• Wang X , SolowayPD , ClarkAG. A survey for novel imprinted genes in the mouse placenta by mRNA-seq. Genetics189(1), 109–122 (2011).
   PubMed Web of Science ®Google Scholar
• Andergassen D , DotterCP , WenzelDet al. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. eLife6, e25125 (2017).
   PubMed Web of Science ®Google Scholar
• Hanna CW . Placental imprinting: emerging mechanisms and functions. PLoS Genet.16(4), e1008709 (2020).
   PubMed Web of Science ®Google Scholar
• Hanna CW , Perez-PalaciosR , GahurovaLet al. Endogenous retroviral insertions drive noncanonical imprinting in extra-embryonic tissues. Genome Biol.20(1), 225 (2019).
   PubMed Web of Science ®Google Scholar
• Chen Z , YinQ , InoueA , ZhangC , ZhangY. Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells. Sci. Advan.5(12), eaay7246 (2019).
   PubMed Web of Science ®Google Scholar
• Inoue A , JiangL , LuF , SuzukiT , ZhangY. Maternal H3K27me3 controls DNA methylation-independent imprinting. Nature547(7664), 419–424 (2017).
   PubMed Web of Science ®Google Scholar
• Wanigasuriya I , GouilQ , KinkelSAet al. Smchd1 is a maternal effect gene required for genomic imprinting. eLife9, e55529 (2020).
   PubMed Web of Science ®Google Scholar
• Lewis A , MitsuyaK , UmlaufDet al. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat. Genet.36(12), 1291–1295 (2004).
   PubMed Web of Science ®Google Scholar
• Umlauf D , GotoY , CaoRet al. Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat. Genet.36(12), 1296–1300 (2004).
   PubMed Web of Science ®Google Scholar
• Shinkai Y , TachibanaM. H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev.25(8), 781–788 (2011).
   PubMed Web of Science ®Google Scholar
• Tachibana M , SugimotoK , NozakiMet al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev.16(14), 1779–1791 (2002).
   PubMed Web of Science ®Google Scholar
• Auclair G , BorgelJ , SanzLAet al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos. Genome Res.26(2), 192–202 (2016).
   PubMed Web of Science ®Google Scholar
• Au Yeung WK , Brind’AmourJ , HatanoYet al. Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection. Cell Rep27(1), 282–293, e284 (2019).
   PubMed Web of Science ®Google Scholar
• Zylicz JJ , BorenszteinM , WongFCet al. G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst. eLife7, e33361, (2018).
   PubMed Web of Science ®Google Scholar
• Di Giacomo M , ComazzettoS , SampathSC , SampathSC , O’CarrollD. G9a co-suppresses LINE1 elements in spermatogonia. Epigenet. Chromat.7, 24 (2014).
   PubMed Web of Science ®Google Scholar
• Leung DC , DongKB , MaksakovaIAet al. Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing. Proc. Natl Acad. Sci. USA108(14), 5718–5723 (2011).
   PubMed Web of Science ®Google Scholar
• Maksakova IA , ThompsonPJ , GoyalPet al. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells. Epigenet. Chromat.6(1), 15 (2013).
   PubMedGoogle Scholar
• Jiang Q , AngJYJ , LeeAYet al. G9a plays distinct roles in maintaining DNA methylation, retrotransposon silencing, and chromatin looping. Cell Rep33(4), 108315 (2020).
   PubMed Web of Science ®Google Scholar
• Wagschal A , SutherlandHG , WoodfineKet al. G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol. Cell. Biol.28(3), 1104–1113 (2008).
   PubMed Web of Science ®Google Scholar
• Zeng TB , HanL , PierceN , PfeiferGP , SzaboPE. EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation. Proc. Natl Acad. Sci. USA116(22), 10834–10841 (2019).
   PubMed Web of Science ®Google Scholar
• Koide T , MoriwakiK , UchidaKet al. A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele. Mamm. Genome9(1), 15–19 (1998).
   PubMed Web of Science ®Google Scholar
• Zeng T-B , PierceN , LiaoJ , SinghP , ZhouW , SzabóPE. EHMT2 controls transcriptional noise and the developmental switch after gastrulation in the mouse embryo. bioRxiv doi:10.1101/2021.03.29.437567 (2021) ( Epub ahead of print).
   Google Scholar
• Mccarthy DJ , ChenY , SmythGK. Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Nucleic Acids Res.40(10), 4288–4297 (2012).
   PubMed Web of Science ®Google Scholar
• Robinson MD , MccarthyDJ , SmythGK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics26(1), 139–140 (2010).
   PubMed Web of Science ®Google Scholar
• Krueger F , AndrewsSR. SNPsplit: allele-specific splitting of alignments between genomes with known SNP genotypes. F1000Research5, 1479 (2016).
   PubMedGoogle Scholar
• Wang L , ZhangJ , DuanJet al. Programming and inheritance of parental DNA methylomes in mammals. Cell157(4), 979–991 (2014).
   PubMed Web of Science ®Google Scholar
• Kobayashi H , SakuraiT , ImaiMet al. Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet.8(1), e1002440 (2012).
   PubMed Web of Science ®Google Scholar
• Inoue K , HiroseM , InoueHet al. The rodent-specific microRNA cluster within the Sfmbt2 gene is imprinted and essential for placental development. Cell Rep.19(5), 949–956 (2017).
   PubMed Web of Science ®Google Scholar
• Bogutz AB , Brind’AmourJ , KobayashiHet al. Evolution of imprinting via lineage-specific insertion of retroviral promoters. Na. Commun.10(1), 5674 (2019).
   PubMedGoogle Scholar
• Ohhata T , TachibanaM , TadaMet al. X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a. Genesis40(3), 151–156 (2004).
   PubMed Web of Science ®Google Scholar
• Szanto A , AguilarR , KesnerBet al. A disproportionate impact of G9a methyltransferase deficiency on the X chromosome. Genes Dev.35(13–14), 1035–1054 (2021).
   PubMed Web of Science ®Google Scholar
• Dong KB , MaksakovaIA , MohnFet al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J.27(20), 2691–2701 (2008).
   PubMed Web of Science ®Google Scholar
• Tachibana M , MatsumuraY , FukudaM , KimuraH , ShinkaiY. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J.27(20), 2681–2690 (2008).
   PubMed Web of Science ®Google Scholar
• Sachs M , BrohmannH , ZechnerDet al. Essential role of Gab1 for signaling by the c-Met receptor in vivo. J. Cell Biol.150(6), 1375–1384 (2000).
   PubMed Web of Science ®Google Scholar
• Itoh M , YoshidaY , NishidaK , NarimatsuM , HibiM , HiranoT. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol.20(10), 3695–3704 (2000).
   PubMed Web of Science ®Google Scholar
• Wang Q , ChowJ , HongJet al. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genom.12, 204 (2011).
   PubMed Web of Science ®Google Scholar