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Research Article

Impact of Depression and Stress on Placental DNA Methylation in Ethnically Diverse Pregnant Women

ORCID Icon, , , &
Pages 1485-1496 | Received 28 May 2021, Accepted 15 Sep 2021, Published online: 29 Sep 2021

References

  • Raison CL , MillerAH. The neuroimmunology of stress and depression. Semin. Clin. Neuropsychiatry6(4), 277–294 (2001).
  • APA . Diagnostic Statistical Manual of Mental Disorders (5th Edition). 155American Psychiatric Association Publishing, Washington DC, USA (2013).
  • Tafet GE , NemeroffCB. The links between stress and depression: psychoneuroendocrinological, genetic, and environmental interactions. J. Neuropsychiatry Clin. Neurosci.28(2), 77–88 (2016).
  • Woods SM , MelvilleJL , GuoY , FanMY , GavinA. Psychosocial stress during pregnancy. Am. J. Obstet. Gynecol.202(1), 61.e1–7 (2010).
  • Le Strat Y , DubertretC , LeFoll B. Prevalence and correlates of major depressive episode in pregnant and postpartum women in the United States. J. Affect. Disord.135(1–3), 128–138 (2011).
  • O’Donnell KJ , GloverV , BarkerED , O’ConnorTG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev. Psychopathol.26(2), 393–403 (2014).
  • Pearson RM , EvansJ , KounaliDet al. Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry70(12), 1312–1319 (2013).
  • Bronson SL , BaleTL. The placenta as a mediator of stress effects on neurodevelopmental reprogramming. Neuropsychopharmacology41(1), 207–218 (2016).
  • Lund RJ , KylaniemiM , PetterssonNet al. Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy. Neurobiol. Stress15, 100374 (2021).
  • Ernst LM , GrobmanWA , WolfeKet al. Biological markers of stress in pregnancy: associations with chronic placental inflammation at delivery. Am. J. Perinatol.30(7), 557–564 (2013).
  • Christian LM . Effects of stress and depression on inflammatory immune parameters in pregnancy. Am. J. Obstet. Gynecol.211(3), 275–277 (2014).
  • Bonnin A , GoedenN , ChenKet al. A transient placental source of serotonin for the fetal forebrain. Nature472(7343), 347–350 (2011).
  • Rosenfeld CS . The placenta–brain axis. J. Neurosci. Res.99(1), 271–283 (2020).
  • Frazer S , OtomoK , DayerA. Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes. Transl. Psychiatry5, e644 (2015).
  • Cottrell EC , SecklJR. Prenatal stress, glucocorticoids and the programming of adult disease. Front. Behav. Neurosci.3, 19 (2009).
  • Galbally M , WatsonSJ , VanIMet al. The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation. Psychoneuroendocrinology115, 104611 (2020).
  • Lester BM , MarsitCJ. Epigenetic mechanisms in the placenta related to infant neurodevelopment. Epigenomics10(3), 321–333 (2018).
  • Ryan J , MansellT , FransquetP , SafferyR. Does maternal mental well-being in pregnancy impact the early human epigenome?Epigenomics9(3), 313–332 (2017).
  • Monk C , FengT , LeeS , KrupskaI , ChampagneFA , TyckoB. Distress during pregnancy: epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior. Am. J. Psychiatry173(7), 705–713 (2016).
  • Conradt E , LesterBM , AppletonAA , ArmstrongDA , MarsitCJ. The roles of DNA methylation of NR3C1 and 11beta-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior. Epigenetics8(12), 1321–1329 (2013).
  • Grewal J , GrantzKL , ZhangCet al. Cohort profile: NICHD fetal growth studies – singletons and twins. Int. J. Epidemiol.47(1), 25–25l (2018).
  • Cox JL , HoldenJM , SagovskyR. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression scale. Br. J. Psychiatry150, 782–786 (1987).
  • Cohen S , WilliamsonG. Perceived stress in a probability sample of the United States. In: The Social Psychology of Health, SpacapanSOskampS ( Ed.). SAGE, CA, USA, 31–67 (1988).
  • Workalemahu T , OuidirM , ShresthaD , WuJ , GrantzKL , Tekola-AyeleF. Differential DNA methylation in placenta associated with maternal blood pressure during pregnancy. Hypertension75(4), 1117–1124 (2020).
  • Delahaye F , DoC , KongYet al. Genetic variants influence on the placenta regulatory landscape. PLoS Genet.14(11), e1007785 (2018).
  • Lennon H , KellyS , SperrinMet al. Framework to construct and interpret latent class trajectory modelling. BMJ Open8(7), e020683 (2018).
  • Leek JT , JohnsonWE , ParkerHS , JaffeAE , StoreyJD. The SVA package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics28(6), 882–883 (2012).
  • Van Iterson M , Van ZwetEW , ConsortiumB , HeijmansBT. Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution. Genome Biol.18(1), 19 (2017).
  • Gaunt TR , ShihabHA , HemaniGet al. Systematic identification of genetic influences on methylation across the human life course. Genome Biol.17, 61 (2016).
  • Yuan V , HuiD , YinY , PenaherreraMS , BeristainAG , RobinsonWP. Cell-specific characterization of the placental methylome. BMC Genomics22(1), 6 (2021).
  • Peng S , DeyssenrothMA , DiNarzo AFet al. Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases. Hum. Mol. Genet.26(17), 3432–3441 (2017).
  • Thul PJ , AkessonL , WikingMet al. A subcellular map of the human proteome. Science356(6340), eaal3321 (2017).
  • Uhlen M , FagerbergL , HallstromBMet al. Proteomics. Tissue-based map of the human proteome. Science347(6220), 1260419 (2015).
  • Uhlen M , ZhangC , LeeSet al. A pathology atlas of the human cancer transcriptome. Science357(6352), eaan2507 (2017).
  • Liang C , CarrelD , OmelchenkoAet al. Cortical neuron migration and dendrite morphology are regulated by carboxypeptidase E. Cereb. Cortex29(7), 2890–2903 (2019).
  • Cheng Y , RodriguizRM , MurthySRet al. Neurotrophic factor-alpha1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. Mol. Psychiatry20(6), 744–754 (2015).
  • Xiao L , ChangSY , XiongZG , SelverajP , PengLoh Y. Absence of carboxypeptidase E/neurotrophic factor-alpha1 in knock-out mice leads to dysfunction of BDNF-TRKB signaling in hippocampus. J. Mol. Neurosci.62(1), 79–87 (2017).
  • Poindexter K , NelsonN , DuboseRF , BlackRA , CerrettiDP. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. Gene237(1), 61–70 (1999).
  • Markus-Koch A , SchmittO , SeemannSet al. ADAM23 promotes neuronal differentiation of human neural progenitor cells. Cell Mol. Biol. Lett.22, 16 (2017).
  • Mitchell AM , ChristianLM. Financial strain and birth weight: the mediating role of psychological distress. Arch. Womens Ment. Health20(1), 201–208 (2017).
  • Sun YP , DengKJ , WangFet al. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. Gene325, 171–178 (2004).
  • Goes FS , McgrathJ , AvramopoulosDet al. Genome-wide association study of schizophrenia in Ashkenazi Jews. Am. J. Med. Genet. B Neuropsychiatr. Genet.168(8), 649–659 (2015).
  • Smith EN , BlossCS , BadnerJAet al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol. Psychiatry14(8), 755–763 (2009).
  • Pal M , EbrahimiS , OhGet al. High precision DNA modification analysis of HCG9 in major psychosis. Schizophr. Bull.42(1), 170–177 (2016).
  • Kaminsky Z , TochigiM , JiaPet al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol. Psychiatry17(7), 728–740 (2012).
  • Constantinof A , MoisiadisVG , KostakiA , SzyfM , MatthewsSG. Antenatal glucocorticoid exposure results in sex-specific and transgenerational changes in prefrontal cortex gene transcription that relate to behavioural outcomes. Sci. Rep.9(1), 764 (2019).
  • Rossini L , HashimotoY , SuzukiHet al. VSTM2L is a novel secreted antagonist of the neuroprotective peptide humanin. FASEB J.25(6), 1983–2000 (2011).
  • Su L , LeiX , MaH , FengC , JiangJ , JiaoJ. PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain. Cell Death Differ.27(8), 2313–2329 (2020).
  • Zhou M , HaqueRU , DammerEBet al. Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s disease. Clin. Proteomics17, 19 (2020).
  • Judd LL , AkiskalHS , PaulusMP. The role and clinical significance of subsyndromal depressive symptoms (SSD) in unipolar major depressive disorder. J. Affect. Disord.45(1–2), 5–17; discussion 17–18 (1997).
  • Jensen Pena C , MonkC , ChampagneFA. Epigenetic effects of prenatal stress on 11beta-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain. PLoS ONE7(6), e39791 (2012).
  • Dhobale MV , PisalHR , MehendaleSS , JoshiSR. Differential expression of human placental neurotrophic factors in preterm and term deliveries. Int. J. Dev. Neurosci.31(8), 719–723 (2013).
  • Lokk K , ModhukurV , RajashekarBet al. DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biol.15(4), r54 (2014).

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