Epigenetic extracellular vesicle-based biomarkers for urological malignancies: is the hope worth the hype?

References

• Kalluri R , LebleuVS. The biology, function, and biomedical applications of exosomes. Science367(6478), eaau6977 (2020).
   PubMed Web of Science ®Google Scholar
• Théry C , WitwerKW , AikawaEet al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J. Extracell. Vesicles7(1), 1535750–1535750 (2018).
   PubMed Web of Science ®Google Scholar
• Qian Z , ShenQ , YangX , QiuY , ZhangW. The role of extracellular vesicles: an epigenetic view of the cancer microenvironment. Biomed. Res. Int.2015, 649161 (2015).
   PubMed Web of Science ®Google Scholar
• Hu CY , ChenJ , QinXHet al. Long non-coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer. J. Exp. Clin. Cancer Res.40(1), 1–16 (2021).
   PubMed Web of Science ®Google Scholar
• Chen C , ZhengH , LuoYet al. SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer. J. Clin. Invest.131(8), e146431 (2021).
   PubMed Web of Science ®Google Scholar
• Royo F , Zuñiga-GarciaP , TorranoVet al. Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. Oncotarget7(6), 6835–6846 (2016).
   PubMedGoogle Scholar
• Lee J , MckinneyKQ , PavlopoulosAJet al. Altered proteome of extracellular vesicles derived from bladder cancer patients urine. Mol. Cells41(3), 179–187 (2018).
   PubMed Web of Science ®Google Scholar
• Mckiernan J , DonovanMJ , MargolisEet al. A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2–10 ng/ml at initial biopsy. Eur. Urol.74(6), 731–738 (2018).
   PubMed Web of Science ®Google Scholar
• Yu W , HurleyJ , RobertsDet al. Exosome-based liquid biopsies in cancer: opportunities and challenges. Ann. Oncol.32(4), 466–477 (2021).
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov . Clinical evaluation of the miR Sentinel BCa™ test to diagnose bladder cancer in hematuria patients (2019). www.clinicaltrials.gov/ct2/show/NCT04155359?term=exosomes&cond=bladder&draw=2&rank=1
   Google Scholar
• Rimmer MP , GregoryCD , MitchellRT. Extracellular vesicles in urological malignancies. Biochim. Biophys. Acta Rev. Cancer1876(1), 188570–188570 (2021).
   PubMed Web of Science ®Google Scholar
• Berrondo C , FlaxJ , KucherovVet al. Expression of the long non-coding RNA HOTAIR correlates with disease progression in bladder cancer and is contained in bladder cancer patient urinary exosomes. PLoS ONE11(1), e0147236 (2016).
   PubMed Web of Science ®Google Scholar
• Urabe F , KimuraT , ItoKet al. Urinary extracellular vesicles: a rising star in bladder cancer management. Transl. Androl. Urol.10(4), 1878–1889 (2021).
   PubMed Web of Science ®Google Scholar
• Long JD , SullivanTB , HumphreyJet al. A non-invasive miRNA based assay to detect bladder cancer in cell-free urine. Am. J. Transl. Res.7(11), 2500–2509 (2015).
   PubMed Web of Science ®Google Scholar
• Chen T , WangC , YuHet al. Increased urinary exosomal microRNAs in children with idiopathic nephrotic syndrome. EBioMedicine39, 552–561 (2019).
   PubMed Web of Science ®Google Scholar
• Lourenço C , ConstâncioV , HenriqueR , Carvalho , JerónimoC. Urinary extracellular vesicles as potential biomarkers for urologic cancers: an overview of current methods and advances. Cancers (Basel)13(7), 1529 (2021).
   PubMed Web of Science ®Google Scholar
• Erdbrügger U , BurgerD , BlijdorpCJet al. Urinary extracellular vesicles: a position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J. Extracell. Vesicles10(7), e12093 (2021).
   PubMed Web of Science ®Google Scholar
• Hatano K , FujitaK. Extracellular vesicles in prostate cancer: a narrative review. Transl. Androl. Urol.10(11), 1890–1907 (2021).
   PubMedGoogle Scholar
• Işın M , UysalerE , ÖzgürEet al. Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease. Front. Genet. 6, 168 (2015).
   PubMed Web of Science ®Google Scholar
• Kilpeläinen T , TammelaT , MäättänenLet al. False-positive screening results in the Finnish prostate cancer screening trial. Br J Cancer. 102, 469–474 (2010).
   PubMed Web of Science ®Google Scholar
• Li W , DongY , WangKJ , DengZ , ZhangW , ShenHF. Plasma exosomal miR-125a-5p and miR-141-5p as non-invasive biomarkers for prostate cancer. Neoplasma67(6), 1314–1318 (2020).
   PubMed Web of Science ®Google Scholar
• Xu R , RaiA , ChenM , SuwakulsiriW , GreeningDW , SimpsonRJ. Extracellular vesicles in cancer – implications for future improvements in cancer care. Nat. Rev. Clin. Oncol.15(10), 617–638 (2018).
   PubMed Web of Science ®Google Scholar
• Zhou B , XuK , ZhengXet al. Application of exosomes as liquid biopsy in clinical diagnosis. Signal Transd. Targeted Ther.5(1), 144 (2020).
   PubMed Web of Science ®Google Scholar
• Lee DH , YoonH , ParkSet al. Urinary exosomal and cell-free DNA detects somatic mutation and copy number alteration in urothelial carcinoma of bladder. Sci. Rep.8(1), 4–10 (2018).
   PubMedGoogle Scholar
• Yang Z , LariviereMJ , KoJet al. A multianalyte panel consisting of extracellular vesicle miRNAs and mRNAs, cfDNA, and CA19-9 shows utility for diagnosis and staging of pancreatic ductal adenocarcinoma. Clin. Cancer Res.26(13), 3248–3258 (2020).
   PubMed Web of Science ®Google Scholar
• Contreras-Naranjo JC , WuHJ , UgazVM. Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine. Lab Chip17(21), 3558–3577 (2017).
   PubMed Web of Science ®Google Scholar
• Zhang J , NguyenLTH , HickeyRet al. Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids. Sci. Rep.11(1), 1–17 (2021).
   PubMed Web of Science ®Google Scholar
• Franceschini T , GiunchiF , MontironiRet al. Liquid biopsies in urological cancers: what we need to know before starting using them. Exp. Rev. Mol. Diag.20(2), 135–139 (2020).
   PubMed Web of Science ®Google Scholar