Advanced search
Publication Cover
Epigenomics Volume 13, 2021 - Issue 23
Submit an article Journal homepage
807
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Beyond the Transcription Factor: The Under-Studied Role of Epigenomics in Lung Differentiation

Laurence St. Pierre1 Departments of Biochemistry & Molecular Medicine, University of Southern California, CA 90089, USA;2 Departments of Surgery, University of Southern California, CA90089, USA;3 Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA 90089, USAORCID Iconhttps://orcid.org/0000-0002-3019-186XView further author information
ORCID Icon &
Crystal N Marconett1 Departments of Biochemistry & Molecular Medicine, University of Southern California, CA 90089, USA;2 Departments of Surgery, University of Southern California, CA90089, USA;3 Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA 90089, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8463-7126View further author information
ORCID Icon
Pages 1845-1848 | Received 07 Sep 2021, Accepted 27 Sep 2021, Published online: 19 Oct 2021

References

  • Metzger RJ , KleinOD , MartinGR , KrasnowMA. The branching programme of mouse lung development. Nature453(7196), 745–750 (2008).
  • Little DR , LynchAM , YanY , AkiyamaH , KimuraS , ChenJ. Differential chromatin binding of the lung lineage transcription factor Nkx2-1 resolves opposing murine alveolar cell fates in vivo. Nat. Commun.12(1), 2509 (2021).
  • Penkala IJ , LibertiDC , PankinJet al. Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration. Cell Stem CellS1934–5909(21), 00184–00193 (2021).
  • Ardini-Poleske ME , ClarkRF , AnsongCet al. LungMAP: the molecular atlas of lung development program. Am. J. Physiol. Lung Cell. Mol. Physiol.313(5), L733–L740 (2017).
  • Tran E , ShiT , LiXet al. Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease. Biorxiv. doi:10.1101/2020.12.25.424415 (2020) ( Epub ahead of print).
  • Travaglini KJ , NabhanAN , PenlandL , SinhaR , GillichA , SitRVet al. A molecular cell atlas of the human lung from single-cell RNA sequencing. Nature587(7835), 619–25 (2020).
  • Neumark N , CosmeC , RoseKA , KaminskiN. The idiopathic pulmonary fibrosis cell atlas. Am. J. Physiol. Lung Cell Mol. Physiol.319(6), L887–L893 (2020).
  • Gurdon JB . Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal. J. Embryol. Exp. Morphol.36(3), 523–40 (1976).
  • Imschenetzky M , PuchiM , MassoneR , OyarceAM , RoccoM. Remodeling of chromatin during male pronucleus formation in the sea urchin Tetrapygus niger. Arch. Biol. Med. Exp.21(3–4), 409–16 (1988).
  • Ding J , AhangariF , EspinozaCRet al. Integrating multiomics longitudinal data to reconstruct networks underlying lung development. Am. J. Physiol. Lung Cell. Mol. Physiol.317(5), L556–L568 (2019).
  • Liberti DC , ZeppJA , BartoniCAet al. Dnmt1 is required for proximal–distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate. Dev. Biol.454(2), 108–117 (2019).
  • Li Q , WangHY , ChepelevIet al. Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. PLoS Genet.10(7), e1004524 (2014).
  • Cuna A , HalloranB , Faye-PetersenOet al. Alterations in gene expression and DNA methylation during murine and human lung alveolar septation. Am. J. Respir. Cell Mol. Biol.53(1), 60–73 (2015).
  • Dong X , ShiM , LeeMet al. Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. Epigenetics13(3), 264–274 (2018).
  • Shi J , MarconettCN , DuanJet al. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat. Commun.5, 3365(2014).
  • Weng JS , NakamuraT , MoriizumiH , TakanoH , YaoR , TakekawaM. Mcrip1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing. Commun. Biol.2, 227 (2019).
  • Galvis LA , HolikAZ , ShortKMet al. Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development142(8), 1458–1469 (2015).
  • Zepp JA , MorleyMP , LoebelCet al. Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus. Science371(6534), eabc3172 (2021).
  • Marconett CN , ZhouB , RiegerMEet al. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet.9(6), e1003513 (2013).
  • Zhou B , StueveTR , MihalakakousEAet al. Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity. Biorxiv. doi:10.1101/2021.04.14.439786 (2021) ( Epub ahead of print).
  • Li X , XieF , JinJet al. Tet2-mediated spatiotemporal changes of 5-hydroxymethylcytosine during organogenesis in the late mouse fetus. Anat. Rec. (Hoboken).302(6), 954–963 (2019).
  • Barkauskas CE , CronceMJ , RackleyCRet al. Type 2 alveolar cells are stem cells in adult lung. J. Clin. Invest.123(7), 3025–3036 (2013).
  • Zacharias WJ , FrankDB , ZeppJAet al. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature555(7695), 251–255 (2018).

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.