102
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How do Sphingolipids Play a Role in Epigenetic Mechanisms and Gene Expression?

ORCID Icon, ORCID Icon & ORCID Icon
Pages 219-222 | Received 31 Oct 2021, Accepted 15 Nov 2021, Published online: 15 Dec 2021

References

  • Hait NC , AllegoodJ , MaceykaMet al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science325(5945), 1254–1257 (2009).
  • Gardner NM , RileyRT , ShowkerJLet al. Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. Toxicol. Appl. Pharmacol.298, 56–65 (2016).
  • Ahuja G , BartschD , YaoWet al. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep.20(4), e47407 (2019).
  • Ebenezer DL , BerdyshevEV , BronovaIAet al. Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. Thorax74(6), 579–591 (2019).
  • Hait NC , MaitiA , XuPet al. Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate. FASEB J.34(3), 4293–4310 (2020).
  • Fu P , RamchandranR , SudhadeviTet al. NOX4 mediates Pseudomonas aeruginosa–induced nuclear reactive oxygen species generation and chromatin remodeling in lung epithelium. Antioxidants (Basel)10(3), 477 (2021).
  • Ebenezer DL , RamchandranR , FuPet al. Nuclear sphingosine-1-phosphate lyase generated Δ2-hexadecenal is a regulator of HDAC activity and chromatin remodeling in lung epithelial cells. Cell Biochem. Biophys.79(3), 575–592 (2021).
  • Wooten-Blanks LG , SongP , SenkalCE , OgretmenB. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J.21(12), 3386–3397 (2007).
  • Wooten LG , OgretmenB. Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. J. Biol. Chem.280(32), 28867–28876 (2005).
  • Debret R , Brassart-PascoS , LorinJet al. Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation. Biochim. Biophys. Acta1783(10), 1718–1727 (2008).
  • Tempera I , BuchettiB , LococoEet al. GD3 nuclear localization after apoptosis induction in HUT-78 cells. Biochem. Biophys. Res. Commun.368(3), 495–500 (2008).
  • Khoei SG , SadeghiH , SamadiP , NajafiR , SaidijamM. Relationship between SphK1/S1P and microRNAs in human cancers. Biotechnol. Appl. Biochem.68(2), 279–287 (2021).
  • Nguyen-Tran DH , HaitNC , SperberHet al. Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Dis. Model. Mech.7(1), 41–54 (2014).
  • Czubowicz K , JęśkoH , WencelP , LukiwWJ , StrosznajderRP. The role of ceramide and sphingosine-1-phosphate in Alzheimer’s disease and other neurodegenerative disorders. Mol. Neurobiol.56(8), 5436–5455 (2019).
  • Elsherbini A , BieberichE. Ceramide and exosomes: a novel target in cancer biology and therapy. Adv. Cancer Res.140, 121–154 (2018).
  • Filippenkov IB , SudarkinaOY , LimborskaSA , DergunovaLV. Circular RNA of the human sphingomyelin synthase 1 gene: multiple splice variants, evolutionary conservatism and expression in different tissues. RNA Biol.12(9), 1030– 1042 (2015).
  • Castro K , NtranosA , AmatrudaMet al. Body mass index in multiple sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine43, 392–410 (2019).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.