Global DNA Hypomethylation and the Expression Profile of DNA Methyltransferase Genes in Late-Onset Neonatal Sepsis

References

• Tam PYI , BendelC. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr. Res.82, 574–583 (2017).
   PubMed Web of Science ®Google Scholar
• Reinhart K , DanielsR , KissoonN , MachadoFR , SchachterRD , FinferS. Recognizing sepsis as a global health priority – a WHO resolution. N. Engl. J. Med.377, 414–417 (2017).
   PubMed Web of Science ®Google Scholar
• Franck V , AliceB , AlexandreM. The new sepsis definition. Curr. Opinion Anaesthesiol.30(2), 200–204 (2017).
   PubMed Web of Science ®Google Scholar
• Collins A , WeitkampJ , WynnJL. Why are preterm newborns at increased risk of infection?Arch. Dis. Child. Educ. Pract. Ed.103, F391–F394 (2018).
   Google Scholar
• Yu JC , KhodadadiH , MalikAet al. Innate immunity of neonates and infants. Front. Immunol.9, 1759 (2018).
   PubMed Web of Science ®Google Scholar
• Tsafaras GP , NtontsiP , XanthouG. Advantages and limitations of the neonatal immune system. Front. Pediatr.8, 5 (2020).
   PubMed Web of Science ®Google Scholar
• Basha S , SurendranN , PichicheroM. Immune responses in neonates. Expert Rev. Clin. Immunol.10(9), 1171–1184 (2014).
   PubMed Web of Science ®Google Scholar
• Hassani EMS , BerkhoutDJC , NiemarktHJet al. Risk factors for late-onset sepsis in preterm infants: a multicenter case-control study. Neonatology116, 42–51 (2019).
   PubMed Web of Science ®Google Scholar
• Tsai MH , HsuJF , ChuSMet al. Incidence, clinical characteristics, and risk factors for adverse outcome in neonates with late-onset sepsis. Pediatr. Infect. Dis. J.33(1), e7–e13 (2014).
   PubMed Web of Science ®Google Scholar
• Raymond SL , StortzJA , MiraJC , LarsonSD , WynnJL , MoldawerLL. Immunological defects in neonatal sepsis and potential therapeutic approaches. Front. Pediatr.5, 14 (2017).
   PubMed Web of Science ®Google Scholar
• Hibbert JE , CurrieA , StrunkT. Sepsis-induced immunosuppression in neonates. Front. Pediatr.6, 357 (2018).
   PubMed Web of Science ®Google Scholar
• Tollefsbol T . Handbook of Epigenetics: The New Molecular and Medical Genetics.Academic Press, Elsevier Inc, Oxford, UK (2011).
   Google Scholar
• Bierne H , HamonM , CossartP. Epigenetics and bacterial infections. Cold Spring Harb. Perspect. Med.2(12), a010272 (2012).
   PubMed Web of Science ®Google Scholar
• Okano M , BellDW , HaberDA , LiE. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell99, 247–257 (1999).
   PubMed Web of Science ®Google Scholar
• Chen LL , YangL. ALUternative regulation for gene expression. Trends Cell. Biol.27, 480–490 (2017).
   PubMed Web of Science ®Google Scholar
• Bakshi A , HerkeSW , BatzerMA , KimJ. DNA methylation variation of human-specific Alu repeats. Epigenetics11, 163–173 (2016).
   PubMed Web of Science ®Google Scholar
• Xie H , WangM , BonaldoMde Fet al. Epigenomic analysis of Alu repeats in human ependymomas. Proc. Natl Acad. Sci. USA.107, 6952–6957 (2010).
   PubMed Web of Science ®Google Scholar
• Dakhlallah DA , WislerJ , GenchevaMet al. Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock. J. Extracell. Vesicles8(1), 1669881 (2019).
   PubMedGoogle Scholar
• Levy A , SelaN , AstG. TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates. Nucleic Acids Res.36, D47–D52 (2008).
   PubMed Web of Science ®Google Scholar
• Luo Y , LuX , XieH. Dynamic Alu methylation during normal development, aging, and tumorigenesis. Biomed. Res. Int.2014, 784706 (2014).
   PubMed Web of Science ®Google Scholar
• Pfaffl MW . A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res.29(9), e45 (2001).
   PubMed Web of Science ®Google Scholar
• Dhas BB , AntonyHA , BhatV , NewtonB , ParijaSC. Global DNA methylation in neonatal sepsis. Indian J. Pediatr.82(4), 340–344 (2015).
   PubMed Web of Science ®Google Scholar
• Zhang Q , CaoX. Epigenetic regulation of the innate immune response to infection. Nat. Rev. Immunol.19, 417–432 (2019).
   PubMed Web of Science ®Google Scholar
• Binnie A , TsangJLY , HuP , CarrasqueiroG , Castelo-BrancoP , DosSantos CC. Epigenetics of sepsis. Crit. Care Med.8, 745–756 (2020).
   Google Scholar
• Deininger P . Alu elements: know the SINEs. Genome Biol.12(12), 236 (2011).
   PubMed Web of Science ®Google Scholar
• Maruthai K , SubramanianM. Methylation status of alu repetitive elements in children with tuberculosis disease. Int. J. Mycobacteriol.7(3), 242–246 (2018).
   PubMedGoogle Scholar
• Maruthai K , KalaiarasanE , JosephNM , ParijaSC , MahadevanS. Assessment of global DNA methylation in children with tuberculosis disease. Int. J. Mycobacteriol.7(4), 338–342 (2018).
   PubMedGoogle Scholar
• Masrani KM , SalunkePP , AhmedJ , KabraNS. Elizabethkingia meningoseptica – an emerging cause of neonatal meningitis. Perinatology9, 139–142 (2019).
   Google Scholar
• Lorente-Sorolla C , Garcia-GomezA , Català-MollFet al. Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis. Genome Med.11, 66 (2019).
   PubMed Web of Science ®Google Scholar
• Dhas DB , AshmiAH , BhatBV , KalaivaniS , ParijaSC. Comparison of genomic DNA methylation pattern among septic and non-septic newborns – an epigenome wide association study. Genom. Data.3, 36–40 (2015).
   PubMedGoogle Scholar
• Tendl KA , SchulzSM , MechtlerTPet al. DNA methylation pattern of CALCA in preterm neonates with bacterial sepsis as a putative epigenetic biomarker. Epigenetics8, 1261–1267 (2013).
   PubMed Web of Science ®Google Scholar
• Cao L , ZhuT , LangXet al. Inhibiting DNA methylation improves survival in severe sepsis by regulating Nf-κb pathway. Front. Immunol.11, 1360 (2020).
   PubMed Web of Science ®Google Scholar
• McGrath-Morrow SA , NdehR , HelminKAet al. DNA methylation regulates the neonatal CD4+ t-cell response to pneumonia in mice. J. Biol. Chem.293(30), 11772–11783 (2018).
   PubMed Web of Science ®Google Scholar
• Takahashi K . Influence of Bacteria on Epigenetic Gene Control. Cell. Mol. Life Sci.71, 1045–1054 (2014).
   PubMed Web of Science ®Google Scholar
• Takahashi K , SugiY , NakanoKet al. Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells. J. Biol. Chem.286, 35755–35762 (2011).
   PubMed Web of Science ®Google Scholar
• Tolg C , BägliDJ. Uropathogenic Escherichia coli infection: potential importance of epigenetics. Epigenomics.4, 229–235 (2012).
   PubMed Web of Science ®Google Scholar
• Bobetsis YA , BarrosSP , LinDMet al. Bacterial infection promotes DNA hypermethylation. J Dent Res.86, 169–174 (2007).
   PubMed Web of Science ®Google Scholar
• Qin W , SciclunaBP , vander Poll T. The role of host cell DNA methylation in the immune response to bacterial infection. Front. Immunol.12, 696280 (2021).
   PubMedGoogle Scholar
• Nätt D , JohanssonI , FaresjöT , LudvigssonJ , ThorsellA. High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases. Clin. Epigenetics7(1), 91 (2015).
   PubMedGoogle Scholar
• Misiak B , RicceriL , SąsiadekMM. Transposable elements and their epigenetic regulation in mental disorders: current evidence in the field. Front. Genet.10, 580 (2019).
   PubMed Web of Science ®Google Scholar
• Qin W , BrandsX , van’tVeer Cet al. Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection. PLoS Pathog.17(4), e1009491 (2021).
   PubMed Web of Science ®Google Scholar
• Hopp L , Loeffler-WirthH , NersisyanL , ArakelyanA , BinderH. Footprints of sepsis framed within community acquired pneumonia in the blood transcriptome. Front. Immunol.9, 1620 (2018).
   PubMed Web of Science ®Google Scholar
• Dakhlallah DA , WislerJ , GenchevaMet al. Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock. J. Extracell. Vesicles8, 1669881 (2019).
   PubMedGoogle Scholar
• Sajjanar B , TrakooljulN , WimmersK , PonsuksiliS. DNA methylation analysis of porcine mammary epithelial cells reveals differentially methylated loci associated with immune response against Escherichia coli challenge. BMC Genomics20, 623 (2019).
   PubMed Web of Science ®Google Scholar
• El Gazzar M , LiuT , YozaBK , McCallCE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J. Biol. Chem.285(2), 1259–1271 (2010).
   PubMed Web of Science ®Google Scholar
• El Gazzar M , YozaBK , ChenX , HuJ , HawkinsGA , McCallCE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J. Biol. Chem.283(47), 32198–32208 (2008).
   PubMed Web of Science ®Google Scholar
• Sharma A , ThakurA , BhardwajCet al. Potential biomarkers for diagnosing neonatal sepsis. Curr. Med. Res. Pract.10(1), 12–17 (2020).
   Google Scholar