Epigenetics and its Therapeutic Potential in Colorectal Cancer

References

• Sung H , FerlayJ , SiegelRLet al. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.71(3), 209–249 (2021).
   PubMed Web of Science ®Google Scholar
• Dyba T , RandiG , BrayFet al. The European cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers. Eur. J. Cancer157, 308–347 (2021).
   PubMed Web of Science ®Google Scholar
• Siegel RL , MillerKD , FuchsHE , JemalA. Cancer statistics, 2022. CA Cancer J. Clin.72(1), 7–33 (2022).
   PubMed Web of Science ®Google Scholar
• Adam R , HallerDG , PostonGet al. Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer – an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009. Ann. Oncol.21(8), 1579–1584 (2010).
   PubMed Web of Science ®Google Scholar
• Berger SL , KouzaridesT , ShiekhattarR , ShilatifardA. An operational definition of epigenetics. Genes Dev.23(7), 781–783 (2009).
   PubMed Web of Science ®Google Scholar
• Turner BM . Epigenetic responses to environmental change and their evolutionary implications. Philos. Trans. R Soc. Lond. B. Biol. Sci.364(1534), 3403–3418 (2009).
   PubMed Web of Science ®Google Scholar
• Choi M , GenereuxDP , GoodsonJet al. Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells. PLoS Genet.13(11), e1007060, (2017).
   PubMed Web of Science ®Google Scholar
• Marmol I , Sanchez-de-DiegoC , PradillaDieste A , CerradaE , RodriguezYoldi MJ. Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. Int. J. Mol. Sci.18(1), 197–236 (2017).
   PubMed Web of Science ®Google Scholar
• Stoffel EM , MurphyCC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology158(2), 341–353 (2020).
   PubMed Web of Science ®Google Scholar
• La Vecchia S , SebastianC. Metabolic pathways regulating colorectal cancer initiation and progression. Semin. Cell Dev. Biol.98, 63–70 (2020).
   PubMed Web of Science ®Google Scholar
• Dekker E , TanisPJ , VleugelsJLA , KasiPM , WallaceMB. Colorectal cancer. Lancet394(10207), 1467–1480 (2019).
   PubMed Web of Science ®Google Scholar
• Yu H , HemminkiK. Genetic epidemiology of colorectal cancer and associated cancers. Mutagenesis35(3), 207–219 (2020).
   PubMed Web of Science ®Google Scholar
• Brenner H , KloorM , PoxCP. Colorectal cancer. Lancet383(9927), 1490–1502 (2014).
   PubMed Web of Science ®Google Scholar
• Koliarakis I , MessaritakisI , NikolouzakisTKet al. Oral bacteria and intestinal dysbiosis in colorectal cancer. Int. J. Mol. Sci.20(17), 4146–4175 (2019).
   PubMed Web of Science ®Google Scholar
• Lin C , CaiX , ZhangJet al. Role of gut microbiota in the development and treatment of colorectal cancer. Digestion100(1), 72–78 (2019).
   PubMed Web of Science ®Google Scholar
• Nguyen LH , GoelA , ChungDC. Pathways of colorectal carcinogenesis. Gastroenterology158(2), 291–302 (2020).
   PubMed Web of Science ®Google Scholar
• Jasperson KW , TuohyTM , NeklasonDW , BurtRW. Hereditary and familial colon cancer. Gastroenterology138(6), 2044–2058 (2010).
   PubMed Web of Science ®Google Scholar
• Wells K , WisePE. Hereditary colorectal cancer syndromes. Surg. Clin. North Am.97(3), 605–625 (2017).
   PubMed Web of Science ®Google Scholar
• Jung G , Hernández-IllánE , MoreiraL , BalaguerF , GoelA. Epigenetics of colorectal cancer: biomarker and therapeutic potential. Nat. Rev. Gastroenterol. Hepatol.17(2), 111–130 (2020).
   PubMed Web of Science ®Google Scholar
• Kasprzak A . Angiogenesis-related functions of Wnt signaling in colorectal carcinogenesis. Cancers (Basel)12(12), 3601–3640(2020).
   PubMed Web of Science ®Google Scholar
• Pitts TM , NewtonTP , Bradshaw-PierceELet al. Dual pharmacological targeting of the MAP kinase and Pi3k/Mtor pathway in preclinical models of colorectal cancer. PLoS One9(11), e113037 (2014).
   PubMed Web of Science ®Google Scholar
• Slattery ML , HerrickJS , PellattDFet al. microRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression. Carcinogenesis37(3), 245–261 (2016).
   PubMed Web of Science ®Google Scholar
• Hong SN . Genetic and epigenetic alterations of colorectal cancer. Intest. Res.16(3), 327–337 (2018).
   PubMed Web of Science ®Google Scholar
• Rao CV , YamadaHY. Genomic instability and colon carcinogenesis: from the perspective of genes. Front. Oncol.3, 130 (2013).
   PubMedGoogle Scholar
• Xie W , SchultzMD , ListerRet al. Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell153(5), 1134–1148 (2013).
   PubMed Web of Science ®Google Scholar
• Jones PA . Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet.13(7), 484–492 (2012).
   PubMed Web of Science ®Google Scholar
• Fraga MF , AgreloR , EstellerM. Cross-talk between aging and cancer: the epigenetic language. Ann. NY Acad. Sci.1100, 60–74 (2007).
   PubMed Web of Science ®Google Scholar
• Kribelbauer JF , LuXJ , RohsR , MannRS , BussemakerHJ. Toward a mechanistic understanding of DNA methylation readout by transcription factors. J. Mol. Biol.432(6), 1801–1815 (2019).
   PubMed Web of Science ®Google Scholar
• Bourc’his D , XuGL , LinCS , BollmanB , BestorTH. DNMT3L and the establishment of maternal genomic imprints. Science294(5551), 2536–2539 (2001).
   PubMed Web of Science ®Google Scholar
• Carmona FJ , AzuaraD , Berenguer-LlergoAet al. DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer. Cancer Prev. Res. (Phila.)6(7), 656–665 (2013).
   PubMed Web of Science ®Google Scholar
• Galanopoulos M , TsoukalasN , PapanikolaouISet al. Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: a review of literature. World J. Gastrointest. Oncol.9(4), 142–152 (2017).
   PubMed Web of Science ®Google Scholar
• Lange CP , LairdPW. Clinical applications of DNA methylation biomarkers in colorectal cancer. Epigenomics5(2), 105–108 (2013).
   PubMed Web of Science ®Google Scholar
• Yang XJ , SetoE. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene26(37), 5310–5318 (2007).
   PubMed Web of Science ®Google Scholar
• Feinberg AP , TyckoB. The history of cancer epigenetics. Nat. Rev. Cancer4(2), 143–153 (2004).
   PubMed Web of Science ®Google Scholar
• Byun DS , AhmedN , NasserSet al. Intestinal epithelial-specific PTEN inactivation results in tumor formation. Am. J. Physiol. Gastrointest. Liver Physiol.301(5), G856–G864 (2011).
   PubMed Web of Science ®Google Scholar
• Donninger H , VosMD , ClarkGJ. The RASSF1A tumor suppressor. J. Cell Sci.120(Pt 18), 3163–3172 (2007).
   PubMed Web of Science ®Google Scholar
• Fernandes MS , CarneiroF , OliveiraC , SerucaR. Colorectal cancer and Rassf family – a special emphasis on Rassf1a. Int. J. Cancer132(2), 251–258 (2013).
   PubMed Web of Science ®Google Scholar
• Harada K , HiraokaS , KatoJet al. Genetic and epigenetic alterations of ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. Br. J. Cancer97(10), 1425–1431 (2007).
   PubMed Web of Science ®Google Scholar
• Marsh V , WintonDJ , WilliamsGTet al. Epithelial PTEN is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat. Genet.40(12), 1436–1444 (2008).
   PubMed Web of Science ®Google Scholar
• Rad R , CadiñanosJ , RadLet al. A genetic progression model of BRAFV600E-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell24(1), 15–29 (2013).
   PubMed Web of Science ®Google Scholar
• Rojas A , MeheremS , KimYHet al. The aberrant methylation of TSP1 suppresses TGF-Beta1 activation in colorectal cancer. Int. J. Cancer123(1), 14–21 (2008).
   PubMed Web of Science ®Google Scholar
• Segditsas S , SieberOM , RowanAet al. Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. Exp. Mol. Pathol.85(3), 201–206 (2008).
   PubMed Web of Science ®Google Scholar
• Shen L , KondoY , HamiltonSR , RashidA , IssaJPJ. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology124(3), 626–633 (2003).
   PubMed Web of Science ®Google Scholar
• Sierra J , YoshidaT , JoazeiroCA , JonesKA. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev.20(5), 586–600 (2006).
   PubMed Web of Science ®Google Scholar
• Mohn F , WeberM , RebhanMet al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell30(6), 755–766 (2008).
   PubMed Web of Science ®Google Scholar
• Ohm JE , McGarveyKM , YuXet al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet.39(2), 237–242 (2007).
   PubMed Web of Science ®Google Scholar
• Fanelli GN , DalPozzo CA , DepetrisIet al. The heterogeneous clinical and pathological landscapes of metastatic BRAF-mutated colorectal cancer. Cancer Cell Int.20, 30 (2020).
   PubMed Web of Science ®Google Scholar
• Fang M , OuJ , HutchinsonL , GreenMR. The BRAF oncoprotein functions through the transcriptional repressor MAFg to mediate the CpG island methylator phenotype. Mol. Cell55(6), 904–915 (2014).
   PubMed Web of Science ®Google Scholar
• Lippman Z , GendrelAV , BlackMet al. Role of transposable elements in heterochromatin and epigenetic control. Nature430(6998), 471–476 (2004).
   PubMed Web of Science ®Google Scholar
• Sheaffer KL , ElliottEN , KaestnerKH. DNA hypomethylation contributes to genomic instability and intestinal cancer initiation. Cancer Prev. Res. (Phila.)9(7), 534–546 (2016).
   PubMed Web of Science ®Google Scholar
• Yamada Y , Jackson-GrusbyL , LinhartHet al. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl Acad. Sci. USA102(38), 13580–13585 (2005).
   PubMed Web of Science ®Google Scholar
• Fussbroich B , WagenerN , Macher-GoeppingerSet al. EZH2 depletion blocks the proliferation of colon cancer cells. PLoS One6(7), e21651 (2011).
   PubMed Web of Science ®Google Scholar
• Veneti Z , GkouskouKK , EliopoulosAG. Polycomb repressor complex 2 in genomic instability and cancer. Int. J. Mol. Sci.18(8), 1657–1672(2017).
   PubMed Web of Science ®Google Scholar
• Ferraro A , MourtzoukouD , KosmidouVet al. EZH2 is regulated by ERK/AKT and targets integrin Alpha2 gene to control epithelial-mesenchymal transition and anoikis in colon cancer cells. Int. J. Biochem. Cell Biol.45(2), 243–254 (2013).
   PubMed Web of Science ®Google Scholar
• Morera L , LübbertM , JungM. Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin. Epigenetics8, 57 (2016).
   PubMed Web of Science ®Google Scholar
• Hansen KH , BrackenAP , PasiniDet al. A model for transmission of the H3K27ME3 epigenetic mark. Nat. Cell Biol.10(11), 1291–1300 (2008).
   PubMed Web of Science ®Google Scholar
• Guo C , ChenLH , HuangYet al. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. Oncotarget4(11), 2144–2153 (2013).
   PubMedGoogle Scholar
• Kang MY , LeeBB , KimYHet al. Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer. Int. J. Cancer121(10), 2192–2197 (2007).
   PubMed Web of Science ®Google Scholar
• Natarajan TG , KallakuryBV , SheehanCEet al. Epigenetic regulator Mll2 shows altered expression in cancer cell lines and tumors from human breast and colon. Cancer Cell Int.10, 13, (2010).
   PubMed Web of Science ®Google Scholar
• Mittal P , RobertsCWM. The SWI/SNF complex in cancer – biology, biomarkers and therapy. Nat. Rev. Clin. Oncol.17(7), 435–448 (2020).
   PubMed Web of Science ®Google Scholar
• Bardhan K , LiuK. Epigenetics and colorectal cancer pathogenesis. Cancers (Basel)5(2), 676–713 (2013).
   PubMedGoogle Scholar
• Weichert W , RöskeA , NiesporekSet al. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res.14(6), 1669–1677 (2008).
   PubMed Web of Science ®Google Scholar
• Ishihama K , YamakawaM , SembaSet al. Expression of HDAC1 and CBP/P300 in human colorectal carcinomas. J. Clin. Pathol.60(11), 1205–1210 (2007).
   PubMed Web of Science ®Google Scholar
• Bosch-Presegué L , VaqueroA. The dual role of Sirtuins in cancer. Genes Cancer2(6), 648–662 (2011).
   PubMedGoogle Scholar
• Nosho K , ShimaK , IraharaNet al. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod. Pathol.22(7), 922–932 (2009).
   PubMed Web of Science ®Google Scholar
• Ferracin M , PedrialiM , VeroneseAet al. microRNA profiling for the identification of cancers with unknown primary tissue-of-origin. J. Pathol.225(1), 43–53 (2011).
   PubMed Web of Science ®Google Scholar
• Yamamoto H , AdachiY , TaniguchiHet al. Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. World J. Gastroenterol.18(22), 2745–2755 (2012).
   PubMed Web of Science ®Google Scholar
• Nagy ZB , WichmannB , KalmárAet al. Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens. Clin. Epigenetics9, 22 (2017).
   PubMed Web of Science ®Google Scholar
• Schetter AJ , LeungSY , SohnJJet al. microRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA299(4), 425–436 (2008).
   PubMed Web of Science ®Google Scholar
• Chang KH , MillerN , KheirelseidEAet al. microRNA signature analysis in colorectal cancer: identification of expression profiles in stage Ii tumors associated with aggressive disease. Int. J. Colorectal Dis.26(11), 1415–1422 (2011).
   PubMed Web of Science ®Google Scholar
• Faltejskova P , SvobodaM , SrutovaKet al. Identification and functional screening of microRNAs highly deregulated in colorectal cancer. J. Cell. Mol. Med.16(11), 2655–2666 (2012).
   PubMed Web of Science ®Google Scholar
• Gattolliat CH , UguenA , PessonMet al. microRNA and targeted mRNA expression profiling analysis in human colorectal adenomas and adenocarcinomas. Eur. J. Cancer51(3), 409–420 (2015).
   PubMed Web of Science ®Google Scholar
• Zhang GJ , ZhouH , XiaoHX , LiY , ZhouT. miR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer. BMC Cancer14, 109 (2014).
   PubMed Web of Science ®Google Scholar
• Zheng K , LiuW , LiuY , JiangC , QianQ. microRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1. Oncol Lett.9(2), 869–874 (2015).
   PubMed Web of Science ®Google Scholar
• Wang FF , ZhangXJ , YanYRet al. FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma. Cancer Lett.388, 85–95 (2017).
   PubMed Web of Science ®Google Scholar
• Fanale D , CastigliaM , BazanV , RussoA. Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer. Adv. Exp. Med. Biol.937, 207–228 (2016).
   PubMed Web of Science ®Google Scholar
• Raza U , ZhangJD , SahinO. microRNAs: master regulators of drug resistance, stemness, and metastasis. J. Mol. Med. (Berl.)92(4), 321–336 (2014).
   PubMed Web of Science ®Google Scholar
• Wu QB , ShengX , ZhangN , YangMW , WangF. Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy. Mol. Clin. Oncol.8(4), 523–527 (2018).
   PubMedGoogle Scholar
• Lampropoulou DI , PliakouE , AravantinosG , FilippouD , GazouliM. The role of exosomal non-coding RNAs in colorectal cancer drug resistance. Int. J. Mol. Sci.23(3), 1473–1498(2022).
   PubMed Web of Science ®Google Scholar
• Donzelli S , MoriF , BiagioniFet al. microRNAs: short non-coding players in cancer chemoresistance. Mol, Cell Ther.2, 16, (2014).
   PubMedGoogle Scholar
• Rezapour S , HosseinzadehE , MarofiF , HassanzadehA. Epigenetic-based therapy for colorectal cancer: prospect and involved mechanisms. J. Cell. Physiol.234(11), 19366–19383 (2019).
   PubMed Web of Science ®Google Scholar
• Thomas ML , MarcatoP. Epigenetic modifications as biomarkers of tumor development, therapy response, and recurrence across the cancer care continuum. Cancers (Basel)10(4), 101–121(2018).
   PubMed Web of Science ®Google Scholar
• Chen B , ZhuY , ChenJ , FengY , XuY. Activation of TC10-like transcription by lysine demethylase KDM4B in colorectal cancer cells. Front. Cell Dev. Biol.9, 617549, (2021).
   PubMed Web of Science ®Google Scholar
• Gerecke C , SchumacherF , EdlichAet al. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget9(67), 32822–32840 (2018).
   PubMedGoogle Scholar
• Raskov H , SøbyJH , TroelsenJ , BojesenRD , GögenurI. Driver gene mutations and epigenetics in colorectal cancer. Ann. Surg.271(1), 75–85 (2020).
   PubMed Web of Science ®Google Scholar
• Cervena K , SiskovaA , BuchlerT , VodickaP , VymetalkovaV. Methylation-based therapies for colorectal cancer. Cells9(6), 1540–1569(2020).
   PubMed Web of Science ®Google Scholar
• Niinuma T , KitajimaH , KaiMet al. UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells. Clin. Epigenetics11(1), 70 (2019).
   PubMedGoogle Scholar
• Pouya FD , GazouliM , RasmiY , LampropoulouDI , NematiM. microRNAs and drug resistance in colorectal cancer with special focus on 5-fluorouracil. Mol. Biol. Rep. (2022).
   PubMed Web of Science ®Google Scholar
• Vodenkova S , BuchlerT , CervenaKet al. 5-Fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future. Pharmacol. Ther.206, 107447 (2020).
   PubMed Web of Science ®Google Scholar
• Ahadi A . The significance of microRNA deregulation in colorectal cancer development and the clinical uses as a diagnostic and prognostic biomarker and therapeutic agent. Non-coding RNA Research5(3), 125–134 (2020).
   PubMed Web of Science ®Google Scholar
• Kadayifci FZ , ZhengS , PanYX. Molecular mechanisms underlying the link between diet and DNA methylation. Int. J. Mol. Sci.19(12), 4055–4074 (2018).
   PubMed Web of Science ®Google Scholar
• Aghabozorgi AS , SharifS , Jafarzadeh-EsfehaniR , VakiliS , AbbaszadeganMR. Role of miRNA gene variants in the susceptibility and pharmacogenetics of colorectal cancer. Pharmacogenomics22(5), 303–318 (2021).
   PubMed Web of Science ®Google Scholar
• Kashani E , HadizadehM , ChaleshiVet al. The differential DNA hypermethylation patterns of microRNA-137 and microRNA-342 locus in early colorectal lesions and tumours. Biomolecules9(10), 519–532 (2019).
   PubMed Web of Science ®Google Scholar
• Marcuello M , VymetalkovaV , NevesRPLet al. Circulating biomarkers for early detection and clinical management of colorectal cancer. Mol. Aspects Med.69, 107–122 (2019).
   PubMed Web of Science ®Google Scholar
• Roberti A , ValdesAF , TorrecillasR , FragaMF , FernandezAF. Epigenetics in cancer therapy and nanomedicine. Clin. Epigenetics11(1), 81 (2019).
   PubMed Web of Science ®Google Scholar