References
- Alegría M , NeMoyerA , FalgàsBagué Iet al. Social determinants of mental health: where we are and where we need to go. Curr. Psychiatry Rep.20(11), 95 (2018).
- Goldberg JF . Diagnosis and pharmacotherapy of bipolar depression in adults. J. Clin. Psychiatry82(4), SU120014BR1C (2021).
- Jain R , MaleticV , McIntyreRS. Diagnosing and treating patients with mixed features. J. Clin. Psychiatry78(8), 1091–1102 (2017).
- Correll CU , HowesOD. Treatment-resistant schizophrenia: definition, predictors, and therapy options. J. Clin. Psychiatry82(5), MY20096AH1C (2021).
- Behlke LM , LenzeEJ , CarneyRM. The cardiovascular effects of newer antidepressants in older adults and those with or at high risk for cardiovascular diseases. CNS Drugs34(11), 1133–1147 (2020).
- Kahl KG , StapelB , CorrellCU. Psychological and psychopharmacological interventions in psychocardiology. Front. Psychiatry13, 831359 (2022).
- Cubeddu LX . Drug-induced inhibition and trafficking disruption of ion channels pathogenesis of QT abnormalities and drug-induced fatal arrhythmias. Curr. Cardiol. Rev.12, 141–154 (2016).
- Swenson RS , Murphy-EndeK. Prolonged QT interval in patients receiving psychotropic medications. J. Am. Psychiatr. Nurses Assoc.26(4), 344–353 (2020).
- Stella F , LoureiroJC , PaisMVet al. Safety limits of antidepressant use plus combinations: focus on cardiovascular function. Curr. Drug Metab.19(8), 641–652 (2018).
- Prasitlumkum N , CheungpasitpornW , TokavanichNet al. Antidepressants and risk of sudden cardiac death: a network meta-analysis and systematic review. Med. Sci. (Basel).9(2), 26 (2021).
- Jacobson I , CarlssonL , DukeG. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetized methoxamine-sensitized rabbit. J. Pharmacol. Toxicol. Methods.63, 40–46 (2011).
- Johannesen L , VicenteJ , GrayRAet al. Improving the assessment of heart toxicity for all new drugs through translational regulatory science. Clin. Pharmacol. Ther.95(5), 501–508 (2014).
- Vicente J , ZusterzeelR , JohannesenLet al. Mechanistic model-informed proarrhythmic risk assessment of drugs: review of the ‘CiPA’ initiative and design of a prospective clinical validation study. Clin. Pharmacol. Ther.103(1), 54–66 (2018).
- Garcia-Elias A , BenitoB. Ion channel disorders and sudden cardiac death. Int. J. Mol. Sci.19(3), 692 (2018).
- Barro-Soria R , RebolledoS , LiinSIet al. KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channel into two steps. Nat. Commun.5, 3750 (2014).
- Wilde AAM , AminAS. Clinical spectrum of SCN5A mutations. Long QT syndrome, Brugada syndrome and cardiomyopathy. JACC Clin. Electrophysiol.4(5), 569–579 (2018).
- Medeiros-Domingo A , Iturralde-TorresP , AckermanMJ. Clinical and genetic characteristics of long QT syndrome. Rev. Esp. Cardiol.60(7), 739–752 (2007).
- Desai N , VenkateshCR , KumarSS. QT prolongation and torsades de pointes with psychotropic agents. Indian J. Psychiatry57(3), 305–308 (2015).
- Manikandan P , NaginiS. Cytochrome P450 structure, function and clinical significance: a review. Curr. Drug Targets.19(1), 38–54 (2018).
- Hoehe MR , Morris-RosendahlDJ. The role of genetics and genomics in clinical psychiatry. Dialogues Clin. Neurosci.20(3), 169–177 (2018).
- Zhang L , LuQ , ChangC. Epigenetics in health and disease. Adv. Exp. Med. Biol.1253, 3–55 (2020).
- Boyadjieva N , VaradinovaM. Epigenetics of psychoactive drugs. J. Pharm. Pharmacol.64(10), 1349–58 (2012).
- Fiori LM , LinR , JuCet al. Using epigenetic tools to investigate antidepressant response. Prog. Mol. Biol. Transl. Sci.158, 255–272 (2018).
- Hack LM , FriesGR , EyreHAet al. Moving pharmacoepigenetics tools for depression toward clinical use. J. Affect. Disord.249, 336–346 (2019).
- Schuebel K , GitikM , DomschkeK , GoldmanD. Making sense of epigenetics. Int. J. Neuropsychopharmacol.19(11), pyw058 (2016).
- Webb LM , PhillipsKE , HoMCet al. The relationship between DNA methylation and antidepressant medications: a systematic review. Int. J. Mol. Sci.21(3), 826 (2020).
- Ohya S , KitoH , HatanoN , MurakiK. Recent advances in therapeutic strategies that focus on the regulation of ion channel expression. Pharmacol. Ther.160, 11–43 (2016).
- Bazett HC . The time relations of the blood-pressure changes after excision of the adrenal glands, with some observations on blood volume changes. J. Physiol.53(5), 320–39 (1920).
- Grundmann M , KacirovaI , UrinovskaR. Therapeutic monitoring of psychoactive drugs – antidepressants: a review. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub.159(1), 35–43 (2015).
- Lu HR , YanGX , GallacherDJ. A new biomarker – index of cardiac electrophysiological balance (iCEB) – plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). J. Pharmacol. Toxicol. Methods.68(2), 250–259 (2013).
- Houtepen LC , van BergenAH , VinkersCH , BoksMP. DNA methylation signatures of mood stabilizers and antipsychotics in bipolar disorder. Epigenomics8(2), 197–208 (2016).
- Kanherkar RR , GetachewB , Ben-SheetritJet al. The effect of citalopram on genome-wide DNA methylation of human cells. Int. J. Genomics2018, 8929057 (2018).
- Lyko F . The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat. Rev. Genet.19(2), 81–92 (2018).
- Zimmermann N , ZschockeJ , PerisicTet al. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem. J.448(1), 93–102 (2012).
- Ferreira HJ , EstellerM. CpG islands in cancer: heads, tails, and sides. Methods Mol. Biol.1766, 49–80 (2018).
- Tomaselli Muensterman E , TisdaleJE. Predictive analytics for identification of patients at risk for QT interval prolongation: a systematic review. Pharmacotherapy38(8), 813–821 (2018).
- Wenzel-Seifert K , WittmannM , HaenE. QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes. Dtsch. Arztebl Int.108(41), 687–693 (2011).
- Petkovich DA , PodolskiyDI , LobanovAVet al. Using DNA methylation profiling to evaluate biological age and longevity interventions. Cell Metab.25(4), 954–960.e6 (2017).
- Gintant GA , GallacherDJ , PugsleyMK. The ‘overly-sensitive’ heart: sodium channel block and QRS interval prolongation. Br. J. Pharmacol.164(2), 254–9 (2011).
- Houseman EA , KimS , KelseyKT , WienckeJK. DNA methylation in whole blood: uses and challenges. Curr. Environ. Health Rep.2(2), 145–154 (2015).