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Methodology

Mirnas as Biomarkers of Musculoskeletal Pain in Long-Distance Runners: The Mimus Study Protocol

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Pages 341-349 | Received 10 Mar 2023, Accepted 04 May 2023, Published online: 30 May 2023

References

  • Tüfekci KU , MeuwissenRLJ , GençS. The role of microRNAs in biological processes. Methods Mol. Biol.1107, 15–31 (2014).
  • Catalanotto C , CogoniC , ZardoG. MicroRNA in control of gene expression: an overview of nuclear functions. Int. J. Mol. Sci.17(10), 1712 (2016).
  • Machado MT , NavegaS , DiasFet al. MicroRNAs for peripheral blood fraction identification: origin, pathways and forensic relevance. Life Sci.143, 98–104 (2015).
  • Turchinovich A , WeizL , BurwinkelB. Extracellular miRNAs: the mystery of their origin and function. Trends Biochem. Sci.37(11), 460–465 (2012).
  • Hanson EK , LubenowH , BallantyneJ. Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs. Anal. Biochem.387(2), 303–314 (2009).
  • Di Leva G , CroceCM. miRNA profiling of cancer. Curr. Opin. Genet. Dev.23(1), 3–11 (2013).
  • Khoury S , TranN. Circulating microRNAs: potential biomarkers for common malignancies. Biomark. Med.9(2), 131–151 (2015).
  • Su X , NieM , ZhangG , WangB. MicroRNA in cardio-metabolic disorders. Clin. Chim. Acta.518, 134–141 (2021).
  • Panico A , TumoloMR , LeoCGet al. The influence of lifestyle factors on miRNA expression and signal pathways: a review. Epigenomics13(2), 145–164 (2021).
  • Tumolo MR , PanicoA , DeDonno Aet al. The expression of microRNAs and exposure to environmental contaminants related to human health: a review. Int. J. Environ. Health Res.32(2), 332–354doi:10.1080/09603123.2020.1757043 (2022).
  • Wiegand C , HeusserP , KlingerCet al. Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study. Sci. Rep.8(1), 7112 (2018).
  • Sabina S , PanicoA , MincaronePet al. Expression and biological functions of miRNAs in chronic pain: a review on human studies. Int. J. Mol. Sci.23(11), 6016 (2022).
  • Polli A , GodderisL , GhoshMet al. Epigenetic and miRNA expression changes in people with pain: a systematic review. J. Pain21(7–8), 763–780 (2020).
  • Dinakar P , StillmanAM. Pathogenesis of Pain. Semin. Pediatr. Neurol.23(3), 201–208 (2016).
  • Nicholas M , VlaeyenJWS , RiefWet al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain160(1), 28–37 (2019).
  • World Health Organization . Musculoskeletal health. www.who.int/news-room/fact-sheets/detail/musculoskeletal-conditions (Accessed 20February2023).
  • Teixeira RN , LunardiA , da SilvaRAet al. Prevalence of musculoskeletal pain in marathon runners who compete at the elite level. Int. J. Sports Phys. Ther.11(1), 126–31 (2016).
  • Lopes AD , CostaLOP , SaragiottoBTet al. Musculoskeletal pain is prevalent among recreational runners who are about to compete: an observational study of 1049 runners. J. Physiother.57(3), 179–182 (2011).
  • Hainline B , DermanW , VernecAet al. International Olympic Committee consensus statement on pain management in elite athletes. Br. J. Sports Med.51(17), 1253–1258 (2017).
  • Bahr R . No injuries, but plenty of pain? On the methodology for recording overuse symptoms in sports. Br. J. Sports Med.43(13), 966–972 (2009).
  • Lambert C , ReinertN , StahlLet al. Epidemiology of injuries in track and field athletes: a cross-sectional study of specific injuries based on time loss and reduction in sporting level. Phys. Sportsmed.50(1), 20–29 (2022).
  • Fulton J , WrightK , KellyMet al. Injury risk is altered by previous injury: a systematic review of the literature and presentation of causative neuromuscular factors. Int. J. Sports Phys. Ther.9(5), 583–95 (2014).
  • Owoeye OBA , NemeJR , BuchananPet al. Absence of injury is not absence of pain: prevalence of preseason musculoskeletal pain and associated factors in collegiate soccer and basketball student athletes. Int. J. Environ. Res. Public Health19(15), 9128 (2022).
  • Gatchel R , RayC , SpightsKet al. Applying kinesiology as a multipronged approach to pain management: part 2. Pr. Pain Manag16(6) (2016).
  • El-Tallawy SN , NalamasuR , SalemGIet al. Management of musculoskeletal pain: an update with emphasis on chronic musculoskeletal pain. Pain Ther.10(1), 181–209 (2021).
  • Gazzetta Ufficiale della Repubblica Italiana . Decreto Legislativo 28 febbraio 2021, n.36. www.gazzettaufficiale.it/eli/id/2021/03/18/21G00043/sg (Accessed 16February2023).
  • Thornton JS , CaneiroJP , HartvigsenJet al. Treating low back pain in athletes: a systematic review with meta-analysis. Br. J. Sports Med.55(12), 656–662 (2021).
  • Charlton PC , DrewMK , MentiplayBFet al. Exercise interventions for the prevention and treatment of groin pain and injury in athletes: a critical and systematic review. Sports Med.47(10), 2011–2026 (2017).
  • Vincent HK , BrownsteinM , VincentKR. Injury prevention, safe training techniques, rehabilitation, and return to sport in trail runners. Arthrosc. Sport. Med. Rehabil.4(1), e151–e162 (2022).
  • Xia LX , KeC , LuJM. NEAT1 contributes to neuropathic pain development through targeting miR-381/HMGB1 axis in CCI rat models. J. Cell. Physiol.233(9), 7103–7111 (2018).
  • Quinn JJ , ChangHY. Unique features of long non-coding RNA biogenesis and function. Nat. Rev. Genet.17(1), 47–62 (2016).
  • Salmena L , PolisenoL , TayYet al. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146(3), 353–358 (2011).
  • Song G , YangZ , GuoJet al. Interactions among lncRNAs/circRNAs, miRNAs, and mRNAs in neuropathic pain. Neurotherapeutics17(3), 917–931 (2020).
  • Mannocci A , DiThiene D , DelCimmuto Aet al. International Physical Activity Questionnaire: validation and assessment in an Italian sample. Ital. J. Public Health7(4), 369–376 (2010).
  • Hjermstad MJ , FayersPM , HaugenDFet al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J. Pain Symptom Manage.41(6), 1073–1093 (2011).
  • Chalchat E , CharlotK , Garcia-VicencioSet al. Circulating microRNAs after a 24-h ultramarathon run in relation to muscle damage markers in elite athletes. Scand. J. Med. Sci. Sports31(9), 1782–1795 (2021).
  • Clauss S , WakiliR , HildebrandBet al. MicroRNAs as biomarkers for acute atrial remodeling in marathon runners (the miRathon Study – a sub-study of the Munich Marathon Study). PLoS One11(2), e0148599 (2016).
  • Eyileten C , WicikZ , FitasAet al. Altered circulating microRNA profiles after endurance training: a cohort study of ultramarathon runners. Front. Physiol.12, doi:10.3389/fphys.2021.792931 (2022).
  • Luchting B , HeynJ , HinskeLC , AzadSC. Expression of miRNA-124a in CD4 cells reflects response to a multidisciplinary treatment program in patients with chronic low back pain. Spine (Phila. Pa. 1976).42(4), E226–E233 (2017).
  • Perugia CV . www.calzetti-mariucci.it/shop/prodotti/posture-e-sport-la-prevenzione-dei-traumi-da-carico-iterativo. Calzetti&Mariucci (Ed.). Posture e sport. (2014).
  • Chiarotto A , BoersM , DeyoRAet al. Core outcome measurement instruments for clinical trials in nonspecific low back pain. Pain159(3), 481–495 (2018).
  • Liu K , TongH , LiT , WangX , ChenY. Research progress in molecular biology related quantitative methods of MicroRNA. Am J Transl Res.12(7), 3198–3211 (2020).
  • Canlı K , BillensA , Van OosterwijckJet al. Systemic cytokine level differences in patients with chronic musculoskeletal spinal pain compared to healthy controls and its association with pain severity: a systematic review. Pain Med.23(12), 1947–1964 (2022).
  • Agarwal V , BellGW , NamJW , BartelDP. Predicting effective microRNA target sites in mammalian mRNAs. Elife4, e05005 (2015).
  • Wong N , WangX. miRDB: an online resource for microRNA target prediction and functional annotations. Nucleic Acids Res.43, D146–D152 (2015).
  • Chang L , ZhouG , SoufanO , XiaJ. miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology. Nucleic Acids Res.48(W1), W244–W251 (2020).
  • ENCORI: The Encyclopedia of RNA Interactomes. Sun Yat-sen University. https://starbase.sysu.edu.cn/ (Accessed 18February2023).
  • Heberle H , MeirellesVG , da SilvaFRet al. InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinformatics16(1), 169 (2015).
  • Su G , MorrisJH , DemchakB , BaderGD. Biological network exploration with Cytoscape 3. Curr. Protoc. Bioinforma.47, 8.13.1–8.13.24 (2014).
  • Stöckel D , KehlT , TrampertPet al. Multi-omics enrichment analysis using the GeneTrail2 web service. Bioinformatics32(10), 1502–1508 (2016).
  • Hellhammer DH , WüstS , KudielkaBM. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology34(2), 163–171 (2009).
  • Cooper TR , TrunkfieldHR , ZanellaAJ , BoothWD. An enzyme-linked immunosorbent assay for cortisol in the saliva of man and domestic farm animals. J. Endocrinol.123(2), R13–R16 (1989).
  • Chiu YH , LuFJ-H , LinJHet al. Psychometric properties of the Perceived Stress Scale (PSS): measurement invariance between athletes and non-athletes and construct validity. PeerJ4(12), e2790 (2016).
  • Mondo M , SechiC , CabrasC. Psychometric evaluation of three versions of the Italian Perceived Stress Scale. Curr. Psychol.40(4), 1884–1892 (2021).
  • R Core Team . R: a language and environment for statistical computing. (2020). www.r-project.org/
  • Castro-Villegas C , Pérez-SánchezC , EscuderoAet al. Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNFα. Arthritis Res. Ther.17(1), 49 (2015).
  • Dickinson BA , SemusHM , MontgomeryRLet al. Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure. Eur. J. Heart Fail.15(6), 650–659 (2013).
  • Giannitti C , DePalma A , PascarelliNAet al. Can balneotherapy modify microRNA expression levels in osteoarthritis? A comparative study in patients with knee osteoarthritis. Int. J. Biometeorol.61(12), 2153–2158 (2017).
  • Jeffries J , ZhouW , HsuAY , DengQ. miRNA-223 at the crossroads of inflammation and cancer. Cancer Lett.451, 136–141 (2019).
  • Tian Y , WangT-S , BuHet al. Role of exosomal miR-223 in chronic skeletal muscle inflammation. Orthop. Surg.14(4), 644–651 (2022).

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