Integrated Bioinformatics And Experimental Validation Reveal The Role Of Jarid2 In Ovarian Cancer

References

• Bray F , FerlayJ , SoerjomataramI , SiegelRL , TorreLA , JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
   PubMed Web of Science ®Google Scholar
• Smith RA , AndrewsKS , BrooksDet al. Cancer screening in the United States, 2017: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J. Clin.67(2), 100–121 (2017).
   PubMed Web of Science ®Google Scholar
• Siegel RL , MillerKD , JemalA. Cancer statistics, 2020. CA Cancer J. Clin.70(1), 7–30 (2020).
   PubMed Web of Science ®Google Scholar
• Sieh W , KobelM , LongacreTAet al. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis Consortium study. Lancet Oncol.14(9), 853–862 (2013).
   PubMed Web of Science ®Google Scholar
• Liu J , MatulonisUA. New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances. Clin. Cancer Res.20(20), 5150–5156 (2014).
   PubMed Web of Science ®Google Scholar
• Iasonos A , ChapmanPB , SatagopanJM. Quantifying treatment benefit in molecular subgroups to assess a predictive biomarker. Clin. Cancer Res.22(9), 2114–2120 (2016).
   PubMed Web of Science ®Google Scholar
• De Donato M , BabiniG , MozzettiSet al. KLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer. J. Exp. Clin. Cancer Res.39(1), 265 (2020).
   PubMed Web of Science ®Google Scholar
• Wang H , LiuJ , YangJet al. A novel tumor mutational burden-based risk model predicts prognosis and correlates with immune infiltration in ovarian cancer. Front. Immunol.13, 943389 (2022).
   PubMed Web of Science ®Google Scholar
• Wang PS , WangZ , YangC. Dysregulations of long non-coding RNAs – the emerging ‘lnc’ in environmental carcinogenesis. Semin. Cancer Biol.76, 163–172 (2021).
   PubMed Web of Science ®Google Scholar
• Wang H , MengQ , QianJ , LiM , GuC , YangY. Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer. Pharmacol. Ther.234, 108123 (2022).
   PubMed Web of Science ®Google Scholar
• Wang X , LiX , LinFet al. The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis. J. Exp. Clin. Cancer Res.40(1), 151 (2021).
   PubMed Web of Science ®Google Scholar
• Pan X , GuoZ , ChenYet al. STAT3-induced lncRNA SNHG17 exerts oncogenic effects on ovarian cancer through regulating CDK6. Mol. Ther. Nucleic Acids22, 38–49 (2020).
   PubMedGoogle Scholar
• Zhen J , LiJ , LiXet al. Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis. J. Biomed. Sci.28(1), 53 (2021).
   PubMed Web of Science ®Google Scholar
• Tabury K , MonavarianM , ListikEet al. PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance. Life Sci. Alliance5(11), 202201370 (2022).
   Web of Science ®Google Scholar
• Bao D , GaoL , XinH , WangL. lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure. J. Ovarian Res.16(1), 65 (2023).
   PubMed Web of Science ®Google Scholar
• Zamaraev AV , VolikPI , SukhikhGT , KopeinaGS , ZhivotovskyB. Long non-coding RNAs: a view to kill ovarian cancer. Biochim. Biophys. Acta Rev. Cancer1876(1), 188584 (2021).
   PubMed Web of Science ®Google Scholar
• Bejarano L , JordaoMJC , JoyceJA. Therapeutic targeting of the tumor microenvironment. Cancer Discov.11(4), 933–959 (2021).
   PubMed Web of Science ®Google Scholar
• Kandalaft LE , PowellDJJr , SinghN , CoukosG. Immunotherapy for ovarian cancer: what’s next?J. Clin. Oncol.29(7), 925–933 (2011).
   PubMed Web of Science ®Google Scholar
• Chu CS , KimSH , JuneCH , CoukosG. Immunotherapy opportunities in ovarian cancer. Expert Rev. Anticancer Ther.8(2), 243–257 (2008).
   PubMed Web of Science ®Google Scholar
• Ye L , PanK , FangSet al. Four types of RNA modification writer-related lncRNAs are effective predictors of prognosis and immunotherapy response in serous ovarian carcinoma. Front. Immunol.13, 863484 (2022).
   PubMed Web of Science ®Google Scholar
• Wang X , WangY , SunFet al. Novel lncRNA ZFHX4-AS1 as a potential prognostic biomarker that affects the immune microenvironment in ovarian cancer. Front. Oncol.12, 945518 (2022).
   PubMedGoogle Scholar
• Chen L , WangJ , LiuQ. Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer. Front. Cell Dev. Biol.10, 999174 (2022).
   PubMed Web of Science ®Google Scholar
• Ghoneum A , AlmousaS , WarrenBet al. Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer. Semin. Cancer Biol.77, 83–98 (2021).
   PubMed Web of Science ®Google Scholar
• Jiang Y , WangC , ZhouS. Targeting tumor microenvironment in ovarian cancer: premise and promise. Biochim. Biophys. Acta Rev. Cancer1873(2), 188361 (2020).
   PubMed Web of Science ®Google Scholar
• Odunsi K . Immunotherapy in ovarian cancer. Ann. Oncol.28(Suppl. 8), viii1–viii7 (2017).
   PubMedGoogle Scholar
• Vizan P , BeringerM , BallareC , DiCroce L. Role of PRC2-associated factors in stem cells and disease. FEBS J.282(9), 1723–1735 (2015).
   PubMed Web of Science ®Google Scholar
• Berge-Lefranc JL , JayP , MassacrierAet al. Characterization of the human Jumonji gene. Hum. Mol. Genet.5(10), 1637–1641 (1996).
   PubMed Web of Science ®Google Scholar
• Shen X , KimW , FujiwaraYet al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell139(7), 1303–1314 (2009).
   PubMed Web of Science ®Google Scholar
• Klose RJ , KallinEM , ZhangY. JmjC-domain-containing proteins and histone demethylation. Nat. Rev. Genet.7(9), 715–727 (2006).
   PubMed Web of Science ®Google Scholar
• Pasini D , CloosPA , WalfridssonJet al. JARID2 regulates binding of the polycomb repressive complex 2 to target genes in ES cells. Nature464(7286), 306–310 (2010).
   PubMed Web of Science ®Google Scholar
• Chen S , JiaoL , ShubbarM , YangX , LiuX. Unique structural platforms of SUZ12 dictate distinct classes of PRC2 for chromatin binding. Mol. Cell69(5), 840–852.e5 (2018).
   PubMed Web of Science ®Google Scholar
• Chen S , JiaoL , LiuX , YangX , LiuX. A dimeric structural scaffold for PRC2-PCL targeting to CpG island chromatin. Mol. Cell77(6), 1265–1278.e7 (2020).
   PubMed Web of Science ®Google Scholar
• Celik H , KohWK , KramerACet al. JARID2 functions as a tumor suppressor in myeloid neoplasms by repressing self-renewal in hematopoietic progenitor cells. Cancer Cell34(5), 741–756.e8 (2018).
   PubMed Web of Science ®Google Scholar
• Score J , Hidalgo-CurtisC , JonesAVet al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood119(5), 1208–1213 (2012).
   PubMed Web of Science ®Google Scholar
• Puda A , MilosevicJD , BergTet al. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am. J. Hematol.87(3), 245–250 (2012).
   PubMed Web of Science ®Google Scholar
• Ito K , MurphyD. Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst. Pharmacol.2(10), e79 (2013).
   PubMedGoogle Scholar
• Szklarczyk D , GableAL , NastouKCet al. The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res.49(D1), D605–D612 (2021).
   PubMed Web of Science ®Google Scholar
• Zhou Y , ZhouB , PacheLet al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun.10(1), 1523 (2019).
   PubMed Web of Science ®Google Scholar
• Subramanian A , TamayoP , MoothaVKet al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA102(43), 15545–15550 (2005).
   PubMed Web of Science ®Google Scholar
• Xing J , ZhaiR , WangCet al. DiseaseMeth version 3.0: a major expansion and update of the human disease methylation database. Nucleic Acids Res.50(D1), D1208–D1215 (2022).
   PubMed Web of Science ®Google Scholar
• Wang X , LyuJ , JiA , ZhangQ , LiaoG. JARID2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling. Life Sci.230, 162–168 (2019).
   PubMed Web of Science ®Google Scholar
• Shao FL , LiuQQ , WangS. Identify potential miRNA–mRNA regulatory networks contributing to high-risk neuroblastoma. Invest. New Drugs39(4), 901–913 (2021).
   PubMed Web of Science ®Google Scholar
• Zhao H , WangJ , GaoLet al. MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke44(6), 1706–1713 (2013).
   PubMed Web of Science ®Google Scholar
• Wang J , CheYL , LiGet al. Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma. Mol. Carcinog.50(7), 506–515 (2011).
   PubMed Web of Science ®Google Scholar
• Chen Y , LiS , WeiY , XuZ , WuX. Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2. Bosn. J. Basic Med. Sci.21(5), 555–568 (2021).
   PubMed Web of Science ®Google Scholar
• Cao J , LiH , LiuG , HanS , XuP. Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Mol. Med. Rep.16(3), 3600–3605 (2017).
   PubMed Web of Science ®Google Scholar
• Volders PJ , AnckaertJ , VerheggenKet al. LNCipedia 5: towards a reference set of human long non-coding RNAs. Nucleic Acids Res.47(D1), D135–D139 (2019).
   PubMed Web of Science ®Google Scholar
• Lin Y , PanX , ShenHB. lncLocator 2.0: a cell-line-specific subcellular localization predictor for long non-coding RNAs with interpretable deep learning. Bioinformatics37(16), 2308–2316 (2021).
   PubMed Web of Science ®Google Scholar
• Malta TM , SokolovA , GentlesAJet al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell173(2), 338–354.e15 (2018).
   PubMed Web of Science ®Google Scholar
• Bayik D , LathiaJD. Cancer stem cell–immune cell crosstalk in tumour progression. Nat. Rev. Cancer21(8), 526–536 (2021).
   PubMed Web of Science ®Google Scholar
• Zhang Y , ZhangZ. The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell. Mol. Immunol.17(8), 807–821 (2020).
   PubMed Web of Science ®Google Scholar
• Mao X , XuJ , WangWet al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol. Cancer20(1), 131 (2021).
   PubMed Web of Science ®Google Scholar
• Karagkouni D , ParaskevopoulouMD , TastsoglouSet al. DIANA-LncBase v3: indexing experimentally supported miRNA targets on non-coding transcripts. Nucleic Acids Res.48(D1), D101–D110 (2020).
   PubMed Web of Science ®Google Scholar
• Salmena L , PolisenoL , TayY , KatsL , PandolfiPP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?Cell146(3), 353–358 (2011).
   PubMed Web of Science ®Google Scholar
• Guo L , MaH , KongY , LengG , LiuG , ZhangY. Long non-coding RNA TNK2 AS1/microRNA-125a-5p axis promotes tumor growth and modulated phosphatidylinositol 3 kinase/AKT pathway. J. Gastroenterol. Hepatol.37(1), 124–133 (2022).
   PubMed Web of Science ®Google Scholar
• Gu Y , DingZ , ZhouQ , LiJ , QianW. JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis. Reprod. Biol.23(1), 100729 (2023).
   PubMed Web of Science ®Google Scholar
• Torre LA , TrabertB , DesantisCEet al. Ovarian cancer statistics, 2018. CA Cancer J. Clin.68(4), 284–296 (2018).
   PubMed Web of Science ®Google Scholar
• Cao H , YouD , LanZ , YeH , HouM , XiM. Prognostic value of serum and tissue HE4 expression in ovarian cancer: a systematic review with meta-analysis of 90 studies. Expert Rev. Mol. Diagn.18(4), 371–383 (2018).
   PubMed Web of Science ®Google Scholar
• Zhang R , SiuMKY , NganHYS , ChanKKL. Molecular biomarkers for the early detection of ovarian cancer. Int. J. Mol. Sci.23(19), (2022).
   Web of Science ®Google Scholar
• Zhang C , LiuJ , GuoHet al. m6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer. Bioengineered12(1), 3159–3176 (2021).
   PubMed Web of Science ®Google Scholar
• Li G , MargueronR , KuM , ChambonP , BernsteinBE , ReinbergD. JARID2 and PRC2, partners in regulating gene expression. Genes Dev.24(4), 368–380 (2010).
   PubMed Web of Science ®Google Scholar
• Geng X , ZhaoJ , HuangJet al. lnc-MAP3K13-7:1 inhibits ovarian GC proliferation in PCOS via DNMT1 downregulation-mediated CDKN1A promoter hypomethylation. Mol. Ther.29(3), 1279–1293 (2021).
   PubMed Web of Science ®Google Scholar
• Ni MW , ZhouJ , ZhangYLet al. Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance. Biomark. Med.13(7), 535–543 (2019).
   PubMed Web of Science ®Google Scholar
• Bogdanova N , MarkoffA , GerkeV , McCluskeyM , HorstJ , DworniczakB. Homologues to the first gene for autosomal dominant polycystic kidney disease are pseudogenes. Genomics74(3), 333–341 (2001).
   PubMed Web of Science ®Google Scholar
• Loftus BJ , KimUJ , SneddonVPet al. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics60(3), 295–308 (1999).
   PubMed Web of Science ®Google Scholar
• Cramer DW , EliasKM. A prognostically relevant miRNA signature for epithelial ovarian cancer. Lancet Oncol.17(8), 1032–1033 (2016).
   PubMed Web of Science ®Google Scholar
• Al-Awsi GRL , JasimSA , MustafaYFet al. The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer. Future Oncol.18(38), 4209–4231 (2022).
   PubMed Web of Science ®Google Scholar
• Bose S , SahaP , ChatterjeeB , SrivastavaAK. Chemokines driven ovarian cancer progression, metastasis and chemoresistance: potential pharmacological targets for cancer therapy. Semin. Cancer Biol.86(Pt 2), 568–579 (2022).
   PubMedGoogle Scholar
• Wang K , ZhuG , BaoS , ChenS. Long non-coding RNA LINC00511 mediates the effects of ESR1 on proliferation and invasion of ovarian cancer through miR-424-5p and miR-370-5p. Cancer Manag. Res.11, 10807–10819 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang J , LiuH , HouLet al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol. Cancer16(1), 151 (2017).
   PubMed Web of Science ®Google Scholar
• Chen Q , WangH , LiZet al. Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. J. Hepatol.76(1), 135–147 (2022).
   PubMed Web of Science ®Google Scholar
• Wang J , WangS , ZhouJ , QianQ. miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer. Biomed. Pharmacother.102, 147–152 (2018).
   PubMed Web of Science ®Google Scholar
• Wang P , LiuT , ZhaoZ , WangZ , LiuS , YangX. SPTBN2 regulated by miR-424-5p promotes endometrial cancer progression via CLDN4/PI3K/AKT axis. Cell Death Discov.7(1), 382 (2021).
   PubMed Web of Science ®Google Scholar
• Kasinath V , BeckC , SauerPet al. JARID2 and AEBP2 mimic histone tails to promote PRC2 activity. Cancer Discov.8(3), 264 (2018).
   Web of Science ®Google Scholar
• Kasinath V , BeckC , SauerPet al. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science371(6527), eabc3393 (2021).
   PubMed Web of Science ®Google Scholar
• Qu Y , YangQ , LiuJet al. c-Myc is required for BRAF(V600E)-induced epigenetic silencing by H3K27me3 in tumorigenesis. Theranostics7(7), 2092–2107 (2017).
   PubMed Web of Science ®Google Scholar
• Escobar TM , KanellopoulouC , KuglerDGet al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein JARID2 to relieve polycomb-mediated repression. Immunity40(6), 865–879 (2014).
   PubMed Web of Science ®Google Scholar