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Review

Nutrition, DNA Methylation and Obesity Across Life Stages and Generations

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 991-1015 | Received 17 May 2023, Accepted 20 Oct 2023, Published online: 07 Nov 2023

References

  • Lim H , XueH . WangY. Global trends in obesity. In: Handbook of Eating and Drinking.MeiselmanH ( Ed.). Springer, Cham, Switzerland, 1217–1235 (2020).
  • Rippe JM , CrossleyS , RingerR. Obesity as a chronic disease: modern medical and lifestyle management. J. Am. Diet Assoc.98(10), S9–S15 (1998).
  • Spieker EA , PyzochaN. Economic Impact of Obesity. Primary Care Clin. Office Pract.43(1), 83–95 (2016).
  • Endalifer ML , DiressG. Epidemiology, predisposing factors, biomarkers, and prevention mechanism of obesity: a systematic review. J. Obes.2020, 6134362 (2020).
  • Marti A , OrdovasJ. Epigenetics lights up the obesity field. Obes. Facts4(3), 187 (2011).
  • McKay JA , MathersJC. Diet induced epigenetic changes and their implications for health. Acta Physiol.202(2), 103–118 (2011).
  • Obri A , SerraD , HerreroL , MeraP. The role of epigenetics in the development of obesity. Biochem. Pharmacol.177, 113973 (2020).
  • Herrera BM , KeildsonS , LindgrenCM. Genetics and epigenetics of obesity. Maturitas69(1), 41 (2011).
  • Milagro FI , CampiónJ , García-DíazDFGoyenecheaE , PaternainL , MartínezJA. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J. Physiol. Biochem.65(1), 1–9 (2009).
  • Plagemann A , HarderT , BrunnMet al. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J. Physiol.587(Pt 20), 4963 (2009).
  • Milagro FI , CampionJ , CorderoPet al. A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. FASEB J.25(4), 1378–1389 (2011).
  • Mendelson MM , MarioniRE , JoehanesRet al. Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization approach. PLOS Med.14(1), e1002215 (2017).
  • Wahl S , DrongA , LehneBet al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature541(7635), 81–86 (2016).
  • Wang P , YamabeN , HongC-J , BaiH-W , ZhuBT. Caffeic acid phenethyl ester, a coffee polyphenol, inhibits DNA methylation in vitro and in vivo. Eur. J. Pharmacol.887, 173464 (2020).
  • Yu W , WangZ , ZhangKet al. One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages. Mol. Cell75(6), 1147–1160 (2019).
  • Guo F , PengL , XiongHet al. Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats. Food Res. Int.167, 112634 (2023).
  • Clare CE , BrassingtonAH , KwongWY , SinclairKD. One-carbon metabolism: linking nutritional biochemistry to epigenetic programming of long-term development. Annu. Rev. Anim. Biosci.7, 263–287 (2019).
  • Reuter S , GuptaSC , ParkBet al. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr.6(2), 93–108 (2011).
  • Aggarwal R , JhaM , ShrivastavaA , JhaAK. Natural compounds: Role in reversal of epigenetic changes. Biochemistry (Moscow)80(8), 972–989 (2015).
  • Voerman E , SantosS , PatroGolab Bet al. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: an individual participant data meta-analysis. PLOS Med.16(2), e1002744 (2019).
  • Dolton P , XiaoM. The intergenerational transmission of body mass index across countries. Econ. Hum. Biol.24, 140–152 (2017).
  • Barouki R , GluckmanPD , GrandjeanPet al. Developmental origins of non-communicable disease: implications for research and public health. Environ. Health11(1), 1–9 (2012).
  • Ramírez-Alarcón K , Sánchez-AgurtoÁ , LampertiL , MartorellM. Epigenetics, maternal diet and metabolic programming. Open Biol. J.7(1), 45–51 (2019).
  • Şanlı E , KabaranS. Maternal obesity, maternal overnutrition and fetal programming: effects of epigenetic mechanisms on the development of metabolic disorders. Curr. Genomics20(6), 419 (2019).
  • Godfrey KM , SheppardA , GluckmanPDet al. Epigenetic gene promoter methylation at birth is associated with child’s later adiposity. Diabetes60(5), 1528–1534 (2011).
  • Perkins E , MurphySK , MurthaAPet al. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J. Pediatr.161(1), 31–39 (2012).
  • Pan H , LinX , WuYet al. HIF3A association with adiposity: the story begins before birth. Epigenomics7(6), 937–950 (2015).
  • Jönsson J , RenaultKM , García-CalzónSet al. Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring. Diabetes70(4), 854–866 (2021).
  • Wu G , BazerFW , CuddTAet al. Maternal nutrition and fetal development. J. Nutr.134(9), 2169–2172 (2004).
  • Portrait FRM , van WingerdenTF , DeegDJH. Early life undernutrition and adult height: the Dutch famine of 1944–45. Econ. Hum. Biol.27(Pt B), 339–348 (2017).
  • Heijmans BT , TobiEW , SteinADet al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA105(44), 17046–17049 (2008).
  • Painter RC , OsmondC , GluckmanPet al. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG115(10), 1243–1249 (2008).
  • Haggarty P , HoadG , CampbellDMet al. Folate in pregnancy and imprinted gene and repeat element methylation in the offspring. Am. J. Clin. Nutr.97(1), 94–99 (2013).
  • Hoyo C , DaltveitAK , IversenEet al. Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. Epigenetics9(8), 1120–1130 (2014).
  • Harvey NC , SheppardA , GodfreyKMet al. Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth. J. Bone Min. Res.29(3), 600–607 (2014).
  • Joubert BR , DenDekker HT , FelixJFet al. Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat. Commun.7(1), 10577 (2016).
  • Rijlaarsdam J , CecilCAM , WaltonEet al. Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems. J. Child Psychol. Psychiatry58(1), 19–27 (2017).
  • Pauwels S , GhoshM , DucaRCet al. Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation. Epigenetics12(1), 1 (2017).
  • Gonzalez-Nahm S , MendezM , RobinsonWet al. Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants. Environ. Epigenetics.3(2), dvx007 (2017).
  • McCullough LE , MillerEE , CalderwoodLEet al. Maternal inflammatory diet and adverse pregnancy outcomes: circulating cytokines and genomic imprinting as potential regulators? Epigenetics 12(8), 688–697 (2017).
  • Geraghty AA , Sexton-OatesA , O’BrienECet al. A low glycaemic index diet in pregnancy induces DNA methylation variation in blood of newborns: results from the ROLO randomised controlled trial. Nutrients10(4), 455 (2018).
  • Caffrey A , IrwinRE , McNultyHet al. Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial. Am. J. Clin. Nutr.107(4), 566–575 (2018).
  • House JS , MendezM , MaguireRLet al. Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes. Front. Cell. Dev. Biol.6, 107 (2018).
  • Bianchi M , AlisiA , FabriziMet al. Maternal intake of n-3 polyunsaturated fatty acids during pregnancy is associated with differential methylation profiles in cord blood white cells. Front. Genet.10, 1050 (2019).
  • Liu J , ZhangZ , XuJet al. Genome-wide DNA methylation changes in placenta tissues associated with small for gestational age newborns; cohort study in the Chinese population. Epigenomics11(12), 1399–1412 (2019).
  • Daniels TE , SadovnikoffAI , RidoutKKet al. Associations of maternal diet and placenta leptin methylation. Mol. Cell Endocrinol.505, 110739 (2020).
  • Robinson SL , MumfordSL , GuanWet al. Maternal fatty acid concentrations and newborn DNA methylation. Am. J. Clin. Nutr.111(3), 613–621 (2020).
  • Chiu YH , FadaduRP , GaskinsAJet al. Dietary fat intake during early pregnancy is associated with cord blood DNA methylation at IGF2 and H19 genes in newborns. Environ. Mol. Mutagen.62(7), 388–398 (2021).
  • Taeubert MJ , de Prado-BertP , GeurtsenMLet al. Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis. Clin. Epigenetics14(1), 1–12 (2022).
  • Küpers LK , Fernández-BarrésS , NounuAet al. Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics1–13 (2022).
  • Lecorguillé M , CharlesM-A , LepeuleJet al. Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation. Epigenetics17(7), 715–730 (2022).
  • Xu R , HongX , Ladd-AcostaCet al. Contrasting association of maternal plasma biomarkers of smoking and 1-carbon micronutrients with offspring DNA methylation: evidence of aryl hydrocarbon receptor repressor gene–smoking–folate interaction. J. Nutr.153(8), 2339–2351 (2023).
  • Monasso GS , HoangTT , MancanoGet al. A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation. Epigenetics18(1), 2202835 (2023).
  • Hu FB . Dietary pattern analysis: a new direction in nutritional epidemiology. Curr. Opin. Lipidol.13(1), 3–9 (2002).
  • Amati F , HassounahS , SwakaA. The impact of Mediterranean dietary patterns during pregnancy on maternal and offspring health. Nutrients11(5), 1098 (2019).
  • Heerwagen MJR , MillerMR , BarbourLA , FriedmanJE. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am. J. Physiol. Regul. Integr. Comp. Physiol.299(3), R711–R722 (2010).
  • Küpers LK , Fernández-BarrésS , MancanoGet al. Maternal dietary glycemic index and glycemic load in pregnancy and offspring cord blood DNA methylation. Diabetes Care45(8), 1822–1832 (2022).
  • Haggarty P . Placental regulation of fatty acid delivery and its effect on fetal growth – areview. Placenta23(Suppl. 1), S28–S38 (2002).
  • van Eijsden M , HornstraG , vander Wal MFet al. Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study. Am. J. Clin. Nutr.87(4), 887–895 (2008).
  • Lin J-MG , KourtisS , GhoseRet al. Metabolic modulation of transcription: the role of one-carbon metabolism. Cell Chem. Biol.29(12), 1664–1679 (2022).
  • Guéant J-L , NamourF , Gueant-RodriguezR-M , DavalJ-L. Folate and fetal programming: a play in epigenomics?Trends Endocrinol. Metab.24(6), 279–289 (2013).
  • Guéant J-L , Guéant-RodriguezR-M , KosgeiVJ , CoelhoD. Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism. Crit. Rev. Biochem. Mol. Biol.57(2), 133–155 (2022).
  • Korsmo HW , JiangX. One carbon metabolism and early development: a diet-dependent destiny. Trends Endocrinol. Metab.32(8), 579–593 (2021).
  • Yajnik CS , DeshpandeSS , JacksonAAet al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia51, 29–38 (2008).
  • Ondičová M , IrwinRE , ThursbyS-Jet al. Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms. Clin. Epigenetics14(1), 63 (2022).
  • Altamura S , MarquesO , ColucciSet al. Regulation of iron homeostasis: lessons from mouse models. Mol. Aspects Med.75, 100872 (2020).
  • Niu Y , DesMaraisTL , TongZ , YaoY , CostaM. Oxidative stress alters global histone modification and DNA methylation. Free Radic. Biol. Med.82, 22–28 (2015).
  • Wong CP , RinaldiNA , HoE. Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol. Nutr. Food Res.59(5), 991–999 (2015).
  • Bozack AK , Rifas-ShimanSL , CoullBAet al. Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals. Clin. Epigenetics13(1), 1–18 (2021).
  • Dou JF , MiddletonLYM , ZhuYet al. Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts. Epigenetics Chromatin15(1), 1–16 (2022).
  • Agha G , HousemanEA , KelseyKTet al. Adiposity is associated with DNA methylation profile in adipose tissue. Int. J. Epidemiol.44(4), 1277–1287 (2015).
  • Do WL , GoharJ , McCulloughLE , GalavizKIet al. Examining the association between adiposity and DNA methylation: a systematic review and meta-analysis. Obes. Rev.22(10), e13319 (2021).
  • Aslibekyan S , DemerathEW , MendelsonMet al. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity23(7), 1493–1501 (2015).
  • Campanella G , GunterMJ , PolidoroSet al. Epigenome-wide association study of adiposity and future risk of obesity-related diseases. Int. J. Obes. (Lond.)42(12), 2022–2035 (2018).
  • Ouni M , SchürmannA. Epigenetic contribution to obesity. Mamm. Genome31(5–6), 134–145 (2020).
  • Sanchez H , HossainMB , LeraLet al. High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin. Epigenetics.9(1), 1–11 (2017).
  • Kresovich JK , BulkaCM , JoyceBTet al. The inflammatory potential of dietary manganese in a cohort of elderly men. Biol. Trace. Elem. Res.183, 49–57 (2018).
  • Ramos-Lopez O , SamblasM , MilagroFIet al. Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects. Nutr. Res.50, 53–62 (2018).
  • Lima RPA , RibeiroMR , deFarias Lima KQet al. Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults. Biol. Res.52(1), 21 (2019).
  • Ramos-Lopez O , Riezu-BojJI , MilagroFIet al. Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake. Brain Behav.8(8), 1017 (2018).
  • Ramos-Lopez O , Riezu-BojJI , MilagroFIet al. Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. Genes Nutr.14(1), 1–10 (2019).
  • Ramos-Lopez O , ArpónA , Riezu-BojJIet al. DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population. Appetite120, 230–239 (2018).
  • Ramos-Lopez O , SamblasM , MilagroFIet al. Circadian gene methylation profiles are associated with obesity, metabolic disturbances and carbohydrate intake. Chronobiol. Int.35(7), 969–981 (2018).
  • Wang X , ZhuH , SniederHet al. Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med.8(1), 87 (2010).
  • Bollepalli S , KayeS , HeinonenSet al. Subcutaneous adipose tissue gene expression and DNA methylation respond to both short-and long-term weight loss. Int. J. Obes.42(3), 412 (2018).
  • Arpon A , Riezu-BojJI , MilagroFIet al. Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. J. Physiol. Biochem.73445–455 (2016).
  • do Amaral CL , MilagroFI , CuriR , MartínezJA. DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil. Biomed. Res. Int.2014, 675021 (2014).
  • Duggan C , XiaoL , TerryMB , McTiernanA. No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women. Obesity22(9), 2091–2096 (2014).
  • Garcia-Lacarte M , MilagroFI , ZuletMAet al. LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity. Redox Rep.21(2), 67–74 (2016).
  • Lima RPA , do NascimentoRAF , LunaRCPet al. Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women. Clin. Epigenetics9, 110 (2017).
  • Sun D , HeianzaY , LiXet al. Genetic, epigenetic and transcriptional variations at NFATC2IP locus with weight loss in response to diet interventions: the POUNDS Lost Trial. Diabetes Obes. Metab.20(9), 2298–2303 (2018).
  • Santamarina AB , JamarG , MennittiLVet al. Supplementation of juçara berry (Euterpe edulis Mart.) modulates epigenetic markers in monocytes from obese adults: a double-blind randomized trial. Nutrients10(12), 1899 (2018).
  • Luna RCP , dosSantos Nunes MK , MonteiroMGCAet al. α-Tocopherol influences glycaemic control and miR-9-3 DNA methylation in overweight and obese women under an energy-restricted diet: a randomized, double-blind, exploratory, controlled clinical trial. Nutr. Metab. (Lond.)15, 49 (2018).
  • Keller M , MeirAY , BernhartSHet al. DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial. Genome Med.12(1), 1–18 (2020).
  • Nicoletti CF , Cortes-OliveiraC , NoronhaNYet al. DNA methylation pattern changes following a short-term hypocaloric diet in women with obesity. Eur. J. Clin. Nutr.74(9), 1345–1353 (2020).
  • Stojković L , ZecM , ZivkovicMet al. Polyphenol-rich Aronia melanocarpa juice consumption affects LINE-1 DNA methylation in peripheral blood leukocytes in dyslipidemic women. Front. Nutr.8, 343 (2021).
  • Yaskolka Meir A , KellerM , MüllerLet al. Effects of lifestyle interventions on epigenetic signatures of liver fat: central randomized controlled trial. Liver Int.41(9), 2101–2111 (2021).
  • Li X , ShaoX , BazzanoLAet al. Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS lost trial. Int. J. Obes. (Lond.)46(6), 1122–1127 (2022).
  • Li X , ShaoX , XueQet al. DNA methylation near CPT1A and changes in triglyceride-rich lipoproteins in response to weight-loss diet interventions. J.Clin. Endocrinol. Metab.108(8), e542–e549 (2023).
  • Horvath S . DNA methylation age of human tissues and cell types. Genome Biol.14(10), 3156 (2013).
  • Levine ME , LuAT , QuachAet al. An epigenetic biomarker of aging for lifespan and healthspan. Aging10(4), 573 (2018).
  • Klemp I , HoffmannA , MüllerLet al. DNA methylation patterns reflect individual’s lifestyle independent of obesity. Clin. Transl. Med.12(6), e851 (2022).
  • Fiorito G , CainiS , PalliDet al. DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study. Aging Cell20(10), e13439 (2021).
  • Gensous N , GaragnaniP , SantoroAet al. One-year Mediterranean diet promotes epigenetic rejuvenation with country-and sex-specific effects: a pilot study from the NU-AGE project. Geroscience42(2), 687–701 (2020).
  • Kim Y , HuanT , JoehanesRet al. Higher diet quality relates to decelerated epigenetic aging. Am. J. Clin. Nutr.115(1), 163–170 (2022).
  • Kresovich JK , ParkYMM , KellerJAet al. Healthy eating patterns and epigenetic measures of biological age. Am. J. Clin. Nutr.115(1), 171 (2022).
  • Fiorito G , McCroryC , RobinsonOet al. Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis. Aging11(7), 2045–2070 (2019).
  • Robinson O , ChadeauHyam M , KaramanIet al. Determinants of accelerated metabolomic and epigenetic aging in a UK cohort. Aging Cell19(6), e13149 (2020).
  • Quach A , LevineME , TanakaTet al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging.9(2), 419 (2017).
  • Chen L , DongY , BhagatwalaJet al. Effects of vitamin D3 supplementation on epigenetic aging in overweight and obese African Americans with suboptimal vitamin D status: a randomized clinical trial. J. Gerontol. A74(1), 91–98 (2019).
  • Yaskolka Meir A , KellerM , BernhartSHet al. Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial. Clin. Epigenetics13(1), 1–10 (2021).
  • Waziry R , RyanCP , CorcoranDLet al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat. Aging3(3), 248–257 (2023).
  • Thaker Vv . Genetic and epigenetic causes of obesity. Adolesc. Med. State Art Rev.28(2), 379 (2017).
  • Relton CL , DaveySmith G. Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int. J. Epidemiol.41(1), 161–176 (2012).
  • van Dijk SJ , TellamRL , MorrisonJLet al. Recent developments on the role of epigenetics in obesity and metabolic disease. Clin. Epigenetics7(1), 1–13 (2015).
  • Alfano R , RobinsonO , HandakasEet al. Perspectives and challenges of epigenetic determinants of childhood obesity: a systematic review. Obes. Rev.23, e13389 (2022).
  • Ács O , PéterfiaB , HollósiPet al. Methylation status of CYP27B1 and IGF2 correlate to BMI SDS in children with obesity. Obes. Facts10(4), 353–362 (2017).
  • Ardenkjær-Larsen J , RuparK , SinkevičiūtėGet al. Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes. Adipocyte9(1), 142–152 (2020).
  • Lopes LL , BressanJ , PeluzioM do CG , HermsdorffHHM. LINE-1 in obesity and cardiometabolic diseases: a systematic review. J. Am. Coll. Nutr.38(5), 478–484 (2019).
  • Zhang X , ZhangR , YuJ. New understanding of the relevant role of LINE-1 retrotransposition in human disease and immune modulation. Front. Cell. Dev. Biol.8, 657 (2020).
  • McKay JA , MathersJC. Diet induced epigenetic changes and their implications for health. Acta Physiol (Oxf).202(2), 103–118 (2011).
  • Urich MA , NeryJR , ListerRet al. MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing. Nat. Prot.10(3), 475–483 (2015).

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