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Editorial

Abnormal Placental DNA Methylation Following Environmental Stress: A Mere Biomarker in a Highly Sensitive Target Organ?

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Pages 719-721 | Received 05 Jun 2023, Accepted 13 Jul 2023, Published online: 24 Jul 2023

References

  • Apicella C , RuanoCSM , MehatsC , MirallesF , VaimanD. The role of epigenetics in placental development and the etiology of preeclampsia. Int. J. Mol. Sci.20(11), 1–45 (2019).
  • Mortillo M , MarsitCJ. Select early-life environmental exposures and DNA methylation in the placenta. Curr. Environ. Health Rep.10(1), 22–34 (2023).
  • Elkin ER , HigginsC , AungMT , BakulskiKM. Metals exposures and DNA methylation: current evidence and future directions. Curr. Environ. Health Rep.9(4), 673–696 (2022).
  • Mohanty AF , FarinFM , BammlerTKet al. Infant sex-specific placental cadmium and DNA methylation associations. Environ. Res.138, 74–81 (2015).
  • Auvinen P , VehvilainenJ , MarjonenHet al. Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders. BMC Med.20(1), 1–25 (2022).
  • Rousseaux S , SeyveE , ChuffartFet al. Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions. BMC Med.18(1), 1–20 (2020).
  • van Otterdijk SD , BinderAM , MichelsKB. Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy. Epigenetics12(10), 875–885 (2017).
  • Everson TM , Vives-UsanoM , SeyveEet al. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. Nat. Commun.12(1), 1-13 (2021).
  • Abraham E , RousseauxS , AgierLet al. Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Environ. Int.118, 334–347 (2018).
  • Isaevska E , MocciaC , AstaFet al. Exposure to ambient air pollution in the first 1000days of life and alterations in the DNA methylome and telomere length in children: a systematic review. Environ. Res.193, 1–9 (2021).
  • Neven KY , SaenenND , TarantiniLet al. Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIRONAGE cohort study. Lancet Planet Health2(4), e174–e183 (2018).
  • Jedynak P , TostJ , CalafatAMet al. Pregnancy exposure to synthetic phenols and placental DNA methylation – an epigenome-wide association study in male infants from the EDEN cohort. Environ. Pollut.290, 1–12 (2021).
  • Borrelli KN , WachmanEM , BeierleJAet al. Effect of prenatal opioid exposure on the human placental methylome. Biomedicines10(1150), 1–16 (2022).
  • Czamara D , DieckmannL , RohSet al. Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation. Clin. Epigenetics13(1), 165 (2021).
  • Vandereyken K , SifrimA , ThienpontB , VoetT. Methods and applications for single-cell and spatial multi-omics. Nat. Rev. Genet.1–22 doi: 10.1038/s41576-023-00580-2 (2023).

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