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Editorial

Role of Epigenetics in Innate Lymphoid Cells

ORCID Icon, ORCID Icon & ORCID Icon
Pages 615-618 | Received 19 Jun 2023, Accepted 27 Jun 2023, Published online: 12 Jul 2023

References

  • Artis D , SpitsH. The biology of innate lymphoid cells. Nature517(7534), 293–301 (2015).
  • Tait Wojno ED , ArtisD. Emerging concepts and future challenges in innate lymphoid cell biology. J. Exp. Med.213(11), 2229–2248 (2016).
  • Adolfsson J , ManssonR , Buza-VidasNet al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell121(2), 295–306 (2005).
  • Spits H , ArtisD , ColonnaMet al. Innate lymphoid cells–a proposal for uniform nomenclature. Nat. Rev. Immunol.13(2), 145–149 (2013).
  • Verma D , VermaM , MishraR. Stem cell therapy and innate lymphoid cells. Stem Cells Int.2022, 3530520 (2022).
  • Lim AI , VerrierT , VosshenrichCA , DiSanto JP. Developmental options and functional plasticity of innate lymphoid cells. Curr. Opin. Immunol.44, 61–68 (2017).
  • Harly C , CamM , KayeJ , BhandoolaA. Development and differentiation of early innate lymphoid progenitors. J. Exp. Med.215(1), 249–262 (2018).
  • Califano D , ChoJJ , UddinMNet al. Transcription factor Bcl11b controls identity and function of mature type 2 innate lymphoid cells. Immunity43(2), 354–368 (2015).
  • Ebihara T , SongC , RyuSHet al. Runx3 specifies lineage commitment of innate lymphoid cells. Nat. Immunol.16(11), 1124–1133 (2015).
  • Walker JA , OliphantCJ , EnglezakisAet al. Bcl11b is essential for group 2 innate lymphoid cell development. J. Exp. Med.212(6), 875–882 (2015).
  • Yu Y , WangC , ClareSet al. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J. Exp. Med.212(6), 865–874 (2015).
  • Mowel WK , MccrightSJ , KotzinJJet al. Group 1 innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNA. Immunity47(3), 435–449 (2017).
  • Ohne Y , SilverJS , Thompson-SnipesLet al. IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nat. Immunol.17(6), 646–655 (2016).
  • Liu B , YeB , YangLet al. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat. Immunol.18(5), 499–508 (2017).
  • Qi X , QiuJ , ChangJet al. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol.14(1), 38–52 (2021).
  • Nandakumar V , ChouY , ZangL , HuangXF , ChenSY. Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proc. Natl Acad. Sci. USA110(41), E3927–3936 (2013).
  • Victor AR , WeigelC , ScovilleSDet al. Epigenetic and posttranscriptional regulation of CD16 expression during human NK cell development. J. Immunol.200(2), 565–572 (2018).
  • Antignano F , BraamM , HughesMRet al. G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. J. Exp. Med.213(7), 1153–1162 (2016).
  • Harly C , KenneyD , RenGet al. The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat. Immunol.20(9), 1150–1160 (2019).
  • Ren G , LaiB , HarlyCet al. Transcription factors TCF-1 and GATA3 are key factors for the epigenetic priming of early innate lymphoid progenitors toward distinct cell fates. Immunity55(8), 1402–1413 (2022).
  • Beckstette M , LuCW , HerppichSet al. Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions. J. Exp. Med.219(10), e20210663 (2022).
  • Lau CM , AdamsNM , GearyCDet al. Epigenetic control of innate and adaptive immune memory. Nat. Immunol.19(9), 963–972 (2018).
  • Weizman OE , SongE , AdamsNMet al. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat. Immunol.20(8), 1004–1011 (2019).
  • Nagasawa M , HeestersBA , KradolferCMAet al. KLRG1 and NKp46 discriminate subpopulations of human CD117(+)CRTH2(-) ILCs biased toward ILC2 or ILC3. J. Exp. Med.216(8), 1762–1776 (2019).
  • Verma M , MichalecL , SripadaAet al. The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. J. Exp. Med.218(7), e20201354 (2021).

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