Advanced search
Publication Cover
Epigenomics Volume 15, 2023 - Issue 17
Submit an article Journal homepage
139
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Role of Epigenetic Modifications Mediated by Vitamins and Trace Elements in Inflammatory Bowel Disease

Hao Liu1 Department of Clinical Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
,
Ning Lu2 Department of Gastroenterology, the First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, 710077, China
,
Manli Cui2 Department of Gastroenterology, the First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, 710077, China
&
Mingxin Zhang2 Department of Gastroenterology, the First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, 710077, China;3 The Second Affiliated Hospital of Chinese Medicine, Xianyang, Shaanxi, 712099, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3945-3387
ORCID Icon
Pages 839-843 | Received 23 Jun 2023, Accepted 31 Jul 2023, Published online: 11 Sep 2023

References

  • Kellermayer R . Challenges for epigenetic research in inflammatory bowel diseases. Epigenomics9(4), 527–538 (2017).
  • Oh SK , KimD , KimKet al. RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis. Proc. Natl Acad. Sci. USA116(42), 21140–21149 (2019).
  • Honarbakhsh M , MaltaK , EricssonAet al. β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency. Biochim. Biophys. Acta. Mol. Cell Biol. Lipids1867(5), 159122 (2022).
  • Kim D , KimY , KimY. Effects of β-carotene on expression of selected microRNAs, histone acetylation, and DNA methylation in colon cancer stem cells. J. Cancer. Prev.24(4), 224–232 (2019).
  • Chen M , Peyrin-BirouletL , GeorgeAet al. Methyl deficient diet aggravates experimental colitis in rats. J. Cell. Mol. Med.15(11), 2486–2497 (2011).
  • Zhu S , LiJ , BingYet al. Diet-induced hyperhomocysteinaemia increases intestinal inflammation in an animal model of colitis. J. Crohns Colitis9(9), 708–719 (2015).
  • Kuroishi T . Regulation of immunological and inflammatory functions by biotin. Can. J. Physiol. Pharmacol.93(12), 1091–1096 (2015).
  • Chen Y , LiP , ZhenRet al. Effects of niacin on intestinal epithelial barrier, intestinal immunity, and microbial community in weaned piglets challenged by PDCoV. Int. Immunopharmacol.111, 109054 (2022).
  • Starczak M , ZarakowskaE , ModrzejewskaMet al. In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease. J. Transl. Med.16(1), 204 (2018).
  • Koukos G , PolytarchouC , KaplanJLet al. microRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology145(4), 842–852 (2013).
  • Jo H , LeeD , GoCet al. Preventive effect of vitamin C on dextran sulfate sodium (DSS)-induced colitis via the regulation of IL-22 and IL-6 production in Gulo(-/-) mice. Int. J. Mol. Sci.23(18), 10612 (2022).
  • Battistini C , BallanR , HerkenhoffME , SaadSMI , SunJ. Vitamin D modulates intestinal microbiota in inflammatory bowel diseases. Int. J. Mol. Sci.22(1), 362 (2020).
  • Chen Y , DuJ , ZhangZet al. microRNA-346 mediates tumor necrosis factor α-induced downregulation of gut epithelial vitamin D receptor in inflammatory bowel diseases. Inflamm. Bowel. Dis.20(11), 1910–1918 (2014).
  • Mcgillis L , Bronte-TinkewDM , DangFet al. Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues. Am. J. Physiol. Gastrointest. Liver Physiol.321(2), G171–G184 (2021).
  • Zhu X , ZhuY , LiCet al. 1,25-Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b. Int. Immunopharmacol.67, 106–118 (2019).
  • Matsui M , TerasawaK , KajikuriJet al. Histone deacetylases enhance Ca(2+)-activated K+ channel K(Ca)3.1 expression in murine inflammatory CD4+ T cells. Int. J. Mol. Sci.19(10), 2942 (2018).
  • Horniblow RD , PathakP , BalaccoDLet al. Iron-mediated epigenetic activation of NRF2 targets. J. Nutr. Biochem.101, 108929 (2022).
  • Zhang R . The effect of zinc deficiency on ulcerative colitis and its epigenetics mechanism. TianjinMed. Univ.1(2), 1–74 (2018).
  • Huang LJ , MaoXT , LiYYet al. Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease. Immunity54(8), 1728–1744 (2021).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.