SET Protein as an Epigenetics Target

References

• Di Mambro A , Esposito MT . Thirty years of SET/TAF1β/I2PP2A: from the identification of the biological functions to its implications in cancer and Alzheimer’s disease. Biosci. Rep. 42(11), BSR20221280 (2022).
   PubMed Web of Science ®Google Scholar
• Dillon SC , Zhang X , Trievel RC , Cheng X . The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol. 6(8), 227 (2005).
   PubMed Web of Science ®Google Scholar
• von Lindern M , van Baal S , Wiegant J , Raap A , Hagemeijer A , Grosveld G . Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′-half to different genes: characterization of the set gene. Mol. Cell Biol. 12(8), 3346–3355 (1992).
   PubMed Web of Science ®Google Scholar
• Adachi Y , Pavlakis GN , Copeland TD . Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J. Biol. Chem. 269(3), 2258–2262 (1994).
   PubMed Web of Science ®Google Scholar
• Li M , Guo H , Damuni Z . Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. Biochemistry 34(6), 1988–1996 (1995).
   PubMed Web of Science ®Google Scholar
• Zheng HY , Shen FJ , Tong YQ , Li Y . PP2A inhibits cervical cancer cell migration by dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK signaling pathway. Curr. Med. Sci. 38(1), 115–123 (2018).
   PubMed Web of Science ®Google Scholar
• Richard NP , Pippa R , Cleary MM et al. Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. Oncotarget 7(51), 84214–84227 (2016).
   PubMedGoogle Scholar
• Fan Z , Beresford PJ , Oh DY , Zhang D , Lieberman J . Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112(5), 659–672 (2003).
   PubMed Web of Science ®Google Scholar
• Chae YC , Kim KB , Kang JY , Kim SR , Jung HS , Seo SB . Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription. FEBS Lett. 588(17), 2867–2873 (2014).
   PubMed Web of Science ®Google Scholar
• Okuwaki M , Nagata K . Template activating factor-I remodels the chromatin structure and stimulates transcription from the chromatin template. J. Biol. Chem. 273(51), 34511–34518 (1998).
   PubMed Web of Science ®Google Scholar
• Kalousi A , Hoffbeck AS , Selemenakis PN et al. The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin. Cell Rep. 11(1), 149–163 (2015).
   PubMed Web of Science ®Google Scholar
• Nenasheva VV , Makarova IV , Stepanenko EA et al. Human TAF-Iα promotes oncogenic transformation via enhancement of cell proliferation and suppression of apoptosis. In Vitro Cell Dev. Biol. Anim. 57(5), 531–538 (2021).
   PubMed Web of Science ®Google Scholar
• Cristóbal I , Blanco FJ , Garcia-Orti L et al. SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia. Blood 115(3), 615–625 (2010).
   PubMed Web of Science ®Google Scholar
• Yin L , Zeng Y , Xiao Y , Chen Y , Shen H , Dong J . Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity. Cell Death Dis. 10(6), 385 (2019).
   PubMedGoogle Scholar
• Arriazu E , Vicente C , Pippa R et al. A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia. Blood Cancer J. 10(1), 3 (2020).
   PubMed Web of Science ®Google Scholar
• Han D , Wang L , Long L et al. The E3 ligase TRIM4 facilitates SET ubiquitin-mediated degradation to enhance ER-α action in breast cancer. Adv. Sci. (Weinh.) 9(25), e2201701 (2022).
   PubMedGoogle Scholar
• Pippa R , Dominguez A , Malumbres R et al. MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia. Oncotarget 8(33), 53989–54003 (2017).
   PubMedGoogle Scholar
• Asaka MN , Murano K , Nagata K . Sp1-mediated transcription regulation of TAF-Ialpha gene encoding a histone chaperone. Biochem. Biophys Res. Commun. 376(4), 665–670 (2008).
   PubMed Web of Science ®Google Scholar
• Pan H , Pan Z , Guo F et al. MicroRNA-1915-3p inhibits cell migration and invasion by targeting SET in non-small-cell lung cancer. BMC Cancer 21(1), 1218 (2021).
   PubMed Web of Science ®Google Scholar
• Chao A , Tsai CL , Wei PC et al. Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Cancer Lett. 291(1), 99–107 (2010).
   PubMed Web of Science ®Google Scholar
• Jiang W , Wen D , Gong L , Wang Y , Liu Z , Yin F . Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET. Biochem. Biophys Res. Commun. 500(2), 211–216 (2018).
   PubMed Web of Science ®Google Scholar
• Hu YP , Jin YP , Wu XS et al. LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis. Mol. Cancer 18(1), 167 (2019).
   PubMed Web of Science ®Google Scholar
• Zhong J , Ren X , Chen Z et al. miR-21-5p promotes lung adenocarcinoma progression partially through targeting SET/TAF-Iα. Life Sci. 231, 116539 (2019).
   PubMed Web of Science ®Google Scholar
• Ying X , Wei K , Lin Z et al. MicroRNA-125b suppresses ovarian cancer progression via suppression of the epithelial-mesenchymal transition pathway by targeting the SET protein. Cell Physiol. Biochem. 39(2), 501–510 (2016).
   PubMed Web of Science ®Google Scholar
• Zhang L , Zhang J , Xuan X et al. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression. Cell Rep. 42(8), 112833 (2023).
   PubMed Web of Science ®Google Scholar
• Liu R , Wang JZ . Protein phosphatase 2A in Alzheimer’s disease. Pathophysiology 16(4), 273–277 (2009).
   PubMedGoogle Scholar
• Tanimukai H , Grundke-Iqbal I , Iqbal K . Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer’s disease. Am. J. Pathol. 166(6), 1761–1771 (2005).
   PubMed Web of Science ®Google Scholar
• Qin M , Li H , Bao J et al. SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments. Acta Neuropathol. Commun. 7(1), 21 (2019).
   PubMedGoogle Scholar
• Kim DW , Kim KB , Kim JY , Lee KS , Seo SB . Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ. Biochem. Biophys Res. Commun. 400(3), 419–425 (2010).
   PubMed Web of Science ®Google Scholar
• Serifi I , Besta S , Karetsou Z et al. Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling. Sci. Rep. 11(1), 13940 (2021).
   PubMed Web of Science ®Google Scholar
• Edupuganti RR , Harikumar A , Aaronson Y et al. Alternative SET/TAFI promoters regulate embryonic stem cell differentiation. Stem Cell Reports 9(4), 1291–1303 (2017).
   PubMed Web of Science ®Google Scholar
• Yuan X , Wang X , Gu B et al. Directional migration in esophageal squamous cell carcinoma (ESCC) is epigenetically regulated by SET nuclear oncogene, a member of the inhibitor of histone acetyltransferase complex. Neoplasia 19(11), 868–884 (2017).
   PubMed Web of Science ®Google Scholar
• Luo XG , Zhang CL , Zhao WW et al. Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells. Cancer Lett. 344(1), 129–137 (2014).
   PubMed Web of Science ®Google Scholar
• Azad GK , Swagatika S , Kumawat M , Kumawat R , Tomar RS . Modifying chromatin by histone tail clipping. J. Mol. Biol. 430(18 Pt B), 3051–3067 (2018).
   PubMed Web of Science ®Google Scholar
• Cai LY , Chen SJ , Xiao SH et al. Targeting p300/CBP attenuates hepatocellular carcinoma progression through epigenetic regulation of metabolism. Cancer Res. 81(4), 860–872 (2021).
   PubMed Web of Science ®Google Scholar
• González-Arzola K , Guerra-Castellano A , Rivero-Rodríguez F et al. Mitochondrial cytochrome C shot towards histone chaperone condensates in the nucleus. FEBS Open Bio. 11(9), 2418–2440 (2021).
   PubMed Web of Science ®Google Scholar
• Saavedra F , Rivera C , Rivas E et al. PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4. Nucleic Acids Res. 45(20), 11700–11710 (2017).
   PubMed Web of Science ®Google Scholar
• Xia Z , Kon N , Gu AP , Tavana O , Gu W . Deciphering the acetylation code of p53 in transcription regulation and tumor suppression. Oncogene 41(22), 3039–3050 (2022).
   PubMed Web of Science ®Google Scholar
• Kim JY , Lee KS , Seol JE , Yu K , Chakravarti D , Seo SB . Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Nucleic Acids Res. 40(1), 75–87 (2012).
   PubMed Web of Science ®Google Scholar
• Wang D , Kon N , Lasso G et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature 538(7623), 118–122 (2016).
   PubMed Web of Science ®Google Scholar
• Kim KB , Kim DW , Park JW et al. Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Iβ regulates Ku70-mediated DNA damage response. Cell Mol. Life Sci. 71(14), 2731–2745 (2014).
   PubMed Web of Science ®Google Scholar
• Seibert M , Krüger M , Watson NA et al. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J. Cell Biol. 218(4), 1164–1181 (2019).
   PubMed Web of Science ®Google Scholar
• Sousa LO , Sobral LM , de Almeida LO , Garcia CB , Greene LJ , Leopoldino AM . SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics 12(6), 475–485 (2020).
   PubMed Web of Science ®Google Scholar
• Kato K , Kawaguchi A , Nagata K . Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells. Sci. Rep. 11(1), 17726 (2021).
   PubMed Web of Science ®Google Scholar
• Almeida LO , Neto MPC , Sousa LO , Tannous MA , Curti C , Leopoldino AM . SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. Oncotarget 8(16), 26802–26818 (2017).
   PubMedGoogle Scholar
• Revil T , Pelletier J , Toutant J , Cloutier A , Chabot B . Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform. J. Biol. Chem. 284(32), 21458–21467 (2009).
   PubMed Web of Science ®Google Scholar
• Almeida LO , Garcia CB , Matos-Silva FA , Curti C , Leopoldino AM . Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochem. Biophys Res. Commun. 445(1), 196–202 (2014).
   PubMed Web of Science ®Google Scholar
• Lynch KL , Dillon MR , Bat-Erdene M et al. A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle. Curr. Biol. 31(23), 5227–5237; e5227 (2021).
   PubMed Web of Science ®Google Scholar