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Epigenomics Volume 15, 2023 - Issue 20
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Editorial

MeCP2 is the Protector of Epigenome Integrity, Membrane-Less Nuclear Architecture, and Stability of Chromatin Assembly

Mojgan Rastegar1 Department of Biochemistry&Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, MB, R3E 0J9, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3619-6116
ORCID Icon &
James R Davie1 Department of Biochemistry&Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, MB, R3E 0J9, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0420-6888
ORCID Icon
Pages 1027-1031 | Received 30 Aug 2023, Accepted 26 Oct 2023, Published online: 08 Nov 2023

References

  • Zhang H , QinW , RomeroH , LeonhardtH , CardosoMC. Heterochromatin organization and phase separation. Nucleus14(1), 2159142 (2023).
  • Hansen JC , MaeshimaK , HendzelMJ. The solid and liquid states of chromatin. Epigenetics Chromatin14(1), 50 (2021).
  • Carollo PS , BarraV. Chromatin epigenetics and nuclear lamina keep the nucleus in shape: examples from natural and accelerated aging. Biol. Cell115(1), e2200023 (2023).
  • Vincent JB , AusioJ. MeCP2: latest insights fundamentally change our understanding of its interactions with chromatin and its functional attributes. BioEssays43(3), e2000281 (2021).
  • Skene PJ , IllingworthRS , WebbSet al. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol. Cell37(4), 457–468 (2010).
  • Hansen JC , GhoshRP , WoodcockCL. Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin. IUBMB Life62(10), 732–738 (2010).
  • Fasolino M , ZhouZ. The crucial role of DNA methylation and MeCP2 in neuronal function. Genes (Basel)8(5), 1–19 (2017).
  • Pejhan S , RastegarM. Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease. Biomolecules11(1), 1–27 (2021).
  • Kunert S , LinhardV , WeirichSet al. The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site. Protein Sci.32(1), e4542 (2023).
  • Ghosh RP , Horowitz-SchererRA , NikitinaT , ShlyakhtenkoLS , WoodcockCL. MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites. Mol. Cell. Biol.30(19), 4656–4670 (2010).
  • Parseghian MH . What is the role of histone H1 heterogeneity? A functional model emerges from a 50 year mystery. AIMS Biophys2(4), 724–772 (2015).
  • Ito-Ishida A , YamalanchiliHK , ShaoYet al. Genome-wide distribution of linker histone H1.0 is independent of MeCP2. Nat. Neurosci.21(6), 794–798 (2018).
  • Ishibashi T , ThambirajahAA , AusioJ. MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylation. FEBS Lett.582(7), 1157–1162 (2008).
  • Schmidt A , ZhangH , CardosoMC. MeCP2 and Chromatin Compartmentalization. Cells9(4), 1–31 (2020).
  • Boxer LD , RenthalW , GrebenAWet al. MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes. Mol. Cell77(2), 294–309 e299 (2020).
  • Clemens AW , GabelHW. Emerging Insights into the Distinctive Neuronal Methylome. Trends Genet.36(11), 816–832 (2020).
  • Bonev B , MendelsonCohen N , SzaboQet al. Multiscale 3D Genome Rewiring during Mouse Neural Development. Cell171(3), 557–572; e524 (2017).
  • Wong X , CutlerJA , HoskinsVEet al. Mapping the micro-proteome of the nuclear lamina and lamina-associated domains. Life Sci. Alliance4(5), 1–20 (2021).
  • Tesei G , SchulzeTK , CrehuetR , Lindorff-LarsenK. Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties. Proc. Natl Acad. Sci. USA118(44), 1–10 (2021).
  • Wang L , HuM , ZuoMQet al. Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell Res.30(5), 393–407 (2020).
  • Zhang H , RomeroH , SchmidtAet al. MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid-liquid phase separation and restricted by DNA methylation. Nucleus13(1), 1–34 (2022).
  • Mnatzakanian GN , LohiH , MunteanuIet al. A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome. Nat. Genet.36(4), 339–341 (2004).
  • Kriaucionis S , BirdA. The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res.32(5), 1818–1823 (2004).
  • Shevkoplyas D , VuuYM , DavieJR , RastegarM. The Chromatin Structure at the MECP2 Gene and In Silico Prediction of Potential Coding and Non-Coding MECP2 Splice Variants. Int. J. Mol. Sci.23(24), 1–26 (2022).
  • Martinez de Paz A , KhajaviL , MartinHet al. MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2. Epigenetics Chromatin12(1), 63 (2019).
  • Amiri S , DavieJR , RastegarM. Chronic ethanol exposure alters DNA methylation in neural stem cells: role of mouse strain and sex. Mol. Neurobiol.57(2), 650–667 (2020).

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