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Review

Polycomb Group-Mediated Gene Silencing Mechanisms: Stability Versus Flexibility

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Pages 301-318 | Published online: 03 Dec 2009

Bibliography

  • Bantignies F , CavalliG: Cellular memory and dynamic regulation of Polycomb group proteins.Curr. Opin. Cell Biol.18(3) , 275–283 (2006).
  • Sparmann A , Van Lohuizen M: Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer6(11) , 846–856 (2006).
  • Martinez AM , SchuettengruberB, SakrS, JanicA, GonzalezC, CavalliG: Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.Nat. Genet.41(10) , 1076–1082 (2009).
  • Lewis EB : A gene complex controlling segmentation in drosophila.Nature276(5688) , 565–570 (1978).
  • Schuettengruber B , ChourroutD, VervoortM, LeblancB, CavalliG: Genome regulation by Polycomb and trithorax proteins.Cell128(4) , 735–745 (2007).
  • Ringrose L : Polycomb comes of age: genome-wide profiling of target sites.Curr. Opin. Cell Biol.19(3) , 290–297 (2007).
  • Muller J , VerrijzerP: Biochemical mechanisms of gene regulation by Polycomb group protein complexes.Curr. Opin. Genet. Dev.19(2) , 150–158 (2009).
  • Pasini D , BrackenAP, AggerK et al.: Regulation of stem cell differentiation by histone methyltransferases and demethylases.Cold Spring Harb. Symp. Quant. Biol.73 , 253–263 (2008).
  • Hekimoglu B , RingroseL: Non-coding RNAs in Polycomb/trithorax regulation.RNA Biol.6(2) , (2009).
  • Schuettengruber B , CavalliG: Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.Development136(21) , 3531–3542 (2009).
  • Czermin B , MelfiR, McCabeD, SeitzV, ImhofA, PirrottaV: Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.Cell111 , 185–196 (2002).
  • Müller J , HartCM, FrancisNJ et al.: Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.Cell111 , 197–208 (2002).
  • Nekrasov M , WildB, MullerJ: Nucleosome binding and histone methyltransferase activity of Drosophila PRC2.EMBO Rep.6(4) , 348–353 (2005).
  • Cao R , WangL, WangH et al.: Role of histone H3 lysine 27 methylation in Polycomb-group silencing.Science298 , 1039–1043 (2002).
  • Kuzmichev A , NishiokaK, Erdjument-BromageH, TempstP, ReinbergD: Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein.Genes Dev.16 , 2893–2905 (2002).
  • Nekrasov M , KlymenkoT, FratermanS et al.: Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.EMBO J.26(18) , 4078–4088 (2007).
  • Cao R , WangH, HeJ, Erdjument-BromageH, TempstP, ZhangY: Role of hPHF1 in H3K27 methylation and hox gene silencing.Mol. Cell. Biol.28(5) , 1862–1872 (2008).
  • Sarma K , MargueronR, IvanovA, PirrottaV, ReinbergD: EZH2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.Mol. Cell. Biol.28(8) , 2718–2731 (2008).
  • Shao Z , RaibleF, MollaaghababaR et al.: Stabilization of chromatin structure by PRC1, a Polycomb complex.Cell98(1) , 37–46 (1999).
  • Levine SS , WeissA, Erdjument-BromageH, ShaoZ, TempstP, KingstonRE: The core of the Polycomb repressive complex is compositionally and functionally conserved in flies and humans.Mol. Cell. Biol.22(17) , 6070–6078 (2002).
  • Wang H , WangL, Erdjument-BromageH et al.: Role of histone H2A ubiquitination in Polycomb silencing.Nature431 , 873–878 (2004).
  • De Napoles M , MermoudJE, WakaoR et al.: Polycomb group proteins ring1a/b link ubiquitylation of histone h2A to heritable gene silencing and x inactivation.Dev. Cell7 , 663–676 (2004).
  • Cao R , TsukadaY, ZhangY: Role of Bmi-1 and Ring1a in H2A ubiquitylation and hox gene silencing.Mol. Cell20 , 845–854 (2005).
  • Lagarou A , Mohd-SaripA, MoshkinYM et al.: dkdm2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.Genes Dev.22(20) , 2799–2810 (2008).
  • Klymenko T , PappB, FischleW et al.: A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.Genes Dev.20(9) , 1110–1122 (2006).
  • Grimaud C , NegreN, CavalliG: From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Chromosome Res.14(4) , 363–375. (2006).
  • Schuettengruber B , GanapathiM, LeblancB et al.: Functional anatomy of Polycomb and trithorax chromatin landscapes in Drosophila embryos.PLoS Biol.7(1) , E13 (2009).
  • Muller J , KassisJA: Polycomb response elements and targeting of Polycomb group proteins in Drosophila.Curr. Opin. Genet. Dev.16 , 476–484 (2006).
  • Kwong C , AdryanB, BellI et al.: Stability and dynamics of Polycomb target sites in Drosophila development.PLoS Genet.4(9) , E1000178 (2008).
  • Oktaba K , GutierrezL, GagneurJ et al.: Dynamic regulation by Polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.Dev. Cell15(6) , 877–889 (2008).
  • Brown JL , FritschC, MuellerJ, KassisJA: The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing.Development130 , 285–294 (2003).
  • Déjardin J , RappaillesA, CuvierO et al.: Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.Nature434 , 533–538 (2005).
  • Mishra RK , YamagishiT, VasanthiD, OhtsukaC, KondoT: Involvement of Polycomb-group genes in establishing hoxd temporal colinearity.Genesis45(9) , 570–576 (2007).
  • Sing A , PannellD, KaraiskakisA et al.: A vertebrate Polycomb response element governs segmentation of the posterior hindbrain.Cell138(5) , 885–897 (2009).
  • Boyer LA , PlathK, ZeitlingerJ et al.: Polycomb complexes repress developmental regulators in murine embryonic stem cells.Nature441(7091) , 349–353 (2006).
  • Lee TI , JennerRG, BoyerLA et al.: Control of developmental regulators by Polycomb in human embryonic stem cells.Cell125 , 301–313 (2006).
  • Bracken AP , DietrichN, PasiniD, HansenKH, HelinK: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.Genes Dev.20 , 1123–1136 (2006).
  • Mikkelsen TS , KuM, JaffeDB et al.: Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.Nature448(7153) , 553–560 (2007).
  • Mohn F , WeberM, RebhanM et al.: Lineage-specific Polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.Mol. Cell30(6) , 755–766 (2008).
  • Caretti G , Di Padova M, Micales B, Lyons GE, Sartorelli V: The Polycomb EZH2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev.18(21) , 2627–2638 (2004).
  • Gabellini D , GreenMR, TuplerR: Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle.Cell110(3) , 339–348 (2002).
  • Kim H , KangK, KimJ: AEBP2 as a potential targeting protein for Polycomb repression complex PRC2.Nucleic Acids Res.37(9) , 2940–2950 (2009).
  • Herranz N , PasiniD, DiazVM et al.: Polycomb complex 2 is required for e-cadherin repression by the snail1 transcription factor.Mol. Cell. Biol.28(15) , 4772–4781 (2008).
  • Boukarabila H , SaurinAJ, BatscheE et al.: The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.Genes Dev.23(10) , 1195–1206 (2009).
  • Barna M , MerghoubT, CostoyaJA et al.: Plzf mediates transcriptional repression of hoxD gene expression through chromatin remodeling.Dev. Cell3(4) , 499–510 (2002).
  • Ku M , KocheRP, RheinbayE et al.: Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.PLoS Genet.4(10) , E1000242 (2008).
  • Boyer LA , LeeTI, ColeMF et al.: Core transcriptional regulatory circuitry in human embryonic stem cells.Cell122(6) , 947–956 (2005).
  • Rinn JL , KerteszM, WangJK et al.: Functional demarcation of active and silent chromatin domains in human hox loci by noncoding RNAs.Cell129(7) , 1311–1323 (2007).
  • Zhao J , SunBK, ErwinJA, SongJJ, LeeJT: Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.Science322(5902) , 750–756 (2008).
  • Khalil AM , GuttmanM, HuarteM et al.: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.Proc. Natl Acad. Sci. USA106(28) , 11667–11672 (2009).
  • Francis NJ , KingstonRE, WoodcockCL: Chromatin compaction by a Polycomb group protein complex.Science306 , 1574–1577 (2004).
  • Lo SM , AhujaNK, FrancisNJ: Polycomb group protein suppressor 2 of zeste is a functional homolog of posterior sex combs.Mol. Cell. Biol.29(2) , 515–525 (2009).
  • Margueron R , LiG, SarmaK et al.: EZH1 and EZH2 maintain repressive chromatin through different mechanisms.Mol. Cell32(4) , 503–518 (2008).
  • Boivin A , DuraJM: In vivo chromatin accessibility correlates with gene silencing in Drosophila.Genetics150 , 1539–1549 (1998).
  • Fitzgerald DP , BenderW: Polycomb group repression reduces DNA accessibility.Mol. Cell. Biol.21 , 6585–6597 (2001).
  • Kuzmichev A , JenuweinT, TempstP, ReinbergD: Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.Mol. Cell14 , 183–193 (2004).
  • Mohd-Sarip A , Van Der Knaap JA, Wyman C, Kanaar R, Schedl P, Verrijzer CP: Architecture of a Polycomb nucleoprotein complex. Mol. Cell24(1) , 91–100 (2006).
  • Papp B , MullerJ: Histone trimethylation and the maintenance of transcriptional on and off states by trxG and PcG proteins.Genes Dev.20 , 2041–2054 (2006).
  • Mishra RK , MihalyJ, BargesS et al.: The iab-7 Polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Mol. Cell. Biol.21(4) , 1311–1318 (2001).
  • Mito Y , HenikoffJG, HenikoffS: Histone replacement marks the boundaries of cis-regulatory domains.Science315(5817) , 1408–1411 (2007).
  • Ficz G , HeintzmannR, Arndt-JovinDJ: Polycomb group protein complexes exchange rapidly in living Drosophila.Development132 , 3963–3976 (2005).
  • Breiling A , TurnerBM, BianchiME, OrlandoV: General transcription factors bind promoters repressed by Polycomb group proteins.Nature412(6847) , 651–655 (2001).
  • Breiling A , O‘NeillLP, D‘EliseoD, TurnerBM, OrlandoV: Epigenome changes in active and inactive Polycomb-group-controlled regions.EMBO Rep.5(10) , 976–982 (2004).
  • Chopra VS , HongJW, LevineM: Regulation of hox gene activity by transcriptional elongation in Drosophila.Curr. Biol.19(8) , 688–693 (2009).
  • Dellino GI , SchwartzYB, FarkasG, McCabeD, ElginSC, PirrottaV: Polycomb silencing blocks transcription initiation.Mol. Cell13 , 887–893 (2004).
  • Stock JK , GiadrossiS, CasanovaM et al.: Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells.Nat. Cell Biol.9(12) , 1428–1435 (2007).
  • Hogga I , KarchF: Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with maintenance of Polycomb-mediated silencing.Development129 , 4915–4922 (2002).
  • Rank G , PrestelM, ParoR: Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch.Mol. Cell. Biol.22 , 8026–8034 (2002).
  • Schmitt S , PrestelM, ParoR: Intergenic transcription through a Polycomb group response element counteracts silencing.Genes Dev.19 , 697–708 (2005).
  • Bae E , CalhounVC, LevineM, LewisEB, DrewellRA: Characterization of the intergenic RNA profile at abdominal-a and abdominal-b in the Drosophila bithorax complex.Proc. Natl Acad. Sci. USA99(26) , 16847–16852 (2002).
  • Sanchez-Elsner T , GouD, KremmerE, SauerF: Noncoding RNAs of trithorax response elements recruit Drosophila ash1 to ultrabithorax.Science311 , 1118–1123 (2006).
  • Petruk S , SedkovY, RileyKM et al.: Transcription of bxd noncoding RNAs promoted by trithorax represses ubx in cis by transcriptional interference.Cell127(6) , 1209–1221 (2006).
  • Pandey RR , MondalT, MohammadF et al.: Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.Mol. Cell32(2) , 232–246 (2008).
  • Sexton T , BantigniesF, CavalliG: Genomic interactions: chromatin loops and gene meeting points in transcriptional regulation.Semin. Cell Dev. Biol.20(7) , 849–855 (2009).
  • Schwartz YB , PirrottaV: Polycomb silencing mechanisms and the management of genomic programmes.Nat. Rev. Genet.8(1) , 9–22 (2007).
  • Cleard F , MoshkinY, KarchF, MaedaRK: Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using dam identification.Nat. Genet.38(8) , 931–935 (2006).
  • Comet I , SavitskayaE, SchuettengruberB et al.: Pre-mediated bypass of two su(hw) insulators targets PcG proteins to a downstream promoter.Dev. Cell11(1) , 117–124 (2006).
  • Lanzuolo C , RoureV, DekkerJ, BantigniesF, OrlandoV: Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex.Nat. Cell Biol.9(10) , 1167–1174 (2007).
  • Tiwari VK , McgarveyKM, LicchesiJD et al.: PcG proteins, DNA methylation, and gene repression by chromatin looping.PLoS Biol.6(12) , 2911–2927 (2008).
  • Terranova R , YokobayashiS, StadlerMB et al.: Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.Dev. Cell15(5) , 668–679 (2008).
  • Yuzyuk T , FakhouriTH, KieferJ, MangoSE: The Polycomb complex protein mes-2/e(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.Dev. Cell16(5) , 699–710 (2009).
  • Messmer S , FrankeA, ParoR: Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.Genes Dev.6(7) , 1241–1254 (1992).
  • Buchenau P , HodgsonJ, StruttH, Arndt-JovinDJ: The distribution of Polycomb-group proteins during cell division and development in drosophila embryos: impact on models for silencing.J. Cell Biol.141 , 469–481 (1998).
  • Saurin AJ , ShielsC, WilliamsonJ et al.: The human Polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain.J. Cell Biol.142(4) , 887–898 (1998).
  • Grimaud C , BantigniesF, Pal-BhadraM, GhanaP, BhadraU, CavalliG: RNAi components are required for nuclear clustering of Polycomb group response elements.Cell124(5) , 957–971 (2006).
  • Tolhuis B , De Wit E, Muijrers I et al.: Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat. Genet.38(6) , 694–699 (2006).
  • Schwartz YB , KahnTG, NixDA et al.: Genome-wide analysis of Polycomb targets in Drosophila melanogaster.Nature Genet.38 , 700–705 (2006).
  • Bantignies F , GrimaudC, LavrovS, GabutM, CavalliG: Inheritance of Polycomb-dependent chromosomal interactions in Drosophila.Genes Dev.17 , 2406–2420 (2003).
  • Vazquez J , MullerM, PirrottaV, SedatJW: The mcp element mediates stable long-range chromosome-chromosome interactions in Drosophila.Mol. Biol. Cell17 , 2158–2165 (2006).
  • Tiwari VK , CopeL, McgarveyKM, OhmJE, BaylinSB: A novel 6c assay uncovers Polycomb-mediated higher order chromatin conformations.Genome Res.18(7) , 1171–1179 (2008).
  • Beisel C , BunessA, Roustan-EspinosaIM et al.: Comparing active and repressed expression states of genes controlled by the Polycomb/trithorax group proteins.Proc. Natl Acad. Sci. USA104(42) , 16615–16620 (2007).
  • Bernstein BE , MikkelsenTS, XieX et al.: A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Cell125 , 315–326 (2006).
  • Azuara V , PerryP, SauerS et al.: Chromatin signatures of pluripotent cell lines.Nat. Cell Biol.8 , 532–538 (2006).
  • Pan G , TianS, NieJ et al.: Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.Cell Stem Cell1(3) , 299–312 (2007).
  • Zhao XD , HanX, ChewJL et al.: Whole-genome mapping of histone H3 lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.Cell Stem Cell1(3) , 286–298 (2007).
  • Roh TY , CuddapahS, CuiK, ZhaoK: The genomic landscape of histone modifications in human T cells.Proc. Natl Acad. Sci. USA103(43) , 15782–15787 (2006).
  • Barski A , CuddapahS, CuiK et al.: High-resolution profiling of histone methylations in the human genome.Cell129(4) , 823–837 (2007).
  • Lee MG , VillaR, TrojerP et al.: Demethylation of H3K27 regulates Polycomb recruitment and H2A ubiquitination.Science318(5849) , 447–450 (2007).
  • Agger K , CloosPA, ChristensenJ et al.: Utx and jmjd3 are histone H3K27 demethylases involved in hox gene regulation and development.Nature449(7163) , 731–734 (2007).
  • Cloos PA , ChristensenJ, AggerK, HelinK: Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.Genes Dev.22(9) , 1115–1140 (2008).
  • Issaeva I , ZonisY, RozovskaiaT et al.: Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Mol. Cell. Biol.27(5) , 1889–1903 (2007).
  • Smith ER , LeeMG, WinterB et al.: Drosophila UTX is a histone H3 lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.Mol. Cell. Biol.28(3) , 1041–1046 (2008).
  • Lan F , BaylissPE, RinnJL et al.: A histone H3 lysine 27 demethylase regulates animal posterior development.Nature449(7163) , 689–694 (2007).
  • Nicassio F , CorradoN, VissersJH et al.: Human usp3 is a chromatin modifier required for S phase progression and genome stability.Curr. Biol.17(22) , 1972–1977 (2007).
  • Joo HY , ZhaiL, YangC et al.: Regulation of cell cycle progression and gene expression by H2A deubiquitination.Nature449(7165) , 1068–1072 (2007).
  • Nakagawa T , KajitaniT, TogoS et al.: Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.Genes Dev.22(1) , 37–49 (2008).
  • Zhu P , ZhouW, WangJ et al.: A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.Mol. Cell27(4) , 609–621 (2007).
  • De Santa F , TotaroMG, ProsperiniE, NotarbartoloS, TestaG, NatoliG: The histone H3 lysine-27 demethylase jmjd3 links inflammation to inhibition of Polycomb-mediated gene silencing.Cell130(6) , 1083–1094 (2007).
  • Lim DA , HuangYC, SwigutT et al.: Chromatin remodelling factor MLL1 is essential for neurogenesis from postnatal neural stem cells.Nature458(7237) , 529–533 (2009).
  • Ezhkova E , PasolliHA, ParkerJS et al.: EZH2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.Cell136(6) , 1122–1135 (2009).
  • Cedar H , BergmanY: Linking DNA methylation and histone modification: patterns and paradigms.Nat. Rev. Genet.10(5) , 295–304 (2009).
  • Meissner A , MikkelsenTS, GuH et al.: Genome-scale DNA methylation maps of pluripotent and differentiated cells.Nature454(7205) , 766–770 (2008).
  • Vire E , BrennerC, DeplusR et al.: The Polycomb group protein EZH2 directly controls DNA methylation.Nature439(7078) , 871–874 (2006).
  • Negishi M , SarayaA, MiyagiS et al.: BMI1 cooperates with DNMT1-associated protein 1 in gene silencing.Biochem. Biophys. Res. Commun.353(4) , 992–998 (2007).
  • Gal-Yam EN , EggerG, IniguezL et al.: Frequent switching of Polycomb repressive marks and DNA hypermethylation in the pc3 prostate cancer cell line.Proc. Natl Acad. Sci. USA105(35) , 12979–12984 (2008).
  • Schlesinger Y , StraussmanR, KeshetI et al.: Polycomb-mediated methylation on lys27 of histone H3 pre-marks genes for de novo methylation in cancer.Nat. Genet.39(2) , 232–236 (2007).
  • Ohm JE , McgarveyKM, YuX et al.: A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.Nat. Genet.39(2) , 237–242 (2007).
  • Widschwendter M , FieglH, EgleD et al.: Epigenetic stem cell signature in cancer.Nat. Genet.39(2) , 157–158 (2007).
  • Klebes A , SustarA, KechrisK, LiH, SchubigerG, KornbergTB: Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes.Development132 , 3753–3765 (2005).
  • Maves L , SchubigerG: A molecular basis for transdetermination in Drosophila imaginal discs: interactions between wingless and decapentaplegic signaling.Development125 , 115–124 (1998).
  • Lee N , MaurangeC, RingroseL, ParoR: Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs.Nature438 , 234–237 (2005).
  • Shaw T , MartinP: Epigenetic reprogramming during wound healing: loss of Polycomb-mediated silencing may enable upregulation of repair genes.EMBO Rep.10(8) , 881–886 (2009).
  • Bracken AP , Kleine-KohlbrecherD, DietrichN et al.: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.Genes Dev.21(5) , 525–530 (2007).
  • Agherbi H , Gaussmann-WengerA, VerthuyC, ChassonL, SerranoM, DjabaliM: Polycomb mediated epigenetic silencing and replication timing at the ink4a/arf locus during senescence.PLoS ONE4(5) , E5622 (2009).
  • Agger K , CloosPA, RudkjaerL et al.: The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.Genes Dev.23(10) , 1171–1176 (2009).
  • Barradas M , AndertonE, AcostaJC et al.: Histone demethylase JMJD3 contributes to epigenetic control of INK4A/ARF by oncogenic ras.Genes Dev.23(10) , 1177–1182 (2009).
  • Chen X , HillerM, SancakY, FullerMT: Tissue-specific tafs counteract Polycomb to turn on terminal differentiation.Science310(5749) , 869–872 (2005).
  • Witte V , LaffertB, RosoriusO et al.: HIV-1 nef mimics an integrin receptor signal that recruits the Polycomb group protein eed to the plasma membrane.Mol. Cell13(2) , 179–190 (2004).
  • Su IH , DobeneckerMW, DickinsonE et al.: Polycomb group protein EZH2 controls actin polymerization and cell signaling.Cell121(3) , 425–436 (2005).
  • Voncken JW , SchweizerD, AagaardL, SattlerL, JantschMF, Van Lohuizen M: Chromatin-association of the Polycomb group protein bmi1 is cell cycle-regulated and correlates with its phosphorylation status. J. Cell Sci.112(Pt 24) , 4627–4639 (1999).
  • Voncken JW , NiessenH, NeufeldB et al.: Mapkap kinase 3pK phosphorylates and regulates chromatin association of the Polycomb group protein bmi1.J. Biol. Chem.280(7) , 5178–5187 (2005).
  • Cha TL , ZhouBP, XiaW et al.: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.Science310(5746) , 306–310 (2005).
  • Henikoff S , FuruyamaT, AhmadK: Histone variants, nucleosome assembly and epigenetic inheritance.Trends Genet.20(7) , 320–326 (2004).
  • Hansen KH , BrackenAP, PasiniD et al.: A model for transmission of the H3K27me3 epigenetic mark.Nat. Cell Biol.10(11) , 1291–1300 (2008).
  • Francis NJ , FollmerNE, SimonMD, AghiaG, ButlerJD: Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro.Cell137(1) , 110–122 (2009).
  • Liu J , CaoL, ChenJ et al.: Bmi1 regulates mitochondrial function and the DNA damage response pathway.Nature459(7245) , 387–392 (2009).
  • Takahashi K , YamanakaS: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Cell126 , 663–676 (2006).
  • Yamanaka S : A fresh look at iPS cells.Cell137(1) , 13–17 (2009).
  • Schwartz YB , PirrottaV: Polycomb complexes and epigenetic states.Curr. Opin. Cell Biol.20(3) , 266–273 (2008).
  • Margueron R , JustinN, OhnoK et al.: Role of the polycomb protein EED in the propagation of repressive histone marks.Nature461(7265) , 762–767 (2009).

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