References
- van Lohuizen M , VerbeekS, ScheijenB et al.: Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.Cell65(5) , 737–752 (1991).
- Haupt Y , AlexanderWS, BarriG et al.: Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.Cell65(5) , 753–763 (1991).
- Sparmann A , van Lohuizen M: Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer6(11) , 846–856 (2006).
- Song LB , ZengMS, LiaoWT et al.: Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.Cancer Res.66(12) , 6225–6232 (2006).
- Wang H , PanK, ZhangHK et al.: Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma.J. Cancer Res. Clin. Oncol.134(5) , 535–541 (2008).
- Qin ZK , YangJA, YeYL et al.: Expression of Bmi-1 is a prognostic marker in bladder cancer.BMC Cancer9 , 61 (2009).
- Zhang XW , ShengYP, LiQ et al.: BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.Mol. Cancer9 , 40 (2010).
- Hayry V , TynninenO, HaapasaloHK et al.: Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours.Neuropathol. Appl. Neurobiol.34(5) , 555–563 (2008).
- Vrzalikova K , SkardaJ, EhrmannJ et al.: Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study.J. Cancer Res. Clin. Oncol.134(9) , 1037–1042 (2008).
- Hayry V , MakinenLK, AtulaT et al.: Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.Br. J. Cancer102(5) , 892–897 (2010).
- Yang GF , HeWP, CaiMY et al.: Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.BMC Cancer10 , 133–141 (2010).
- Song W , TaoK, LiH et al.: Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer.Cancer Sci.101(7) , 1754–1760 (2010).
References
- Itahana K , ZouY, ItahanaY et al.: Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.Mol. Cell Biol.23(1) , 389–401 (2003).
- Dimri GP : What has senescence got to do with cancer?Cancer Cell7(6) , 505–512 (2005).
- Guo WJ , DattaS, BandV et al.: Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.Mol. Biol. Cell18(2) , 536–546 (2007).
- Guney I , WuS, SedivyJM: Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).Proc. Natl Acad. Sci. USA103(10) , 3645–3650 (2006).
- Nowak K , KerlK, FehrD et al.: Bmi-1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas.Nucleic Acids Res.34(6) , 1745–1754 (2006).
- Yang J , ChaiL, LiuF et al.: Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.Proc. Natl Acad. Sci. USA104(25) , 10494–10499 (2007).
- Ochiai H , TakenobuH, NakagawaA et al.: Bmi-1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bβ and TSLC1 in neuroblastoma.Oncogene29(18) , 2681–2690 (2010).
References
- Bumcrot D , ManoharanM, KotelianskyV et al.: RNAi therapeutics: a potential new class of pharmaceutical drugs.Nat. Chem. Biol.2(12) , 711–719 (2006).
- Castanotto D , RossiJJ: The promises and pitfalls of RNA-interference-based therapeutics.Nature457(7228) , 426–433 (2009).
- Davis ME , ZuckermanJE, ChoiCH et al.: Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.Nature464(7291) , 1067–1070 (2010).
- Liu L , AndrewsLG, TollefsbolTO: Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death.Oncogene25(31) , 4370–4375 (2006).
- Guo WJ , ZengMS, YadavA et al.: Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.Cancer Res.67(11) , 5083–5089 (2007).
- Cui H , HuB, LiT et al.: Bmi-1 is essential for the tumorigenicity of neuroblastoma cells.Am. J. Pathol.170(4) , 1370–1378 (2007).
- Ochiai H , TakenobuH, NakagawaA et al.: Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bβ and TSLC1 in neuroblastoma.Oncogene29(18) , 2681–2690 (2010).
- Yu Q , SuB, LiuD et al.: Antisense RNA-mediated suppression of Bmi-1 gene expression inhibits the proliferation of lung cancer cell line A549.Oligonucleotides17(3) , 327–335 (2007).
- Qin L , ZhangX, ZhangL et al.: Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells.Biochem. Biophys. Res. Commun.371(3) , 531–535 (2008).
- Jiang Y , SuB, MengX et al.: Effect of siRNA-mediated silencing of Bmi-1 gene expression on HeLa cells.Cancer Sci.101(2) , 379–386 (2010).
- Song W , TaoK, LiH et al.: Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer.Cancer Sci.101(7) , 1754–1760 (2010).
- Rizo A , OlthofS, HanL et al.: Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis.Blood114(8) , 1498–1505 (2009).
- Zhu W , HuangL, XuX, QianH, XuW: Anti-proliferation effect of BMI-1 in U937 cells with siRNA.Int. J. Mol. Med.25(6) , 889–895. (2010).
- Jacobs JJ , ScheijenB, VonckenJW et al.: Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Genes Dev.13(20) , 2678–2690 (1999).
- Jagani Z , WiederschainD, LooA et al.: The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.Cancer Res.70(13) , 5528–5538 (2010).