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Review

Transgenerational Genetic Effects

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Pages 797-806 | Published online: 15 Dec 2010

Bibliography

  • Mayr E : The Growth of Biological Thought: Diversity, Evolution and Inheritance. Harvard University Press, Cambridge, UK (1982).
  • Mendel G : Versuche über pflanzen-hybriden. Verhandlungen des Naturforschenden Vereines in Brünn3–47 (1866).
  • Monaghan F , CorcosA: On the origins of the Mendelian laws.J. Hered.75 , 67–69 (1984).
  • Galton F : Co-relations and their measurement.Proc. R. Soc.45 , 135–145 (1888).
  • Morgan TH : Sex-limited inheritance in Drosophila.Science32 , 120–122 (1910).
  • Sturtevant AH , BridgesCB, MorganTH: The spatial relations of genes.Proc. Natl Acad. Sci. USA5 , 168–173 (1919).
  • Sturtevant AH : Linkage variation and chromosome maps.Proc. Natl Acad. Sci. USA7 , 181–183 (1921).
  • Avery OT , MacleodCM, McCartyM: Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a deoxyribonucleic acid fraction isolated from Pneumococcus Type III.J. Exp. Med.79 , 137–158 (1944).
  • Hershey AD , ChaseM: Independent functions of viral protein and nucleic acid in growth of bacteriophage.J. Genet. Psychol.36 , 39–56 (1952).
  • Fisher RA : On the correlation between relatives on the supposition of Mendelian inheritance.Trans. Roy. Soc. Edinburgh52 , 399–433 (1918).
  • Altshuler D , DalyMJ, LanderES: Genetic mapping in human disease.Science322 , 881–888 (2008).
  • Manolio TA , CollinsFS, CoxNJ et al.: Finding the missing heritability of complex diseases.Nature461 , 747–753 (2009).
  • Clarke AJ , CooperDN: GWAS: heritability missing in action?Eur. J. Hum. Genet.18 , 859–861 (2010).
  • Slatkin M : Epigenetic inheritance and the missing heritability problem.Genetics182 , 845–850 (2009).
  • Rakyan VK , PreisJ, MorganHD, WhitelawE: The marks, mechanisms and memory of epigenetic states in mammals.Biochem. J.356 , 1–10 (2001).
  • Darwin C : The Variation in Animals and Plants under Domestication. Murray J (Ed.). John Murray, UK (1868).
  • Lamarck J -B: Recherches sur l‘osorganisation des Corps Vivants. Paris, France (1802).
  • Weismann A : Studien sur Descendants-Theorie. II. Uber die Letzten Ursachen der Transmutationen. Verlag von Wilhelm Engelmann, Leipzig, Germany (1876).
  • Weismann A : Die Entstehung der Sexualzellen bei den Hydromedusan: Zugleich ein beitrag zur kenntniss des baues und der lebenserscheinungen dieser gruppe. Fischer, Jena, Germany (1883).
  • Weismann A : Die Continuitat des Keimplasmas als Grundlage einer Theorie der Vererbung. Fischer, Jena (1885).
  • Gluckman PD , HansonMA, BeedleAS: Non-genomic transgenerational inheritance of disease risk.Bioessays29 , 145–154 (2007).
  • Jirtle RL , SkinnerMK: Environmental epigenomics and disease susceptibility.Nat. Rev. Genet.8 , 253–262 (2007).
  • Johannes F , PorcherE, TeixeiraFK et al.: Assessing the impact of transgenerational epigenetic variation on complex traits.PLoS Genet.5 , E1000530 (2009).
  • Youngson NA , WhitelawE: Transgenerational epigenetic effects.Ann. Rev. Genom. Hum. Genet.9 , 233–257 (2008).
  • Alcazar RM , RueylingL, FireAZ: Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans.Genetics180 , 1275–1288 (2008).
  • Grishok A Tabara H, Mello CC: Genetic requirements for inheritance of RNAi in C. elegans. Science287 , 2494–2497 (2000).
  • Anway MD , SkinnerMK: Epigenetic transgenerational actions of endocrine disruptors.Endocrinology147 , S43–S49 (2006).
  • Morgan D , WhitelawE: The case for transgenerational epigenetic inheritance in humans.Mamm. Genome19 , 394–397 (2008).
  • Rakyan VK , BeckS: Epigenetic variation and inheritance in mammals.Curr. Opin. Genet. Dev.16 , 573–577 (2006).
  • Richards EJ : Inherited epigenetic variation – revisiting soft inheritance.Nat. Rev. Genet.7 , 395–401 (2006).
  • Anway MD , CuppAS, UzumcuM, SkinnerMK: Epigenetic transgenerational actions of endocrine disruptors and male fertility.Science308 , 1466–1469 (2005).
  • Newbold RR , Padilla-BanksE, JeffersonWN: Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.Endocrinology147 , S11–S17 (2006).
  • Cheng RY -S, Hockman T, Crawford E, Anderson LM, Shiao Y-H: Epigenetic and gene expression changes related to transgenerational carcinogenesis. Mol. Carcinog.40 , 1–11 (2004).
  • Grenier L , RobaireB, HalesBF: Paternal exposure to cyclophosphamide affects the progression of sperm chromatin decondensation and activates a DNA damage response in prepronuclear rat zygotes.Biol. Reprod.83 , 195–204 (2010).
  • Dent P , YacoubA, ContessaJ et al.: Stress and radiation-induced activation of multiple intracellular signaling pathways.Radiat. Res.159 , 283–300 (2003).
  • Wiley LM , BaulchJE, RaabeOG, StraumeT: Impaired cell proliferation in mice persists across at least two generations after paternal irradiation.Radiat. Res.148 , 145–151 (1997).
  • Straume T , RaabeOG, WalshKJ, WileyLM: Inherited effects from irradiated mouse immature oocytes detected in aggregation embryo chimeras.Mutat. Res.287 , 243–251 (1993).
  • Warner P , WileyLM, OudizDJ, OverstreetJVV, RaabeOG: Paternally inherited effects of γ-radiation on mouse preimplantation development detected by the chimera assay.Radiat. Res.128 , 48–58 (1991).
  • Vance MM , BaulchJE, RaabeOG, WileyLM, OverstreetJW: Cellular reprogramming in the F3 mouse with paternal F0 radiation history.Int. J. Radiat. Biol.78 , 513–526 (2002).
  • Baulch JE , RaabeOG, WileyLM: Heritable effects of paternal irradiation in mice on signaling protein kinase activities in F3 offspring.Mutagenesis16 , 17–23 (2001).
  • Baulch JE , RaabeOG: γ irradiation of Type B speratogonia leads to heritable genomic instability in four generations of mice.Mutagenesis20 , 337–343 (2005).
  • Baulch JE , Li M-W, Raabe OG: Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation. Mutat. Res.616 , 34–45 (2007).
  • Dubrova YE : Radiation-induced transgenerational instability.Oncogene22 , 7087–7093 (2003).
  • Dubrova YE : Genomic instability in the offspring of irradiated parents: facts and interpretations.Genetika42 , 1335–1347 (2006).
  • Vorobtsova IE : Transgenerational transmission of radiation induced genomic instability.Radiats. Biol. Radioecol.46 , 441–446 (2006).
  • Kovalchuk O , BaulchJE: Epigenetic and nontargeted radiation effects – is there a link?Environ. Mol. Mutagen.49 , 16–25 (2008).
  • Filkowski JN , IlnytskyyY, TammingaJ et al.: Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression.Carcinogenesis31 , 1110–1115 (2010).
  • Burdge GC , Slater-JefferiesJ, TorrensC et al.: Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations.Br. J. Nutr.97 , 435–439 (2007).
  • Weaver ICG , CervoniN, ChampagneFA et al.: Epigenetic programming by maternal behavior.Nat. Neurosci.7 , 847–854 (2004).
  • Arai JA , LiS, HartleyDM, FeigLA: Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.J. Neurosci.29 , 1496–1502 (2009).
  • Kiyono S , SeoML, ShibagakiM, InouyeM: Facilitative effects of maternal environmental enrichment on maze learning in rat offspring.Physiol. Behav.34 , 431–435 (1985).
  • Curley JP , DavidsonS, BatesonP, ChampagneFA: Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice.Front. Behav. Neurosci.3 , 25 (2009).
  • Kaati G , BygrenLO, PembreyM, SjostromM: Transgenerational response to nutrition, early life circumstances and longevity.Eur. J. Hum. Genet.15 , 784–790 (2007).
  • Pembrey ME , BygrenLO, KaatiG et al.: Sex-specific, male-line transgenerational responses in humans.Eur. J. Hum. Genet.14 , 159–66 (2006).
  • Painter R , OsmondC, GluckmanP et al.: Transgenerational effects of prenatal exposure to the Dutch famine in neonatal adiposity and health in later life.BJOG115 , 1243–1249 (2008).
  • Skinner MK , ManikkamM, Guerrero-BosagnaC: Epigenetic transgenerational actions of environmental factors in disease etiology.Trends Endocrinol. Metab.21 , 214–222 (2010).
  • Rassoulzadegan M , GrandjeanV, GounonP et al.: RNA-mediated non-Mendelian inheritance of an epigenetic change in the mouse.Nature441 , 469–474 (2006).
  • Wandzioch E , EdlingCE, PalmerRH, CarlssonL, HallbergB: Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines.Blood104 , 51–57 (2004).
  • Linnekin D : Early signaling pathways activated by c-Kit in hematopoietic cells.Int. J. Biochem. Cell Biol.31 , 1053–1074 (1999).
  • Reith AD , EllisC, LymanSD et al.: Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.EMBO J.10 , 2451–2459 (1991).
  • Weiler S , MouS, DeberryC et al.: JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.Blood87 , 3688–3693 (1996).
  • Rönnstrand L : Signal transduction via the stem cell factor receptor/c-Kit.Cell. Mol. Life Sci.61 , 2535–2548 (2004).
  • Edling CE , HallbergB: c-Kit – a hematopoietic cell essential receptor tyrosine kinase.Int. J. Biochem. Cell Biol.39 , 1995–1998 (2007).
  • Munugalavadla V , KapurR: Role of c-Kit and erythropoietin receptor in erythropoiesis.Crit. Rev. Oncol. Hematol.54 , 63–75 (2005).
  • Ashman LK : The biology of stem cell factor and its receptor c-kit.Int. J. Biochem. Cell Biol.31 , 1037–1051 (1999).
  • Roskoski R Jr: Signaling by Kit protein-tyrosine kinase – the stem cell factor receptor. Biochem. Biophys. Res. Commun.337 , 1–13 (2005).
  • Arteaga-Vazquez MA , ChandlerVL: Paramutation in maize: RNA mediated trans-generational gene silencing.Curr. Opin. Genet. Dev.20 , 156–163 (2010).
  • Chandler VL , AllemanM: Paramutation: epigenetic instructions passed across generations.Genetics178 , 1839–1844 (2008).
  • Rassoulzadegan M , GrandjeanV, GounonP, CuzinF: Inheritance of an epigenetic change in the mouse: a new role for RNA.Biochem. Soc. Trans.035 , 623–625 (2007).
  • Grandjean V , GounonP, WagnerN et al.: The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth.Development136 , 3647–3655 (2009).
  • Wagner KD , WagnerN, GhanbarianH et al.: RNA Induction and inheritance of epigenetic cardiac hypertrophy in the mouse.Dev. Cell.14 , 962–969 (2008).
  • Heaney JD , Lam M-YJ, Michelson MV, Nadeau JH: Loss of the transmembrane but not the soluble Kit ligand isoform increases testicular germ cell tumor susceptibility in mice. Cancer Res.68 , 5193–5197 (2008).
  • Wolff GL , KodellRL, MooreSR, CooneyCA: Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.FASEB J.12 , 949–957 (1998).
  • Cooney CA , DaveAA, WolffGL: Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring.J. Nutr.132 , S2393–S2400 (2002).
  • Rakyan VK , ChongS, ChampME et al.: Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission.Proc. Natl. Acad. Sci USA100 , 2538–2543 (2003).
  • Waterland RA , DolinoyDC, Lin, J-R, Smith CA, Shi X, Tahiliani KG: Maternal methyl supplements increase offspring DNA methylation at Axin fused. Genesis44 , 401–406 (2006).
  • Bourc‘his D , BestorTH: Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.Nature431 , 96–99 (2004).
  • Parkhurst SM , Ish-HorowiczD: Wimp, a dominant maternal-effect mutation, reduces transcription of a specific subset of segmental genes in Drosophila.Genes Dev.5 , 341–357 (1991).
  • Xing Y , ShiS, LeL et al. Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet. 3 , E151 (2007).
  • Lam M -YJ, Heaney JD, Youngren KK et al.: Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum. Mol. Genet.16 , 2233–2240 (2007).
  • Lam M -YJ, Youngren KK, Nadeau JH: Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics166 , 925–933 (2004).
  • Petersen-Mahrt SK , NeubergerMS: In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).J. Biol. Chem.278 , 19583–19586 (2003).
  • Kedde M , StrasserMJ, BoldajipourB et al.: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.Cell131 , 1273–1286 (2007).
  • Noguchi T , NoguchiM: A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice.J. Natl Cancer Inst.75 , 385–392 (1985).
  • Noguchi T , StevensLC: Primordial germ cell proliferation in fetal testes in mouse strains with high and low incidences of congenital testicular teratomas.J. Natl Cancer Inst.69 , 907–913 (1982).
  • Nelson VR , ShaoH, NadeauJH: Transgenerational genetic effects of the paternal Y chromosome on daughters‘ phenotypes.Epigenomics2 , 513–521 (2010).
  • Nadeau JH , SingerJB, MatinA, LanderES: Analyzing complex genetic traits with chromosome substitution strains.Nat. Genet.24 , 221–225 (2000).
  • Yazbek SN , SpiezioSH, NadeauJH, BuchnerDA: Ancestral paternal genotype determines diet-induced obesity and food intake for multiple generations.Hum. Mol. Genet.19(21) , 4134–4144 (2010).
  • Ng SF , LinRCY, LaybuttDR et al.: Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring.Nature467 , 963–967 (2010).
  • Alcazar RM , RueylingL, FireAZ: Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans.Genetics180 , 1275–1288 (2008)
  • Carmell MA , GirardA, van de Kant HJG et al.: MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Develop. Cell.12 , 503–514 (2007).
  • Farthing CR , FiczG, NgRK et al.: Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.PLoS Genet.4 , E1000116 (2008).
  • Brykczynska U , HisanoM, ErkekS et al.: Repressive and active methylation mark distinct promoters in human and mouse spermatozoa.Nat. Struct. Mol. Biol.17 , 679–687 (2010).
  • Guilbert S , ForneT, WeberM: Dynamic regulation of DNA methylation during mammalian development.Epigenomics1 , 81–98 (2009).
  • Grishok A Tabara H, Mello CC: Genetic requirements for inheritance of RNAi in C. elegans. Science287 , 2494–2497 (2000).
  • Hammoud SS , NixDA, ZhangH, PurwarJ, CarrellDT, CairnsBR: Distinctive chromatin in human sperm packages genes for embryo development.Nature460 , 473–478 (2009).
  • Champagne FA : Epigenetic mechanisms and the transgenerational effects of maternal care.Front. Neuroendocrinol.29 , 386–397 (2008).
  • Grewal SIS , KlarAJS: Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis.Cell86 , 95–101 (1996).
  • Morgan HD , SutherlandHG, MartinDI, WhitelawE: Epigenetic inheritance at the agouti locus in the mouse.Nat. Genet.23 , 314–318 (1999).
  • Margueron RL , ReinbergD: Chromatin structure and the inheritance of epigenetic information.Nat. Rev. Genet.11 , 285–296 (2010).
  • Kaufman PD , RandoOJ: Chromatin as a potential carrier of heritable information.Curr. Opin. Cell Biol.22 , 284–290 (2010).
  • Buchan JR , ParkerR: Eukaryotic stress granules: the ins and outs of translation.Mol. Cell.36 , 932–941 (2009).
  • Anderson P , KedershaN: RNA granules.J. Cell Biol.172 , 803–808 (2006).
  • Anderson P , KedershaN: RNA granules: post-transcriptional and epigenetic modulators of gene expression.Nat. Rev. Mol. Cell Biol.10 , 430–436 (2009).
  • Kedersha N , ChenS, GilksN et al.: Evidence that ternary complex (eIF2-GTP-tRNAiMet)-deficient preinitiation complexes are core constituents of mammalian stress granules.Mol. Biol. Cell.13 , 195–210 (2002).
  • Kedersha NL , GuptaM, LiW et al.: RNA-binding proteins Tia-1 and Tiar link the phosphorylation of Eif2 to the assembly of mammalian stress granules.J. Cell Biol.147 , 1431–1442 (1999).
  • Slanchev K , SteblerJ, Goudarzi et al.: Control of dead end localization and activity – implications for the function of the protein in antagonizing miRNA function. Mech. Dev.126 , 270–277 (2009).
  • Kong A , SteinthorsdottirV, MassonG et al.: Parental origin of sequence variants associated with complex diseases.Nature462 , 868–874 (2009).

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