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Epigenomics Volume 2, 2010 - Issue 6
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Review

Hormonal Gene Regulation Through DNA Methylation And Demethylation

Alexander Kouzmenko1 Institute of Molecular & Cellular Biosciences, University of Tokyo, Tokyo, Japan;2 College of Science, Alfaisal University, Riyadh, Kingdom of Saudi ArabiaCorrespondence[email protected]
,
Fumiaki Ohtake1 Institute of Molecular & Cellular Biosciences, University of Tokyo, Tokyo, Japan
,
Ryoji Fujiki1 Institute of Molecular & Cellular Biosciences, University of Tokyo, Tokyo, Japan
&
Shigeaki Kato1 Institute of Molecular & Cellular Biosciences, University of Tokyo, Tokyo, Japan
Pages 765-774 | Published online: 15 Dec 2010

Bibliography

  • Ooi SKT , O‘DonnellAH, BestorTH: Mammalian cytosine methylation at a glance.J. Cell Sci.122 , 2787–2791 (2009).
  • Bender J : DNA methylation and epigenetics.Annu. Rev. Plant Biol.55 , 41–68 (2004).
  • Bartolomei MS : Genomic imprinting: employing and avoiding epigenetic processes.Genes Dev.23 , 2124–2133 (2009).
  • Guibert S , ForneT, WeberM: Dynamic regulation of DNA methylation during mammalian development.Epigenomics1 , 81–98 (2009).
  • Mohn F , SchubelerD: Genetics and epigenetics: stability and plasticity during cellular differentiation.Trends Genet.25 , 129–36 (2009).
  • Law JA , JacobsenSE: Establishing, maintaining and modifying DNA methylation patterns in plants and animals.Nat. Rev. Genet.11 , 204–220 (2010).
  • Aravin AA , Bourc‘hisD: Small RNA guides for de novo DNA methylation in mammalian germ cells.Genes Dev.22 , 970–975 (2008).
  • Zhu JK : Active DNA demethylation mediated by DNA glycosylases.Annu. Rev. Genet.43 , 143–66 (2009).
  • Huh JH , BauerMJ, HsiehTF, FischerRL: Cellular programming of plant gene imprinting.Cell132 , 735–744 (2008).
  • Chotalia M , SmallwoodSA, RufN et al.: Transcription is required for establishment of germline methylation marks at imprinted genes.Genes Dev.23 , 105–117 (2009).
  • Gehring M , ReikW, HenikoffS: DNA demethylation by DNA repair.Trends Genet.25 , 82–90 (2009).
  • Reid G , GallaisR, MétivierR: Marking time: the dynamic role of chromatin and covalent modification in transcription.Int. J. Biochem. Cell Biol.41 , 155–63 (2009).
  • Métivier R , GallaisR, TiffocheC et al.: Cyclical DNA methylation of a transcriptionally active promoter.Nature452 , 45–50 (2008).
  • Kangaspeska S , StrideB, MétivierR et al.: Transient cyclical methylation of promoter DNA.Nature452 , 112–115 (2008).
  • Laird PW : Principles and challenges of genome-wide DNA methylation analysis.Nat. Rev. Genet.11 , 191–203 (2010).
  • Cheng X , BlumenthalRM: Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.Biochemistry49 , 2999–3008 (2010).
  • Kato S : Genetic mutation in the human 25-hydroxyvitamin D3 1α-hydroxylase gene causes vitamin D-dependent rickets type I.Mol. Cell. Endocrinol.156 , 7–12 (1999).
  • Kato S , YoshizazawaT, KitanakaS, MurayamaA, TakeyamaK: Molecular genetics of vitamin D- dependent hereditary rickets.Horm. Res.57 , 73–78 (2002).
  • Takeyama K , KitanakaS, SatoT, KoboriM, YanagisawaJ, KatoS: 25-hydroxyvitamin D3 1α-hydroxylase and vitamin D synthesis.Science277 , 1827–1830 (1997).
  • Mangelsdorf DJ , ThummelC, BeatoM et al.: The nuclear receptor superfamily: the second decade.Cell83 , 835–839 (1995).
  • Yoshizawa T , HandaY, UematsuY et al.: Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning.Nat. Genet.16 , 391–396 (1997).
  • Bouillon R , CarmelietG, VerlindenL et al.: Vitamin D and human health: lessons from vitamin D receptor null mice.Endocr. Rev.29 , 726–776 (2008).
  • McCullough ML , BostickRM, MayoTL: Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer.Annu. Rev. Nutr.29 , 111–132 (2009).
  • Haussler MR , HausslerCA, BartikL et al.: Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.Nutr. Rev.66(Suppl. 2) , S98–S112 (2008)
  • Rachez C , LemonD, SuldanZ et al.: Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.Nature398 , 824–828 (1999).
  • Glass CK , RosenfeldMG: The coregulator exchange in transcriptional functions of nuclear receptors.Genes Dev.14 , 121–141 (2000).
  • Kitagawa H , FujikiR, YoshimuraK et al.: The chromatin remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams Syndrome.Cell113 , 1–13 (2003).
  • Murayama A , KimMS, YanagisawaJ, TakeyamaK, KatoS: Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.EMBO J.23 , 1598–1608 (2004).
  • DeLuca HF : Overview of general physiologic features and functions of vitamin D.Am. J. Clin. Nutr.80(Suppl.) , 1689S–1696S (2004).
  • Meyer MB , WatanukiM, KimS, ShevdeNK, PikeJW: The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells.Mol. Endocrinol.20 , 1447–1461 (2006).
  • Dusso AS , BrownAJ, SlatopolskyE: Vitamin D.Am. J. Physiol. Renal. Physiol.289 , F8–F28 (2005).
  • Alroy I , TowersTL, FreedmanLP: Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.Mol. Cell. Biol.15 , 5789–5799 (1995).
  • Demay MB , KiernanMS, DeLucaHF, KronenbergHM: Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.Proc. Natl. Acad. Sci. USA89 , 8097–8101 (1992).
  • Falzon M : DNA sequences in the rat parathyroid hormone related peptide gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression.Mol. Endocrinol.10 , 672–681 (1996).
  • Russell J , AshokS, KoszewskiNJ: Vitamin D receptor interactions with the rat parathyroid hormone gene: synergistic effects between two negative vitamin D response elements.J. Bone Miner. Res.14 , 1828–1837 (1999).
  • Kim MS , FujikiR, MurayamaA et al.: 1a,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter.Mol. Endocrinol.21 , 334–342 (2007).
  • Henry HL : Parathyroid hormone modulation of 25-hydroxyvitamin D3 metabolism by cultured chick kidney cells is mimicked and enhanced by forskolin.Endocrinology116 , 503–510 (1985).
  • Fujiki R , KimMS, SasakiY, YoshimuraK, KitagawaH, KatoS: Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.EMBO J.24 , 3881–3894 (2005).
  • Xu W , ChenH, DuK et al.: A transcriptional switch mediated by cofactor methylation.Science294 , 2507–2511 (2001).
  • Kato S , FujikiR, KitagawaH: Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex.J. Steroid Biochem. Mol. Biol.89–90 , 173–178 (2004).
  • Kim MS , KondoT, TakadaI et al.: DNA demethylation in hormone-induced transcriptional derepression.Nature461 , 1007–1012 (2009).
  • Okano M , BellDW, HaberDA, LiE: DNA methyltransferases DNMT3A and DNMT3B are essential for de novo methylation and mammalian development.Cell99 , 247–257 (1999).
  • Howell CY , BestorTH, DingF et al.: Genomic imprinting disrupted by a maternal effect mutation in the DNMT1 gene.Cell104 , 829–838 (2001).
  • Rhee I , BachmanKE, ParkBH et al.: DNMT1 and DNMT3B cooperate to silence genes in human cancer cells.Nature416 , 552–556 (2002).
  • Maison C , AlmouzniG: HP1 and the dynamics of heterochromatin maintenance.Nat. Rev. Mol. Cell Biol.5 , 296–304 (2004).
  • Probst AV , DunleavyE, AlmouzniG: Epigenetic inheritance during the cell cycle.Nat. Rev. Mol. Cell Biol.10 , 192–206 (2009).
  • Lee M , PartridgeNC: Parathyroid hormone signaling in bone and kidney.Curr. Opin. Nephrol. Hypertens.18 , 298–302 (2009).
  • Simonsson S , GurdonJ: DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei.Nat. Cell Biol.6 , 984–990 (2004).
  • Moss TJ , WallrathLL: Connections between epigenetic gene silencing and human disease.Mutat. Res.618 , 163–174 (2007).
  • Hendrich B , BirdA: Identification and characterization of a family of mammalian methyl-CpG binding proteins.Mol. Cell. Biol.18 , 6538–6547 (1998).
  • Hendrich B , HardelandU, NgHH, JiricnyJ, BirdA: The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites.Nature401 , 301–304 (1999).
  • Kondo E , GuZ, HoriiA, FukushigeS: The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes.Mol. Cell. Biol.25 , 4388–4396 (2005).
  • Rai K , HugginsIJ, JamesSR, KarpfAR, JonesDA, CairnsBR: DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45.Cell135 , 1201–1212 (2008).
  • Demple B , SungJS: Molecular and biological roles of Ape1 protein in mammalian base excision repair.DNA Repair4 , 1442–1449 (2005).
  • David SS , O‘SheaVL, KunduS: Base-excision repair of oxidative DNA damage.Nature447 , 941–945 (2007).
  • Métivier R , PenotG, HübnerMR et al.: Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter.Cell115 , 751–763 (2003).
  • Métivier R , HuetG, GallaisR et al.: Dynamics of estrogen receptor-mediated transcriptional activation of responsive genes in vivo: apprehending transcription in four dimensions.Adv. Exp. Med. Biol.617 , 129–138 (2008).
  • Kriaucionis S , HeintzN: The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.Science324 , 929–930 (2009).
  • Tahiliani M , KohKP, ShenY et al.: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.Science324 , 930–935 (2009).
  • Liutkeviciute Z , LukinaviciusG, MaseviciusV, DaujotyteD, KlimasauskasS: Cytosine-5-methyltransferases add aldehydes to DNA.Nat. Chem. Biol.5 , 400–402 (2009).

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