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Epigenomics Volume 3, 2011 - Issue 3
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Review

Epigenetics and Lifestyle

Jorge Alejandro Alegría-Torres1 Departamento de Toxicologia Ambiental, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, MexicoView further author information
,
Andrea Baccarelli2 Exposure, Epidemiology & Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USAView further author information
&
Valentina Bollati3 Center of Molecular & Genetic Epidemiology, Department of Environmental & Occupational Health, Università degli Studi di Milano & Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via San Barnaba 8, Milan20122, Italy.Correspondence[email protected]
View further author information
Pages 267-277 | Published online: 30 Jun 2011

Bibliography

  • APA: Thesaurus of Psychological Index Terms (7th Edition). Gallagher L (Ed.). (2007).
  • Probst AV , DunleavyE, AlmouzniG: Epigenetic inheritance during the cell cycle.Nat. Rev. Mol. Cell. Biol.10(3) , 192–206 (2009).
  • Santos-Reboucas CB , PimentelMM: Implication of abnormal epigenetic patterns for human diseases.Eur. J. Hum. Genet.15(1) , 10–17 (2007).
  • Bartsch H , NairJ: Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis.Cancer Detect. Prev.28(6) , 385–391 (2004).
  • Lawless MW , O‘ByrneKJ, GraySG: Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy.J. Cell. Mol. Med.13(9A) , 2800–2821 (2009).
  • Arsova-Sarafinovska Z , EkenA, MatevskaNet al.: Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer.Clin. Biochem.42(12) , 1228–1235 (2009).
  • Kiec-Wilk B , RaznyU, MathersJC, Dembinska-KiecA: DNA methylation, induced by β-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells.J. Physiol. Pharmacol.60(4) , 49–53 (2009).
  • Nowak J , WeylandtKH, HabbelPet al.: Colitis associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids.Carcinogenesis28(9) , 1991–1995 (2007).
  • Borek C : Dietary antioxidants and human cancer.Integr. Cancer Ther.3(4) , 333–341 (2004).
  • Chen J , XuX: Diet, epigenetic, and cancer prevention.Adv. Genet.71 , 237–255 (2010).
  • Dashwood RH , HoE: Dietary histone deacetylase inhibitors: from cells to mice to man.Semin. Cancer Biol.17(5) , 363–369 (2007).
  • Druesne N , PagniezA, MayeurCet al.: Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines.Carcinogenesis25(7) , 1227–1236 (2004).
  • Zingg JM , JonesPA: Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis.Carcinogenesis18(5) , 869–882 (1997).
  • Gonzalez S , HuertaJM, Alvarez-UriaJ, FernandezS, PattersonAM, LasherasC: Serum selenium is associated with plasma homocysteine concentrations in elderly humans.J. Nutr.134(7) , 1736–1740 (2004).
  • Johnson IT , BelshawNJ: Environment, diet and CpG island methylation: epigenetic signals in gastrointestinal neoplasia.Food Chem. Toxicol.46(4) , 1346–1359 (2008).
  • Kim JM , HongK, LeeJH, LeeS, ChangN: Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats.J. Nutr. Biochem.20(3) , 172–176 (2009).
  • Giovannucci E : Epidemiologic studies of folate and colorectal neoplasia: a review.J. Nutr.132(Suppl. 8) , 2350S–2355S (2002).
  • Jacob RA , GretzDM, TaylorPCet al.: Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women.J. Nutr.128(7) , 1204–1212 (1998).
  • Rampersaud GC , KauwellGP, HutsonAD, CerdaJJ, BaileyLB: Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.Am. J. Clin. Nutr.72(4) , 998–1003 (2000).
  • Shin W , YanJ, AbratteCM, VermeylenF, CaudillMA: Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men.J. Nutr.140(5) , 975–980 (2010).
  • Ross SA , DwyerJ, UmarAet al.: Introduction: diet, epigenetic events and cancer prevention.Nutr. Rev.66(Suppl. 1) , S1–S6 (2008).
  • Bravi F , PoleselJ, BosettiCet al.: Dietary intake of selected micronutrients and the risk of pancreatic cancer: an Italian case–control study.Ann. Oncol.22(1) , 202–206 (2011).
  • Gonzalez CA , TravierN, Lujan-BarrosoLet al.: Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study.Int. J. Cancer (2010) (Epub ahead of print).
  • Shanmugham JR , ZavrasAI, RosnerBA, GiovannucciEL: Alcohol–folate interactions in the risk of oral cancer in women: a prospective cohort study.Cancer Epidemiol. Biomarkers Prev.19(10) , 2516–2524 (2010).
  • Shitara K , MuroK, ItoSet al.: Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer.Cancer Epidemiol. Biomarkers Prev.19(5) , 1311–1319 (2010).
  • Kim YI : Folate: a magic bullet or a double edged sword for colorectal cancer prevention?Gut55(10) , 1387–1389 (2006).
  • Fini L , SelgradM, FoglianoVet al.: Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells.J. Nutr.137(12) , 2622–2628 (2007).
  • Link A , BalaguerF, GoelA: Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.Biochem. Pharmacol.80(12) , 1771–1792 (2010).
  • Paluszczak J , Krajka-KuzniakV, MaleckaZet al.: Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols.Toxicol. In Vitro25(1) , 213–221 (2011).
  • Yuasa Y , NagasakiH, AkiyamaYet al.: DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients.Int. J. Cancer124(11) , 2677–2682 (2009).
  • Yuasa Y , NagasakiH, AkiyamaYet al.: Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients.Carcinogenesis26(1) , 193–200 (2005).
  • Fang MZ , WangY, AiNet al.: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.Cancer Res.63(22) , 7563–7570 (2003).
  • Lee WJ , ShimJY, ZhuBT: Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.Mol. Pharmacol.68(4) , 1018–1030 (2005).
  • Fang M , ChenD, YangCS: Dietary polyphenols may affect DNA methylation.J. Nutr.137(Suppl. 1) , 223S–228S (2007).
  • Lambert JD , LeeMJ, DiamondLet al.: Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues.Drug Metab. Dispos.34(1) , 8–11 (2006).
  • Adlercreutz H , MazurW: Phyto-oestrogens and Western diseases.Ann. Med.29(2) , 95–120 (1997).
  • Qin W , ZhuW, ShiHet al.: Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women.Nutr. Cancer61(2) , 238–244 (2009).
  • Li Y , LiuL, AndrewsLG, TollefsbolTO: Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms.Int. J. Cancer125(2) , 286–296 (2009).
  • Cross HS , KallayE, LechnerD, GerdenitschW, AdlercreutzH, ArmbrechtHJ: Phytoestrogens and vitamin D metabolism: a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas.J. Nutr.134(5) , 1207S–1212S (2004).
  • Xiang N , ZhaoR, SongG, ZhongW: Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells.Carcinogenesis29(11) , 2175–2181 (2008).
  • Davis CD , MilnerJ: Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention.Mutat. Res.551(1–2) , 51–64 (2004).
  • Huang S : Histone methyltransferases, diet nutrients and tumour suppressors.Nat. Rev. Cancer2(6) , 469–476 (2002).
  • Davis CD , UthusEO: DNA methylation, cancer susceptibility, and nutrient interactions.Exp. Biol. Med. (Maywood)229(10) , 988–995 (2004).
  • Cox R , GoorhaS: A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of Friend erythroleukemic cells.Carcinogenesis7(12) , 2015–2018 (1986).
  • Fiala ES , StaretzME, PandyaGA, El-BayoumyK, HamiltonSR: Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation.Carcinogenesis19(4) , 597–604 (1998).
  • Davis CD , UthusEO: Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells.J. Nutr.132(2) , 292–297 (2002).
  • Davis CD , UthusEO, FinleyJW: Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon.J. Nutr.130(12) , 2903–2909 (2000).
  • Gastaldelli A , BastaG: Ectopic fat and cardiovascular disease: what is the link?Nutr. Metab. Cardiovasc. Dis.20(7) , 481–490 (2010).
  • Allender S , RaynerM: The burden of overweight and obesity-related ill health in the UK.Obes. Rev.8(5) , 467–473 (2007).
  • Klein S , AllisonDB, HeymsfieldSBet al.: Waist circumference and cardiometabolic risk: a consensus statement from Shaping America‘s Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.Obesity (Silver Spring)15(5) , 1061–1067 (2007).
  • Lomba A , MilagroFI, Garcia-DiazDF, MartiA, CampionJ, MartinezJA: Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis.Lipids Health Dis.9 , 60 (2010).
  • Campion J , MilagroFI, MartinezJA: Individuality and epigenetics in obesity.Obes. Rev.10(4) , 383–392 (2009).
  • Zhang FF , CardarelliR, CarrollJet al.: Physical activity and global genomic DNA methylation in a cancer-free population.Epigenetics6(3) , 293–299 (2011).
  • Schulz WA , SteinhoffC, FlorlAR: Methylation of endogenous human retroelements in health and disease.Curr. Top. Microbiol. Immunol.310 , 211–250 (2006).
  • Baccarelli A , WrightR, BollatiVet al.: Ischemic heart disease and stroke in relation to blood DNA methylation.Epidemiology21(6) , 819–828 (2010).
  • Mcgee SL , FairlieE, GarnhamAP, HargreavesM: Exercise-induced histone modifications in human skeletal muscle.J. Physiol.587(Pt 24) , 5951–5958 (2009).
  • Radom-Aizik S , ZaldivarF Jr, Oliver S, Galassetti P, Cooper DM: Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes. J. Appl. Physiol.109(1) , 252–261 (2010).
  • Tommasi S , KimSI, ZhongX, WuX, PfeiferGP, BesaratiniaA: Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells.PLoS ONE5(5) , e10594 (2010).
  • Marwick JA , KirkhamPA, StevensonCSet al.: Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.Am. J. Respir. Cell Mol. Biol.31(6) , 633–642 (2004).
  • Van Den Broeck A , BrambillaE, Moro-SibilotDet al.: Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer.Clin. Cancer Res.14(22) , 7237–7245 (2008).
  • Toyooka S , TokumoM, ShigematsuHet al.: Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.Cancer Res.66(3) , 1371–1375 (2006).
  • Liu F , KillianJK, YangMet al.: Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.Oncogene29(25) , 3650–3664 (2010).
  • Woodson K , MasonJ, ChoiSWet al.: Hypomethylation of p53 in peripheral blood DNA is associated with the development of lung cancer.Cancer Epidemiol. Biomarkers Prev.10(1) , 69–74 (2001).
  • Pogribny IP , BasnakianAG, MillerBJ, LopatinaNG, PoirierLA, JamesSJ: Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.Cancer Res.55(9) , 1894–1901 (1995).
  • Kim YI , PogribnyIP, BasnakianAGet al.: Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.Am. J. Clin. Nutr.65(1) , 46–52 (1997).
  • Breton CV , ByunHM, WentenM, PanF, YangA, GillilandFD: Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.Am. J. Respir. Crit. Care Med.180(5) , 462–467 (2009).
  • Pineles BL , RomeroR, MontenegroDet al.: Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia.Am. J. Obstet. Gynecol.196(3) , e261–e266 (2007).
  • Maccani MA , Avissar-WhitingM, BanisterCE, McGonnigalB, PadburyJF, MarsitCJ: Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21 and miR-146a in the placenta.Epigenetics5(7) , 583–589 (2010).
  • Izzotti A , LargheroP, LongobardiMet al.: Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung.Mutat Res. (2010) (Epub ahead of print).
  • Irigaray P , NewbyJA, ClappRet al.: Lifestyle-related factors and environmental agents causing cancer: an overview.Biomed. Pharmacother.61(10) , 640–658 (2007).
  • Van Engeland M , WeijenbergMP, RoemenGMet al.: Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer.Cancer Res.63(12) , 3133–3137 (2003).
  • De Vogel S , BongaertsBW, WoutersKAet al.: Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.Carcinogenesis29(9) , 1765–1773 (2008).
  • Hou L , WangH, SartoriSet al.: Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population.Int. J. Cancer127(8) , 1866–1874 (2010).
  • Marutha Ravindran CR , TickuMK: Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice.Brain Res. Mol. Brain Res.121(1–2) , 19–27 (2004).
  • Marutha Ravindran CR , TickuMK: Role of CpG islands in the up-regulation of NMDA receptor NR2B gene expression following chronic ethanol treatment of cultured cortical neurons of mice.Neurochem. Int.46(4) , 313–327 (2005).
  • Hicks SD , MiddletonFA, MillerMW: Ethanol-induced methylation of cell cycle genes in neural stem cells.J. Neurochem.114(6) , 1767–1780 (2010).
  • Liu Y , BalaramanY, WangG, NephewKP, ZhouFC: Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.Epigenetics4(7) , 500–511 (2009).
  • Zhou FC , ZhaoQ, LiuYet al.: Alteration of gene expression by alcohol exposure at early neurulation.BMC Genomics12 , 124–140 (2001).
  • Bollati V , BaccarelliA: Environmental epigenetics.Heredity105(1) , 105–112 (2010).
  • Baccarelli A , BollatiV: Epigenetics and environmental chemicals.Curr. Opin. Pediatr.21(2) , 243–251 (2009).
  • Chanda S , DasguptaUB, GuhamazumderDet al.: DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy.Toxicol. Sci.89(2) , 431–437 (2006).
  • Pilsner JR , LiuX, AhsanHet al.: Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults.Am. J. Clin. Nutr.86(4) , 1179–1186 (2007).
  • Pilsner JR , LiuX, AhsanHet al.: Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions.Environ. Health Perspect.117(2) , 254–260 (2009).
  • Baccarelli A , CassanoPA, LitonjuaAet al.: Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms.Circulation117(14) , 1802–1809 (2008).
  • Brook RD , FranklinB, CascioWet al.: Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.Circulation109(21) , 2655–2671 (2004).
  • Peters A : Particulate matter and heart disease: evidence from epidemiological studies.Toxicol. Appl. Pharmacol.207(Suppl. 2) , 477–482 (2005).
  • Samet JM , DominiciF, CurrieroFC, CoursacI, ZegerSL: Fine particulate air pollution and mortality in 20 U.S. cities, 1987–1994.N. Engl. J. Med.343(24) , 1742–1749 (2000).
  • Vineis P , Husgafvel-PursiainenK: Air pollution and cancer: biomarker studies in human populations.Carcinogenesis26(11) , 1846–1855 (2005).
  • Tarantini L , BonziniM, ApostoliPet al.: Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation.Environ. Health Perspect.117(2) , 217–222 (2009).
  • Alexeeff SE , LitonjuaAA, WrightROet al.: Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging study.Occup. Environ. Med.65(11) , 736–742 (2008).
  • Baccarelli A , ZanobettiA, MartinelliIet al.: Air pollution, smoking, and plasma homocysteine.Environ. Health Perspect.115(2) , 176–181 (2007).
  • Chahine T , BaccarelliA, LitonjuaAet al.: Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort.Environ. Health Perspect.115(11) , 1617–1622 (2007).
  • Ehrlich M : DNA hypomethylation in cancer cells.Epigenomics1(2) , 239–259 (2009).
  • Castro R , RiveraI, StruysEAet al.: Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease.Clin. Chem.49(8) , 1292–1296 (2003).
  • Bollati V , MarinelliB, ApostoliPet al.: Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes.Environ. Health Perspect.118(6) , 763–768 (2010).
  • Snyder R : Benzene and leukemia.Crit. Rev. Toxicol.32(3) , 155–210 (2002).
  • Bollati V , BaccarelliA, HouLet al.: Changes in DNA methylation patterns in subjects exposed to low-dose benzene.Cancer Res.67(3) , 876–880 (2007).
  • Costantini AS , BenvenutiA, VineisPet al.: Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: evidence from the Italian multicenter case–control study.Am. J. Ind. Med.51(11) , 803–811 (2008).
  • Kirkeleit J , RiiseT, BratveitM, MoenBE: Increased risk of acute myelogenous leukemia and multiple myeloma in a historical cohort of upstream petroleum workers exposed to crude oil.Cancer Causes Control19(1) , 13–23 (2008).
  • Ji Z , ZhangL, PengV, RenX, McHaleCM, SmithMT: A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide.Leukemia24(5) , 986–991 (2010).
  • Pavanello S , BollatiV, PesatoriACet al.: Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals.Int. J. Cancer125(7) , 1692–1697 (2009).
  • Perera F , TangWY, HerbstmanJet al.: Relation of DNA methylation of 5´-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.PLoS ONE4(2) , e4488 (2009).
  • Rusiecki JA , BaccarelliA, BollatiV, TarantiniL, MooreLE, Bonefeld-JorgensenEC: Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit.Environ. Health Perspect.116(11) , 1547–1552 (2008).
  • Jirtle RL , SkinnerMK: Environmental epigenomics and disease susceptibility.Nat. Rev. Genet.8(4) , 253–262 (2007).
  • Miller CA , SweattJD: Covalent modification of DNA regulates memory formation.Neuron53(6) , 857–869 (2007).
  • Szyf M , McGowanP, MeaneyMJ: The social environment and the epigenome.Environ. Mol. Mutagen.49(1) , 46–60 (2008).
  • Miller CA , GavinCF, WhiteJAet al.: Cortical DNA methylation maintains remote memory.Nat. Neurosci.13(6) , 664–666 (2010).
  • Murgatroyd C , PatchevAV, WuYet al.: Dynamic DNA methylation programs persistent adverse effects of early-life stress.Nat. Neurosci.12(12) , 1559–1566 (2009).
  • McGowan PO , SasakiA, D‘AlessioACet al.: Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.Nat. Neurosci.12(3) , 342–348 (2009).
  • Weaver IC : Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let‘s call the whole thing off.Epigenetics2(1) , 22–28 (2007).
  • Weaver IC , CervoniN, ChampagneFAet al.: Epigenetic programming by maternal behavior.Nat. Neurosci.7(8) , 847–854 (2004).
  • Nakahata Y , GrimaldiB, SaharS, HirayamaJ, Sassone-CorsiP: Signaling to the circadian clock: plasticity by chromatin remodeling.Curr. Opin. Cell Biol.19(2) , 230–237 (2007).
  • Hirayama J , SaharS, GrimaldiBet al.: CLOCK-mediated acetylation of BMAL1 controls circadian function.Nature450(7172) , 1086–1090 (2007).
  • Grimaldi B , NakahataY, KaluzovaM, MasubuchiS, Sassone-CorsiP: Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1.Int. J. Biochem. Cell Biol.41(1) , 81–86 (2009).
  • Costa G : The problem: shiftwork.Chronobiol. Int.14(2) , 89–98 (1997).
  • Zhu Y , ZhengT, StevensRG, ZhangY, BoyleP: Does ‘clock‘ matter in prostate cancer?Cancer Epidemiol. Biomarkers Prev.15(1) , 3–5 (2006).
  • Sahar S , Sassone-CorsiP: Circadian clock and breast cancer: a molecular link.Cell Cycle6(11) , 1329–1331 (2007).
  • Bollati V , BaccarelliA, SartoriSet al.: Epigenetic effects of shiftwork on blood DNA methylation.Chronobiol. Int.27(5) , 1093–1104 (2010).
  • Morgan DK , WhitelawE: The case for transgenerational epigenetic inheritance in humans.Mamm. Genome19(6) , 394–397 (2008).
  • Chao MJ , RamagopalanSV, HerreraBMet al.: Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex.Hum. Mol. Genet.18(2) , 261–266 (2009).
  • Daxinger L , WhitelawE: Transgenerational epigenetic inheritance: more questions than answers.Genome Res.20(12) , 1623–1628 (2010).
  • Nelson VR , NadeauJH: Transgenerational genetic effects.Epigenomics2(6) , 797–806 (2010).
  • Skinner MK , Guerrero-BosagnaC: Environmental signals and transgenerational epigenetics.Epigenomics1(1) , 111–117 (2009).
  • Skinner MK , ManikkamM, Guerrero-BosagnaC: Epigenetic transgenerational actions of environmental factors in disease etiology.Trends Endocrinol. Metab.21(4) , 214–222 (2010).

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