Role of miR-224 in Hepatocellular Carcinoma: A Tool for Possible Therapeutic Intervention?

• Parkin DM , BrayF, FerlayJ, PisaniP: Global cancer statistics, 2002.CA Cancer J. Clin.55 , 74–108 (2005).
   PubMed Web of Science ®Google Scholar
• Johnson PJ : Hepatocellular carcinoma: is current therapy really altering outcome?Gut51 , 459–462 (2002).
   PubMed Web of Science ®Google Scholar
• Lee RC , FeinbaumRL, AmbrosV: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.Cell75 , 843–854 (1993).
   PubMed Web of Science ®Google Scholar
• Sullivan CS , GrundhoffA, TevethiaSet al.: Expression and function of microRNAs in viruses great and small.Cold Spring Harb. Symp. Quant. Biol.71 , 351–356 (2006).
   PubMedGoogle Scholar
• Mallory AC ,Vaucheret H: Functions of microRNAs and related small RNAs in plants. Nat. Genet.38Suppl , S31–S36 (2006).
   PubMed Web of Science ®Google Scholar
• Stefani G ,Slack FJ: Small noncoding RNAs in animal development. Nat. Rev. Mol. Cell Biol.9 , 219–230 (2008).
   PubMed Web of Science ®Google Scholar
• Griffiths-Jones S : The microRNA Registry.Nucleic Acids Res.32 , D109–D111 (2004).
   PubMed Web of Science ®Google Scholar
• Griffiths-Jones S , GrocockRJ, Van Dongen S, Bateman A, Enright AJ: miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res.34 , D140–D144 (2006).
   PubMed Web of Science ®Google Scholar
• Griffiths-Jones S , SainiHK, Van Dongen S, Enright AJ: miRBase: tools for microRNA genomics. Nucleic Acids Res.36 , D154–D158 (2008).
   PubMed Web of Science ®Google Scholar
• Murakami Y , YasudaT, SaigoKet al.: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.Oncogene25 , 2537–2545 (2006).
   PubMed Web of Science ®Google Scholar
• Gramantieri L , FerracinM, FornariFet al.: Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma.Cancer Res.67 , 6092–6099 (2007).
   PubMed Web of Science ®Google Scholar
• Meng F , HensonR, Wehbe-JanekHet al.: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.Gastroenterology133 , 647–658 (2007).
   PubMed Web of Science ®Google Scholar
• Huang YS , DaiY, YuXFet al.: Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis.J. Gastroenterol. Hepatol.23 , 87–94 (2008).
   PubMed Web of Science ®Google Scholar
• Wang Y , LeeAT, MaJZet al.: Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.J. Biol. Chem.283(19) , 13205–13215 (2008).
   PubMed Web of Science ®Google Scholar
• Jiang J , GusevY, AdercaIet al.: Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.Clin. Cancer Res.14 , 419–427 (2008).
   PubMed Web of Science ®Google Scholar
• Varnholt H , DrebberU, SchulzeFet al.: MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma.Hepatology47 , 1223–1232 (2008).
   PubMed Web of Science ®Google Scholar
• Ladeiro Y , CouchyG, BalabaudCet al.: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations.Hepatology47 , 1955–1963 (2008).
   PubMed Web of Science ®Google Scholar
• Connolly E , MelegariM, LandgrafPet al.: Elevated expression of the miR-17–92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.Am. J. Pathol.173 , 856–864 (2008).
   PubMed Web of Science ®Google Scholar
• Su H , YangJR, XuTet al.: MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity.Cancer Res.69 , 1135–1142 (2009).
   PubMed Web of Science ®Google Scholar
• Huang XH , WangQ, ChenJSet al.: Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated.Hepatol. Res.39 , 786–794 (2009).
   PubMed Web of Science ®Google Scholar
• Ura S , HondaM, YamashitaTet al.: Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma.Hepatology49 , 1098–1112 (2009).
   PubMed Web of Science ®Google Scholar
• Pineau P , VoliniaS, McjunkinKet al.: miR-221 overexpression contributes to liver tumorigenesis.Proc. Natl Acad. Sci. USA107 , 264–269 (2010).
   PubMed Web of Science ®Google Scholar
• Wong QW , ChingAK, ChanAWet al.: MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling.Clin. Cancer Res.16 , 867–875 (2010).
   PubMed Web of Science ®Google Scholar
• Varnholt H : The role of microRNAs in primary liver cancer.Ann Hepatol.7 , 104–113 (2008).
   PubMed Web of Science ®Google Scholar
• Volinia S , CalinGA, LiuCGet al.: A microRNA expression signature of human solid tumors defines cancer gene targets.Proc. Natl Acad. Sci. USA103 , 2257–2561 (2006).
   PubMed Web of Science ®Google Scholar
• Selcuklu SD , DonoghueMT, SpillaneC: miR-21 as a key regulator of oncogenic processes.Biochem. Soc. Trans.37 , 918–925 (2009).
   PubMed Web of Science ®Google Scholar
• Galardi S , MercatelliN, GiordaEet al.: miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.J. Biol. Chem.282 , 23716–24 (2007).
   PubMed Web of Science ®Google Scholar
• Garofalo M , Di Leva G, Romano G et al.: miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell16 , 498–509 (2009).
   PubMed Web of Science ®Google Scholar
• Esau C , DavisS, MurraySFet al.: miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.Cell Metab.3 , 87–98 (2006).
   PubMed Web of Science ®Google Scholar
• Coulouarn C , FactorVM, AndersenJB, DurkinME, ThorgeirssonSS: Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.Oncogene28 , 3526–3536 (2009).
   PubMed Web of Science ®Google Scholar
• Xiao F , ZuoZ, CaiGet al.: miRecords: an integrated resource for microRNA-target interactions.Nucleic Acids Res.37 , D105–D110 (2009).
   PubMed Web of Science ®Google Scholar
• Li Q , WangG, ShanJLet al.: MicroRNA-224 is upregulated in HepG2 cells and involved in cellular migration and invasion.J. Gastroenterol. Hepatol.25 , 164–171 (2010).
   PubMed Web of Science ®Google Scholar
• Yao G , YinM, LianJet al.: MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.Mol. Endocrinol.24 , 540–551 (2010).
   PubMedGoogle Scholar
• Lowe SW , LinAW: Apoptosis in cancer.Carcinogenesis21 , 485–495 (2000).
   PubMed Web of Science ®Google Scholar
• Evan G , LittlewoodT: A matter of life and cell death.Science281 , 1317–1322 (1998).
   PubMed Web of Science ®Google Scholar
• Hsu PP , SabatiniDM: Cancer cell metabolism: Warburg and beyond.Cell134 , 703–7 (2008).
   PubMed Web of Science ®Google Scholar
• Chiaradonna F , SaccoE, ManzoniRet al.: Ras-dependent carbon metabolism and transformation in mouse fibroblasts.Oncogene25 , 5391–5404 (2006).
   PubMed Web of Science ®Google Scholar
• Dang CV : MYC, microRNAs and glutamine addiction in cancers.Cell Cycle8 , 3243–3245 (2009).
   PubMed Web of Science ®Google Scholar
• Li X , ShenY, IchikawaH, AntesT, GoldbergGS: Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration.Oncogene28 , 4272–4283 (2009).
   PubMed Web of Science ®Google Scholar
• Wang Y , LuY, TohSTet al.: Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3.J. Hepatol.53 , 57–66 (2010).
   PubMed Web of Science ®Google Scholar
• Sanlaville D , Schluth-BolardC, TurleauC: Distal Xq duplication and functional Xq disomy.Orphanet. J. Rare Dis.4 , 4 (2009).
   PubMed Web of Science ®Google Scholar
• Ramocki MB , TavyevYJ, PetersSU: The MECP2 duplication syndrome.Am. J. Med. Genet. A.152A , 1079–1088 (2010).
   PubMed Web of Science ®Google Scholar
• Simpson AJ , CaballeroOL, JungbluthA, ChenYT, OldLJ: Cancer/testis antigens, gametogenesis and cancer.Nat. Rev. Cancer5 , 615–625 (2005).
   PubMed Web of Science ®Google Scholar
• Wurmbach E , ChenYB, KhitrovGet al.: Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma.Hepatology45 , 938–947 (2007).
   PubMed Web of Science ®Google Scholar
• Fu XY , WangHY, TanLet al.: Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.World J. Gastroenterol.8 , 638–643 (2002).
   PubMed Web of Science ®Google Scholar
• Zhu L , YeZ, ChengK, MillerDD, MahatoRI: Site-specific delivery of oligonucleotides to hepatocytes after systemic administration.Bioconjug. Chem.19 , 290–298 (2008).
   PubMed Web of Science ®Google Scholar
• Hrzenjak A , MoinfarF, KremserMLet al.: Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.Mol. Cancer9 , 49 (2010).
   PubMed Web of Science ®Google Scholar
• Steel LF , ShumpertD, TrotterMet al.: A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.Proteomics3 , 601–609 (2003).
   PubMed Web of Science ®Google Scholar
• Gilad S , MeiriE, YogevYet al.: Serum microRNAs are promising novel biomarkers.PLoS ONE3 , e3148 (2008).
   PubMed Web of Science ®Google Scholar
• Wang Y , LeeCG: MicroRNA and cancer – focus on apoptosis.J. Cell Mol. Med.13 , 12–23 (2009).
   PubMed Web of Science ®Google Scholar
• He H , JazdzewskiK, LiWet al.: The role of microRNA genes in papillary thyroid carcinoma.Proc. Natl Acad. Sci. USA102 , 19075–19080 (2005).
   PubMed Web of Science ®Google Scholar
• Gui J , TianY, WenXet al.: Serum microRNA characterization identifies miR-885–5p as a potential marker for detecting liver pathologies.Clin. Sci.120(5) , 183–193 (2010).
   Web of Science ®Google Scholar

▪ Websites

• Boyle P, Levin B: World Cancer Report 2008. International Agency for Research on Cancer (2008) http://apps.who.int/bookorders/anglais/detart1.jsp?sesslan=1&codlan=1&codcol=76&codcch=26
   Google Scholar
• Generic Gene Ontology (GO) Term Mapper http://go.princeton.edu/cgi-bin/GOTermMapper
   Google Scholar