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Editorial

The Hunt for 5-Hydroxymethylcytosine: The Sixth Base

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Pages 521-523 | Published online: 13 Oct 2011

Bibliography

  • Kriaucionis S , HeintzN. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science324(5929) , 929–930 (2009).
  • Tahiliani M , KohKP, ShenYet al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929) , 930–935 (2009).
  • Munzel M , GlobischD, BrucklTet al. Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew. Chem. Int. Ed. Engl. 49(31) , 5375–5377 (2010).
  • Jin SG , WuX, LiAX, PfeiferGP. Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res.39(12) , 5015–5024 (2011).
  • Wu H , D‘AlessioAC, ItoSet al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 25(7) , 679–684 (2011).
  • Williams K , ChristensenJ, PedersenMTet al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 473(7347) , 343–348 (2011).
  • Ficz G , BrancoMR, SeisenbergerSet al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 473(7347) , 398–402 (2011).
  • Pastor WA , PapeUJ, HuangYet al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473(7347) , 394–397 (2011).
  • Höbartner C . Enzymatic Labeling of 5-hydroxymethylcytosine in DNA. Angew. Chem. Int. Ed.50(19) , 4268–4270 (2011).
  • Szwagierczak A , BultmannS, SchmidtCS, SpadaF, LeonhardtH. Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res.38(19) , e181 (2010).
  • Song C -X, Szulwach KE, Fu Y et al. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol.29(1) , 68–72 (2011).
  • Ko M , HuangY, JankowskaAMet al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468(7325) , 839–843 (2010).
  • Song C -X, Sun Y, Dai Q et al. Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage β-glucosyltransferase. Chembiochem.12(11) , 1682–1685 (2011).
  • Robertson AB , DahlJA, VagboCBet al. A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res. 39(8) , e55 (2011).
  • Liutkevičiūtė Z , KriukienėE, GrigaitytėI, MasevičiusV, KlimašauskasS. Methyltransferase-directed derivatization of 5-hydroxymethylcytosine in DNA. Angew. Chem. Int. Ed.50(9) , 2090–2093 (2011).
  • Flusberg BA , WebsterDR, LeeJHet al. Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat. Methods. 7(6) , 461–465 (2010).
  • Wanunu M , Cohen-KarniD, JohnsonRRet al. Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules. J. Am. Chem. Soc. 133(3) , 486–492 (2010).
  • Huang Y , PastorWA, ShenYet al. The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS ONE 5(1) , e8888 (2010).
  • Song C -X, Yu M, Dai Q, He C. Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(α) I. Bioorg. Med. Chem. Lett.21(17) , 5075–5077 (2011).
  • Munzel M , GlobischD, CarellT. 5-hydroxymethylcytosine, the sixth base of the genome. Angew. Chem. Int. Ed. Engl.50(29) , 6460–6468 (2011).

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