69
Views
0
CrossRef citations to date
0
Altmetric
Perspective

Blood Chromatin as a Biosensor of the Epigenetic Milieu: A Tool for Studies in Living Psychiatric Patients

Pages 551-559 | Published online: 06 Nov 2012

References

  • Sims RJ 3rd, Nishioka K, Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet.19(11) , 629–639 (2003).
  • Gavin DP , KartanS, ChaseKA, JayaramanS, SharmaRP. Histone deacetylase inhibitors and candidate gene expression: an in vivo and in vitro approach to studying chromatin remodeling in a clinical population. J. Psychiatr. Res.43(9) , 870–876 (2009).
  • Gavin DP , RosenC, ChaseKA, GraysonDR, SharmaRP. Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. J. Psychiatr. Neurosci.34(3) , 232–237 (2009).
  • Gavin DP , KartanS, ChaseKA, GraysonDR, SharmaRP. Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophr. Res.103(1–3) , 330–332 (2008).
  • Sharma RP , RosenC, KartanSet al. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophr. Res. 88(1–3) , 227–231 (2006).
  • Wang Z , ZangC, RosenfeldJAet al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat. Genet. 40(7) , 897–903 (2008).
  • Barski A , CuddapahS, CuiKet al. High-resolution profiling of histone methylations in the human genome. Cell 129(4) , 823–837 (2007).
  • Maze I , CovingtonHE 3rd, Dietz DM et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science327(5962) , 213–216 (2010).
  • Schaefer A , SampathSC, IntratorAet al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron 64(5) , 678–691 (2009).
  • Sharma RP , GavinDP, ChaseKA. Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illness. Pharmacogenomics J. doi:10.1038/tpj.2011.64 (2012) (Epub ahead of print).
  • Rahman I , MarwickJ, KirkhamP. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression. Biochem. Pharmacol.68(6) , 1255–1267 (2004).
  • Takizawa N , WatanabeK, NounoK, KobayashiN, NagataK. Association of functional influenza viral proteins and RNAs with nuclear chromatin and sub-chromatin structure. Microbes Infect.8(3) , 823–833 (2006).
  • Jones DR , DivechaN. Linking lipids to chromatin. Curr. Opin Genet. Dev.14(2) , 196–202 (2004).
  • Tsankova N , RenthalW, KumarA, NestlerEJ. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci.8(5) , 355–367 (2007).
  • Pandey SC , UgaleR, ZhangH, TangL, PrakashA. Brain chromatin remodeling: a novel mechanism of alcoholism. J. Neurosci.28(14) , 3729–3737 (2008).
  • Levine A , HuangY, DrisaldiBet al. Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Sci. Transl Med. 3(107) , 107ra109 (2011).
  • Aoyagi S , ArcherTK. Dynamic histone acetylation/deacetylation with progesterone receptor-mediated transcription. Mol. Endocrinol.21(4) , 843–856 (2007).
  • Sun JM , ChenHY, DavieJR. Effect of estradiol on histone acetylation dynamics in human breast cancer cells. J. Biol. Chem.276(52) , 49435–49442 (2001).
  • McKenna NJ , O‘MalleyBW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell108(4) , 465–474 (2002).
  • Sharma RP . Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics. Schizophr. Res.72(2–3) , 79–90 (2005).
  • Kirillova GP , HrutkayRJ, ShurinMRet al. Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays. J. Neurosci. Methods 174(2) , 272–280 (2008).
  • Vile JM , StrangePG. High-affinity binding sites for neuroleptic drugs in human peripheral blood lymphocytes and their relation to dopamine receptors. A long-standing controversy. Biochem. Pharmacol.49(6) , 747–753 (1995).
  • Vetoshkin AV , FomenkoAM, ZozuliaAA. Lymphocyte serotonin receptors: a radioreceptor study. Biull. Eksp Biol. Med.94(7) , 52–53 (1982).
  • Kohm AP , SandersVM. Norepinephrine: a messenger from the brain to the immune system. Immunol. Today21(11) , 539–542 (2000).
  • Marazziti D , Catena Dell‘osso M et al. Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. Psychiatry Res.175(1–2) , 54–57 (2010).
  • Fujii T , Takada-TakatoriY, KawashimaK. Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J. Pharmacol. Sci.106(2) , 186–192 (2008).
  • Mehrishi JN , MillsIH. Opiate receptors on lymphocytes and platelets in man. Clin. Immunol. Immunopathol.27(2) , 240–249 (1983).
  • Guidotti A , DongE, KundakovicMet al. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol. Sci. 30(2) , 55–60 (2009).
  • Fischer A , SananbenesiF, WangX, DobbinM, TsaiLH. Recovery of learning and memory is associated with chromatin remodelling. Nature447(7141) , 178–182 (2007).
  • Korzus E , RosenfeldMG, MayfordM. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron42(6) , 961–972 (2004).
  • Hsieh J , GageFH. Epigenetic control of neural stem cell fate. Curr. Opin Genet. Dev.14(5) , 461–469 (2004).
  • Martinowich K , HattoriD, WuHet al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302(5646) , 890–893 (2003).
  • Caron H , van Schaik B, van der Mee M et al. The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science291(5507) , 1289–1292 (2001).
  • Versteeg R , van Schaik BD, van Batenburg MF et al. The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res.13(9) , 1998–2004 (2003).
  • Middleton FA , PatoCN, GentileKLet al. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am. J. Med. Genet. B Neuropsychiatr. Genet. 136B(1) , 12–25 (2005).
  • Sullivan PF , FanC, PerouCM. Evaluating the comparability of gene expression in blood and brain. Am. J. Med. Genet. B Neuropsychiatr. Genet.141B(3) , 261–268 (2006).
  • Guidotti A , AutaJ, ChenYet al. Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropharmacology 60(7–8) , 1007–1016 (2011).
  • Cheung I , ShulhaHP, JiangYet al. Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc. Natl Acad. Sci. USA 107(19) , 8824–8829 (2010).
  • Wen B , WuH, ShinkaiY, IrizarryRA, FeinbergAP. Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat. Genet.41(2) , 246–250 (2009).
  • Lee SA , TsaoTT, YangKCet al. Construction and analysis of the protein–protein interaction networks for schizophrenia, bipolar disorder, and major depression. BMC Bioinformatics 12(Suppl. 13) , S20 (2011).
  • Shelton RC , ClaiborneJ, Sidoryk-WegrzynowiczMet al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol. Psychiatry 16(7) , 751–762 (2011).
  • Garbett K , Gal-ChisR, GasznerG, LewisDA, MirnicsK. Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacol. Hung.10(1) , 9–14 (2008).
  • Arion D , UngerT, LewisDA, LevittP, MirnicsK. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol. Psychiatry62(7) , 711–721 (2007).
  • Tang B , CapitaoC, DeanB, ThomasEA. Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. Psychiatry Res.196(2–3) , 201–206 (2012).
  • Issidorides MR , StefanisCN, VarsouE, KatsorchisT. Altered chromatin ultrastructure in neutrophils of schizophrenics. Nature258(5536) , 612–614 (1975).
  • Stefanis CN , IssidoridesMR. Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment. Biol. Psychiatry11(1) , 53–68 (1976).
  • Kosower NS , GeradL, GoldsteinMet al. Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia. Am. J. Med. Genet. 60(2) , 133–138 (1995).
  • Kloukina-Pantazidou I , HavakiS, Chrysanthou-PiterouMet al. Chromatin alterations in leukocytes of first-episode schizophrenic patients. Ultrastruct. Pathol. 34(3) , 106–116 (2010).
  • Fraga MF , BallestarE, PazMFet al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102(30) , 10604–10609 (2005).
  • Mill J , DempsterE, CaspiAet al. Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B(4) , 421–425 (2006).
  • Kuratomi G , IwamotoK, BundoMet al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol. Psychiatry 13(4) , 429–441 (2008).
  • Petronis A , GottesmanII, KanPet al. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr. Bull. 29(1) , 169–178 (2003).
  • Tsujita T , NiikawaN, YamashitaHet al. Genomic discordance between monozygotic twins discordant for schizophrenia. Am. J. Psychiatry 155(3) , 422–424 (1998).
  • de Ruijter AJ , van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J.370(3) , 737–749 (2003).
  • Dangond F , GullansSR. Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. Biochem. Biophys. Res. Commun.247(3) , 833–837 (1998).
  • Migliore M , ShepherdGM. Opinion: an integrated approach to classifying neuronal phenotypes. Nat. Rev. Neurosci.6(10) , 810–818 (2005).
  • Rohlfing CL , WiedmeyerHM, LittleRR, EnglandJD, TennillA, GoldsteinDE. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care25(2) , 275–278 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.